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Entry version 67 (07 Oct 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Disease resistance protein RGA2

Gene

RGA2

Organism
Solanum bulbocastanum (Wild potato)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein. That triggers a defense system which restricts the pathogen growth. Confers a broad resistance to all known races of P.infestans.

Miscellaneous

Belongs to a four-gene family located at the same locus. Although the four genes are expressed in the resistant haplotype, only RGA2 confers the resistance to P.infestans. In the susceptible haplotype, RGA1 and RGA3 are likely to be pseudogenes created by deletions and mutations, while RGA2 contains also several modifications.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi182 – 189ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPlant defense
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disease resistance protein RGA2
Alternative name(s):
Blight resistance protein RPI
RGA2-blb
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGA2
Synonyms:177O13.40, CB3A14.5, RB, RPI-BLB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSolanum bulbocastanum (Wild potato)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri147425 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Can be introduced into cultivated potato (S.tuberosum) or tomato (L.esculentum) to transfer a broad-spectrum late blight resistance to cultivated Solanaceae from sexually incompatible host species.

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002127781 – 970Disease resistance protein RGA2Add BLAST970

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q7XBQ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Constitutively expressed.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini135 – 438NB-ARCAdd BLAST304
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati525 – 548LRR 1Add BLAST24
Repeati550 – 571LRR 2Add BLAST22
Repeati573 – 594LRR 3Add BLAST22
Repeati595 – 619LRR 4Add BLAST25
Repeati638 – 662LRR 5Add BLAST25
Repeati672 – 697LRR 6Add BLAST26
Repeati752 – 777LRR 7Add BLAST26
Repeati787 – 811LRR 8Add BLAST25
Repeati813 – 832LRR 9Add BLAST20
Repeati833 – 857LRR 10Add BLAST25
Repeati859 – 882LRR 11Add BLAST24
Repeati884 – 906LRR 12Add BLAST23
Repeati907 – 931LRR 13Add BLAST25
Repeati946 – 970LRR 14Add BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the disease resistance NB-LRR family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14798, RX-CC_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR002182, NB-ARC
IPR027417, P-loop_NTPase
IPR038005, RX-like_CC
IPR041118, Rx_N
IPR036388, WH-like_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855, LRR_8, 1 hit
PF00931, NB-ARC, 1 hit
PF18052, Rx_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7XBQ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAFIQVLL DNLTSFLKGE LVLLFGFQDE FQRLSSMFST IQAVLEDAQE
60 70 80 90 100
KQLNNKPLEN WLQKLNAATY EVDDILDEYK TKATRFSQSE YGRYHPKVIP
110 120 130 140 150
FRHKVGKRMD QVMKKLKAIA EERKNFHLHE KIVERQAVRR ETGSVLTEPQ
160 170 180 190 200
VYGRDKEKDE IVKILINNVS DAQHLSVLPI LGMGGLGKTT LAQMVFNDQR
210 220 230 240 250
VTEHFHSKIW ICVSEDFDEK RLIKAIVESI EGRPLLGEMD LAPLQKKLQE
260 270 280 290 300
LLNGKRYLLV LDDVWNEDQQ KWANLRAVLK VGASGASVLT TTRLEKVGSI
310 320 330 340 350
MGTLQPYELS NLSQEDCWLL FMQRAFGHQE EINPNLVAIG KEIVKKSGGV
360 370 380 390 400
PLAAKTLGGI LCFKREERAW EHVRDSPIWN LPQDESSILP ALRLSYHQLP
410 420 430 440 450
LDLKQCFAYC AVFPKDAKME KEKLISLWMA HGFLLSKGNM ELEDVGDEVW
460 470 480 490 500
KELYLRSFFQ EIEVKDGKTY FKMHDLIHDL ATSLFSANTS SSNIREINKH
510 520 530 540 550
SYTHMMSIGF AEVVFFYTLP PLEKFISLRV LNLGDSTFNK LPSSIGDLVH
560 570 580 590 600
LRYLNLYGSG MRSLPKQLCK LQNLQTLDLQ YCTKLCCLPK ETSKLGSLRN
610 620 630 640 650
LLLDGSQSLT CMPPRIGSLT CLKTLGQFVV GRKKGYQLGE LGNLNLYGSI
660 670 680 690 700
KISHLERVKN DKDAKEANLS AKGNLHSLSM SWNNFGPHIY ESEEVKVLEA
710 720 730 740 750
LKPHSNLTSL KIYGFRGIHL PEWMNHSVLK NIVSILISNF RNCSCLPPFG
760 770 780 790 800
DLPCLESLEL HWGSADVEYV EEVDIDVHSG FPTRIRFPSL RKLDIWDFGS
810 820 830 840 850
LKGLLKKEGE EQFPVLEEMI IHECPFLTLS SNLRALTSLR ICYNKVATSF
860 870 880 890 900
PEEMFKNLAN LKYLTISRCN NLKELPTSLA SLNALKSLKI QLCCALESLP
910 920 930 940 950
EEGLEGLSSL TELFVEHCNM LKCLPEGLQH LTTLTSLKIR GCPQLIKRCE
960 970
KGIGEDWHKI SHIPNVNIYI
Length:970
Mass (Da):110,347
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3727029C3CAD9C47
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAP45164 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAP45188 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti22V → A in susceptible haplotype. 1
Natural varianti449 – 540Missing in susceptible haplotype. Add BLAST92
Natural varianti889 – 894Missing in susceptible haplotype. 6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY336128 Genomic DNA Translation: AAP86601.1
AY303170 Genomic DNA Translation: AAP45164.2 Sequence problems.
AY303171 Genomic DNA Translation: AAP45188.2 Sequence problems.
AY426259 Genomic DNA Translation: AAR29069.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336128 Genomic DNA Translation: AAP86601.1
AY303170 Genomic DNA Translation: AAP45164.2 Sequence problems.
AY303171 Genomic DNA Translation: AAP45188.2 Sequence problems.
AY426259 Genomic DNA Translation: AAR29069.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ7XBQ9

Family and domain databases

CDDicd14798, RX-CC_like, 1 hit
Gene3Di1.10.10.10, 1 hit
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR002182, NB-ARC
IPR027417, P-loop_NTPase
IPR038005, RX-like_CC
IPR041118, Rx_N
IPR036388, WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF13855, LRR_8, 1 hit
PF00931, NB-ARC, 1 hit
PF18052, Rx_N, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGA2_SOLBU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7XBQ9
Secondary accession number(s): Q7XA18, Q7XA41
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: October 7, 2020
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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