UniProtKB - Q7YRN2 (CD3E_PIG)
T-cell surface glycoprotein CD3 epsilon chain
CD3E
Functioni
GO - Molecular functioni
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- cell surface receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell surface glycoprotein CD3 epsilon chainAlternative name(s): CD_antigen: CD3e |
Gene namesi | Name:CD3E |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 116 | ExtracellularSequence analysisAdd BLAST | 95 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 138 – 196 | CytoplasmicSequence analysisAdd BLAST | 59 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000014610 | 22 – 196 | T-cell surface glycoprotein CD3 epsilon chainAdd BLAST | 175 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 91 | PROSITE-ProRule annotation | ||
Modified residuei | 177 | PhosphotyrosinePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 188 | PhosphotyrosinePROSITE-ProRule annotationBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
PaxDbi | Q7YRN2 |
PeptideAtlasi | Q7YRN2 |
Interactioni
Subunit structurei
The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
Interacts with CD6.
Interacts with NCK1.
Interacts with NUMB; this interaction is important for TCR-CD3 internalization and subsequent degradation.
By similarityProtein-protein interaction databases
STRINGi | 9823.ENSSSCP00000016015 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 102 | Ig-likeAdd BLAST | 75 | |
Domaini | 167 – 194 | ITAMPROSITE-ProRule annotationAdd BLAST | 28 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 164 – 181 | NUMB-binding regionBy similarityAdd BLAST | 18 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S8KB, Eukaryota |
InParanoidi | Q7YRN2 |
OrthoDBi | 1362562at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015484, CD3_esu/gsu/dsu IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003598, Ig_sub2 IPR003110, Phos_immunorcpt_sig_ITAM |
PANTHERi | PTHR10570, PTHR10570, 1 hit |
Pfami | View protein in Pfam PF02189, ITAM, 1 hit |
SMARTi | View protein in SMART SM00408, IGc2, 1 hit SM00077, ITAM, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51055, ITAM_1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MPSGNLWKVL GLCLLSVGAW GQEDIERPDE DTQKTFKVSI SGDKVELTCP
60 70 80 90 100
EDPESEKMTW KRNDMQIYES YDNYMLLESF SEVENSGYYT CTVGEKTSHR
110 120 130 140 150
LYLKARVCEN CVEVDLMAVV TIIVVDICIT LGLLMVVYYY SKSRKAKAMP
160 170 180 190
VTRGAGAGGR PRGQNRERPP PVPNPDYEPI RKGQRDLYSG LNQRGR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY323829 mRNA Translation: AAP85530.1 |
RefSeqi | NP_999392.1, NM_214227.1 |
Genome annotation databases
GeneIDi | 397455 |
KEGGi | ssc:397455 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY323829 mRNA Translation: AAP85530.1 |
RefSeqi | NP_999392.1, NM_214227.1 |
3D structure databases
SMRi | Q7YRN2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000016015 |
Proteomic databases
PaxDbi | Q7YRN2 |
PeptideAtlasi | Q7YRN2 |
Genome annotation databases
GeneIDi | 397455 |
KEGGi | ssc:397455 |
Organism-specific databases
CTDi | 916 |
Phylogenomic databases
eggNOGi | ENOG502S8KB, Eukaryota |
InParanoidi | Q7YRN2 |
OrthoDBi | 1362562at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015484, CD3_esu/gsu/dsu IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003598, Ig_sub2 IPR003110, Phos_immunorcpt_sig_ITAM |
PANTHERi | PTHR10570, PTHR10570, 1 hit |
Pfami | View protein in Pfam PF02189, ITAM, 1 hit |
SMARTi | View protein in SMART SM00408, IGc2, 1 hit SM00077, ITAM, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51055, ITAM_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD3E_PIG | |
Accessioni | Q7YRN2Primary (citable) accession number: Q7YRN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |