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Entry version 49 (07 Apr 2021)
Sequence version 1 (01 Oct 2003)
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Protein

Homogentisate geranylgeranyltransferase

Gene

HGGT

Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the synthesis of tocotrienol (vitamin E). Catalyzes the condensation of homogentisate and geranylgeranyl diphosphate to form 2-methyl-6-geranylgeranylbenzoquinol. Possesses low activity with phytyl diphosphate as substrate.

By similarity

Miscellaneous

Seeds of most monocots are enriched in tocotrienols and contain only small amounts of tocopherols.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tocopherol biosynthesis

This protein is involved in the pathway tocopherol biosynthesis, which is part of Cofactor biosynthesis.Curated
View all proteins of this organism that are known to be involved in the pathway tocopherol biosynthesis and in Cofactor biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00160

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homogentisate geranylgeranyltransferase1 Publication (EC:2.5.1.116By similarity)
Short name:
HGGT1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HGGT1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTriticum aestivum (Wheat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4565 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000019116 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei122 – 142Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei149 – 169Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei194 – 214Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei217 – 237Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei248 – 268Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei286 – 306Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei329 – 349Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei352 – 372Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei386 – 406Helical; Name=9Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 68ChloroplastSequence analysisAdd BLAST68
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043073769 – 408Homogentisate geranylgeranyltransferaseSequence analysisAdd BLAST340

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q7XB13

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7XB13, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4565.Traes_7AL_3B0FC6F2A.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QZ7Z, Eukaryota

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPERVYW

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13960, PT_UbiA_HPT1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR044502, AtHST-like
IPR000537, UbiA_prenyltransferase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01040, UbiA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7XB13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQATTAAAAA QLLTDTRRGP RCSRARLGAT RLSWPGRFAV EAFAGRCQSS
60 70 80 90 100
ATTVTHRFSA ISQATSPRRK ARRQCSDDQS ALQAGCSKVN RDQHGYDVNW
110 120 130 140 150
FEEISQEVSK KLRAFYQFCR PHTIFGTIIG ITSVSLLPMK SIDDFTATVL
160 170 180 190 200
KGYLEALAAA LCMNIYVVGL NQLYDIQIDK INKPGLPLAA GEFSVATGVF
210 220 230 240 250
LVVTFLIMSF SIGIHSGSVP LMYALVVSFL LGSAYSIEAP LLRWKRHALL
260 270 280 290 300
AASCILFVRA ILVQLAFFAH MQQHVLKRPL AATKSLVFAT LFMCCFSAVI
310 320 330 340 350
ALFKDIPDVD GDRDFGIQSL SVRLGPQRVY QLCISILLTA YLAATVVGAS
360 370 380 390 400
STHLLQKIIT VSGHGLLALT LWQRARHLEV ENQARVTSFY MFIWKLFYAE

YFLIPFVQ
Length:408
Mass (Da):45,138
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i21B8983BAE491A6C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B6RNQ7A0A3B6RNQ7_WHEAT
Homogentisate geranylgeranyltransfe...
407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY222861 mRNA Translation: AAP43912.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
TraesCAD_scaffold_097383_01G000300.1; TraesCAD_scaffold_097383_01G000300.1; TraesCAD_scaffold_097383_01G000300
TraesCS7A02G510700.1; TraesCS7A02G510700.1; TraesCS7A02G510700
TraesPAR_scaffold_119489_01G000300.1; TraesPAR_scaffold_119489_01G000300.1; TraesPAR_scaffold_119489_01G000300
TraesROB_scaffold_024134_01G000300.1; TraesROB_scaffold_024134_01G000300.1; TraesROB_scaffold_024134_01G000300
TraesWEE_scaffold_060322_01G000100.1; TraesWEE_scaffold_060322_01G000100.1; TraesWEE_scaffold_060322_01G000100

Gramene; a comparative resource for plants

More...
Gramenei
TraesCAD_scaffold_097383_01G000300.1; TraesCAD_scaffold_097383_01G000300.1; TraesCAD_scaffold_097383_01G000300
TraesCS7A02G510700.1; TraesCS7A02G510700.1; TraesCS7A02G510700
TraesPAR_scaffold_119489_01G000300.1; TraesPAR_scaffold_119489_01G000300.1; TraesPAR_scaffold_119489_01G000300
TraesROB_scaffold_024134_01G000300.1; TraesROB_scaffold_024134_01G000300.1; TraesROB_scaffold_024134_01G000300
TraesWEE_scaffold_060322_01G000100.1; TraesWEE_scaffold_060322_01G000100.1; TraesWEE_scaffold_060322_01G000100

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY222861 mRNA Translation: AAP43912.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi4565.Traes_7AL_3B0FC6F2A.1

Proteomic databases

PRIDEiQ7XB13

Genome annotation databases

EnsemblPlantsiTraesCAD_scaffold_097383_01G000300.1; TraesCAD_scaffold_097383_01G000300.1; TraesCAD_scaffold_097383_01G000300
TraesCS7A02G510700.1; TraesCS7A02G510700.1; TraesCS7A02G510700
TraesPAR_scaffold_119489_01G000300.1; TraesPAR_scaffold_119489_01G000300.1; TraesPAR_scaffold_119489_01G000300
TraesROB_scaffold_024134_01G000300.1; TraesROB_scaffold_024134_01G000300.1; TraesROB_scaffold_024134_01G000300
TraesWEE_scaffold_060322_01G000100.1; TraesWEE_scaffold_060322_01G000100.1; TraesWEE_scaffold_060322_01G000100
GrameneiTraesCAD_scaffold_097383_01G000300.1; TraesCAD_scaffold_097383_01G000300.1; TraesCAD_scaffold_097383_01G000300
TraesCS7A02G510700.1; TraesCS7A02G510700.1; TraesCS7A02G510700
TraesPAR_scaffold_119489_01G000300.1; TraesPAR_scaffold_119489_01G000300.1; TraesPAR_scaffold_119489_01G000300
TraesROB_scaffold_024134_01G000300.1; TraesROB_scaffold_024134_01G000300.1; TraesROB_scaffold_024134_01G000300
TraesWEE_scaffold_060322_01G000100.1; TraesWEE_scaffold_060322_01G000100.1; TraesWEE_scaffold_060322_01G000100

Phylogenomic databases

eggNOGiENOG502QZ7Z, Eukaryota
OMAiGPERVYW

Enzyme and pathway databases

UniPathwayiUPA00160

Gene expression databases

ExpressionAtlasiQ7XB13, baseline

Family and domain databases

CDDicd13960, PT_UbiA_HPT1, 1 hit
InterProiView protein in InterPro
IPR044502, AtHST-like
IPR000537, UbiA_prenyltransferase
PfamiView protein in Pfam
PF01040, UbiA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHGGT_WHEAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7XB13
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: October 1, 2003
Last modified: April 7, 2021
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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