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Protein

Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

Gene

Pdpr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine.By similarity

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-204174 Regulation of pyruvate dehydrogenase (PDH) complex

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
Short name:
PDPr
Gene namesi
Name:Pdpr
Synonyms:Kiaa1990
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2442188 Pdpr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 93MitochondrionSequence analysisAdd BLAST93
ChainiPRO_000032874194 – 878Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrialAdd BLAST785

Proteomic databases

EPDiQ7TSQ8
MaxQBiQ7TSQ8
PaxDbiQ7TSQ8
PeptideAtlasiQ7TSQ8
PRIDEiQ7TSQ8

PTM databases

iPTMnetiQ7TSQ8
PhosphoSitePlusiQ7TSQ8

Expressioni

Gene expression databases

BgeeiENSMUSG00000033624 Expressed in 239 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiQ7TSQ8 baseline and differential
GenevisibleiQ7TSQ8 MM

Interactioni

Subunit structurei

Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046639

Structurei

3D structure databases

ProteinModelPortaliQ7TSQ8
SMRiQ7TSQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2844 Eukaryota
COG0404 LUCA
GeneTreeiENSGT00530000063120
HOGENOMiHOG000251716
HOVERGENiHBG103854
InParanoidiQ7TSQ8
KOiK17509
OMAiSMYTAIC
OrthoDBiEOG091G01FW
PhylomeDBiQ7TSQ8
TreeFamiTF314735

Family and domain databases

Gene3Di3.30.1360.120, 2 hits
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
IPR032503 FAO_M
IPR013977 GCV_T_C
IPR006222 GCV_T_N
IPR029043 GcvT/YgfZ_C
IPR027266 TrmE/GcvT_dom1
PfamiView protein in Pfam
PF01266 DAO, 1 hit
PF16350 FAO_M, 1 hit
PF01571 GCV_T, 1 hit
PF08669 GCV_T_C, 1 hit
SUPFAMiSSF101790 SSF101790, 1 hit
SSF51905 SSF51905, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q7TSQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLYRLLSIVQ RQRTSPGWQT WSSARSSTST AEAHSIALPA QAQVVICGGG
60 70 80 90 100
IMGTSVAYHL SKMGWQDIVL LEQGRLAAGS TRFCAGILST ARHSSVEQKM
110 120 130 140 150
ANYSNKLYHQ LEQETGIQTG YLRTGSISLA QTQDRLISLK RINSRLNVVG
160 170 180 190 200
IPSEIISPKK VAELHPLLNV HDLVGAMYVP EDAVVSSADV ALALASAASQ
210 220 230 240 250
NGVQIYDRTS VLHVLIKKGQ VTGVETDKGQ IECQYFVNCA GQWAYELGLS
260 270 280 290 300
NEEPLSIPLH ACEHFYLLTR PWDTPLQSNT PTIVDADGRI YIRNWQGGIL
310 320 330 340 350
SGGFEKNPKP IFTEGKNQLE IQNLREDWDH FEPLLSSLLR RMPALETLEI
360 370 380 390 400
LKLVNCPETF TPDMKCIMGE SPVVQGYFVL AGMNSAGLSL GGGAGKFLAE
410 420 430 440 450
WMVYGYPSEN VWELDLQRFG ALQSSRTFLR HRVMEVMPLI YDLKVPRWDF
460 470 480 490 500
QTGRQLRTSP LYDRLDAQGA RWMEKHGFER PKYFVPPNKD LLALEQSKTF
510 520 530 540 550
YKPDWFDIVE SEVKCCKEAV CVIDMSSFTK FEITSTGDEA LESLQYLFCN
560 570 580 590 600
DLDVPVGHIV HTGMLNEYGG YENDCSIARL TKRSFFMISP TDQQVHCWAW
610 620 630 640 650
LNKYLPKDSN LLLEDVTWKY TALNLIGPRA VDVLSELSYA PMTPDHFPTL
660 670 680 690 700
FCKEMSVGYA NGIRVMSMTH TGEPGFMLYI PIEYALHVYN EVMSVGQKYG
710 720 730 740 750
IRNAGYYALR SLRIEKFFAF WGQDLNTLTT PLECGGESRV KLEKGIDFIG
760 770 780 790 800
RDALLQQKQT GVYKRLAMFI LDDHDTDLDL WPWWGEPIYR NGKYAGKTTS
810 820 830 840 850
SAYSYTLERH VCLGYVHNFS EDSGEEQVVT TDFINRGEYE IDIAGHRFQA
860 870
KAKLYPVTSF FTHKRRKDDV ELSDFHGK
Length:878
Mass (Da):99,230
Last modified:October 1, 2003 - v1
Checksum:i16A8C9ED77613525
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RD07D6RD07_MOUSE
Pyruvate dehydrogenase phosphatase ...
Pdpr
671Annotation score:
D3Z443D3Z443_MOUSE
Pyruvate dehydrogenase phosphatase ...
Pdpr
145Annotation score:

Sequence cautioni

The sequence BAC98282 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti438P → H in BAC98282 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY223867 mRNA Translation: AAP20649.1
AK129472 mRNA Translation: BAC98282.1 Different initiation.
BC120745 mRNA Translation: AAI20746.1
BC125425 mRNA Translation: AAI25426.1
CCDSiCCDS22670.1
RefSeqiNP_938050.1, NM_198308.1
XP_006531147.1, XM_006531084.3
UniGeneiMm.28350
Mm.370024

Genome annotation databases

EnsembliENSMUST00000039333; ENSMUSP00000046639; ENSMUSG00000033624
GeneIDi319518
KEGGimmu:319518
UCSCiuc009nlw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPDPR_MOUSE
AccessioniPrimary (citable) accession number: Q7TSQ8
Secondary accession number(s): Q6ZPF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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