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Protein

Protocadherin-8

Gene

Pcdh8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway (By similarity). In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-8
Alternative name(s):
Arcadlin
Paraxial protocadherin
Gene namesi
Name:Pcdh8
Synonyms:Papc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1306800 Pcdh8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 747ExtracellularSequence analysisAdd BLAST718
Transmembranei748 – 768HelicalSequence analysisAdd BLAST21
Topological domaini769 – 1070CytoplasmicSequence analysisAdd BLAST302

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000040429630 – 1070Protocadherin-8Add BLAST1041

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi616N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1053PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ7TSK3
PRIDEiQ7TSK3

PTM databases

iPTMnetiQ7TSK3
PhosphoSitePlusiQ7TSK3

Expressioni

Gene expression databases

BgeeiENSMUSG00000036422 Expressed in 153 organ(s), highest expression level in substantia nigra
GenevisibleiQ7TSK3 MM

Interactioni

Subunit structurei

The N-terminal extracellular domain forms homophilic interactions; these interactions activate p38 MAPK via TAOK2 and trigger endocytosis. Interacts with CDH2; this interaction may lead to CDH2 cointernalization. Interacts with CDH11. Interacts with TAOK2.By similarity

Protein-protein interaction databases

BioGridi202045, 1 interactor
IntActiQ7TSK3, 1 interactor
STRINGi10090.ENSMUSP00000045333

Structurei

3D structure databases

ProteinModelPortaliQ7TSK3
SMRiQ7TSK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 135Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini136 – 245Cadherin 2PROSITE-ProRule annotationAdd BLAST110
Domaini247 – 354Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini393 – 497Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini498 – 609Cadherin 5PROSITE-ProRule annotationAdd BLAST112
Domaini615 – 721Cadherin 6PROSITE-ProRule annotationAdd BLAST107

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ7TSK3
KOiK16499
OMAiGPALQWD
OrthoDBiEOG091G00QD
PhylomeDBiQ7TSK3
TreeFamiTF352008

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030711 Protocadherin-8
PANTHERiPTHR24028:SF46 PTHR24028:SF46, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7TSK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPAKRWGSP CLFPLQLFSL CWVLSVAQSK TVRYSTFEED APGTVIGTLA
60 70 80 90 100
EDLHMKVSGD TSFRLMKQFN SSLLRVREGD GQLTVGDAGL DRERLCGPSP
110 120 130 140 150
QCVLAFDVVS FSQEQFRLVH VEVEVRDVND HAPRFPRAQI PVEVSESAPV
160 170 180 190 200
GTRIPLEVPV DEDVGANGLQ SVRLAEPHSP FRVELQTRAD GAQCADLVLL
210 220 230 240 250
QELDRESQAS YSLELVAQDG GRPPRSATAA LSVRVLDAND HSPAFPQGAV
260 270 280 290 300
AEVELAEDAP VGSLLLDLDA ADPDEGPNGD VVFTFGARTP PEARHLFRLD
310 320 330 340 350
PRSGRLTLAG QVDYERQDTY ELDVRAQDRG PGPRTATCKV IVRIRDVNDN
360 370 380 390 400
APEISITPLA APGAPATSPF AAAAAAAALG GADAASSTGS GTQEAGITSL
410 420 430 440 450
VPEGAARESL VALVSTSDRD SGANGQVRCA LYGHEHFRLQ PAYAGSYLVV
460 470 480 490 500
TAASLDRERI AEYNLTLVAE DRGTPPLRTV RPYTVRVGDE NDNAPIFTKP
510 520 530 540 550
VYEVSVRENN PPGAYLATVA ARDPDVGRNG QVTYRLVEAE VGRSGEAVST
560 570 580 590 600
YVSVDPATGA IYALRSFDYE TLRQLDVRVQ ASDGGSPQLS SNALVQVRVL
610 620 630 640 650
DQNDHSPILV HPAPANGSLE VAVPGRSTKD TAVARIQARD ADEGANGELA
660 670 680 690 700
FDLLQQEPRE AFSIGRHTGE IMLTGDLSQE PPGRVFKALL VISDGGRPPL
710 720 730 740 750
TTTATVSFVV TAGGGSAVPA SSGSPEHSRP PGSRLAPSGP SLQWDTPLIV
760 770 780 790 800
IIVLAGSCTL LLAAIIAIAT TCNRRKKEVR KGGALREERP GAAGGGASAP
810 820 830 840 850
GSPDETARGT GPRPNMFDVL TFPGSGKAPF GSPAADAPPP AVAAAEVPGS
860 870 880 890 900
EGGSATGESA CHFEGQQRLR GAHAEPYGAS PGFGKEPAAP PVAVWKGHSF
910 920 930 940 950
NTISGREAEK FSGKDSGKGD SDFNDSDSDI SGDALKKDLI NHMQSGLWAC
960 970 980 990 1000
TAECKILGHS DRCWSPSCAG PNVHPPPHPP AQMSTFCKST SLPRDPLRRD
1010 1020 1030 1040 1050
NYYQAQLPKT VGLQSVYEKV LHRDYDRTVT LLSPPRPGRL PDLQEIGVPL
1060 1070
YESPPGSRYV SPKKGINENV
Length:1,070
Mass (Da):113,260
Last modified:October 1, 2003 - v1
Checksum:iFFC2D87D63F6856E
GO
Isoform 2 (identifier: Q7TSK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     779-875: Missing.

Note: No experimental confirmation available.
Show »
Length:973
Mass (Da):103,842
Checksum:iBC8494994C566FA2
GO
Isoform 3 (identifier: Q7TSK3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     876-966: PYGASPGFGK...LGHSDRCWSP → VRPSFGWAPP...FIQHHLGPRS
     967-1070: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:966
Mass (Da):101,886
Checksum:iCE582FF648E07A6F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58S → F in AAF63319 (Ref. 1) Curated1
Sequence conflicti160V → A in AAF63319 (Ref. 1) Curated1
Sequence conflicti222R → TG in AAF63319 (Ref. 1) Curated1
Sequence conflicti237D → G in BAC33404 (PubMed:16141072).Curated1
Sequence conflicti393Q → H in AAF63319 (Ref. 1) Curated1
Sequence conflicti403E → Q in AAF63319 (Ref. 1) Curated1
Sequence conflicti590S → P in AAH52388 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040562779 – 875Missing in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_040563876 – 966PYGAS…RCWSP → VRPSFGWAPPSVLCGQAGRR ETGGVRVGSHREMFNLSHLL FCVLSNPHTFPPPPFPAAAL RCLSRLREGACCAPCYSLEG SFIQHHLGPRS in isoform 3. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_040564967 – 1070Missing in isoform 3. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231125 mRNA Translation: AAF63319.1
AK048638 mRNA Translation: BAC33404.1
CH466535 Genomic DNA Translation: EDL35755.1
BC052388 mRNA Translation: AAH52388.1
BC053008 mRNA Translation: AAH53008.1
CCDSiCCDS27303.1 [Q7TSK3-1]
CCDS79349.1 [Q7TSK3-2]
RefSeqiNP_001036191.1, NM_001042726.3 [Q7TSK3-2]
NP_067518.2, NM_021543.4 [Q7TSK3-1]
UniGeneiMm.390715

Genome annotation databases

EnsembliENSMUST00000039568; ENSMUSP00000045333; ENSMUSG00000036422 [Q7TSK3-1]
ENSMUST00000195355; ENSMUSP00000141417; ENSMUSG00000036422 [Q7TSK3-2]
GeneIDi18530
KEGGimmu:18530
UCSCiuc007uti.3 mouse [Q7TSK3-1]
uc007utj.3 mouse [Q7TSK3-2]
uc029smd.1 mouse [Q7TSK3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231125 mRNA Translation: AAF63319.1
AK048638 mRNA Translation: BAC33404.1
CH466535 Genomic DNA Translation: EDL35755.1
BC052388 mRNA Translation: AAH52388.1
BC053008 mRNA Translation: AAH53008.1
CCDSiCCDS27303.1 [Q7TSK3-1]
CCDS79349.1 [Q7TSK3-2]
RefSeqiNP_001036191.1, NM_001042726.3 [Q7TSK3-2]
NP_067518.2, NM_021543.4 [Q7TSK3-1]
UniGeneiMm.390715

3D structure databases

ProteinModelPortaliQ7TSK3
SMRiQ7TSK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202045, 1 interactor
IntActiQ7TSK3, 1 interactor
STRINGi10090.ENSMUSP00000045333

PTM databases

iPTMnetiQ7TSK3
PhosphoSitePlusiQ7TSK3

Proteomic databases

PaxDbiQ7TSK3
PRIDEiQ7TSK3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039568; ENSMUSP00000045333; ENSMUSG00000036422 [Q7TSK3-1]
ENSMUST00000195355; ENSMUSP00000141417; ENSMUSG00000036422 [Q7TSK3-2]
GeneIDi18530
KEGGimmu:18530
UCSCiuc007uti.3 mouse [Q7TSK3-1]
uc007utj.3 mouse [Q7TSK3-2]
uc029smd.1 mouse [Q7TSK3-3]

Organism-specific databases

CTDi5100
MGIiMGI:1306800 Pcdh8

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiQ7TSK3
KOiK16499
OMAiGPALQWD
OrthoDBiEOG091G00QD
PhylomeDBiQ7TSK3
TreeFamiTF352008

Miscellaneous databases

PROiPR:Q7TSK3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036422 Expressed in 153 organ(s), highest expression level in substantia nigra
GenevisibleiQ7TSK3 MM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030711 Protocadherin-8
PANTHERiPTHR24028:SF46 PTHR24028:SF46, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCDH8_MOUSE
AccessioniPrimary (citable) accession number: Q7TSK3
Secondary accession number(s): Q05BD0, Q8C824, Q9JKP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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