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UniProtKB - Q7VMZ4 (DSBD_HAEDU)

Entry version 115 (11 Dec 2019)
Sequence version 1 (01 Oct 2003)
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Protein

Thiol:disulfide interchange protein DsbD

Gene

dsbD

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processCytochrome c-type biogenesis, Electron transport, Transport
LigandNAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		HDUC233412:G1G0H-664-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbDUniRule annotation (EC:1.8.1.8UniRule annotation)
Alternative name(s):
Protein-disulfide reductaseUniRule annotation
Short name:
Disulfide reductaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dsbDUniRule annotation
Ordered Locus Names:HD_0807
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri233412 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001022 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 175PeriplasmicSequence analysisAdd BLAST155
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei176 – 196HelicalUniRule annotationAdd BLAST21
Topological domaini197 – 227CytoplasmicSequence analysisAdd BLAST31
Transmembranei228 – 248HelicalUniRule annotationAdd BLAST21
Topological domaini249 – 251PeriplasmicSequence analysis3
Transmembranei252 – 272HelicalUniRule annotationAdd BLAST21
Topological domaini273 – 292CytoplasmicSequence analysisAdd BLAST20
Transmembranei293 – 313HelicalUniRule annotationAdd BLAST21
Topological domaini314 – 331PeriplasmicSequence analysisAdd BLAST18
Transmembranei332 – 352HelicalUniRule annotationAdd BLAST21
Topological domaini353 – 365CytoplasmicSequence analysisAdd BLAST13
Transmembranei366 – 386HelicalUniRule annotationAdd BLAST21
Topological domaini387 – 393PeriplasmicSequence analysis7
Transmembranei394 – 414HelicalUniRule annotationAdd BLAST21
Topological domaini415 – 425CytoplasmicSequence analysisAdd BLAST11
Transmembranei426 – 446HelicalUniRule annotationAdd BLAST21
Topological domaini447 – 573PeriplasmicSequence analysisAdd BLAST127

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20UniRule annotationAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000737521 – 573Thiol:disulfide interchange protein DsbDAdd BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi121 ↔ 126Redox-activeUniRule annotation
Disulfide bondi191 ↔ 313Redox-activeUniRule annotation
Disulfide bondi490 ↔ 493Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bond

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		233412.HD_0807

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7VMZ4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini440 – 573ThioredoxinUniRule annotationAdd BLAST134

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thioredoxin family. DsbD subfamily.UniRule annotation

Keywords - Domaini

Redox-active center, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105CSG Bacteria
COG4232 LUCA

KEGG Orthology (KO)

More...KOi		K04084

Identification of Orthologs from Complete Genome Data

More...OMAi		FVYVQGM

Family and domain databases

Conserved Domains Database

More...CDDi		cd02953 DsbDgamma, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.1250, 1 hit
3.40.30.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00399 DbsD, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003834 Cyt_c_assmbl_TM_dom
IPR035671 DsbD_gamma
IPR028250 DsbDN
IPR036929 DsbDN_sf
IPR022910 Thiol_diS_interchange_DbsD
IPR012336 Thioredoxin-like_fold
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain

The PANTHER Classification System

More...PANTHERi		PTHR32234:SF0 PTHR32234:SF0, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11412 DsbC, 1 hit
PF02683 DsbD, 1 hit
PF13098 Thioredoxin_2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52833 SSF52833, 1 hit
SSF74863 SSF74863, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q7VMZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKRFFLLLS SLLLVCNVQA GLFNNKPQYL TAAEAFIFSS SQQDGQLQLH 
        60         70         80         90        100
WQIADGYYLY QKEIQLSAQN ATLGDVTFPT AEKYQDEFFG EVAIFRDQLK 
       110        120        130        140        150
LPVKLTDLKE NPSLKIRYQG CTKGFCYPPE TVVIPLNPSL QGNNSANSAA 
       160        170        180        190        200
LPSTIATPNA PQTELAENLS NNYLSIFGFL LLGIGLAFTP CVLPMLPLLS 
       210        220        230        240        250
AIVIGHKNRP NTSRALLLSF TYVQGMALTY TLLGLTVAAI GLPFQVALQS 
       260        270        280        290        300
PAVLISLAVL FTLLAASMFG LFEIRLPNTW QQKLNALSQQ QQGGAVGNVF 
       310        320        330        340        350
IMGIIAGLVA SPCTSAPLSG ALLYVAQSGN LLIGGLALYL LALGMGLPLI 
       360        370        380        390        400
LITVFGNQIL PKSGEWLFKV KTAFGFVMLA LPIFLISRIL PSHYEPFLWS 
       410        420        430        440        450
TLALAFLGWL ISSLNYSTML KQAVRILLFI AFGLTAYPWA NLVWQTTSNT 
       460        470        480        490        500
AQPTTPHLAM EKITSLTELE QKLTAYQGKK VMLDLYADWC VACKEFEKYT 
       510        520        530        540        550
FTDPQVQQQL ATMAVLQIDM TKNSAENTAL MKHFNVLGLP TILFFDENGH 
       560        570 
EMTNVRITGF LTANQFLAWL NRL
Length:573
Mass (Da):63,070
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D1D3A9C7E3632D6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE017143 Genomic DNA Translation: AAP95707.1

NCBI Reference Sequences

More...RefSeqi		WP_010944757.1, NC_002940.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAP95707; AAP95707; HD_0807

Database of genes from NCBI RefSeq genomes

More...GeneIDi		24944704

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hdu:HD_0807

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017143 Genomic DNA Translation: AAP95707.1
RefSeqiWP_010944757.1, NC_002940.2

3D structure databases

SMRiQ7VMZ4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi233412.HD_0807

Genome annotation databases

EnsemblBacteriaiAAP95707; AAP95707; HD_0807
GeneIDi24944704
KEGGihdu:HD_0807

Phylogenomic databases

eggNOGiENOG4105CSG Bacteria
COG4232 LUCA
KOiK04084
OMAiFVYVQGM

Enzyme and pathway databases

BioCyciHDUC233412:G1G0H-664-MONOMER

Family and domain databases

CDDicd02953 DsbDgamma, 1 hit
Gene3Di2.60.40.1250, 1 hit
3.40.30.10, 1 hit
HAMAPiMF_00399 DbsD, 1 hit
InterProiView protein in InterPro
IPR003834 Cyt_c_assmbl_TM_dom
IPR035671 DsbD_gamma
IPR028250 DsbDN
IPR036929 DsbDN_sf
IPR022910 Thiol_diS_interchange_DbsD
IPR012336 Thioredoxin-like_fold
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PANTHERiPTHR32234:SF0 PTHR32234:SF0, 1 hit
PfamiView protein in Pfam
PF11412 DsbC, 1 hit
PF02683 DsbD, 1 hit
PF13098 Thioredoxin_2, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF74863 SSF74863, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSBD_HAEDU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7VMZ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2003
Last modified: December 11, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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