Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 112 (11 Dec 2019)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Polycystin 1

Gene

PKD1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Polycystin 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PKD1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3081 – 3101HelicalSequence analysisAdd BLAST21
Transmembranei3287 – 3308HelicalSequence analysisAdd BLAST22
Transmembranei3328 – 3350HelicalSequence analysisAdd BLAST23
Transmembranei3563 – 3583HelicalSequence analysisAdd BLAST21
Transmembranei3905 – 3924HelicalSequence analysisAdd BLAST20
Transmembranei3944 – 3967HelicalSequence analysisAdd BLAST24
Transmembranei3987 – 4008HelicalSequence analysisAdd BLAST22
Transmembranei4034 – 4056HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500429817124 – 4311Sequence analysisAdd BLAST4288

Keywords - PTMi

Disulfide bondSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini177 – 271WSCInterPro annotationAdd BLAST95
Domaini299 – 359PKDInterPro annotationAdd BLAST61
Domaini418 – 534C-type lectinInterPro annotationAdd BLAST117
Domaini961 – 1017PKDInterPro annotationAdd BLAST57
Domaini1053 – 1131PKDInterPro annotationAdd BLAST79
Domaini1129 – 1217PKDInterPro annotationAdd BLAST89
Domaini1238 – 1295PKDInterPro annotationAdd BLAST58
Domaini1315 – 1385PKDInterPro annotationAdd BLAST71
Domaini1411 – 1469PKDInterPro annotationAdd BLAST59
Domaini1487 – 1551PKDInterPro annotationAdd BLAST65
Domaini1573 – 1628PKDInterPro annotationAdd BLAST56
Domaini1721 – 1807PKDInterPro annotationAdd BLAST87
Domaini1833 – 1891PKDInterPro annotationAdd BLAST59
Domaini2075 – 2149PKDInterPro annotationAdd BLAST75
Domaini2147 – 2842REJInterPro annotationAdd BLAST696
Domaini3018 – 3067GPSInterPro annotationAdd BLAST50
Domaini3124 – 3239PLATInterPro annotationAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni614 – 645DisorderedSequence analysisAdd BLAST32
Regioni4168 – 4219DisorderedSequence analysisAdd BLAST52
Regioni4255 – 4311DisorderedSequence analysisAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2690 – 2710Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4172 – 4206PolarSequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3599 Eukaryota
ENOG410XTGE LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168445

KEGG Orthology (KO)

More...
KOi
K04985

Database of Orthologous Groups

More...
OrthoDBi
1276906at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01752 PLAT_polycystin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 11 hits
3.10.100.10, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000483 Cys-rich_flank_reg_C
IPR000203 GPS
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR000434 PC1
IPR022409 PKD/Chitinase_dom
IPR002859 PKD/REJ-like
IPR013122 PKD1_2_channel
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR042060 PLAT_polycystin1
IPR006228 Polycystin_cat
IPR014010 REJ_dom
IPR002889 WSC_carb-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00059 Lectin_C, 1 hit
PF13855 LRR_8, 1 hit
PF00801 PKD, 14 hits
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PF02010 REJ, 1 hit
PF01822 WSC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00500 POLYCYSTIN1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 1 hit
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit
SM00369 LRR_TYP, 2 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00089 PKD, 15 hits
SM00321 WSC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49299 SSF49299, 11 hits
SSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00864 PCC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS50221 GPS, 1 hit
PS51450 LRR, 2 hits
PS50093 PKD, 12 hits
PS50095 PLAT, 1 hit
PS51111 REJ, 1 hit
PS51212 WSC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7YQK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPAAPGRLA LALGLGLWLG ALAGGPGRGC GPCAPPCLCG PAPGAACRVN
60 70 80 90 100
CSGGGLRTLG PALRIPAAAT ALDVSHNLLR ALDVGLLANL SALTELDISN
110 120 130 140 150
NKISTLEEGI FSNLFNLSEI NLSGNPLECN CGLAWLPRWA KEQQVHVVRP
160 170 180 190 200
EAATCAGPGP LAGQPLLGVP LLDGGCGEEY IACLPDNSSG AVALVAFSAA
210 220 230 240 250
HEGPLTPEAC GAFCFAAGNG LGAFSDQGWC LCGAAQPPNT SSACLPFCSG
260 270 280 290 300
APLALAPACG GPTLLQNIFP ASPGAALVGP QGPLASGQPA AFHVTASLPV
310 320 330 340 350
SSTRWDFGDG SPKVDIAGPA TTHRYLLPGL YHVTVVLALG AGSAQVETQV
360 370 380 390 400
HVEAAPASLE LTCLTSVRSD ETLKFGIRNR GGSDLEATYS IVAVGEEPAQ
410 420 430 440 450
DPAVVHPLCP SDTVIFPGNG HCYRLVAEKA AWLQAQEQCR AWAGAALAMV
460 470 480 490 500
DSPAIQHFLV SQVTRSLDVW IGFSAVEGAE AGPVVQGAAF SLESCQNWLP
510 520 530 540 550
GEPHPATAER CVRLGPAGQC NTDLCSAPHS YVCELRPGGP VWDAENFLVG
560 570 580 590 600
APIGDLQGPL SPLAQQEALS APQELIEVMV FPSLGLSREA FLTAAEFGTQ
610 620 630 640 650
ELRRPTQLRL QVFRPVGEAG APGNSREPES GSRESRTESV PECTPEGRWC
660 670 680 690 700
PRASIHLPPD DPCGPWACAN GSMSGPGLPG ASCVLLREFL FSVPAGPPSQ
710 720 730 740 750
YSVTFRGQDG PLKPGDLIAL QHDAGPGALL CCSPALGAPG AEAPYFSATS
760 770 780 790 800
PAWLVHLPAQ LEAAPAGPAC ALRLLVATER LTTLLGLRPN PGLRRPGRYE
810 820 830 840 850
VRATVGNSVS THNLSCSFDV LSPVAGLRVA HPIPHDGRLY VPTNSSVLVL
860 870 880 890 900
QVDSGTNATA TARWPGGNAS APFEATCPAT VAALVPSCTL EANDTLFAVL
910 920 930 940 950
VLPGLSEGEH AVEIMVENSA GHANLSLRVK AEEPICGLRA APSPEARVLQ
960 970 980 990 1000
GVLVRYSPVV EAGSDVVFRW TIDDKQSLTF HNVVFNVIYQ SAAVFKLSLT
1010 1020 1030 1040 1050
ASNHVSNVTV NYNVTVERMH KMKGLRVSAV PPVLPPNTTL ELAAHVLVDS
1060 1070 1080 1090 1100
AVEVAFLWTF GDGDQVLGQF KPPYNESWVP DPTVAQVLVE HSVTHVYAVP
1110 1120 1130 1140 1150
GEYNLTLLVS NAFENLTQQV PVSVRATLPA VAVAVGSHVL VAGQPVTFSP
1160 1170 1180 1190 1200
HPLPSPGGIL YTWDFGDGSP AVTQHQTEVS HTYASRGIYR IHLEVNNTVS
1210 1220 1230 1240 1250
SVTAWTSVRV FEELRGLSVS LSPSVEQGAP VTVSATLESG DNVTWTFDMG
1260 1270 1280 1290 1300
DGTVLVGPEA MVEHVYLRAQ NHTVTVGVSS PAGYLALSLP VHVFVLEVLR
1310 1320 1330 1340 1350
IEPAACIPVQ PHTWFMAHVT GDPAHYIFDW TFGDGSSNTT IFGDPTVTHN
1360 1370 1380 1390 1400
FTRSGTFPLA LVLSSHVNKA HYFTSVCVEP EVGNVTLWPE RQFVRLGDEA
1410 1420 1430 1440 1450
HLVARAWPPF PYRYTWDFGP EDAPRVGGPE ATFTYADPGS YLVTVAVSNN
1460 1470 1480 1490 1500
ISAANDSALV EVEEPVELTG IGVNGSGVLE LQRPYLFSAV GRGHPATYLW
1510 1520 1530 1540 1550
ELGDGGRLEG PSIKHTYNST GHFTVRVSAW NEVSRGEAWL NITVQRRVQG
1560 1570 1580 1590 1600
LSVNASRTVV PLNGSVSFTT SLEAGSDVRY SWVLCDRCTP IPGGPTISYT
1610 1620 1630 1640 1650
FRSVGTFNII VTAENEVGSA QDSIFIYVLR HIEGLQVAGG GGGCCFPTNC
1660 1670 1680 1690 1700
TLQLQAVVSD GTNIFYSWSA QRDGGPALAG SGKAFSLTVL EAGTYHVQLR
1710 1720 1730 1740 1750
AANMLGTSWA NRTVDFVEPV GALAAAASPN PAIVNSSVTL CAELAGGSGV
1760 1770 1780 1790 1800
TYTWSPEGGL SWETPEPSST HVFPSPGLYL VRVTATNWLG SANVTIEVAV
1810 1820 1830 1840 1850
QVPVSGLSIR AGDIDRGFVA AGSAVPFWGQ LDSGTNVSWC WTVPGGSRRG
1860 1870 1880 1890 1900
QHVAVVFRDA GAFSVRLNAS NAVSWVTATR ELTVEEPIAG LVVWADSKVV
1910 1920 1930 1940 1950
EPGQLVHFQV MLAAGSAVRF HLQVSGAAVE ALPGPRFSRS FPRVGDYMVS
1960 1970 1980 1990 2000
VQAENHVSRA QAQVRILVLE AVGGLQVPHC CELGIPTGTE RNFTARVQRG
2010 2020 2030 2040 2050
SRVAYAWYFS LQKVQGDSLV ILSGRDVTYT PVAAGLLEIH VRAFNDLGGV
2060 2070 2080 2090 2100
NLTLLMEVQD AIQHVVLRSG RCFTNRTARF EAATSPSPRR VAYRWDFGDG
2110 2120 2130 2140 2150
AVVEDTEEPW AEHSYLRPGD YRIEVNASNL VSFFVAQATV TVHVLACREP
2160 2170 2180 2190 2200
EVDVALPPQV LMRRSQRNYL EAHVNLRDCV TYQTEYRWQV YRAASCQRPG
2210 2220 2230 2240 2250
RLAPVALPSV DMSRPQLVVP RLALPVGHYC FVFMVSFGDT PLARSIQANV
2260 2270 2280 2290 2300
TVVPERLVPI VEGGSYRVWS DTQDLVLDGS KSYDPNLEDG DQTPLSFHWA
2310 2320 2330 2340 2350
CVASTQSETG GCTLTFGPRG SSVVIVPRER LQAGVEYTFN LTVWKAGRKE
2360 2370 2380 2390 2400
EATNQTVLIR RGRVPIVSLE CVSCKAQSVY AVSRSSYVYL EGRCDNCSEG
2410 2420 2430 2440 2450
SKRGRWAART FSNQTLVLDE TTTSTGSSGM RLVLRRGVLR DGEGYTFTLT
2460 2470 2480 2490 2500
VLGRSGEEEG CASIRLSANR PPRGGSCRLF PLDAVRALTT KVHFECTGWQ
2510 2520 2530 2540 2550
DAEDASAPLV YALLLRRCRQ GHCEEFCVYR GSLSAYGAVL PPGFAPHFQV
2560 2570 2580 2590 2600
GLAVVVQDQL GAAVVALNRS LAITLPQPPG DPQGGPTDLT SWLHGLTESM
2610 2620 2630 2640 2650
LPRLLRQADP QHVIEYSLAL ITVLNEASAG SEQVLAVVAE EDARRQLQAQ
2660 2670 2680 2690 2700
IRKNVTETLV SLRVNTVDDI QQIAAALAQC TVSSRELVCH SCLKKTLHKL
2710 2720 2730 2740 2750
EAMMRILQAE TAAGTGTPTG IADSILNITG DLIHLASVDM QGLQPSELGT
2760 2770 2780 2790 2800
EPPSLMVASR AYHLSSALMC ILMRSRVLNE EPLTLAGEEI VAQGKRSDPL
2810 2820 2830 2840 2850
SLLCQGNASV PSCHFSIPTA FSGALSNLSD VVQLMFLVDS NPFPFGYISN
2860 2870 2880 2890 2900
YTVSTKVASM AFQTQAGTQI PIGQLASERA IIVKVPNSSD QAAPGHRAPA
2910 2920 2930 2940 2950
GSAVIQPQAS ISVAVTPENS NPAAGLHLQL TYTLLSERYL PEEPEPYLAV
2960 2970 2980 2990 3000
YFDSVPGPNE HNCSASRRIS LEELAGGDHR PYTFFIAPGT RDSGGTYYLN
3010 3020 3030 3040 3050
LTSRFHWSAL EVSVGLYTSL CQYFSEKEMM WKTEGLVPLE ETSPSQAVCL
3060 3070 3080 3090 3100
TRHLTAFGAS LFVPPSHVHF IFPEPASGVN YIVLLTCIVC LVTYTVMAVI
3110 3120 3130 3140 3150
LRKLDQLDVS RVRIIPFCGK GGLFKYEILV KTGWGRGSGT TAHVGIMLYG
3160 3170 3180 3190 3200
AEGRSGHRHL DGDRAFRRNS LDVFQIATPH SLGSVRKIRV WHDNKGLSPA
3210 3220 3230 3240 3250
WFLQHIIVRD LQNARSTFFL VNDWLSVETE ANGGLVEKEV LAASEAALRR
3260 3270 3280 3290 3300
SRRLLVAELQ RGFFDKHIWL SIWDRPPRSR FTRVQRATCC ILLVCLFLGA
3310 3320 3330 3340 3350
NAVWYGVVGD TASSAGPVST LIPLSVDTIA VGLVSSVVVY PVYLVILFLF
3360 3370 3380 3390 3400
RMSRSKVAGA PSPTPSGQQV LDVDSYLDSS VLDSSFLTFP GLRTEAFAGQ
3410 3420 3430 3440 3450
MKSDLFLDDS KSLVCWPSSE GTLNWPDLLS DPSIMGSTLQ RLARGRTGHT
3460 3470 3480 3490 3500
LGPEDDGLSL LSPSSPAKYF SASDEDLIQQ ILAEGASSLA PTQDTQVETD
3510 3520 3530 3540 3550
LLTSLSSAPG ETTETLTLQR LGERGPPCSS GVTWEQPTSA RLSGTGLADG
3560 3570 3580 3590 3600
LQKRLLPAWC ASLAHGLSLL LAAVAVGVSG WVGSSFPPGV SVMWLLSSSS
3610 3620 3630 3640 3650
SFLASFLGWE PLKVLLEALY FSLVAKRLHP DEDDTLVESP AVTPVSERVP
3660 3670 3680 3690 3700
RVRPPHGFAL FLAKEEARKV KRLHGMLRSL LVYMLFLLVT LLANHGDASC
3710 3720 3730 3740 3750
HNHAYRLQSA IKQELGSQAF LAITRSDEFW PWMSHVLLPY IHGNQSGPEL
3760 3770 3780 3790 3800
GPPRLRQVRL QEALCPDPPG AAVHACSAGQ DAFSTGDYSI GWGSAAQNCS
3810 3820 3830 3840 3850
ETWAYSAPDL LGIWSWGYCA VYDSGGYVQE LGLSLEESRA QLGFLQLHNW
3860 3870 3880 3890 3900
IDNRSRAVFV ELTRYSPAVG LHAAVTLRLE FPAAGHAVTA VSVRPFPLQR
3910 3920 3930 3940 3950
LSTGLSLPLL TSVSLLLFAL YFSVAEVRTW RREGCRRAAQ PGAWARWLLV
3960 3970 3980 3990 4000
ALTAAAALVR LAQLGVADRQ WARFLRRRPR RFTSFEQVAQ LSAAARGLAA
4010 4020 4030 4040 4050
SLLFLLLVKA AQQLRFVRQW SVFGKTLCRA LPELVGAALG LVALAVAYAH
4060 4070 4080 4090 4100
LAVLLVSSCV DSFRSAARAL LVLCPGSGGP ALCPAESWRL SPLLCTGLWA
4110 4120 4130 4140 4150
LRLWGALRLG AVLLRWRYHA LRGELYRPAW EPQDYEMVEL FLRRLRLWMG
4160 4170 4180 4190 4200
FSKVKEFRHK VRFEGMEPLP SRSSRGSKSS PDAPPPSGGS DTSRPSTSSS
4210 4220 4230 4240 4250
QLDTLSGGLG RLGPRGEPEP SRLQAVFEAL LTQFDRLNQA TEDVYQLEQR
4260 4270 4280 4290 4300
LQSLRGRRST VPPASPPHSP CSALQPALPS RLARASRGMG LASGPSRASL
4310
RAKNKVHPSS T
Length:4,311
Mass (Da):462,172
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55CCA172C25C46E5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY102170 mRNA Translation: AAM45378.1

NCBI Reference Sequences

More...
RefSeqi
NP_001006651.1, NM_001006650.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
606755

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cfa:606755

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY102170 mRNA Translation: AAM45378.1
RefSeqiNP_001006651.1, NM_001006650.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi606755
KEGGicfa:606755

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5310

Phylogenomic databases

eggNOGiKOG3599 Eukaryota
ENOG410XTGE LUCA
HOGENOMiHOG000168445
KOiK04985
OrthoDBi1276906at2759

Family and domain databases

CDDicd01752 PLAT_polycystin, 1 hit
Gene3Di2.60.40.10, 11 hits
3.10.100.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000483 Cys-rich_flank_reg_C
IPR000203 GPS
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR000434 PC1
IPR022409 PKD/Chitinase_dom
IPR002859 PKD/REJ-like
IPR013122 PKD1_2_channel
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR042060 PLAT_polycystin1
IPR006228 Polycystin_cat
IPR014010 REJ_dom
IPR002889 WSC_carb-bd
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF13855 LRR_8, 1 hit
PF00801 PKD, 14 hits
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PF02010 REJ, 1 hit
PF01822 WSC, 1 hit
PRINTSiPR00500 POLYCYSTIN1
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit
SM00369 LRR_TYP, 2 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00089 PKD, 15 hits
SM00321 WSC, 1 hit
SUPFAMiSSF49299 SSF49299, 11 hits
SSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit
TIGRFAMsiTIGR00864 PCC, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS50221 GPS, 1 hit
PS51450 LRR, 2 hits
PS50093 PKD, 12 hits
PS50095 PLAT, 1 hit
PS51111 REJ, 1 hit
PS51212 WSC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7YQK5_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7YQK5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: December 11, 2019
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again