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Entry version 101 (16 Oct 2019)
Sequence version 1 (01 Oct 2003)
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Protein

NADH-ubiquinone oxidoreductase chain 1

Gene

ND1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandNADUniRule annotation, UbiquinoneUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 1UniRule annotation (EC:7.1.1.2UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ND1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrionImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 23HelicalSequence analysisAdd BLAST18
Transmembranei68 – 86HelicalSequence analysisAdd BLAST19
Transmembranei98 – 119HelicalSequence analysisAdd BLAST22
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei172 – 191HelicalSequence analysisAdd BLAST20
Transmembranei220 – 243HelicalSequence analysisAdd BLAST24
Transmembranei255 – 273HelicalSequence analysisAdd BLAST19
Transmembranei293 – 314HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q7YED6

PRoteomics IDEntifications database

More...
PRIDEi
Q7YED6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I subunit 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4770 Eukaryota
COG1005 LUCA

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01350 NDH1_NuoH, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001694 NADH_UbQ_OxRdtase_su1/FPO
IPR018086 NADH_UbQ_OxRdtase_su1_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11432 PTHR11432, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00146 NADHdh, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00667 COMPLEX1_ND1_1, 1 hit
PS00668 COMPLEX1_ND1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7YED6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMANLLLLI VPILIAMAFL MLTERKILGY MQLRKGPNVV GPYGLLQPFA
60 70 80 90 100
DAMKLFTKEP LKPATSTITL YITAPTLALT IALLLWTPLP MPNPLVNLNL
110 120 130 140 150
GLLFILATSS LAVYSILWSG WASNSNYALI GALRAVAQTI SYEVTLAIIL
160 170 180 190 200
LSTLLMSGSF NLSTLITTQE HLWLLLPSWP LAMMWFISTL AETNRTPFDL
210 220 230 240 250
AEGESELVSG FNIEYAAGPF ALFFMAEYTN IIMMNTLTTT IFLGTTYDAL
260 270 280 290 300
SPELYTTYFV TKALLLTSLF LWIRTAYPRF RYDQLMHLLW KNFLPLTLAL
310
LMWYVSMPIT ISSIPPQT
Length:318
Mass (Da):35,631
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA770FDE9500258B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY289093 Genomic DNA Translation: AAP48425.1
AY714020 Genomic DNA Translation: AAU02696.1
EF153781 Genomic DNA Translation: ABL60139.1
EU330890 Genomic DNA Translation: ABX83648.1
FJ383705 Genomic DNA Translation: ACM76291.1
GQ119045 Genomic DNA Translation: ACS49052.1
GQ337626 Genomic DNA Translation: ACU10704.1
GQ337627 Genomic DNA Translation: ACU10717.1
GQ337632 Genomic DNA Translation: ACU10782.1
HM156687 Genomic DNA Translation: ADG95569.1
HM156690 Genomic DNA Translation: ADG95608.1
HQ873565 Genomic DNA Translation: ADY75383.1
JX289129 Genomic DNA Translation: AFP96419.1
JX289132 Genomic DNA Translation: AFP96458.1
JX508852 Genomic DNA Translation: AFR60199.1
JX508853 Genomic DNA Translation: AFR60212.1
JX900500 Genomic DNA Translation: AGC17514.1
KF056258 Genomic DNA Translation: AGT52541.1
KF056259 Genomic DNA Translation: AGT52554.1
KF056260 Genomic DNA Translation: AGT52567.1
KC990667 Genomic DNA Translation: AGV04292.1
KF148193 Genomic DNA Translation: AGZ97356.1
KF148516 Genomic DNA Translation: AHA01543.1
KF148518 Genomic DNA Translation: AHA01569.1
KF148521 Genomic DNA Translation: AHA01608.1
KF148524 Genomic DNA Translation: AHA01647.1
KF148529 Genomic DNA Translation: AHA01712.1
KT587498 Genomic DNA Translation: AMZ82267.1
KT726034 Genomic DNA Translation: ANA94242.1
KX834328 Genomic DNA Translation: AOO85236.1
KX456586 Genomic DNA Translation: APD54648.1
KX456632 Genomic DNA Translation: APD55246.1
KX456637 Genomic DNA Translation: APD55311.1
KX456997 Genomic DNA Translation: APD59990.1
KX457000 Genomic DNA Translation: APD60029.1
KX457002 Genomic DNA Translation: APD60055.1
KX457242 Genomic DNA Translation: APD63175.1
KX457507 Genomic DNA Translation: APD66619.1
KX457631 Genomic DNA Translation: APD68231.1
KY686212 Genomic DNA Translation: ARH56256.1
MG272698 Genomic DNA Translation: AVL86494.1
MG272699 Genomic DNA Translation: AVL86507.1
MG272735 Genomic DNA Translation: AVL86975.1
MG272786 Genomic DNA Translation: AVL87638.1
MG272790 Genomic DNA Translation: AVL87690.1
MG272792 Genomic DNA Translation: AVL87716.1
MG272793 Genomic DNA Translation: AVL87729.1
MG272795 Genomic DNA Translation: AVL87755.1
MG272798 Genomic DNA Translation: AVL87794.1
MG272799 Genomic DNA Translation: AVL87807.1
MG272800 Genomic DNA Translation: AVL87820.1
MG272804 Genomic DNA Translation: AVL87872.1
MG272808 Genomic DNA Translation: AVL87924.1
MG272810 Genomic DNA Translation: AVL87950.1
MG272818 Genomic DNA Translation: AVL88054.1
MG272831 Genomic DNA Translation: AVL88223.1
MG272864 Genomic DNA Translation: AVL88652.1
MG272869 Genomic DNA Translation: AVL88717.1
MG272876 Genomic DNA Translation: AVL88808.1
MG272879 Genomic DNA Translation: AVL88847.1
MG272885 Genomic DNA Translation: AVL88925.1
MG273016 Genomic DNA Translation: AVL90628.1
MG273035 Genomic DNA Translation: AVL90875.1
MG273038 Genomic DNA Translation: AVL90914.1
MH449079 Genomic DNA Translation: AYW05739.1
MH449410 Genomic DNA Translation: AYW10039.1
MH449415 Genomic DNA Translation: AYW10104.1
AP012415 Genomic DNA Translation: BAM25967.1
MK484611 Genomic DNA Translation: QBC88012.1
MH553902 Genomic DNA Translation: QBY39595.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY289093 Genomic DNA Translation: AAP48425.1
AY714020 Genomic DNA Translation: AAU02696.1
EF153781 Genomic DNA Translation: ABL60139.1
EU330890 Genomic DNA Translation: ABX83648.1
FJ383705 Genomic DNA Translation: ACM76291.1
GQ119045 Genomic DNA Translation: ACS49052.1
GQ337626 Genomic DNA Translation: ACU10704.1
GQ337627 Genomic DNA Translation: ACU10717.1
GQ337632 Genomic DNA Translation: ACU10782.1
HM156687 Genomic DNA Translation: ADG95569.1
HM156690 Genomic DNA Translation: ADG95608.1
HQ873565 Genomic DNA Translation: ADY75383.1
JX289129 Genomic DNA Translation: AFP96419.1
JX289132 Genomic DNA Translation: AFP96458.1
JX508852 Genomic DNA Translation: AFR60199.1
JX508853 Genomic DNA Translation: AFR60212.1
JX900500 Genomic DNA Translation: AGC17514.1
KF056258 Genomic DNA Translation: AGT52541.1
KF056259 Genomic DNA Translation: AGT52554.1
KF056260 Genomic DNA Translation: AGT52567.1
KC990667 Genomic DNA Translation: AGV04292.1
KF148193 Genomic DNA Translation: AGZ97356.1
KF148516 Genomic DNA Translation: AHA01543.1
KF148518 Genomic DNA Translation: AHA01569.1
KF148521 Genomic DNA Translation: AHA01608.1
KF148524 Genomic DNA Translation: AHA01647.1
KF148529 Genomic DNA Translation: AHA01712.1
KT587498 Genomic DNA Translation: AMZ82267.1
KT726034 Genomic DNA Translation: ANA94242.1
KX834328 Genomic DNA Translation: AOO85236.1
KX456586 Genomic DNA Translation: APD54648.1
KX456632 Genomic DNA Translation: APD55246.1
KX456637 Genomic DNA Translation: APD55311.1
KX456997 Genomic DNA Translation: APD59990.1
KX457000 Genomic DNA Translation: APD60029.1
KX457002 Genomic DNA Translation: APD60055.1
KX457242 Genomic DNA Translation: APD63175.1
KX457507 Genomic DNA Translation: APD66619.1
KX457631 Genomic DNA Translation: APD68231.1
KY686212 Genomic DNA Translation: ARH56256.1
MG272698 Genomic DNA Translation: AVL86494.1
MG272699 Genomic DNA Translation: AVL86507.1
MG272735 Genomic DNA Translation: AVL86975.1
MG272786 Genomic DNA Translation: AVL87638.1
MG272790 Genomic DNA Translation: AVL87690.1
MG272792 Genomic DNA Translation: AVL87716.1
MG272793 Genomic DNA Translation: AVL87729.1
MG272795 Genomic DNA Translation: AVL87755.1
MG272798 Genomic DNA Translation: AVL87794.1
MG272799 Genomic DNA Translation: AVL87807.1
MG272800 Genomic DNA Translation: AVL87820.1
MG272804 Genomic DNA Translation: AVL87872.1
MG272808 Genomic DNA Translation: AVL87924.1
MG272810 Genomic DNA Translation: AVL87950.1
MG272818 Genomic DNA Translation: AVL88054.1
MG272831 Genomic DNA Translation: AVL88223.1
MG272864 Genomic DNA Translation: AVL88652.1
MG272869 Genomic DNA Translation: AVL88717.1
MG272876 Genomic DNA Translation: AVL88808.1
MG272879 Genomic DNA Translation: AVL88847.1
MG272885 Genomic DNA Translation: AVL88925.1
MG273016 Genomic DNA Translation: AVL90628.1
MG273035 Genomic DNA Translation: AVL90875.1
MG273038 Genomic DNA Translation: AVL90914.1
MH449079 Genomic DNA Translation: AYW05739.1
MH449410 Genomic DNA Translation: AYW10039.1
MH449415 Genomic DNA Translation: AYW10104.1
AP012415 Genomic DNA Translation: BAM25967.1
MK484611 Genomic DNA Translation: QBC88012.1
MH553902 Genomic DNA Translation: QBY39595.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ7YED6
PRIDEiQ7YED6

Phylogenomic databases

eggNOGiKOG4770 Eukaryota
COG1005 LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ND1 human

Family and domain databases

HAMAPiMF_01350 NDH1_NuoH, 1 hit
InterProiView protein in InterPro
IPR001694 NADH_UbQ_OxRdtase_su1/FPO
IPR018086 NADH_UbQ_OxRdtase_su1_CS
PANTHERiPTHR11432 PTHR11432, 1 hit
PfamiView protein in Pfam
PF00146 NADHdh, 1 hit
PROSITEiView protein in PROSITE
PS00667 COMPLEX1_ND1_1, 1 hit
PS00668 COMPLEX1_ND1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7YED6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7YED6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: October 16, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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