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Entry version 96 (25 May 2022)
Sequence version 1 (01 Oct 2003)
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Protein

Probable RNA-dependent RNA polymerase 2

Gene

RDR2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, RNA-directed RNA polymerase, Transferase
Biological processRNA-mediated gene silencing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable RNA-dependent RNA polymerase 2 (EC:2.7.7.48)
Short name:
OsRDR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RDR2
Ordered Locus Names:Os04g0465700, LOC_Os04g39160
ORF Names:OSJNBb0048E02.13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. japonica (Rice)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39947 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000059680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4
  • UP000000763 Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003784461 – 1136Probable RNA-dependent RNA polymerase 2Add BLAST1136

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7XM31

PRoteomics IDEntifications database

More...
PRIDEi
Q7XM31

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7XM31, OS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4530.OS04T0465700-01

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q7XM31

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7XM31

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni965 – 989DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi967 – 981Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RdRP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0988, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001366_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7XM31

Database of Orthologous Groups

More...
OrthoDBi
63910at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007855, RNA-dep_RNA_pol_euk-typ

The PANTHER Classification System

More...
PANTHERi
PTHR23079, PTHR23079, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05183, RdRP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7XM31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTAAAAATA SLRVSNIPPS AVAAELLAFF DSAVAVAGGA FACEIAAAHR
60 70 80 90 100
GWLSRGHGTV QFGSAAAAAA AAGLASSGRL PRFLGALLSV SPSPVDLLPR
110 120 130 140 150
ASDLSLRAAG AGLVVGDRVA ERVFEAADAW DGVRAEVIPG KRRVDLYLEH
160 170 180 190 200
DSQRYKLEVL FEDMKDCLGC TLDGMGAILL QLNYAPRIHT AISGPAVNSR
210 220 230 240 250
FMDDRFHACK EDAKFSWVRA LDFTPNYSFG RCSTLVLKLG KSALVSDILK
260 270 280 290 300
SLPFSGNLGE LTMNSMDGVG ASSNVVPLVH CPRDYSVPYE VLFRLNSLMH
310 320 330 340 350
MGKIVAKHVN ADLFKALQEL PVDVSRRIFE KMHKLESTCY GPLQFIQQEA
360 370 380 390 400
YSMKRSHNVL LSNEGEGEGE RKLMKCYRVN ITPSKIFCFG PEEEVTNYVV
410 420 430 440 450
KHHSAYASDF VRVTFVDEDW SKLSSNAISA RIEQGFFSKP FKTGLYYRIL
460 470 480 490 500
SILKKGFSIG PKNFEFLAFS ASQLRGNSVW MFASNASLNA GGIRRWMGHF
510 520 530 540 550
ENIRSVSKCA ARMGQLFSSS RQTFEVLRWD VEVIPDIEIT TDGSKYIFSD
560 570 580 590 600
GIGKISLRFA KRVAHHVGLD PTNLPSAFQI RYGGYKGVIA IDPMSSIDLS
610 620 630 640 650
LRPSMKKFES ESRMLNITSW SKSQPCYVNR EIISLLSTLG IRDEIFVAMQ
660 670 680 690 700
QDEMRETEEM LTNKEVALSV LGKLGGSETK TAVKMLLQGY EPSSEPYLSM
710 720 730 740 750
ILKAHQENRL TDIRTRCKIH VPKGRVLIGC LDETGVLEYG QVYIRITKNS
760 770 780 790 800
KEQKDSNQSY FYNDDGKTAT VVGKVAITKN PCLHPGDIRV LEAIYDPDLV
810 820 830 840 850
GMVDCLVFPQ RGERPHPNEC SGGDLDGDLY FITWDDKLIP EKVDTPMDYT
860 870 880 890 900
ATRPRIMDHV VTLEEIQKHF VDYMINDSLG AISTAHLIHA DRSPLKARSP
910 920 930 940 950
ECLQLATLHS MAVDFAKTGA PAEMPRTLRP REYPDFMERW EKPMYISNGV
960 970 980 990 1000
LGKLYRSAMG HMEKSGDSGA LSSSSAQPSP TYDPDLEVPG SDEFLQAAEE
1010 1020 1030 1040 1050
YYELYEEKLT TLMNYYRAEL EDEILTGNIR NKMLYLKRDN KRYFEMKDRI
1060 1070 1080 1090 1100
VAAVDALHRE ARGWLLSSRK EEDASRMASA WYRVTYHPDR RRGKRFWSFP
1110 1120 1130
WIACDNLLAI KASSQLRRRR QKDDDSTAVV QMDCSA
Length:1,136
Mass (Da):126,925
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i308B542CCB45AB09
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0P0WB44A0A0P0WB44_ORYSJ
RNA-dependent RNA polymerase
Os04g0465700, OSNPB_040465700
377Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAF14941 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti993E → G in AK064379 (PubMed:12869764).Curated1
Sequence conflicti1052A → V in AK064379 (PubMed:12869764).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL606653 Genomic DNA Translation: CAE04828.1
AP008210 Genomic DNA Translation: BAF14941.1 Sequence problems.
AP014960 Genomic DNA No translation available.
AK064379 mRNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_015636884.1, XM_015781398.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4336092

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
osa:4336092

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606653 Genomic DNA Translation: CAE04828.1
AP008210 Genomic DNA Translation: BAF14941.1 Sequence problems.
AP014960 Genomic DNA No translation available.
AK064379 mRNA No translation available.
RefSeqiXP_015636884.1, XM_015781398.1

3D structure databases

AlphaFoldDBiQ7XM31
SMRiQ7XM31
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4530.OS04T0465700-01

Proteomic databases

PaxDbiQ7XM31
PRIDEiQ7XM31

Genome annotation databases

GeneIDi4336092
KEGGiosa:4336092

Phylogenomic databases

eggNOGiKOG0988, Eukaryota
HOGENOMiCLU_001366_1_1_1
InParanoidiQ7XM31
OrthoDBi63910at2759

Gene expression databases

GenevisibleiQ7XM31, OS

Family and domain databases

InterProiView protein in InterPro
IPR007855, RNA-dep_RNA_pol_euk-typ
PANTHERiPTHR23079, PTHR23079, 1 hit
PfamiView protein in Pfam
PF05183, RdRP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDR2_ORYSJ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7XM31
Secondary accession number(s): Q0JCJ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: October 1, 2003
Last modified: May 25, 2022
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families
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