UniProtKB - Q7Y2C9 (EXLYS_BPKMV)
Protein
Peptidoglycan hydrolase gp36
Gene
gp36
Organism
Pseudomonas phage phiKMV
Status
Functioni
Component of the cylindrical core that assembles on the inner surface of the capsid during procapsid formation. Plays a role in ejection of the bacteriophage DNA into the host cell at the initiation of infection. Functions as an exolysin that catalyzes the cleavage of the host peptidoglycans.2 Publications
Catalytic activityi
- Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.Imported EC:3.2.1.17
pH dependencei
Optimum pH is 6.1 Publication
Temperature dependencei
The enzyme is highly thermoresistant, but not thermostable.1 Publication
GO - Molecular functioni
- lysozyme activity Source: UniProtKB-EC
GO - Biological processi
- cytolysis Source: UniProtKB-KW
- defense response to bacterium Source: UniProtKB-KW
- disruption by virus of host cell wall peptidoglycan during virus entry Source: UniProtKB-KW
- entry into host Source: UniProtKB
- metabolic process Source: UniProtKB-KW
- viral genome ejection through host cell envelope, short tail mechanism Source: UniProtKB-KW
Keywordsi
Protein family/group databases
CAZyi | GH24, Glycoside Hydrolase Family 24 |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidoglycan hydrolase gp36Curated (EC:3.2.1.17Imported)Alternative name(s): Gene product 36Curated Short name: Gp36 |
Gene namesi | Name:gp36Imported |
Organismi | Pseudomonas phage phiKMVImported |
Taxonomic identifieri | 204270 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Uroviricota › Caudoviricetes › Caudovirales › Autographiviridae › Krylovirinae › Phikmvvirus › |
Virus hosti | Pseudomonas aeruginosa [TaxID: 287] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000432973 | 1 – 898 | Peptidoglycan hydrolase gp36Add BLAST | 898 |
Family & Domainsi
Family and domain databases
InterProi | View protein in InterPro IPR023346, Lysozyme-like_dom_sf |
SUPFAMi | SSF53955, SSF53955, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7Y2C9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAESQRASQE LGINVGQTQL QPGQSARRGV RDSEVNYSGP SVGSQILDGI
60 70 80 90 100
LGAGQQIAGK WFEHNVQQEV LRGERARMAG EAEEAVDSNV LAKPFVKGGW
110 120 130 140 150
RKQDYRIAQA DFSLKMQRFI ANKGREMTPE EFRKYLSQEA THVLDSTEGM
160 170 180 190 200
NPNDALQALA QQQKAEEQLF GMQAKAYMDW SIDQAARGFR TQGNSILAKA
210 220 230 240 250
VQAQATGDEL SRQLSLEEAG LFYTNIMTSE DIPLEVRDKV GMQFLAASLD
260 270 280 290 300
MNQRGIYEGL RDAGFLDSMS FDDRRALNGL YEKSKAQTRA KESMATLRAD
310 320 330 340 350
ADFQQRVANG AITDLAEVEA YSRGMVEEGR WSDAQAISFM TKAMTGLGNA
360 370 380 390 400
QRMQGIMAAL EAGDINALHT LGTNVTEALE QWDKMQAANG SSLTDRLVQG
410 420 430 440 450
TQLGLRLGTF PKTYGESVGS AVRMIQAAKE GEANPELVNT LNSIFEQVAS
460 470 480 490 500
AQEINPSAGN VMLSGIPEAE QGAVAWALKQ MKMGIAPAQA LREFSANAEV
510 520 530 540 550
VKQMDEFEKG QNTKAFKDNL GKQVNDKFVN NIFGRAWNML TGESDLSNNE
560 570 580 590 600
AVLSMYRRAT IDEANWLASD RKHAGLLTSD TGREALLEIA AANVRNRTIQ
610 620 630 640 650
VGEGRNLKEG DLFSRRDSAP LILPRGTTAE QLFGTNDTET IGTVLAEQHK
660 670 680 690 700
PHVEGLLGYK SVVAFEYDRT SGSLLAVEYD ENGVALDRTR VDPQAVGKEV
710 720 730 740 750
LKRNADKLNA MRGAEYGANV KVSGTDIRMN GGNSAGMLKQ DVFNWRKELA
760 770 780 790 800
QFEAYRGEAY KDADGYSVGL GHYLGSGNAG AGTTVTPEQA AQWFAEDTDR
810 820 830 840 850
ALDQGVRLAD ELGVTNNASI LGLAGMAFQM GEGRARQFRN TFQAIKDRNK
860 870 880 890
EAFEAGVRNS KWYTQTPDRA EAFIKRMAPH FDTPSQIGVD WYSAATAE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ505558 Genomic DNA Translation: CAD44227.1 |
RefSeqi | NP_877475.1, NC_005045.1 |
Genome annotation databases
GeneIDi | 1482616 |
KEGGi | vg:1482616 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ505558 Genomic DNA Translation: CAD44227.1 |
RefSeqi | NP_877475.1, NC_005045.1 |
3D structure databases
SMRi | Q7Y2C9 |
ModBasei | Search... |
Protein family/group databases
CAZyi | GH24, Glycoside Hydrolase Family 24 |
Genome annotation databases
GeneIDi | 1482616 |
KEGGi | vg:1482616 |
Family and domain databases
InterProi | View protein in InterPro IPR023346, Lysozyme-like_dom_sf |
SUPFAMi | SSF53955, SSF53955, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EXLYS_BPKMV | |
Accessioni | Q7Y2C9Primary (citable) accession number: Q7Y2C9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2015 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries