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Protein

Circadian clock protein kinase KaiC

Gene

kaiC

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core component of the KaiBC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiBC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi291MagnesiumUniRule annotation1
Metal bindingi314MagnesiumUniRule annotation1
Metal bindingi315MagnesiumUniRule annotation1
Metal bindingi374MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi42 – 49ATPUniRule annotation8
Nucleotide bindingi284 – 291ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processBiological rhythms, Transcription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR74547:AKG35_RS07565-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Circadian clock protein kinase KaiCUniRule annotation (EC:2.7.11.1UniRule annotation)
Gene namesi
Name:kaiCUniRule annotation
Ordered Locus Names:PMT_1418
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001423 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002177771 – 499Circadian clock protein kinase KaiCAdd BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei428Phosphothreonine; by autocatalysisUniRule annotation1

Post-translational modificationi

Phosphorylated on serine/threonine residues by autocatalysis. Both phosphorylated and unphosphorylated forms exist. Can probably autophosphorylate and autodephosphorylate. Phosphorylated form correlates with clock speed.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homohexamer; hexamerization is dependent on ATP-binding. Component of the KaiBC complex with KaiB. Interacts directly with SasA.UniRule annotation

Protein-protein interaction databases

STRINGi74547.PMT1418

Structurei

3D structure databases

ProteinModelPortaliQ7V5W7
SMRiQ7V5W7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 256KaiC 1UniRule annotationAdd BLAST242
Domaini257 – 489KaiC 2UniRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the KaiC family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105EHU Bacteria
COG0467 LUCA
KOiK08482
OMAiHSITDSH
OrthoDBiPOG091H0SAA

Family and domain databases

HAMAPiMF_01836 KaiC, 1 hit
InterProiView protein in InterPro
IPR013503 Circadian_KaiC_bact
IPR030665 KaiC
IPR014774 KaiC-like_dom
IPR010624 KaiC_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF06745 ATPase, 2 hits
PIRSFiPIRSF039117 KaiC, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR02655 circ_KaiC, 1 hit
PROSITEiView protein in PROSITE
PS51146 KAIC, 2 hits

Sequencei

Sequence statusi: Complete.

Q7V5W7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSSSAGGSS HMQVQKLPTG IEGFDDICHG GLPSGRSTLI SGTSGTGKTV
60 70 80 90 100
FSLHFLHNGI TQFDEPGIFV TFEESPSDIL RNSASFGWNL QEMVEQDKLF
110 120 130 140 150
ILDASPDPDG QDVAGSFDLS GLIERINYAI VKYKAKRVAI DSMTAVFQQY
160 170 180 190 200
DAISVVRREI FRLIARLKVI GVTTVMTTER IDEYGPIARY GVEEFVSDNV
210 220 230 240 250
VILRNVLETE KRRRTVEILK LRGTTHMKGE FPFTMGTHGV SVFPLGAMRL
260 270 280 290 300
TQRSSNVRIS SGVPNLDEMC GGGFFKDSII LVTGATGTGK TLLVSKFIED
310 320 330 340 350
AFRNQERAIL FAYEESRAQL LRNATSWGID FEEMERQGLL KIICAYPEST
360 370 380 390 400
GLEDHLEIIK TAIGQFKPSR MAIDSLSALA RGVSLNAFRQ FVIGVTGYAK
410 420 430 440 450
QEEIAGFFTN TAEEFMGSHS ITDSHISTIT DTILLLQYVE IRGEMARAVN
460 470 480 490
VFKMRGSWHD KRIREYVITD NGPQIKDSFS NFERIFSGAP HRITDDERA
Length:499
Mass (Da):55,454
Last modified:October 1, 2003 - v1
Checksum:i1B0BE2D96431C869
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA Translation: CAE21593.1
RefSeqiWP_011130786.1, NC_005071.1

Genome annotation databases

EnsemblBacteriaiCAE21593; CAE21593; PMT_1418
KEGGipmt:PMT_1418

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA Translation: CAE21593.1
RefSeqiWP_011130786.1, NC_005071.1

3D structure databases

ProteinModelPortaliQ7V5W7
SMRiQ7V5W7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi74547.PMT1418

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE21593; CAE21593; PMT_1418
KEGGipmt:PMT_1418

Phylogenomic databases

eggNOGiENOG4105EHU Bacteria
COG0467 LUCA
KOiK08482
OMAiHSITDSH
OrthoDBiPOG091H0SAA

Enzyme and pathway databases

BioCyciPMAR74547:AKG35_RS07565-MONOMER

Family and domain databases

HAMAPiMF_01836 KaiC, 1 hit
InterProiView protein in InterPro
IPR013503 Circadian_KaiC_bact
IPR030665 KaiC
IPR014774 KaiC-like_dom
IPR010624 KaiC_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF06745 ATPase, 2 hits
PIRSFiPIRSF039117 KaiC, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR02655 circ_KaiC, 1 hit
PROSITEiView protein in PROSITE
PS51146 KAIC, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKAIC_PROMM
AccessioniPrimary (citable) accession number: Q7V5W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2003
Last modified: June 20, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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