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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104NADPBy similarity1
Binding sitei104SubstrateBy similarity1
Active sitei185Proton acceptorBy similarity1
Active sitei192Proton donorBy similarity1
Binding sitei193SubstrateBy similarity1
Binding sitei262Substrate; via amide nitrogenBy similarity1
Binding sitei289SubstrateBy similarity1
Binding sitei447Substrate; shared with dimeric partnerBy similarity1
Binding sitei453Substrate; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADPBy similarity6
Nucleotide bindingi34 – 36NADPBy similarity3
Nucleotide bindingi76 – 78NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGluconate utilization, Pentose shunt
LigandNADP

Enzyme and pathway databases

BioCyciHDUC233412:G1G0H-684-MONOMER
UniPathwayiUPA00115; UER00410

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:HD_0833
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000001022 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000900401 – 4846-phosphogluconate dehydrogenase, decarboxylatingAdd BLAST484

Proteomic databases

PRIDEiQ7VMX4

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi233412.HD0833

Structurei

3D structure databases

ProteinModelPortaliQ7VMX4
SMRiQ7VMX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni130 – 132Substrate bindingBy similarity3
Regioni188 – 189Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C7Q Bacteria
COG0362 LUCA
KOiK00033
OMAiNSHYPDS
OrthoDBiPOG091H01QF

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006114 6PGDH_C
IPR006113 6PGDH_Gnd/GntZ
IPR006115 6PGDH_NADP-bd
IPR006184 6PGdom_BS
IPR036291 NAD(P)-bd_dom_sf
IPR006183 Pgluconate_DH
PfamiView protein in Pfam
PF00393 6PGD, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000109 6PGD, 1 hit
PRINTSiPR00076 6PGDHDRGNASE
SMARTiView protein in SMART
SM01350 6PGD, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00873 gnd, 1 hit
PROSITEiView protein in PROSITE
PS00461 6PGD, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VMX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIKGDIGVI GLAVMGQNLI LNMNDNGFKV VAYNRTASKV DEFLAGEAKD
60 70 80 90 100
TNIIGAYSLE DLAAKLEKPR KIMLMVRAGE VVDQFIDALL PHLEAGDIII
110 120 130 140 150
DGGNSNYPDT NRRTITLAEK GIRFIGTGVS GGEEGARHGP SIMPGGNEEA
160 170 180 190 200
WPFVKPILQA ISAKTDKDEP CCDWVGKEGA GHFVKMVHNG IEYGDMQLIC
210 220 230 240 250
EAYQFLKDGL GLNYEEMHAI FADWKNTELD SYLIDITADI LAYKDADGEP
260 270 280 290 300
LVEKILDTAG QKGTGKWTGI NALDFGIPLT LITEAVFARC VSAFKDQRVA
310 320 330 340 350
VSQLFNKTIT PISDDKKEWI EAVRKALLAS KIISYAQGFM LIREASENFE
360 370 380 390 400
WNINYGATAL LWREGCIIRS AFLGNIRDAY EANPGLVFLG SDPYFQNILQ
410 420 430 440 450
SAMADWRKVV AKSIEIGIPM PCMAAAITFL DGYSSEHLPA NLLQAQRDYF
460 470 480
GAHTYERTDK PRCSFFHTNW TGRGGNTAST TYDV
Length:484
Mass (Da):53,272
Last modified:October 1, 2003 - v1
Checksum:iBA23A9A770615B23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017143 Genomic DNA Translation: AAP95728.1
RefSeqiWP_010944778.1, NC_002940.2

Genome annotation databases

EnsemblBacteriaiAAP95728; AAP95728; HD_0833
GeneIDi24943692
KEGGihdu:HD_0833

Similar proteinsi

Entry informationi

Entry namei6PGD_HAEDU
AccessioniPrimary (citable) accession number: Q7VMX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2003
Last modified: February 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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