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Protein

Probable D-2-hydroxyglutarate dehydrogenase, mitochondrial

Gene

D2HGDH

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate.By similarity

Catalytic activityi

(R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.

Cofactori

FADBy similarityNote: Binds 1 FAD per monomer.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-OSA-880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC:1.1.99.39)
Gene namesi
Name:D2HGDH
Ordered Locus Names:Os07g0187200, LOC_Os07g08950
ORF Names:OsJ_23376, OSJNBb0084L07.2, P0506C07.26
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 80MitochondrionSequence analysisAdd BLAST80
ChainiPRO_000039339081 – 559Probable D-2-hydroxyglutarate dehydrogenase, mitochondrialAdd BLAST479

Proteomic databases

PaxDbiQ7XI14

Expressioni

Gene expression databases

ExpressionAtlasiQ7XI14 differential

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os07g08950.1

Structurei

3D structure databases

ProteinModelPortaliQ7XI14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 310FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST180

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi137 – 140Poly-Leu4

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1232 Eukaryota
COG0277 LUCA
InParanoidiQ7XI14
KOiK18204

Family and domain databases

Gene3Di1.10.45.10, 1 hit
3.30.43.10, 1 hit
InterProiView protein in InterPro
IPR016166 FAD-bd_PCMH
IPR036318 FAD-bd_PCMH-like_sf
IPR016167 FAD-bd_PCMH_sub1
IPR016164 FAD-linked_Oxase-like_C
IPR004113 FAD-linked_oxidase_C
IPR006094 Oxid_FAD_bind_N
IPR016171 Vanillyl_alc_oxidase_C-sub2
PfamiView protein in Pfam
PF02913 FAD-oxidase_C, 1 hit
PF01565 FAD_binding_4, 1 hit
SUPFAMiSSF55103 SSF55103, 1 hit
SSF56176 SSF56176, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7XI14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRAAAGLL RRHLGPLAAG ETLQARGMYP KQYGAANHAF SRFYSIQGQQ
60 70 80 90 100
RSLYGFRTNV ETDDTQQSAR MNFEVQKRSF SSAAAHVQRN PAYSVLNSDD
110 120 130 140 150
VSYFKSILGD SGVVQDEDRV SVANMDWMGK YKGSSQLLLL PKSTAEVSKI
160 170 180 190 200
LSYCNSRRLA VVPQGGNTGL VGGSVPVYDE VIISLGGMDK IITFDNVNGI
210 220 230 240 250
LTCEAGCVLE NLSSYVENKG FIMPLDLGAK GSCHIGGNIS TNAGGLRFIR
260 270 280 290 300
YGSLHGSVLG LEVVLADGTV LDMLTTLRKD NTGYDLKHLF IGSEGSLGIV
310 320 330 340 350
TKIAILTPAK LPSTNVAFLS CNDYISCQKL LLAARRSLGE ILSAFEFMDR
360 370 380 390 400
HCINLAMKYL EGVHNPLPVS PFNFYVLIET TGSDESYDKA KLEAFLLRSM
410 420 430 440 450
EDGLVADGVI AQDISQASNF WRIREGISEA SVKVGAVYKY DLSIPVEKLY
460 470 480 490 500
DIVEEMRSRV GDMGQVLGYG HLGDGNLHLN ILSTKYSDKM LAQIEPFVYE
510 520 530 540 550
WTSKQRGSIS AEHGLGLMKA EKIHYSKSSE AVQLMASIKK LLDPNSILNP

YKVLPQSVL
Length:559
Mass (Da):61,097
Last modified:October 1, 2003 - v1
Checksum:iF4BDDA06DA0F0EF3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C7J4R4C7J4R4_ORYSJ
Os07g0187200 protein
Os07g0187200 Os07g0187200, OSNPB_070187200
106Annotation score:

Sequence cautioni

The sequence EEE66707 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004384 Genomic DNA Translation: BAC79943.1
AP005179 Genomic DNA Translation: BAD31069.1
AP014963 Genomic DNA No translation available.
CM000144 Genomic DNA Translation: EEE66707.1 Sequence problems.
RefSeqiXP_015646834.1, XM_015791348.1
XP_015646835.1, XM_015791349.1
UniGeneiOs.15252

Genome annotation databases

GeneIDi4342598
KEGGiosa:4342598

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004384 Genomic DNA Translation: BAC79943.1
AP005179 Genomic DNA Translation: BAD31069.1
AP014963 Genomic DNA No translation available.
CM000144 Genomic DNA Translation: EEE66707.1 Sequence problems.
RefSeqiXP_015646834.1, XM_015791348.1
XP_015646835.1, XM_015791349.1
UniGeneiOs.15252

3D structure databases

ProteinModelPortaliQ7XI14
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os07g08950.1

Proteomic databases

PaxDbiQ7XI14

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4342598
KEGGiosa:4342598

Phylogenomic databases

eggNOGiKOG1232 Eukaryota
COG0277 LUCA
InParanoidiQ7XI14
KOiK18204

Enzyme and pathway databases

ReactomeiR-OSA-880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate

Gene expression databases

ExpressionAtlasiQ7XI14 differential

Family and domain databases

Gene3Di1.10.45.10, 1 hit
3.30.43.10, 1 hit
InterProiView protein in InterPro
IPR016166 FAD-bd_PCMH
IPR036318 FAD-bd_PCMH-like_sf
IPR016167 FAD-bd_PCMH_sub1
IPR016164 FAD-linked_Oxase-like_C
IPR004113 FAD-linked_oxidase_C
IPR006094 Oxid_FAD_bind_N
IPR016171 Vanillyl_alc_oxidase_C-sub2
PfamiView protein in Pfam
PF02913 FAD-oxidase_C, 1 hit
PF01565 FAD_binding_4, 1 hit
SUPFAMiSSF55103 SSF55103, 1 hit
SSF56176 SSF56176, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD2HDH_ORYSJ
AccessioniPrimary (citable) accession number: Q7XI14
Secondary accession number(s): B9FVX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: October 1, 2003
Last modified: October 10, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
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Main funding by: National Institutes of Health

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