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Protein

Arginase 1, mitochondrial

Gene

ARG1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of L-arginine to urea and L-ornithine. The latter can be utilized in the urea cycle or as a precursor for the synthesis of both polyamines and proline (By similarity).By similarity

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase 1, mitochondrial (ARG1)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi159Manganese 1PROSITE-ProRule annotation1
Metal bindingi183Manganese 1PROSITE-ProRule annotation1
Metal bindingi183Manganese 2PROSITE-ProRule annotation1
Metal bindingi185Manganese 2PROSITE-ProRule annotation1
Metal bindingi187Manganese 1PROSITE-ProRule annotation1
Metal bindingi268Manganese 1PROSITE-ProRule annotation1
Metal bindingi268Manganese 2PROSITE-ProRule annotation1
Metal bindingi270Manganese 2PROSITE-ProRule annotation1
Binding sitei311SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processArginine metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-OSA-351143 Agmatine biosynthesis
UniPathwayiUPA00158; UER00270

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase 1, mitochondrial (EC:3.5.3.1By similarity)
Alternative name(s):
Arginine amidohydrolase 1
Gene namesi
Name:ARG1
Ordered Locus Names:Os04g0106300, LOC_Os04g01590
ORF Names:OsJ_13517, OSJNBb0004G23.10, OSJNBb0085F13.5
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionSequence analysisAdd BLAST24
ChainiPRO_000042425825 – 340Arginase 1, mitochondrialAdd BLAST316

Proteomic databases

PaxDbiQ7X7N2
PRIDEiQ7X7N2

Expressioni

Gene expression databases

ExpressionAtlasiQ7X7N2 differential
GenevisibleiQ7X7N2 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os04g01590.1

Structurei

3D structure databases

ProteinModelPortaliQ7X7N2
SMRiQ7X7N2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni185 – 189Substrate bindingBy similarity5
Regioni193 – 195Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2964 Eukaryota
COG0010 LUCA
InParanoidiQ7X7N2
KOiK01476
OMAiCIDAGFV
OrthoDBiEOG09360FUJ

Family and domain databases

InterProiView protein in InterPro
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
SUPFAMiSSF52768 SSF52768, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7X7N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGVAAGTRW IHHVRRLSAA KVSADALERG QSRVIDASLT LIRERAKLKA
60 70 80 90 100
ELLRALGGVK ASACLLGVPL GHNSSFLQGP AFAPPRIREA IWCGSTNSST
110 120 130 140 150
EEGKELNDPR VLTDVGDVPI QEIRDCGVED DRLMNVVSES VKTVMEEDPL
160 170 180 190 200
RPLVLGGDHS ISYPVVRAVS EKLGGPVDIL HLDAHPDIYD AFEGNIYSHA
210 220 230 240 250
SSFARIMEGG YARRLLQVGI RSITKEGREQ GKRFGVEQYE MRTFSKDREK
260 270 280 290 300
LESLKLGEGV KGVYISVDVD CLDPAFAPGV SHIEPGGLSF RDVLNILHNL
310 320 330 340
QGDVVAGDVV EFNPQRDTVD GMTAMVAAKL VRELTAKISK
Length:340
Mass (Da):36,944
Last modified:October 1, 2003 - v1
Checksum:i7407D7E5BD2885B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606620 Genomic DNA Translation: CAE02758.1
AL662992 Genomic DNA Translation: CAE04612.2
AP008210 Genomic DNA Translation: BAF13927.1
AP014960 Genomic DNA Translation: BAS87540.1
CM000141 Genomic DNA Translation: EAZ29443.1
AK059655 mRNA Translation: BAG87067.1
RefSeqiXP_015636156.1, XM_015780670.1
UniGeneiOs.25208

Genome annotation databases

EnsemblPlantsiOs04t0106300-01; Os04t0106300-01; Os04g0106300
GeneIDi4334912
GrameneiOs04t0106300-01; Os04t0106300-01; Os04g0106300
KEGGiosa:4334912

Similar proteinsi

Entry informationi

Entry nameiARGI1_ORYSJ
AccessioniPrimary (citable) accession number: Q7X7N2
Secondary accession number(s): A0A0P0W6F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2013
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

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