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Entry version 132 (12 Aug 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Brefeldin A-inhibited guanine nucleotide-exchange protein 2

Gene

Arfgef2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by brefeldin A.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Brefeldin A-inhibited guanine nucleotide-exchange protein 2
Short name:
Brefeldin A-inhibited GEP 2
Alternative name(s):
ADP-ribosylation factor guanine nucleotide-exchange factor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arfgef2
Synonyms:Arfgep2, Big2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
631430, Arfgef2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Disease mutation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004193331 – 1791Brefeldin A-inhibited guanine nucleotide-exchange protein 2Add BLAST1791

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei214PhosphoserineBy similarity1
Modified residuei218PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei244PhosphothreonineBy similarity1
Modified residuei277PhosphoserineBy similarity1
Modified residuei355PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei621PhosphoserineBy similarity1
Modified residuei623PhosphothreonineBy similarity1
Modified residuei624PhosphoserineBy similarity1
Modified residuei633PhosphothreonineBy similarity1
Modified residuei707PhosphoserineBy similarity1
Modified residuei1518PhosphoserineCombined sources1
Modified residuei1520PhosphoserineCombined sources1
Modified residuei1521PhosphoserineCombined sources1
Modified residuei1532PhosphoserineCombined sources1
Modified residuei1535PhosphoserineCombined sources1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1788PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

In vitro phosphorylated by PKA reducing its GEF activity and dephosphorylated by phosphatase PP1.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7TSU1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TSU1

PRoteomics IDEntifications database

More...
PRIDEi
Q7TSU1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TSU1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TSU1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain (at protein level).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000007485, Expressed in testis and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TSU1, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with ARFGEF1/BIG1; both proteins are probably part of the same or very similar macromolecular complexes.

Interacts with PRKAR1A, PRKAR2A, PRKAR1B, PRKAR2B, PPP1CC, PDE3A, TNFRSF1A, MYCBP and EXOC7 (By similarity).

Interacts with GABRB1, GABRB2 and GABRB3.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q7TSU1, 9 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000010054

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini661 – 792SEC7PROSITE-ProRule annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 224DCB; DCB:DCB domain and DCB:HUS domain interactionBy similarityAdd BLAST223
Regioni515 – 535HUS; DCB:HUS domain interactionBy similarityAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0929, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158950

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000691_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TSU1

KEGG Orthology (KO)

More...
KOi
K18442

Identification of Orthologs from Complete Genome Data

More...
OMAi
FRMYSDP

Database of Orthologous Groups

More...
OrthoDBi
815698at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7TSU1

TreeFam database of animal gene trees

More...
TreeFami
TF300714

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00171, Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1000.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR032629, DCB_dom
IPR015403, Sec7_C
IPR023394, Sec7_C_sf
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf
IPR032691, Sec7_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16213, DCB, 1 hit
PF09324, DUF1981, 1 hit
PF01369, Sec7, 1 hit
PF12783, Sec7_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00222, Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF48425, SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50190, SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7TSU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQESQTKSMF VSRALEKILA DKEVKRPQHS QLRRACQVAL DEIKAELEKQ
60 70 80 90 100
RLGAAAPPKA NFIEADKYFL PFELACQSKS PRVVSTSLDC LQKLIAYGHI
110 120 130 140 150
TGNAPDSGAP GKRLIDRIVE TVCNCFQGPQ TDEGVQLQII KALLTAVTSP
160 170 180 190 200
HIEIHEGTIL QTVRTCYNIY LASKNLINQT TAKATLTQML NVIFTRMENQ
210 220 230 240 250
VLQEARELEK PIQSKPQSPV IQATAGSPKF SRLKQSQAQS KPTTPEKTEL
260 270 280 290 300
PNGDHARSSL GKVNSENGEA HRERGSSISG RAEPSGGSDN GAQEVVKDIL
310 320 330 340 350
EDVVTSAVKE AAEKQGLPEP DQAPGVPECQ ECTVPPAVDE NSQTNGIADD
360 370 380 390 400
RQSLSSADNL EPDAQGHPVA ARFSHILQKD AFLVFRSLCK LSMKPLGEGP
410 420 430 440 450
PDPKSHELRS KVVSLQLLLS VLQNAGPVFR SHEMFVTAIK QYLCVALSKN
460 470 480 490 500
GVSSVPDVFE LSLAIFLTLL SNFKMHLKMQ IEVFFKEIFL NILETSTSSF
510 520 530 540 550
EHRWMVIQTL TRICADAQCV VDIYVNYDCD LNAANIFERL VNDLSKIAQG
560 570 580 590 600
RSGHELGMTP LQELSLRKKG LECLVSILKC MVEWSKDLYV NPNHQATLGQ
610 620 630 640 650
ERLPDQEMGD GKGLDMARRC SVTSVESTVS SGTQTAIPDD PEQFEVIKQQ
660 670 680 690 700
KEIIEHGIEL FNKKPKRGIQ FLQEQGMLGA AVEDIAQFLH QEERLDSTQV
710 720 730 740 750
GEFLGDSTRF NKEVMYAYVD QLDFCEKEFV SALRTFLEGF RLPGEAQKID
760 770 780 790 800
RLMEKFAARY IECNQGQTLF ASADTAYVLA YSIIMLTTDL HSPQVKNKMT
810 820 830 840 850
KEQYIKMNRG INDSKDLPEE YLSSIYEEIE GKKIAMKETK EHTMATKSTK
860 870 880 890 900
QNVASEKQRR LLYNVEMEQM AKTAKALMEA VSHAKAPFTS ATHLDHVRPM
910 920 930 940 950
FKLVWTPLLA AYSIGLQNCD DTEVASLCLE GIRCAVRIAC IFGMQLERDA
960 970 980 990 1000
YVQALARFSL LTASSSITEM KQKNIDTIKT LITVAHTDGN YLGNSWHEIL
1010 1020 1030 1040 1050
KCISQLELAQ LIGTGVKTRY LSGSGREREG SLKGHSLAGE EFMGLGLGNL
1060 1070 1080 1090 1100
VSGGVDKRQM ASFQESVGET SSQSVVVAVD RIFTGSTRLD GNAIVDFVRW
1110 1120 1130 1140 1150
LCAVSMDELA SPHHPRMFSL QKIVEISYYN MNRIRLQWSR IWHVIGDHFN
1160 1170 1180 1190 1200
KVGCNPNEDV AIFAVDSLRQ LSMKFLEKGE LANFRFQKDF LRPFEHIMKK
1210 1220 1230 1240 1250
NRSPTIRDMV IRCIAQMVSS QAANIRSGWK NIFAVFHQAA SDHDGNIVEL
1260 1270 1280 1290 1300
AFQTTGHIVS TIFQHHFPAA IDSFQDAVKC LSEFACNAAF PDTSMEAIRL
1310 1320 1330 1340 1350
IRFCGKYVSE RPRVLQEYTS DDMNVAPGDR VWVRGWFPIL FELSCIINRC
1360 1370 1380 1390 1400
KLDVRTRGLT VMFEIMKSYG HTFAKHWWQD LFRIVFRIFD NMKLPEQQSE
1410 1420 1430 1440 1450
KSEWMTTTCN HALYAICDVF TQFYEALHEV LLSDVFAQLQ WCVKQDNEQL
1460 1470 1480 1490 1500
ARSGTNCLEN LVISNGEKFS PAVWDETCNC MLDIFRTTIP HVLLTWRPAG
1510 1520 1530 1540 1550
MEEEVSDRHL DVDLDRQSLS SIDRNASERG QSQLSNPTDD SWKGAPYANQ
1560 1570 1580 1590 1600
KLLASLLIKC VVQLELIQTI DNIVFYPATS KKEDAEHMVA AQQDTLDADI
1610 1620 1630 1640 1650
HIETENQGMY KFMSSQHLFK LLDCLQESHS FSKAFNSNYE QRTVLWRAGF
1660 1670 1680 1690 1700
KGKSKPNLLK QETSSLACCL RILFRMYVDE NRRDSWGEIQ QRLLTVCSEA
1710 1720 1730 1740 1750
LAYFITVNSE SHREAWTSLL LLLLTKTLKI NDEKFKAHAS VYYPYLCEMM
1760 1770 1780 1790
QFDLIPELRA VLRKFFLRIG LVYKIWVPEE PSQVPAASTA W
Length:1,791
Mass (Da):201,974
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i397CB889C2ABF569
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY255526 mRNA Translation: AAP04588.2
AABR06027654 Genomic DNA No translation available.
AABR06027655 Genomic DNA No translation available.
AABR06027656 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_851597.2, NM_181083.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000010054; ENSRNOP00000010054; ENSRNOG00000007485

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
296380

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:296380

UCSC genome browser

More...
UCSCi
RGD:631430, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY255526 mRNA Translation: AAP04588.2
AABR06027654 Genomic DNA No translation available.
AABR06027655 Genomic DNA No translation available.
AABR06027656 Genomic DNA No translation available.
RefSeqiNP_851597.2, NM_181083.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ7TSU1, 9 interactors
STRINGi10116.ENSRNOP00000010054

PTM databases

iPTMnetiQ7TSU1
PhosphoSitePlusiQ7TSU1

Proteomic databases

jPOSTiQ7TSU1
PaxDbiQ7TSU1
PRIDEiQ7TSU1

Genome annotation databases

EnsembliENSRNOT00000010054; ENSRNOP00000010054; ENSRNOG00000007485
GeneIDi296380
KEGGirno:296380
UCSCiRGD:631430, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10564
RGDi631430, Arfgef2

Phylogenomic databases

eggNOGiKOG0929, Eukaryota
GeneTreeiENSGT00940000158950
HOGENOMiCLU_000691_1_1_1
InParanoidiQ7TSU1
KOiK18442
OMAiFRMYSDP
OrthoDBi815698at2759
PhylomeDBiQ7TSU1
TreeFamiTF300714

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q7TSU1

Gene expression databases

BgeeiENSRNOG00000007485, Expressed in testis and 20 other tissues
GenevisibleiQ7TSU1, RN

Family and domain databases

CDDicd00171, Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR032629, DCB_dom
IPR015403, Sec7_C
IPR023394, Sec7_C_sf
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf
IPR032691, Sec7_N
PfamiView protein in Pfam
PF16213, DCB, 1 hit
PF09324, DUF1981, 1 hit
PF01369, Sec7, 1 hit
PF12783, Sec7_N, 1 hit
SMARTiView protein in SMART
SM00222, Sec7, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF48425, SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50190, SEC7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIG2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TSU1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: October 1, 2003
Last modified: August 12, 2020
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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