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UniProtKB - Q7VMZ4 (DSBD_HAEDU)
Protein
Thiol:disulfide interchange protein DsbD
Gene
dsbD
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Functioni
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.
UniRule annotationCatalytic activityi
GO - Molecular functioni
- electron transfer activity Source: UniProtKB-UniRule
- protein-disulfide reductase (NAD(P)) activity Source: UniProtKB-UniRule
GO - Biological processi
- cytochrome complex assembly Source: UniProtKB-UniRule
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Cytochrome c-type biogenesis, Electron transport, Transport |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | Recommended name: Thiol:disulfide interchange protein DsbDUniRule annotation (EC:1.8.1.8UniRule annotation)Alternative name(s): Protein-disulfide reductaseUniRule annotation Short name: Disulfide reductaseUniRule annotation |
Gene namesi | Name:dsbDUniRule annotation Ordered Locus Names:HD_0807 |
Organismi | Haemophilus ducreyi (strain 35000HP / ATCC 700724) |
Taxonomic identifieri | 233412 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 175 | PeriplasmicSequence analysisAdd BLAST | 155 | |
Transmembranei | 176 – 196 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 197 – 227 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 228 – 248 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 249 – 251 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 252 – 272 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 273 – 292 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 293 – 313 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 314 – 331 | PeriplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 332 – 352 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 353 – 365 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 366 – 386 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 387 – 393 | PeriplasmicSequence analysis | 7 | |
Transmembranei | 394 – 414 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 415 – 425 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 426 – 446 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 447 – 573 | PeriplasmicSequence analysisAdd BLAST | 127 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | UniRule annotationAdd BLAST | 20 | |
ChainiPRO_0000007375 | 21 – 573 | Thiol:disulfide interchange protein DsbDAdd BLAST | 553 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 121 ↔ 126 | Redox-activeUniRule annotation | ||
Disulfide bondi | 191 ↔ 313 | Redox-activeUniRule annotation | ||
Disulfide bondi | 490 ↔ 493 | Redox-activeUniRule annotation |
Keywords - PTMi
Disulfide bondFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 440 – 573 | ThioredoxinUniRule annotationAdd BLAST | 134 |
Sequence similaritiesi
Keywords - Domaini
Redox-active center, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG4232, Bacteria |
HOGENOMi | CLU_014657_3_0_6 |
OMAi | YRHRFQF |
Family and domain databases
CDDi | cd02953, DsbDgamma, 1 hit |
Gene3Di | 2.60.40.1250, 1 hit |
HAMAPi | MF_00399, DbsD, 1 hit |
InterProi | View protein in InterPro IPR003834, Cyt_c_assmbl_TM_dom IPR035671, DsbD_gamma IPR028250, DsbDN IPR036929, DsbDN_sf IPR022910, Thiol_diS_interchange_DbsD IPR012336, Thioredoxin-like_fold IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
PANTHERi | PTHR32234:SF0, PTHR32234:SF0, 1 hit |
Pfami | View protein in Pfam PF11412, DsbC, 1 hit PF02683, DsbD, 1 hit PF13098, Thioredoxin_2, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit SSF74863, SSF74863, 1 hit |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q7VMZ4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKRFFLLLS SLLLVCNVQA GLFNNKPQYL TAAEAFIFSS SQQDGQLQLH
60 70 80 90 100
WQIADGYYLY QKEIQLSAQN ATLGDVTFPT AEKYQDEFFG EVAIFRDQLK
110 120 130 140 150
LPVKLTDLKE NPSLKIRYQG CTKGFCYPPE TVVIPLNPSL QGNNSANSAA
160 170 180 190 200
LPSTIATPNA PQTELAENLS NNYLSIFGFL LLGIGLAFTP CVLPMLPLLS
210 220 230 240 250
AIVIGHKNRP NTSRALLLSF TYVQGMALTY TLLGLTVAAI GLPFQVALQS
260 270 280 290 300
PAVLISLAVL FTLLAASMFG LFEIRLPNTW QQKLNALSQQ QQGGAVGNVF
310 320 330 340 350
IMGIIAGLVA SPCTSAPLSG ALLYVAQSGN LLIGGLALYL LALGMGLPLI
360 370 380 390 400
LITVFGNQIL PKSGEWLFKV KTAFGFVMLA LPIFLISRIL PSHYEPFLWS
410 420 430 440 450
TLALAFLGWL ISSLNYSTML KQAVRILLFI AFGLTAYPWA NLVWQTTSNT
460 470 480 490 500
AQPTTPHLAM EKITSLTELE QKLTAYQGKK VMLDLYADWC VACKEFEKYT
510 520 530 540 550
FTDPQVQQQL ATMAVLQIDM TKNSAENTAL MKHFNVLGLP TILFFDENGH
560 570
EMTNVRITGF LTANQFLAWL NRL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017143 Genomic DNA Translation: AAP95707.1 |
RefSeqi | WP_010944757.1, NC_002940.2 |
Genome annotation databases
EnsemblBacteriai | AAP95707; AAP95707; HD_0807 |
KEGGi | hdu:HD_0807 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017143 Genomic DNA Translation: AAP95707.1 |
RefSeqi | WP_010944757.1, NC_002940.2 |
3D structure databases
AlphaFoldDBi | Q7VMZ4 |
SMRi | Q7VMZ4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 233412.HD_0807 |
Genome annotation databases
EnsemblBacteriai | AAP95707; AAP95707; HD_0807 |
KEGGi | hdu:HD_0807 |
Phylogenomic databases
eggNOGi | COG4232, Bacteria |
HOGENOMi | CLU_014657_3_0_6 |
OMAi | YRHRFQF |
Family and domain databases
CDDi | cd02953, DsbDgamma, 1 hit |
Gene3Di | 2.60.40.1250, 1 hit |
HAMAPi | MF_00399, DbsD, 1 hit |
InterProi | View protein in InterPro IPR003834, Cyt_c_assmbl_TM_dom IPR035671, DsbD_gamma IPR028250, DsbDN IPR036929, DsbDN_sf IPR022910, Thiol_diS_interchange_DbsD IPR012336, Thioredoxin-like_fold IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
PANTHERi | PTHR32234:SF0, PTHR32234:SF0, 1 hit |
Pfami | View protein in Pfam PF11412, DsbC, 1 hit PF02683, DsbD, 1 hit PF13098, Thioredoxin_2, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit SSF74863, SSF74863, 1 hit |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DSBD_HAEDU | |
Accessioni | Q7VMZ4Primary (citable) accession number: Q7VMZ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | October 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families