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Entry version 64 (11 Dec 2019)
Sequence version 1 (01 Oct 2003)
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Protein

Mediator of RNA polymerase II transcription subunit 12

Gene

MED12

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 12
Alternative name(s):
Mediator complex subunit 12
Trinucleotide repeat-containing gene 11 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED12
Synonyms:TNRC11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPan troglodytes (Chimpanzee)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9598 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002277 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003129581 – 2027Mediator of RNA polymerase II transcription subunit 12Add BLAST2027

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13PhosphotyrosineBy similarity1
Modified residuei482PhosphoserineBy similarity1
Modified residuei512PhosphoserineBy similarity1
Modified residuei545PhosphoserineBy similarity1
Modified residuei547PhosphoserineBy similarity1
Modified residuei1105PhosphoserineBy similarity1
Modified residuei1116PhosphoserineBy similarity1
Modified residuei1645N6-acetyllysineBy similarity1
Modified residuei1746Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei1746Omega-N-methylarginine; alternateBy similarity1
Modified residuei1757Omega-N-methylarginineBy similarity1
Modified residuei1844Asymmetric dimethylarginineBy similarity1
Modified residuei1865Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7YQK8

PRoteomics IDEntifications database

More...
PRIDEi
Q7YQK8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

Also interacts with CTNNB1 and GLI3 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9598.ENSPTRP00000047374

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1463 – 1901Interaction with CTNNB1 and GLI3By similarityAdd BLAST439

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1579 – 1624Pro-richAdd BLAST46
Compositional biasi1747 – 2018Gln-richAdd BLAST272

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 12 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3598 Eukaryota
ENOG410XP2V LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7YQK8

KEGG Orthology (KO)

More...
KOi
K15162

Database of Orthologous Groups

More...
OrthoDBi
15873at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021989 Mediator_Med12_catenin-bd
IPR021990 Mediator_Med12_LCEWAV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12145 Med12-LCEWAV, 1 hit
PF12144 Med12-PQL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7YQK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAAWLIKMT CAYYAAISET KVKKRHVDPF MEWTQIITKY LWEQLQKMAE
60 70 80 90 100
YYRPGPAGSG GCGSTIGPLP HDVEVAIRQW DYTEKLAMFM FQDGMLDRHE
110 120 130 140 150
FLTWVLECFE KIRPGEDELL KLLLPLLLRY SGEFVQSAYL SRRLAYFCTR
160 170 180 190 200
RLALQLDGVS SHSSHVISAQ STSTLPTTPA PQPPTSSTPS TPFSDLLMCP
210 220 230 240 250
QHRPLVFGLS CILQTILLCC PSALVWHYSL TDSRIKTGSP LDHLPIAPSN
260 270 280 290 300
LPMPEGNSAF TQQVRAKLRE IEQQIKERGQ AVEVRWSFDK CQEATAGFTI
310 320 330 340 350
GRVLHTLEVL DSHSFERSDF SNSLDSLCNR IFGLGPSKDG HEISSDDDAV
360 370 380 390 400
VSLLCEWAVS CKRSGRHRAM VVAKLLEKRQ AEIEAERCGE SEAADEKGSI
410 420 430 440 450
ASGSLSAPSA PIFQDVLLQF LDTQAPMLTD PRSENERVEF FNLVLLFCEL
460 470 480 490 500
IRHDVFSHNM YTCTLISRGD LAFGAPGPRP PSPFDDPADD AEHKEAEGSS
510 520 530 540 550
SSKLEDPGLS ESMDIDPSSS VLFEDMEKPD FSLFSPTMPC EGKGSPSPEK
560 570 580 590 600
PDVEKEVKPP PKEKIEGTLG ILYDQPRHVQ YATHFPIPQE ESCSHECNQR
610 620 630 640 650
LVVLFGVGKQ RDDARHAIKK ITKDILKVLN RKGTAETDQL APIVPLNPGD
660 670 680 690 700
LTFLGGEDGQ KRRRNRPEAF PTAEDIFAKF QHLSHYDQHQ VTAQVSRNVL
710 720 730 740 750
EQITSFALGM SYHLPLVQHV QFIFDLMEYS LSISGLIDFA IQLLNELSVV
760 770 780 790 800
EAELLLKSSD LVGSYTTSLC LCIVAVLRHY HACLILNQDQ MAQVFEGLCG
810 820 830 840 850
VVKHGMNRSD GSSAERCILA YLYDLYTSCS HLKNKFGELF SDFCSKVKNT
860 870 880 890 900
IYCNVEPSES NMRWAPEFMI DTLENPAAHT FTYTGLGKSL SENPANRYSF
910 920 930 940 950
VCNALMHVCV GHHDPDRVND IAILCAELTG YCKSLSAEWL GVLKALCCSS
960 970 980 990 1000
NNGTCGFNDL LCNVDVSDLS FHDSLATFVA ILIARQCLLL EDLIRCAAIP
1010 1020 1030 1040 1050
SLLNAACSEQ DSEPGARLTC RILLHLFKTP QLNPCQSDGN KPTVGIRSSC
1060 1070 1080 1090 1100
DRHLLAASQN RIVDGAVFAV LKAVFVLGDA ELKGSGFTVT GGTEELPEEE
1110 1120 1130 1140 1150
GGGGSGGRRQ GGRNISVETA SLDVYAKYVL RSICQQEWVG ERCLKSLCED
1160 1170 1180 1190 1200
SNDLQDPVLS SAQAQRLMQL ICYPHRLLDN EDGENPQRQR IKRILQNLDQ
1210 1220 1230 1240 1250
WTMRQSSLEL QLMIKQTPNN EMNSLLENIA KATIEVFQQS AETGSSSGST
1260 1270 1280 1290 1300
ASNMPSSSKT KPVLSSLERS GVWLVAPLIA KLPTSVQGHV LKAAGEELEK
1310 1320 1330 1340 1350
GQHLGSSSRK ERDRQKQKSM SLLSQQPFLS LVLTCLKGQD EQREGLLTSL
1360 1370 1380 1390 1400
YSQVHQIVNN WRDDQYLDDC KPKQLMHEAL KLRLNLVGGM FDTVQRSTQQ
1410 1420 1430 1440 1450
TTEWAMLLLE IIISGTVDMQ SNNELFTTVL DMLSVLINGT LAADMSSISQ
1460 1470 1480 1490 1500
GSMEENKRAY MNLAKKLQKE LGERQSDSLE KVRQLLPLPK QTRDVITCEP
1510 1520 1530 1540 1550
QGSLIDTKGN KIAGFDSIFK KEGLQVSTKQ KISPWDLFEG LKPSAPLSWG
1560 1570 1580 1590 1600
WFGTVRVDRR VARGEEQQRL LLYHTHLRPR PRAYYLEPLP LPPEDEEPPA
1610 1620 1630 1640 1650
PTLLEPEKKA PEPPKTDKPG AAPPSTEERK KKSTKGKKRS QPATKTEDYG
1660 1670 1680 1690 1700
MGPGRSGPYG VTVPPDLLHH PNPGSITHLN YRQGSIGLYT QNQPLPAGGP
1710 1720 1730 1740 1750
RVDPYRPVRL PMQKLPTRPT YPGVLPTTMT GVMGLEPSSY KTSVYRQQQP
1760 1770 1780 1790 1800
AVPQGQRLRQ QLQAKIQSQG MLGQSSVHQM TPSSSYGLQT SQGYTPYVSH
1810 1820 1830 1840 1850
VGLQQHTGPA GTMVPPSYSS QPYQSTHPST NPTLVDPTRH LQQRPSGYVH
1860 1870 1880 1890 1900
QQAPTYGHGL TSTQRFSHQT LQQTPMISTM TPMSAQGVQA GVRSTAILPE
1910 1920 1930 1940 1950
QQQQQQQQQQ QQQQQQQQQQ QQQQQQYHIR QQQQQQILRQ QQQQQQQQQQ
1960 1970 1980 1990 2000
QQQQQQQQQQ QQQQQHQQQQ QQQAAPPQPQ PQSQPQFQRQ GLQQTQQQQQ
2010 2020
TAALVRQLQQ QLSNTQPQPS TNIFGRY
Length:2,027
Mass (Da):226,338
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD598B3534ED56057
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB102669 mRNA Translation: BAC81138.1

NCBI Reference Sequences

More...
RefSeqi
NP_001009019.1, NM_001009019.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
449626

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ptr:449626

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB102669 mRNA Translation: BAC81138.1
RefSeqiNP_001009019.1, NM_001009019.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000047374

Proteomic databases

PaxDbiQ7YQK8
PRIDEiQ7YQK8

Genome annotation databases

GeneIDi449626
KEGGiptr:449626

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9968

Phylogenomic databases

eggNOGiKOG3598 Eukaryota
ENOG410XP2V LUCA
InParanoidiQ7YQK8
KOiK15162
OrthoDBi15873at2759

Family and domain databases

InterProiView protein in InterPro
IPR021989 Mediator_Med12_catenin-bd
IPR021990 Mediator_Med12_LCEWAV
PfamiView protein in Pfam
PF12145 Med12-LCEWAV, 1 hit
PF12144 Med12-PQL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED12_PANTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7YQK8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2003
Last modified: December 11, 2019
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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