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Protein

Seizure protein 6

Gene

Sez6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity.1 Publication

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • cerebellar Purkinje cell layer development Source: MGI
  • excitatory postsynaptic potential Source: MGI
  • negative regulation of dendrite development Source: MGI
  • positive regulation of dendrite development Source: MGI
  • regulation of dendrite development Source: MGI
  • regulation of protein kinase C signaling Source: MGI
  • synapse maturation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Seizure protein 6
Short name:
SEZ-6
Alternative name(s):
Brain-specific receptor-like protein C
Short name:
BSRP-C
Gene namesi
Name:Sez6
Synonyms:Kiaa4158
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104745 Sez6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 922ExtracellularSequence analysisAdd BLAST903
Transmembranei923 – 943HelicalSequence analysisAdd BLAST21
Topological domaini944 – 991CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Secreted, Synapse

Pathology & Biotechi

Disruption phenotypei

Mice show reduced exploratory behavior and motor coordination, altered maze performance, and poorer memory retention. Molecular, morphological, and electrophysiological evidence of defects in dendritic arbor patterning was also seen. Secreted and membrane-bound isoforms in null mutants exerted opposite actions. The secreted isoform showed an increased neurite number, while, the membrane-bound isoform displayed a decrease in dendritic arborization. Embryos were viable, fertile and normal in other respects. Mice lacking Sez6, Sez6l1, Sez6l2 exhibited motor discordination, and Purkinje cells were often innervated by multiple climbing fibers with different neuronal origins in the cerebellum.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000034134820 – 991Seizure protein 6Add BLAST972

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi241 ↔ 268By similarity
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi354 ↔ 394By similarity
Disulfide bondi380 ↔ 409By similarity
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi413 ↔ 440By similarity
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi529 ↔ 571By similarity
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi556 ↔ 586By similarity
Disulfide bondi590 ↔ 616By similarity
Disulfide bondi707 ↔ 749By similarity
Disulfide bondi735 ↔ 762By similarity
Disulfide bondi768 ↔ 810By similarity
Disulfide bondi796 ↔ 827By similarity
Disulfide bondi835 ↔ 877By similarity
Disulfide bondi863 ↔ 892By similarity

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7TSK2
PRIDEiQ7TSK2

PTM databases

iPTMnetiQ7TSK2
PhosphoSitePlusiQ7TSK2

Expressioni

Tissue specificityi

Brain-specific. Expressed in extrasynaptic and synaptic subcellular fractions (at protein level). Expression correlates with the most active periods of cortical neurogenesis and neuronal maturation. Expression is restricted to the gray matter with higher levels in the forebrain including the olfactory bulb, anterior olfactory nuclei, olfactory tubercle, striatum, hippocampal CA1 pyramidal cell layer and cerebral cortex. Expression is up-regulated with the convulsant drug, pentylenetetrazole.3 Publications

Developmental stagei

At E11.5, expression is localized to the preplate and is absent from the ventricular zone which is the most prominent layer during early cortical development. At E13 highly expressed in postmitotic, maturing neurons of the developing cortical plate and subplate. At E15 expression is closely tied with the emergence of the neocortical layers and hippocampus. In the cortex, expression diminishes after birth, but continues in the deep layer pyramidal neurons and neuronal subpopulations of layer II/III. In the hippocampus, expression persists in CA1 pyramidal neurons and in the dentate gyrus. Postnatally, expression remains high in specific cortical neuron populations, particularly those of the deep cortical layers.2 Publications

Gene expression databases

BgeeiENSMUSG00000000632 Expressed in 144 organ(s), highest expression level in striatum
ExpressionAtlasiQ7TSK2 baseline and differential
GenevisibleiQ7TSK2 MM

Interactioni

Protein-protein interaction databases

IntActiQ7TSK2, 1 interactor
MINTiQ7TSK2
STRINGi10090.ENSMUSP00000091532

Structurei

3D structure databases

ProteinModelPortaliQ7TSK2
SMRiQ7TSK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 353CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini352 – 411Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini413 – 524CUB 2PROSITE-ProRule annotationAdd BLAST112
Domaini527 – 588Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini590 – 701CUB 3PROSITE-ProRule annotationAdd BLAST112
Domaini705 – 764Sushi 3PROSITE-ProRule annotationAdd BLAST60
Domaini766 – 829Sushi 4PROSITE-ProRule annotationAdd BLAST64
Domaini833 – 894Sushi 5PROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 196Pro-richAdd BLAST110
Compositional biasi202 – 234Thr-richAdd BLAST33

Sequence similaritiesi

Belongs to the SEZ6 family.Curated

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJTP Eukaryota
ENOG410ZD9C LUCA
GeneTreeiENSGT00760000118803
HOGENOMiHOG000038008
HOVERGENiHBG057885
InParanoidiQ7TSK2
OMAiARFRCAT
OrthoDBiEOG091G019A
PhylomeDBiQ7TSK2
TreeFamiTF330037

Family and domain databases

CDDicd00033 CCP, 5 hits
cd00041 CUB, 3 hits
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00084 Sushi, 5 hits
SMARTiView protein in SMART
SM00032 CCP, 5 hits
SM00042 CUB, 3 hits
SUPFAMiSSF49854 SSF49854, 3 hits
SSF57535 SSF57535, 5 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS50923 SUSHI, 5 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TSK2-1) [UniParc]FASTAAdd to basket
Also known as: Type 2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPAALLLLP SLLALLAHGL SSEAPITGEG HATGIRETDG ELTAAPTPEQ
60 70 80 90 100
SDRGVHFVTT APTLKLLNHH PLLEEFLQEG LEREEAPQPA LPFQPDSPTH
110 120 130 140 150
FTPSPLPRLT NQDNRPVFTS PTPAVAAAPT QPHSREKPWN LESKPPELSI
160 170 180 190 200
TSSLPPGPSM AVPTLLPEDR PSTTPPSQAW TPTQEGPGDM DRPWVPEVMS
210 220 230 240 250
KTTGLGVEGT IATSTASGDD EETTTTIITT TVTTVQPPGP CSWNFSGPEG
260 270 280 290 300
SLDSPTAPSS PSDVGLDCFY YISVYPGYGV EIKVENISLQ EGETITVEGL
310 320 330 340 350
GGPDPLPLAN QSFLLRGQVI RSPTHQAALR FQSLPLPAGP GTFHFRYQAY
360 370 380 390 400
LLSCHFPRRP AYGDVTVTSL HPGGSAHFHC ATGYQLKGAR FLTCLNATQP
410 420 430 440 450
FWDSQEPVCI AACGGVIRNA TTGRIVSPGF PGNYSNNLTC HWLLEAPESQ
460 470 480 490 500
RLHLHFEKVS LAEDDDRLII RNGNNVEAPP VYDSYEVEYL PIEGLLSSGR
510 520 530 540 550
HFFVEFSTDS SGAAAGMALR YEAFQQGHCY EPFVKYGNFS SSAPSYPVGT
560 570 580 590 600
TVEFSCDPGY TLEQGSIIIE CVDLHDPQWN ETEPACRAVC SGEITDSAGV
610 620 630 640 650
VLSPNWPEPY GRGQDCIWGV HVEEDKRIML DIRVLRIGSG DVLTFYDGDD
660 670 680 690 700
LTARVLGQYS GPRGHFKLFT SMADVTIQFQ SDPGTSALGY QQGFVIHFFE
710 720 730 740 750
VPRNDTCPEL PEIPNGWKNP SQPELVHGTV VTYQCYPGYQ VVGSSILMCQ
760 770 780 790 800
WDLSWSEDLP SCQRVTSCHD PGDVEHSRRL ISSPKFPVGA TVQYVCDQGF
810 820 830 840 850
VLTGSAILTC HDRQAGSPKW SDRAPKCLLE QFKPCHGLSA PENGARSPEK
860 870 880 890 900
RLHPAGATIH FSCAPGYVLK GQASIKCVPG HPSHWSDPPP ICRAASLDGF
910 920 930 940 950
YNGRSLDVAK APAASSALDA AHLAAAIFLP LVAMVLLVGG VYLYFSRFQG
960 970 980 990
KSPLQLPRTH PRPYNRITVE SAFDNPTYET GSLSFAGDER I
Length:991
Mass (Da):107,433
Last modified:October 1, 2003 - v1
Checksum:i4B3DAA14AD2A29F3
GO
Isoform 2 (identifier: Q7TSK2-2) [UniParc]FASTAAdd to basket
Also known as: Type 1

The sequence of this isoform differs from the canonical sequence as follows:
     895-907: Missing.
     982-991: SLSFAGDERI → ETREYEVSI

Show »
Length:977
Mass (Da):106,067
Checksum:i736583FE610FD1D2
GO
Isoform 3 (identifier: Q7TSK2-3) [UniParc]FASTAAdd to basket
Also known as: Type 3

The sequence of this isoform differs from the canonical sequence as follows:
     588-605: AVCSGEITDSAGVVLSPN → GQQAPVGGSARATSRVGP
     606-991: Missing.

Show »
Length:605
Mass (Da):65,095
Checksum:i3D83BB499167DDA8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6XNR8F6XNR8_MOUSE
Seizure protein 6
Sez6
452Annotation score:
F6SXT0F6SXT0_MOUSE
Seizure protein 6
Sez6
278Annotation score:

Sequence cautioni

The sequence BAE36472 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216A → G in BAA10889 (PubMed:7488116).Curated1
Sequence conflicti216A → G in BAA10890 (PubMed:7488116).Curated1
Sequence conflicti216A → G in BAA06167 (PubMed:7723619).Curated1
Sequence conflicti216A → G in BAE44444 (PubMed:16814779).Curated1
Sequence conflicti446A → P in BAA10889 (PubMed:7488116).Curated1
Sequence conflicti446A → P in BAA10890 (PubMed:7488116).Curated1
Sequence conflicti446A → P in BAA06167 (PubMed:7723619).Curated1
Sequence conflicti446A → P in BAE44444 (PubMed:16814779).Curated1
Sequence conflicti527G → R in BAA10889 (PubMed:7488116).Curated1
Sequence conflicti527G → R in BAA10890 (PubMed:7488116).Curated1
Sequence conflicti527G → R in BAA06167 (PubMed:7723619).Curated1
Sequence conflicti527G → R in BAE44444 (PubMed:16814779).Curated1
Sequence conflicti705D → N in BAA10889 (PubMed:7488116).Curated1
Sequence conflicti705D → N in BAA06167 (PubMed:7723619).Curated1
Sequence conflicti705D → N in BAE44444 (PubMed:16814779).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034254588 – 605AVCSG…VLSPN → GQQAPVGGSARATSRVGP in isoform 3. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_034255606 – 991Missing in isoform 3. 2 PublicationsAdd BLAST386
Alternative sequenceiVSP_034256895 – 907Missing in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_034257982 – 991SLSFAGDERI → ETREYEVSI in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64009 mRNA Translation: BAA10889.1
D64010 mRNA Translation: BAA10890.1
D29763 mRNA Translation: BAA06167.1
AB206791 mRNA Translation: BAE44444.1
AL591065, AL845484 Genomic DNA Translation: CAI24432.1
AL845484, AL591065 Genomic DNA Translation: CAI25225.1
BC053011 mRNA Translation: AAH53011.1
BC055345 mRNA Translation: AAH55345.1
AK161576 mRNA Translation: BAE36472.1 Different initiation.
CCDSiCCDS25087.1 [Q7TSK2-1]
CCDS70255.1 [Q7TSK2-2]
PIRiI52657
RefSeqiNP_001278154.1, NM_001291225.1 [Q7TSK2-2]
NP_067261.2, NM_021286.4 [Q7TSK2-1]
XP_006532703.1, XM_006532640.2
UniGeneiMm.229330

Genome annotation databases

EnsembliENSMUST00000000646; ENSMUSP00000000646; ENSMUSG00000000632 [Q7TSK2-2]
ENSMUST00000093995; ENSMUSP00000091532; ENSMUSG00000000632 [Q7TSK2-1]
GeneIDi20370
KEGGimmu:20370
UCSCiuc007khn.2 mouse [Q7TSK2-3]
uc007kho.2 mouse [Q7TSK2-2]
uc007khp.2 mouse [Q7TSK2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64009 mRNA Translation: BAA10889.1
D64010 mRNA Translation: BAA10890.1
D29763 mRNA Translation: BAA06167.1
AB206791 mRNA Translation: BAE44444.1
AL591065, AL845484 Genomic DNA Translation: CAI24432.1
AL845484, AL591065 Genomic DNA Translation: CAI25225.1
BC053011 mRNA Translation: AAH53011.1
BC055345 mRNA Translation: AAH55345.1
AK161576 mRNA Translation: BAE36472.1 Different initiation.
CCDSiCCDS25087.1 [Q7TSK2-1]
CCDS70255.1 [Q7TSK2-2]
PIRiI52657
RefSeqiNP_001278154.1, NM_001291225.1 [Q7TSK2-2]
NP_067261.2, NM_021286.4 [Q7TSK2-1]
XP_006532703.1, XM_006532640.2
UniGeneiMm.229330

3D structure databases

ProteinModelPortaliQ7TSK2
SMRiQ7TSK2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7TSK2, 1 interactor
MINTiQ7TSK2
STRINGi10090.ENSMUSP00000091532

PTM databases

iPTMnetiQ7TSK2
PhosphoSitePlusiQ7TSK2

Proteomic databases

PaxDbiQ7TSK2
PRIDEiQ7TSK2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000646; ENSMUSP00000000646; ENSMUSG00000000632 [Q7TSK2-2]
ENSMUST00000093995; ENSMUSP00000091532; ENSMUSG00000000632 [Q7TSK2-1]
GeneIDi20370
KEGGimmu:20370
UCSCiuc007khn.2 mouse [Q7TSK2-3]
uc007kho.2 mouse [Q7TSK2-2]
uc007khp.2 mouse [Q7TSK2-1]

Organism-specific databases

CTDi124925
MGIiMGI:104745 Sez6
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJTP Eukaryota
ENOG410ZD9C LUCA
GeneTreeiENSGT00760000118803
HOGENOMiHOG000038008
HOVERGENiHBG057885
InParanoidiQ7TSK2
OMAiARFRCAT
OrthoDBiEOG091G019A
PhylomeDBiQ7TSK2
TreeFamiTF330037

Miscellaneous databases

ChiTaRSiSez6 mouse
PROiPR:Q7TSK2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000632 Expressed in 144 organ(s), highest expression level in striatum
ExpressionAtlasiQ7TSK2 baseline and differential
GenevisibleiQ7TSK2 MM

Family and domain databases

CDDicd00033 CCP, 5 hits
cd00041 CUB, 3 hits
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00084 Sushi, 5 hits
SMARTiView protein in SMART
SM00032 CCP, 5 hits
SM00042 CUB, 3 hits
SUPFAMiSSF49854 SSF49854, 3 hits
SSF57535 SSF57535, 5 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS50923 SUSHI, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSEZ6_MOUSE
AccessioniPrimary (citable) accession number: Q7TSK2
Secondary accession number(s): Q3TT53
, Q62223, Q62224, Q62269, Q7TPC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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