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Entry version 105 (18 Sep 2019)
Sequence version 1 (01 Oct 2003)
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Protein

Vacuolar protein sorting-associated protein 35A

Gene

VPS35A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. Also involved in the efficient sorting of seed storage proteins (Probable). Binds alone to endosomal membranes and is required for recruitment of VPS26 and VPS29 to membrane (PubMed:23362252). The VPS29-VPS26-VPS35 subcomplex may be involved in recycling of specific cargos from endosome to the plasma membrane (PubMed:20086190).1 Publication2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 35A
Alternative name(s):
Protein ZIG SUPPRESSOR 3
Vesicle protein sorting 35A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VPS35A
Synonyms:ZIP3
Ordered Locus Names:At2g17790
ORF Names:T17A5.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G17790

The Arabidopsis Information Resource

More...
TAIRi
locus:2827896 AT2G17790

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004147241 – 787Vacuolar protein sorting-associated protein 35AAdd BLAST787

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7X659

PRoteomics IDEntifications database

More...
PRIDEi
Q7X659

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7X659

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7X659 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7X659 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the retromer complex which consists of VPS29 (MAG1), VPS26 (VPS26A or VPS26B), VPS35 (VPS35A or VPS35B or VPS35C), VPS5/17 (SNX1 or SNX2A or SNX2B).

Component of a retromer subcomplex consisting of VPS29 (MAG1), VPS26 (VPS26A or VPS26B), VPS35 (VPS35A or VPS35B or VPS35C) (Probable).

Interacts with RABG3F (PubMed:23362252).

1 Publication1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q7X659, 2 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT2G17790.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS35 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1107 Eukaryota
ENOG410XNXC LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000196946

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7X659

KEGG Orthology (KO)

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KOi
K18468

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYPHVME

Database of Orthologous Groups

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OrthoDBi
316875at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7X659

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.660, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005378 Vps35
IPR042491 Vps35_C

The PANTHER Classification System

More...
PANTHERi
PTHR11099 PTHR11099, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03635 Vps35, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF009375 Retromer_Vps35, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7X659-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIADGSEDEE KWLAAGAAAF KQNAFYMQRA IDSNNLKDAL KYSAQMLSEL
60 70 80 90 100
RTSKLSPHKY YDLYMRAFDE LRKLEIFFME ETRRGCSVIE LYELVQHAGN
110 120 130 140 150
ILPRLYLLCT AGSVYIKTKE APAKEILKDL VEMCRGIQHP LRGLFLRSYL
160 170 180 190 200
AQISRDKLPD IGSEYEGDAD TVIDAVEFVL LNFTEMNKLW VRMQHQGPAR
210 220 230 240 250
EKERREKERG ELRDLVGKNL HVLSQLEGVD LDMYRDTVLP RVLEQIVNCR
260 270 280 290 300
DEIAQYYLID CIIQVFPDEY HLQTLDVLLG ACPQLQASVD IMTVLSRLME
310 320 330 340 350
RLSNYAALNA EVLPYFLQVE AFSKLNNAIG KVIEAQEDMP ILSAVTLYSS
360 370 380 390 400
LLKFTLHVHP DRLDYADQVL GSCVKQLSGK GKIDDTRATK ELVSLLSAPL
410 420 430 440 450
EKYNDVVTAL KLTNYPLVVE YLDTETKRIM ATVIVRSIMK NNTLITTAEK
460 470 480 490 500
VEALFELIKG IINDLDEPQG LEVDEDDFQE EQNSVALLIH MLYNDDPEEM
510 520 530 540 550
FKIVNVLKKH FLTGGPKRLK FTIPPLVVST LKLIRRLPVE GDNPFGKEAS
560 570 580 590 600
VTATKIFQFL NQIIEALPNV PSPDLAFRLY LQCAEAADKC DEEPIAYEFF
610 620 630 640 650
TQAYILYEEE ISDSKAQVTA LQLIIGTLQR MQVFGVENRD TLTHKATGYA
660 670 680 690 700
AKLLKKPDQC RAVYACSHLF WLEDRETIQD GERVLLCLKR ALKIANSAQQ
710 720 730 740 750
VANTARGSTG SVTLFIEILN KYLYFYEKGV PQITVESVES LIKLIKNEES
760 770 780
MPSDPSAESF FATTLEFMEF QKQKEGAIGE RYQAIKV
Length:787
Mass (Da):89,493
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB4A591B9AA90687
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002685 Genomic DNA Translation: AEC06688.1
BT008553 mRNA Translation: AAP40380.1
BT008664 mRNA Translation: AAP40476.1
AK229772 mRNA Translation: BAF01607.1

NCBI Reference Sequences

More...
RefSeqi
NP_179370.2, NM_127333.5

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G17790.1; AT2G17790.1; AT2G17790

Database of genes from NCBI RefSeq genomes

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GeneIDi
816289

Gramene; a comparative resource for plants

More...
Gramenei
AT2G17790.1; AT2G17790.1; AT2G17790

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G17790

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002685 Genomic DNA Translation: AEC06688.1
BT008553 mRNA Translation: AAP40380.1
BT008664 mRNA Translation: AAP40476.1
AK229772 mRNA Translation: BAF01607.1
RefSeqiNP_179370.2, NM_127333.5

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ7X659, 2 interactors
STRINGi3702.AT2G17790.1

PTM databases

iPTMnetiQ7X659

Proteomic databases

PaxDbiQ7X659
PRIDEiQ7X659

Genome annotation databases

EnsemblPlantsiAT2G17790.1; AT2G17790.1; AT2G17790
GeneIDi816289
GrameneiAT2G17790.1; AT2G17790.1; AT2G17790
KEGGiath:AT2G17790

Organism-specific databases

AraportiAT2G17790
TAIRilocus:2827896 AT2G17790

Phylogenomic databases

eggNOGiKOG1107 Eukaryota
ENOG410XNXC LUCA
HOGENOMiHOG000196946
InParanoidiQ7X659
KOiK18468
OMAiNYPHVME
OrthoDBi316875at2759
PhylomeDBiQ7X659

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q7X659

Gene expression databases

ExpressionAtlasiQ7X659 baseline and differential
GenevisibleiQ7X659 AT

Family and domain databases

Gene3Di1.25.40.660, 1 hit
InterProiView protein in InterPro
IPR005378 Vps35
IPR042491 Vps35_C
PANTHERiPTHR11099 PTHR11099, 1 hit
PfamiView protein in Pfam
PF03635 Vps35, 1 hit
PIRSFiPIRSF009375 Retromer_Vps35, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVP35A_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7X659
Secondary accession number(s): Q0WMP3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: October 1, 2003
Last modified: September 18, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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