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Protein

Interferon kappa

Gene

Ifnk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the regulation of immune cell function.

Miscellaneous

Transgenic mice overexpressing IFNK in the pancreas, develop insulin-dependent (type I) diabete.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon kappa
Short name:
IFN-kappa
Gene namesi
Name:Ifnk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2683287 Ifnk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001641122 – 199Interferon kappaAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 119By similarity
Disulfide bondi49 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ7TSL0
PRIDEiQ7TSL0

Expressioni

Tissue specificityi

Expressed at low levels in peritoneal macrophages.1 Publication

Inductioni

Upon exposure to double-stranded RNA and interferon-gamma.1 Publication

Gene expression databases

BgeeiENSMUSG00000042993 Expressed in 14 organ(s), highest expression level in liver
CleanExiMM_IFNK
ExpressionAtlasiQ7TSL0 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054273

Structurei

3D structure databases

ProteinModelPortaliQ7TSL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1FR Eukaryota
ENOG41114KE LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230501
HOVERGENiHBG052088
InParanoidiQ7TSL0
KOiK05441
OMAiFCAWKIV
OrthoDBiEOG091G0R88
PhylomeDBiQ7TSL0
TreeFamiTF336177

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TSL0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPKFLWLVA LVALYIPPIQ SLNCVYLDDS ILENVKLLGS TMTGFPLRCL
60 70 80 90 100
KDITDFKFPK EILPYIQHMK REINAVSYRI SSLALTIFNL KGSIPPVTEE
110 120 130 140 150
HWERIRSGLF KQVRQAQECF MDEEKENREH PHSEDFLTVY LELGKYFFRI
160 170 180 190
KKFLINKKYS FCAWKIVTVE IRRCFIIFSK SRKLLKMISE SPTFKQELK
Length:199
Mass (Da):23,581
Last modified:October 1, 2003 - v1
Checksum:i400851D060A376A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF547990 Genomic DNA Translation: AAP43908.1
CCDSiCCDS18037.1
RefSeqiNP_954608.1, NM_199157.2
UniGeneiMm.386929

Genome annotation databases

EnsembliENSMUST00000058595; ENSMUSP00000054273; ENSMUSG00000042993
GeneIDi387510
KEGGimmu:387510
UCSCiuc008sgu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF547990 Genomic DNA Translation: AAP43908.1
CCDSiCCDS18037.1
RefSeqiNP_954608.1, NM_199157.2
UniGeneiMm.386929

3D structure databases

ProteinModelPortaliQ7TSL0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054273

Proteomic databases

PaxDbiQ7TSL0
PRIDEiQ7TSL0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058595; ENSMUSP00000054273; ENSMUSG00000042993
GeneIDi387510
KEGGimmu:387510
UCSCiuc008sgu.1 mouse

Organism-specific databases

CTDi56832
MGIiMGI:2683287 Ifnk

Phylogenomic databases

eggNOGiENOG410J1FR Eukaryota
ENOG41114KE LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230501
HOVERGENiHBG052088
InParanoidiQ7TSL0
KOiK05441
OMAiFCAWKIV
OrthoDBiEOG091G0R88
PhylomeDBiQ7TSL0
TreeFamiTF336177

Miscellaneous databases

PROiPR:Q7TSL0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042993 Expressed in 14 organ(s), highest expression level in liver
CleanExiMM_IFNK
ExpressionAtlasiQ7TSL0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFNK_MOUSE
AccessioniPrimary (citable) accession number: Q7TSL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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