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Protein

T-box transcription factor TBX3

Gene

Tbx3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi107 – 220T-box; first partPROSITE-ProRule annotationAdd BLAST114
DNA bindingi241 – 305T-box; second partPROSITE-ProRule annotationAdd BLAST65

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX3
Short name:
T-box protein 3
Gene namesi
Name:Tbx3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi735203 Tbx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844301 – 743T-box transcription factor TBX3Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei371PhosphoserineBy similarity1
Modified residuei434PhosphoserineCombined sources1
Modified residuei440PhosphoserineBy similarity1
Modified residuei458PhosphoserineBy similarity1
Modified residuei707PhosphoserineCombined sources1
Modified residuei738PhosphoserineBy similarity1
Modified residuei740PhosphoserineBy similarity1
Modified residuei742PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7TST9
PRIDEiQ7TST9

PTM databases

iPTMnetiQ7TST9
PhosphoSitePlusiQ7TST9

Expressioni

Gene expression databases

BgeeiENSRNOG00000008706 Expressed in 9 organ(s), highest expression level in lung
ExpressionAtlasiQ7TST9 baseline and differential
GenevisibleiQ7TST9 RN

Interactioni

Subunit structurei

Interacts with PML.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011552

Structurei

3D structure databases

ProteinModelPortaliQ7TST9
SMRiQ7TST9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00760000118897
HOGENOMiHOG000038046
HOVERGENiHBG000412
InParanoidiQ7TST9
KOiK10177
OMAiPSQFAMG
OrthoDBiEOG091G0I8R
PhylomeDBiQ7TST9
TreeFamiTF106341

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR022582 TBX
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PF12598 TBX, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q7TST9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLSMRDPVI PGTSMAYHPF LPHRAPDFAM SAVLGHQPPF FPALTLPPNG
60 70 80 90 100
AAALSLPGAL AKPIMDQLVG AAETGIPFSS LGPQAHLRPL KTMEPEEDVE
110 120 130 140 150
DDPKVHLEAK ELWDQFHKRG TEMVITKSGR RMFPPFKVRC SGLDKKAKYI
160 170 180 190 200
LLMDIIAADD CRYKFHNSRW MVAGKADPEM PKRMYIHPDS PATGEQWMSK
210 220 230 240 250
VVTFHKLKLT NNISDKHGFT LAFPSDHATW QGNYSFGTQT ILNSMHKYQP
260 270 280 290 300
RFHIVRANDI LKLPYSTFRT YLFPETEFIA VTAYQNDKIT QLKIDNNPFA
310 320 330 340 350
KGFRDTGNGR REKRKQLTLQ SMRVFDERHK KETGTSDESS SEQAAFNCFA
360 370 380 390 400
QASSPAVSTV GTSNLKDLCP SEAESDAEAE SKEEHGPEAC DTAKISTTTA
410 420 430 440 450
EEPGRDKGSP ATRAQLFPAE PSRARDTARL DKASPDSRHS PATISSSTRV
460 470 480 490 500
PGADEHRSPG REGPVSAKVD EARALPAKDA FAPLSVQTDA TAHLTQGPLP
510 520 530 540 550
GLGFAPGLAG QQFFNGHPLF LHPGQFAMGG AFSSMAAGMG PLLATVSGAS
560 570 580 590 600
TGVSGLDSTA MASAAAAQGL SGASAATLPF HLQQHVLASQ GLAMSPFGSL
610 620 630 640 650
FPYPYTYMAA AAAASSAAAS SSVHRHPFLN LNSMRPRLRY SPYSIPVPVP
660 670 680 690 700
DSSSLLATAL PSMASAAGPL DGKSAVLAAS PASVAVDSGS ELNSRSSTLS
710 720 730 740
SGSVSLSPKL CSEKEAATSE LQSIQRLVSG LEAKPDRSCS GSP
Length:743
Mass (Da):79,335
Last modified:October 1, 2003 - v1
Checksum:iA1D3C92A1F0ECAFB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K8D7A0A0G2K8D7_RAT
T-box transcription factor TBX3
Tbx3
723Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY289619 mRNA Translation: AAP43504.1
RefSeqiNP_853669.1, NM_181638.1
XP_006249477.1, XM_006249415.2
XP_006249478.1, XM_006249416.3
XP_006249479.1, XM_006249417.3
UniGeneiRn.162144

Genome annotation databases

EnsembliENSRNOT00000011552; ENSRNOP00000011552; ENSRNOG00000008706
GeneIDi353305
KEGGirno:353305
UCSCiRGD:735203 rat

Similar proteinsi

Entry informationi

Entry nameiTBX3_RAT
AccessioniPrimary (citable) accession number: Q7TST9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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