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Entry version 104 (12 Aug 2020)
Sequence version 1 (01 Oct 2003)
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Protein
Submitted name:

Nonribosomal peptide synthetase McyB

Gene

mcyB

Organism
Anabaena sp. 90
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ASP46234:G1HCB-1013-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nonribosomal peptide synthetase McyBImported
Submitted name:
Peptide synthetaseImported
Submitted name:
Peptide sythetaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mcyBImported
ORF Names:ANA_C10986Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnabaena sp. 90Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri46234 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaenaunclassified Anabaena
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010101 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome chANA01

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1014O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2091O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
46234.ANA_C10986

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini979 – 1054CarrierInterPro annotationAdd BLAST76
Domaini2056 – 2131CarrierInterPro annotationAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1964 – 1984Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1020, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_0_12_3

KEGG Orthology (KO)

More...
KOi
K16131

Database of Orthologous Groups

More...
OrthoDBi
572620at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 2 hits
3.30.559.10, 2 hits
3.40.50.12780, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 2 hits
PF00550, PP-binding, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 2 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7WRQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVEKSQKNK NVESIYPLSP MQQGMLFHSI YAPDSGVYCN QTLITICTDI
60 70 80 90 100
NVIAFKRAWE QVVERYSVLR TLFLWEKRQQ PLQVVRKQVD LPWNYQDWRN
110 120 130 140 150
LSSIEQQQRL DSLLQTEYQE GFQLNQAPLM RCTLIRLSDQ SYKFLWNWHH
160 170 180 190 200
ILLDGWCLPI IYKEVLTFYT AYSQGQNCYL PSPRPYQDYI IWLQQQDLSV
210 220 230 240 250
AEMFWRRTLK GFTAPTPLVV DRPQLSNSGV QPTYQEQELH LSRATTKGLQ
260 270 280 290 300
SLGLQYGLTL STLIQAAWAI LLSRYSGSGE SEVLFGVTVS GRPASLPMVE
310 320 330 340 350
NMVGLFINTL PLRVSTPKSE LIIPWLQQLQ QKQAELQEYT YSTLAEVQNM
360 370 380 390 400
SDVPPGVPLF ESLVVFENYP MDSLSEEPNQ LLPVSKVENF EQTNYPLTVA
410 420 430 440 450
AIPKQELLIK FSYDTSRFTG DTIVRMAGHL QTLLTAIVAN PQQQIAELPL
460 470 480 490 500
LTQAERHQLL VEWNDTQTDY PLDKCIHQLF EEQVERNPNA VAVIFEGQQL
510 520 530 540 550
TYQQLNQKAN QLAHYLRTKG VEPEVLVGIF VERSIEMLIG LLGILKAGGA
560 570 580 590 600
YVPLDPSYPS DRLIYMLTDA AVSILLTQQS LVDSLEANSA EVVCLDRDWH
610 620 630 640 650
IIANYSQHNP VKLVKAENLA YVIYTSGSTG KPKGVMNIHK GICNNLLRTI
660 670 680 690 700
DTYPLIAGDC ILHIGVLSFD VSVWEIFWSL TSGTTLVVAK PEGHKDIAYL
710 720 730 740 750
INLIAQQQVT QVFFVPSMLR IFLQQPNLES CRCLKRVFSG AETLSYELTQ
760 770 780 790 800
RFFERLDCEL HNLYGPTEAA VDATCWQCQP QSNYQVIPIG RPIANTQTYI
810 820 830 840 850
LDQYLQPVPI GIAGELHIGG VQLARGYLNQ PELTNERFIS NPFGEGKLYK
860 870 880 890 900
TGDKARYLSD GNIEYLGRID HQVKLRGLRI ELGEIEFLLD THPQVEQTVV
910 920 930 940 950
VLQADTSENQ RLVAYVVRKN SSLTPSELRR FLQQKLPAYM IPSAFVVLSE
960 970 980 990 1000
LPLNPNGKID RRKLPQPDET SIVELPYLPP RNSSERILVS IWQQVLQVSK
1010 1020 1030 1040 1050
VGVNDNFFDL GGHSLKAIAL VNQIQEKLGL SFQIKQVFLH PTIAEQAELL
1060 1070 1080 1090 1100
TASTPINVQV IPHLSKQENY ETSHAQKRFF VLQQMDLNNV AYHIVSTLKI
1110 1120 1130 1140 1150
KGNFDPDAFE KAMQVLIARH ETLRTSFVLI NGEPRQKVLA HSPFHVGFQD
1160 1170 1180 1190 1200
WSNQPHAESH ILEIIKQSQE PFDLENSPLL RANIYKLPEQ QYILCMEIHH
1210 1220 1230 1240 1250
IICDGWSMDL LAKECLKYYN YFVKGLQPNP DKLSIQYKDY AAWQANILRS
1260 1270 1280 1290 1300
DEYRKNLDYW RQKLDNGQIP RIHLPTDFQR PSIKTFNGSH LSWTFKPEIV
1310 1320 1330 1340 1350
CGLRGICQQR ESTLFMALLT AVKVLLYRYS GQHDISIGTE IATRNHPQLQ
1360 1370 1380 1390 1400
SLIGLFLNTL VLRDQIEPEQ GYKNLLAQVR QTVTEAFEHA DYPFDILVEE
1410 1420 1430 1440 1450
LAISKEINRT PLFDVLLLLQ NFGQPIAIEE LQIKSLNSLT PTSKFDLSFV
1460 1470 1480 1490 1500
FIEQNEQLRL DLIYNTDLFQ AERMQKCLSH FDKLLTEMLN NPSQPICKIS
1510 1520 1530 1540 1550
LLSPTETAFF ESFIQPIPRL ERRTVIHDFI EQVRALPDKT SIIYSQGELS
1560 1570 1580 1590 1600
YLELDTLTNS WANIFKYLGI QKDNICGVIL EGDYRQVLAM LAVFKAGGIY
1610 1620 1630 1640 1650
LPLRLDEPEE RSLRMMSKTS PTMIVVDSEN LDIIKPRLAL LPKPPQILVI
1660 1670 1680 1690 1700
NAHEIQQYYQ WDGTNYQCLL VEANHDKKVL IMPDADDSNY IMFTSGSTGE
1710 1720 1730 1740 1750
PKAILGSHGS LRHFINWEKL EFGINSNWRC LQIAQINFDA YLRETLVTLC
1760 1770 1780 1790 1800
SGGTLYIPDS TDREDLEKLL LRLGEWQINL LHTVPSVMRL FLKIGRNLTN
1810 1820 1830 1840 1850
ADQLLKNLRV LVLGGEPLFV KELREWHQVF GSQTEFVNIY GASETTFVKH
1860 1870 1880 1890 1900
FHRIPDPNKI TYARVPGGKT LPEAAFAVID GTRPCAVGEV GEIFVKSPYL
1910 1920 1930 1940 1950
TKGYYQDQRL TNSVFIPNPL NHGADIVYCT GDLGRLLPDL TVEVIGRSDK
1960 1970 1980 1990 2000
QVKLNGVRIE LGEIEDALAA IDGVEKALVI AEEKEELVTV IAYYQAKNAI
2010 2020 2030 2040 2050
NHQHISSQLK QVLPIYMQPN HLMQLADFPL LPNGKINRLG LPKAEANIAQ
2060 2070 2080 2090 2100
TSHQITSFNP QEALLASIWT ELLEVEVSDT NQSFFELGGN SLKAMRLVSH
2110 2120 2130
IRNQFGVALR LREIFTQNTL KAQADLIQLR QEK
Length:2,133
Mass (Da):243,074
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF806DB0F9372FE7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY212249 Genomic DNA Translation: AAO62587.1
CP003284 Genomic DNA Translation: AFW93776.1
AJ536156 Genomic DNA Translation: CAD60102.1

NCBI Reference Sequences

More...
RefSeqi
WP_015078940.1, NC_019427.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AFW93776; AFW93776; ANA_C10986

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
anb:ANA_C10986

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|46234.3.peg.1095

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212249 Genomic DNA Translation: AAO62587.1
CP003284 Genomic DNA Translation: AFW93776.1
AJ536156 Genomic DNA Translation: CAD60102.1
RefSeqiWP_015078940.1, NC_019427.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi46234.ANA_C10986

Genome annotation databases

EnsemblBacteriaiAFW93776; AFW93776; ANA_C10986
KEGGianb:ANA_C10986
PATRICifig|46234.3.peg.1095

Phylogenomic databases

eggNOGiCOG1020, Bacteria
HOGENOMiCLU_000022_0_12_3
KOiK16131
OrthoDBi572620at2

Enzyme and pathway databases

BioCyciASP46234:G1HCB-1013-MONOMER

Family and domain databases

Gene3Di1.10.1200.10, 2 hits
3.30.559.10, 2 hits
3.40.50.12780, 2 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 2 hits
PF00550, PP-binding, 2 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 2 hits
SUPFAMiSSF47336, SSF47336, 2 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 2 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7WRQ4_9NOST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7WRQ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: August 12, 2020
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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