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UniProtKB - Q7V4A7 (DNCH_PROMM)
Protein
1,4-dihydroxy-2-naphthoyl-CoA hydrolase
Gene
PMT_2055
Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Functioni
Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.
UniRule annotationCatalytic activityi
- EC:3.1.2.28UniRule annotation
: phylloquinone biosynthesis Pathwayi
This protein is involved in the pathway phylloquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway phylloquinone biosynthesis and in Cofactor biosynthesis.
Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis
This protein is involved in step 7 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 19 | UniRule annotation | 1 |
GO - Molecular functioni
- thiolester hydrolase activity Source: UniProtKB-UniRule
GO - Biological processi
- phylloquinone biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
UniPathwayi | UPA00995 UPA01057;UER01033 |
Names & Taxonomyi
Protein namesi | Recommended name: 1,4-dihydroxy-2-naphthoyl-CoA hydrolaseUniRule annotation (EC:3.1.2.28UniRule annotation)Short name: DHNA-CoA hydrolaseUniRule annotation Alternative name(s): DHNA-CoA thioesteraseUniRule annotation |
Gene namesi | Ordered Locus Names:PMT_2055 |
Organismi | Prochlorococcus marinus (strain MIT 9313) |
Taxonomic identifieri | 74547 [NCBI] |
Taxonomic lineagei | Bacteria › Cyanobacteria › Synechococcales › Prochlorococcaceae › Prochlorococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000377022 | 1 – 151 | 1,4-dihydroxy-2-naphthoyl-CoA hydrolaseAdd BLAST | 151 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q7V4A7 |
SMRi | Q7V4A7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q7V4A7 |
Family & Domainsi
Sequence similaritiesi
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.UniRule annotation
Phylogenomic databases
eggNOGi | COG0824, Bacteria |
HOGENOMi | CLU_101141_5_3_3 |
OMAi | IVNCEAN |
OrthoDBi | 1786865at2 |
Family and domain databases
HAMAPi | MF_02101, DHNA_CoA_hydrolase, 1 hit |
InterProi | View protein in InterPro IPR022829, DHNA_CoA_hydrolase IPR029069, HotDog_dom_sf |
SUPFAMi | SSF54637, SSF54637, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7V4A7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPENWLLLR RVVRFGDTDA AGVMHFHQLF RWCHESWEES LESYGLNPAD
60 70 80 90 100
IFPGSRKSEV TPEVALPIIH CQADFRRPIH TGDALAMELR PERLNPNSFQ
110 120 130 140 150
VHFEFRCEEQ IAAHALIRHL AINAQTRHRC ALPEGIDRWL EASGVGKIGS
I
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX548175 Genomic DNA Translation: CAE22229.1 |
RefSeqi | WP_011131420.1, NC_005071.1 |
Genome annotation databases
EnsemblBacteriai | CAE22229; CAE22229; PMT_2055 |
KEGGi | pmt:PMT_2055 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX548175 Genomic DNA Translation: CAE22229.1 |
RefSeqi | WP_011131420.1, NC_005071.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2HX5 | X-ray | 1.50 | A | 1-151 | [»] | |
AlphaFoldDBi | Q7V4A7 | |||||
SMRi | Q7V4A7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 74547.PMT_2055 |
Protocols and materials databases
DNASUi | 1729478 |
Genome annotation databases
EnsemblBacteriai | CAE22229; CAE22229; PMT_2055 |
KEGGi | pmt:PMT_2055 |
Phylogenomic databases
eggNOGi | COG0824, Bacteria |
HOGENOMi | CLU_101141_5_3_3 |
OMAi | IVNCEAN |
OrthoDBi | 1786865at2 |
Enzyme and pathway databases
UniPathwayi | UPA00995 UPA01057;UER01033 |
Miscellaneous databases
EvolutionaryTracei | Q7V4A7 |
Family and domain databases
HAMAPi | MF_02101, DHNA_CoA_hydrolase, 1 hit |
InterProi | View protein in InterPro IPR022829, DHNA_CoA_hydrolase IPR029069, HotDog_dom_sf |
SUPFAMi | SSF54637, SSF54637, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DNCH_PROMM | |
Accessioni | Q7V4A7Primary (citable) accession number: Q7V4A7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 16, 2009 |
Last sequence update: | October 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families