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Protein

CMRF35-like molecule

Gene

Clm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an activating receptor in mast cells and macrophages.3 Publications

GO - Biological processi

  • immune system process Source: UniProtKB-KW
  • positive regulation of cytokine secretion Source: MGI

Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
CMRF35-like molecule
Short name:
CLM
Alternative name(s):
Dendritic cell-derived Ig-like receptor 1
Short name:
DIgR1
Immunoglobulin superfamily member 7
Short name:
IgSF7
Leukocyte mono-Ig-like receptor 2
Myeloid-associated immunoglobulin-like receptor 2
Short name:
MAIR-2
Short name:
MAIR-II
Gene namesi
Name:Clm
Synonyms:Cd300c, Igsf7, Lmir2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2153249 AF251705

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 189ExtracellularSequence analysisAdd BLAST165
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 230CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi197K → A: Abolishes interaction with TYROBP or FcR gamma. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000032012725 – 230CMRF35-like moleculeAdd BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 110PROSITE-ProRule annotation
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7TSN2
PRIDEiQ7TSN2

Expressioni

Tissue specificityi

Present on the surface of mast cells, dendritic cells, peritoneal macrophages and a subset of B-cells (at protein level).3 Publications

Gene expression databases

BgeeiENSMUSG00000044811 Expressed in 121 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_AF251705
MM_CD300C
ExpressionAtlasiQ7TSN2 baseline and differential
GenevisibleiQ7TSN2 MM

Interactioni

Subunit structurei

Interacts with TYROBP, HCST and FcR gamma.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei197Interaction with TYROBP or FcR gamma1

Protein-protein interaction databases

BioGridi228270, 3 interactors
STRINGi10090.ENSMUSP00000090121

Structurei

3D structure databases

ProteinModelPortaliQ7TSN2
SMRiQ7TSN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 126Ig-like V-typeAdd BLAST102

Sequence similaritiesi

Belongs to the CD300 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCC5 Eukaryota
ENOG4111BBB LUCA
GeneTreeiENSGT00470000042273
HOGENOMiHOG000231065
HOVERGENiHBG063279
InParanoidiQ7TSN2
KOiK06719
OMAiKLPVHTW
OrthoDBiEOG091G0RAD
TreeFamiTF334441

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TSN2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPRVIRLWL PSALFLSQVP GCVPLHGPST ITGAVGESLS VSCQYEEKFK
60 70 80 90 100
TKDKFWCRGS LKVLCKDIVK TSSSEEVRNG RVTIRDHPDN LTFTVTYESL
110 120 130 140 150
TLEDADTYMC AVDISLFDGS LGFDKYFKIE LSVVPSEDPV PVTGSSLESG
160 170 180 190 200
RDILESPTSS VGHTHPSVTT DDTIPAPCPQ PRSLRSSLYF WVLVSLKLFL
210 220 230
FLSMLGAVLW VNRPQRCSGG SSSRPCYENQ
Length:230
Mass (Da):25,402
Last modified:October 1, 2003 - v1
Checksum:i28992E9A0D5DAE3C
GO
Isoform 2 (identifier: Q7TSN2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-140: Missing.

Show »
Length:228
Mass (Da):25,206
Checksum:i8A52679EEC27E7C4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CYN3E0CYN3_MOUSE
CD300C molecule 2
Cd300c2 AF251705
80Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → T in BAC80269 (PubMed:12893283).Curated1
Sequence conflicti37E → K in BAC80269 (PubMed:12893283).Curated1
Sequence conflicti176A → T in BAC80269 (PubMed:12893283).Curated1
Sequence conflicti191W → R in BAC80269 (PubMed:12893283).Curated1
Sequence conflicti216R → K in BAC80269 (PubMed:12893283).Curated1
Sequence conflicti223 – 224SR → TQ in BAC80269 (PubMed:12893283).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031607139 – 140Missing in isoform 2. 3 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098476 mRNA Translation: BAC80269.1
AB091767 mRNA Translation: BAC77076.1
AB091768 mRNA Translation: BAC77077.1
AY457050 mRNA Translation: AAR27941.1
AL607025 Genomic DNA No translation available.
BC006801 mRNA Translation: AAH06801.1
CCDSiCCDS25616.1 [Q7TSN2-2]
PIRiJC7761
RefSeqiNP_598919.1, NM_134158.1 [Q7TSN2-2]
UniGeneiMm.2699

Genome annotation databases

EnsembliENSMUST00000092464; ENSMUSP00000090121; ENSMUSG00000044811 [Q7TSN2-2]
GeneIDi140497
KEGGimmu:140497
UCSCiuc007mge.1 mouse [Q7TSN2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098476 mRNA Translation: BAC80269.1
AB091767 mRNA Translation: BAC77076.1
AB091768 mRNA Translation: BAC77077.1
AY457050 mRNA Translation: AAR27941.1
AL607025 Genomic DNA No translation available.
BC006801 mRNA Translation: AAH06801.1
CCDSiCCDS25616.1 [Q7TSN2-2]
PIRiJC7761
RefSeqiNP_598919.1, NM_134158.1 [Q7TSN2-2]
UniGeneiMm.2699

3D structure databases

ProteinModelPortaliQ7TSN2
SMRiQ7TSN2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228270, 3 interactors
STRINGi10090.ENSMUSP00000090121

Proteomic databases

PaxDbiQ7TSN2
PRIDEiQ7TSN2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092464; ENSMUSP00000090121; ENSMUSG00000044811 [Q7TSN2-2]
GeneIDi140497
KEGGimmu:140497
UCSCiuc007mge.1 mouse [Q7TSN2-2]

Organism-specific databases

CTDi140497
MGIiMGI:2153249 AF251705

Phylogenomic databases

eggNOGiENOG410JCC5 Eukaryota
ENOG4111BBB LUCA
GeneTreeiENSGT00470000042273
HOGENOMiHOG000231065
HOVERGENiHBG063279
InParanoidiQ7TSN2
KOiK06719
OMAiKLPVHTW
OrthoDBiEOG091G0RAD
TreeFamiTF334441

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:Q7TSN2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044811 Expressed in 121 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_AF251705
MM_CD300C
ExpressionAtlasiQ7TSN2 baseline and differential
GenevisibleiQ7TSN2 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLM_MOUSE
AccessioniPrimary (citable) accession number: Q7TSN2
Secondary accession number(s): Q7TN55, Q8JZM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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