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Protein

Kin of IRRE-like protein 2

Gene

Kirrel2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate basal insulin secretion.1 Publication

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

GO - Biological processi

  • cell-cell adhesion Source: MGI
  • negative regulation of protein phosphorylation Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-373753 Nephrin family interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Kin of IRRE-like protein 2
Alternative name(s):
Kin of irregular chiasm-like protein 2
Gene namesi
Name:Kirrel2
Synonyms:Neph3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2442334 Kirrel2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 507ExtracellularSequence analysisAdd BLAST488
Transmembranei508 – 528HelicalSequence analysisAdd BLAST21
Topological domaini529 – 700CytoplasmicSequence analysisAdd BLAST172

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. However basal insulin secretion is modestly increased in pancreatic islets of KIRREL2 deficient mice.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi595 – 596YY → FF: Enhances stability. Modifies the structure of cell contacts. Localization at the plasma membrane is increased. Does not affect dimerization. No change in shedding activity. 1 Publication2
Mutagenesisi631 – 632YY → FF: Does not modifies the structure of cell contacts. No effect on localization at the plasma membrane. No change in shedding activity. 1 Publication2
Mutagenesisi653Y → F: Does not modifies the structure of cell contacts. No effect on localization at the plasma membrane. No change in shedding activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001509720 – 700Kin of IRRE-like protein 2Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 100PROSITE-ProRule annotation
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 201PROSITE-ProRule annotation
Disulfide bondi245 ↔ 288PROSITE-ProRule annotation
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi330 ↔ 372PROSITE-ProRule annotation
Disulfide bondi416 ↔ 482PROSITE-ProRule annotation
Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei563Phosphoserine1 Publication1
Modified residuei595Phosphotyrosine1 Publication1
Modified residuei596Phosphotyrosine1 Publication1
Modified residuei653Phosphotyrosine1 Publication1

Post-translational modificationi

N-glycosylated.1 Publication
Phosphorylated at Ser-548 or Ser-549; due to site ambiguity, the exact position of the serine phosphorylation could not be determined. Phosphorylation at residues Tyr-631 and/or Tyr-632. FYN mediates tyrosine phosphorylation in pancreatic beta-cells.1 Publication
The extracellular domain is cleaved leading to the generation of a soluble fragment and a membrane-bound C-terminal fragment, which is further cleaved by gamma-secretase.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ7TSU7
PRIDEiQ7TSU7

PTM databases

iPTMnetiQ7TSU7
PhosphoSitePlusiQ7TSU7

Expressioni

Tissue specificityi

Highly expressed in beta-cells of the pancreatic islets. Expression is seen in podocytes of kidney glomeruli, and in the cerebellum and hindbrain at E12.5, in the spinal cord at E10.5, and in the retina and hypothalamus at E13.5.3 Publications

Gene expression databases

BgeeiENSMUSG00000036915 Expressed in 31 organ(s), highest expression level in fourth ventricle
CleanExiMM_KIRREL2
ExpressionAtlasiQ7TSU7 baseline and differential

Interactioni

Subunit structurei

Homodimer (PubMed:26324709). Interacts with NPHS2/podocin (via the C-terminus). Interacts with NPHS1 (via the Ig-like domains). Interacts wit FYN (PubMed:26324709).3 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039395

Structurei

3D structure databases

ProteinModelPortaliQ7TSU7
SMRiQ7TSU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 115Ig-like C2-type 1Add BLAST95
Domaini120 – 219Ig-like C2-type 2Add BLAST100
Domaini224 – 304Ig-like C2-type 3Add BLAST81
Domaini309 – 391Ig-like C2-type 4Add BLAST83
Domaini395 – 497Ig-like C2-type 5Add BLAST103

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi146 – 148Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3510 Eukaryota
ENOG410XPX0 LUCA
GeneTreeiENSGT00550000074545
HOGENOMiHOG000020211
HOVERGENiHBG052260
InParanoidiQ7TSU7
OMAiGQGPGLI
OrthoDBiEOG091G0UW4
PhylomeDBiQ7TSU7
TreeFamiTF327139

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TSU7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLASALLVFL CCFKGHAGSS PHFLQQPEDM VVLLGEEARL PCALGAYRGL
60 70 80 90 100
VQWTKDGLAL GGERDLPGWS RYWISGNSAS GQHDLHIKPV ELEDEASYEC
110 120 130 140 150
QASQAGLRSR PAQLHVMVPP EAPQVLGGPS VSLVAGVPGN LTCRSRGDSR
160 170 180 190 200
PAPELLWFRD GIRLDGSSFH QTTLKDKATG TVENTLFLTP SSHDDGATLI
210 220 230 240 250
CRARSQALPT GRDTAVTLSL QYPPMVTLSA EPQTVQEGEK VTFLCQATAQ
260 270 280 290 300
PPVTGYRWAK GGSPVLGARG PRLEVVADAT FLTEPVSCEV SNAVGSANRS
310 320 330 340 350
TALEVLYGPI LQAKPKSVSV DVGKDASFSC VWRGNPLPRI TWTRMGGSQV
360 370 380 390 400
LSSGPTLRLP SVALEDAGDY VCRAEPRRTG LGGGKAQARL TVNAPPVVTA
410 420 430 440 450
LQPAPAFLRG PARLQCVVFA SPAPDSVVWS WDEGFLEAGS LGRFLVEAFP
460 470 480 490 500
APEVEGGQGP GLISVLHISG TQESDFTTGF NCSARNRLGE GRVQIHLGRR
510 520 530 540 550
DLLPTVRIVA GAASAATSLL MVITGVVLCC WRHGSLSKQK NLVRIPGSSE
560 570 580 590 600
GSSSRGPEEE TGSSEDRGPI VHTDHSDLVL EEKEALETKD PTNGYYRVRG
610 620 630 640 650
VSVSLSLGEA PGGGLFLPPP SPIGLPGTPT YYDFKPHLDL VPPCRLYRAR
660 670 680 690 700
AGYLTTPHPR AFTSYMKPTS FGPPELSSGT PPFPYATLSP PSHQRLQTHV
Length:700
Mass (Da):74,529
Last modified:October 1, 2003 - v1
Checksum:i5D9404C2E13B18B8
GO
Isoform 2 (identifier: Q7TSU7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-136: Missing.

Show »
Length:681
Mass (Da):72,773
Checksum:i8230C4F2A0542BB4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6WZB3F6WZB3_MOUSE
Kin of IRRE-like protein 2
Kirrel2
175Annotation score:
A0A171EBL3A0A171EBL3_MOUSE
Kin of IRRE-like protein 2
Kirrel2
310Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48R → W (PubMed:12837264).Curated1
Sequence conflicti166G → A in AAP72168 (PubMed:12837264).Curated1
Sequence conflicti376P → A in AAP72168 (PubMed:12837264).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011786118 – 136Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052773 mRNA Translation: AAH52773.1
AY305303 mRNA Translation: AAP72168.1
CCDSiCCDS39883.1 [Q7TSU7-1]
RefSeqiNP_766486.1, NM_172898.3 [Q7TSU7-1]
UniGeneiMm.113908

Genome annotation databases

EnsembliENSMUST00000045817; ENSMUSP00000039395; ENSMUSG00000036915 [Q7TSU7-1]
GeneIDi243911
KEGGimmu:243911
UCSCiuc009gel.1 mouse [Q7TSU7-1]
uc012fho.1 mouse [Q7TSU7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052773 mRNA Translation: AAH52773.1
AY305303 mRNA Translation: AAP72168.1
CCDSiCCDS39883.1 [Q7TSU7-1]
RefSeqiNP_766486.1, NM_172898.3 [Q7TSU7-1]
UniGeneiMm.113908

3D structure databases

ProteinModelPortaliQ7TSU7
SMRiQ7TSU7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039395

PTM databases

iPTMnetiQ7TSU7
PhosphoSitePlusiQ7TSU7

Proteomic databases

PaxDbiQ7TSU7
PRIDEiQ7TSU7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045817; ENSMUSP00000039395; ENSMUSG00000036915 [Q7TSU7-1]
GeneIDi243911
KEGGimmu:243911
UCSCiuc009gel.1 mouse [Q7TSU7-1]
uc012fho.1 mouse [Q7TSU7-2]

Organism-specific databases

CTDi84063
MGIiMGI:2442334 Kirrel2

Phylogenomic databases

eggNOGiKOG3510 Eukaryota
ENOG410XPX0 LUCA
GeneTreeiENSGT00550000074545
HOGENOMiHOG000020211
HOVERGENiHBG052260
InParanoidiQ7TSU7
OMAiGQGPGLI
OrthoDBiEOG091G0UW4
PhylomeDBiQ7TSU7
TreeFamiTF327139

Enzyme and pathway databases

ReactomeiR-MMU-373753 Nephrin family interactions

Miscellaneous databases

PROiPR:Q7TSU7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036915 Expressed in 31 organ(s), highest expression level in fourth ventricle
CleanExiMM_KIRREL2
ExpressionAtlasiQ7TSU7 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKIRR2_MOUSE
AccessioniPrimary (citable) accession number: Q7TSU7
Secondary accession number(s): Q7TQ98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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