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Entry version 77 (07 Apr 2021)
Sequence version 1 (01 Oct 2003)
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Protein
Submitted name:

Penicillin G amidase

Gene
N/A
Organism
Providencia rettgeri
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+UniRule annotationNote: Binds 1 Ca2+ ion per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi173CalciumUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei285NucleophileUniRule annotation1
Metal bindingi357CalciumUniRule annotationCombined sources1
Metal bindingi359Calcium; via carbonyl oxygenUniRule annotationCombined sources1
Metal bindingi360CalciumUniRule annotationCombined sources1
Metal bindingi489Calcium; via carbonyl oxygenUniRule annotation1
Metal bindingi536CalciumUniRule annotationCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation
LigandCalciumUniRule annotationCombined sources, Metal-bindingUniRule annotationCombined sources

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S45.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Penicillin G amidaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiProvidencia rettgeriImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri587 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeProvidencia

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500429371624 – 837Sequence analysisAdd BLAST814

Keywords - PTMi

ZymogenARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7WZI9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7WZI9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S45 family.ARBA annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03748, Ntn_PGA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1400.10, 1 hit
1.10.439.10, 1 hit
2.30.120.10, 1 hit
3.60.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029055, Ntn_hydrolases_N
IPR014395, Pen/GL7ACA/AHL_acylase
IPR043147, Penicillin_amidase_A-knob
IPR023343, Penicillin_amidase_dom1
IPR043146, Penicillin_amidase_N_B-knob
IPR033813, PGA_C
IPR002692, S45

The PANTHER Classification System

More...
PANTHERi
PTHR34218, PTHR34218, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01804, Penicil_amidase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001227, Pen_acylase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56235, SSF56235, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7WZI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKHLISIAI VLSLSSLSLS SFSQSTQIKI ERDNYGVPHI YANDTYSLFY
60 70 80 90 100
GYGYAVAQDR LFQMEMAKRS TQGTVSEVFG KDYISFDKEI RNNYWPDSIH
110 120 130 140 150
KQINQLPSQE QDILRGYADG MNAWIKQINT KPDDLMPKQF IDYDFLPSQW
160 170 180 190 200
TSFDVAMIMV GTMANRFSDM NSEIDNLALL TALKDKYGEQ LGVEFFNQIN
210 220 230 240 250
WLNNPNAPTT ISSEEFTYSD SQKTKNISQL NQISDYRLTA PMFERTAKDT
260 270 280 290 300
TGKVLALSSQ ENNALIAKQY EQSGANGLAG YPTTSNVWLV GKTKASGAKA
310 320 330 340 350
ILLNGPQFGW FNPAYTYGIG LHGAGFNIVG NTPFAYPAIL FGHNGHVSWG
360 370 380 390 400
STAGFGDGVD IFAEQVSPED PNSYLHQGQW KKMLSRQETL NVKGEQPITF
410 420 430 440 450
EIYRTVHGNV VKRDKTTHTA YSKARAWDGK ELTSLMAWVK QGQAQNWQQW
460 470 480 490 500
LDQAQNQALT INWYYADKDG NIGYVHTGHY PDRQINHDPR LPVSGTGEWD
510 520 530 540 550
WKGIQPFANN PKVYNPKSGY IANWNNSPAK NYPASDLFAF LWGSADRVKE
560 570 580 590 600
IDNRIEAYDK LTADDMWAIL QQTSRVDLNH RLFTPFLTQA TQGLPSNDNS
610 620 630 640 650
VKLVSMLQQW DGINQLSSDG KHYIHPGSAI LDIWLKEMLK ATLGQTVPAP
660 670 680 690 700
FDKWYLASGY ETTQEGPTGS LNISTGAKLL YESLLEDKSP ISQSIDLFSG
710 720 730 740 750
QPQNDVIRKT LNTTYQKMIE KYGDNPANWQ TPATALTFRE NNFFGIPQAL
760 770 780 790 800
PQENFHQNEY HNRGTENDLI VFTEEGVSAW DVVAPGQSGF ISPQGKPSPH
810 820 830
YQDQLSLYQQ FGKKPLWLNS EDVAPYIEST ETLIIER
Length:837
Mass (Da):94,373
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE980C504CB303627
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M86533 Genomic DNA Translation: AAP86197.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86533 Genomic DNA Translation: AAP86197.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CP9X-ray2.50A24-228[»]
B285-837[»]
SMRiQ7WZI9
ModBaseiSearch...
PDBe-KBiSearch...

Protein family/group databases

MEROPSiS45.001

Miscellaneous databases

EvolutionaryTraceiQ7WZI9

Family and domain databases

CDDicd03748, Ntn_PGA, 1 hit
Gene3Di1.10.1400.10, 1 hit
1.10.439.10, 1 hit
2.30.120.10, 1 hit
3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055, Ntn_hydrolases_N
IPR014395, Pen/GL7ACA/AHL_acylase
IPR043147, Penicillin_amidase_A-knob
IPR023343, Penicillin_amidase_dom1
IPR043146, Penicillin_amidase_N_B-knob
IPR033813, PGA_C
IPR002692, S45
PANTHERiPTHR34218, PTHR34218, 1 hit
PfamiView protein in Pfam
PF01804, Penicil_amidase, 1 hit
PIRSFiPIRSF001227, Pen_acylase, 1 hit
SUPFAMiSSF56235, SSF56235, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7WZI9_PRORE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7WZI9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: April 7, 2021
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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