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UniProtKB - Q7TSJ2 (MAP6_MOUSE)

Entry version 124 (29 Sep 2021)
Sequence version 2 (22 Jul 2008)
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Protein

Microtubule-associated protein 6

Gene

Map6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in microtubule stabilization in many cell types, including neuronal cells (PubMed:9600916).

Specifically has microtubule cold stabilizing activity (PubMed:9600916).

Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (By similarity).

Regulates KIF5A-mediated axonal cargo transport (By similarity).

Regulates axonal growth during neuron polarization (PubMed:28521134).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding
Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein 6
Short name:
MAP-6
Alternative name(s):
Stable tubule-only polypeptide
Short name:
STOP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Map6
Synonyms:Mtap6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1201690, Map6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000055407

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are devoid of cold-stable microtubules and show no detectable defects in brain anatomy but show synaptic defects, with depleted synaptic vesicle pools and impaired synaptic plasticity, associated with severe behavioral disorders, including a disorganized activity with disruption of normal behavioral sequences and episodes of hyperlocomotion or apparent prostration, anxiety, severe social withdrawal and complete nurturing defects (PubMed:12231625). The behavioral defects are alleviated by long-term treatment with neuroleptics (PubMed:12231625). RNAi-mediated knockdown in brain at the 14.5 dpc stage disrupts proper neuron migration resulting in their accumulation in the ventricular and subventricular zones (PubMed:28521134).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003440451 – 906Microtubule-associated protein 6Add BLAST906

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi5S-palmitoyl cysteineBy similarity1
Lipidationi10S-palmitoyl cysteineBy similarity1
Lipidationi11S-palmitoyl cysteineBy similarity1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei98PhosphoserineCombined sources1
Modified residuei141PhosphotyrosineCombined sources1
Modified residuei185PhosphoserineBy similarity1
Modified residuei207PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei905PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated. Probably depalmitoylated by ABHD17A, ABHD17B and ABHD17C. During neuronal polarization, palmitoylation and depalmitoylation cycles regulate MAP6 shuttling between secretory vesicles and microtubules, and its polarized distribution in the axon.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7TSJ2

PeptideAtlas

More...PeptideAtlasi		Q7TSJ2

PRoteomics IDEntifications database

More...PRIDEi		Q7TSJ2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		295817 [Q7TSJ2-1]
295818 [Q7TSJ2-2]
295819 [Q7TSJ2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7TSJ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7TSJ2

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q7TSJ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is specifically expressed in adult brain. Isoform 2 is predominantly expressed in embryonic brain; expression persists at low levels in the adult brain. Isoform 3 is expressed at high levels in lung and at lower levels in testis, heart, muscle and kidney (at protein level). Oligodendrocytes express a major isoform of 89 kDa (O-STOP). Astrocytes also express an isoform of 60 kDa (A-STOP).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 2 is expressed in embryonic brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000055407, Expressed in hindbrain and 270 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7TSJ2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca2+ (PubMed:14516200).

Interacts with TMEM106B (By similarity).

Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635).

Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635).

By similarity2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		201587, 17 interactors

Protein interaction database and analysis system

More...IntActi		Q7TSJ2, 7 interactors

Molecular INTeraction database

More...MINTi		Q7TSJ2

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000064787

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7TSJ2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7TSJ2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati222 – 267Mc-1By similarityAdd BLAST46
Repeati268 – 313Mc-2By similarityAdd BLAST46
Repeati314 – 359Mc-3By similarityAdd BLAST46
Repeati360 – 405Mc-4By similarityAdd BLAST46

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 15Calmodulin-bindingBy similarityAdd BLAST15
Regioni37 – 56DisorderedSequence analysisAdd BLAST20
Regioni65 – 411DisorderedSequence analysisAdd BLAST347
Regioni116 – 139Mn 1By similarityAdd BLAST24
Regioni124 – 138Calmodulin-bindingBy similarityAdd BLAST15
Regioni151 – 174Mn 2By similarityAdd BLAST24
Regioni160 – 174Calmodulin-bindingBy similarityAdd BLAST15
Regioni187 – 201Calmodulin-bindingBy similarityAdd BLAST15
Regioni222 – 4054 X approximate tandem repeat McBy similarityAdd BLAST184
Regioni235 – 249Calmodulin-bindingBy similarityAdd BLAST15
Regioni280 – 294Calmodulin-bindingBy similarityAdd BLAST15
Regioni325 – 339Calmodulin-bindingBy similarityAdd BLAST15
Regioni375 – 389Calmodulin-bindingBy similarityAdd BLAST15
Regioni427 – 450Mn 3By similarityAdd BLAST24
Regioni435 – 449Calmodulin-bindingBy similarityAdd BLAST15
Regioni441 – 651DisorderedSequence analysisAdd BLAST211
Regioni486 – 500Calmodulin-bindingBy similarityAdd BLAST15
Regioni513 – 527Calmodulin-bindingBy similarityAdd BLAST15
Regioni674 – 782DisorderedSequence analysisAdd BLAST109
Regioni817 – 906DisorderedSequence analysisAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi40 – 54Pro residuesSequence analysisAdd BLAST15
Compositional biasi150 – 164Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi367 – 383Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi479 – 502Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi544 – 575Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi721 – 745Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the STOP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QS1F, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063947

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018049_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7TSJ2

Identification of Orthologs from Complete Genome Data

More...OMAi		KKPGPAW

Database of Orthologous Groups

More...OrthoDBi		577082at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7TSJ2

TreeFam database of animal gene trees

More...TreeFami		TF338320

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007882, MAP6

The PANTHER Classification System

More...PANTHERi		PTHR14759, PTHR14759, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: Comment: Additional isoforms seem to exist.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TSJ2-1) [UniParc]FASTAAdd to basket
Also known as: N-STOP, Neuronal STOP

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWPCITRAC CIARFWNQLD KADIAVPLVF TKYSEATEHP GAPPQPPAPL 
        60         70         80         90        100
QPALAPPSRA VAIETQPAQG ESDAVARATG PAPGPSVDRE TVAAPGRSGL 
       110        120        130        140        150
GLGAASASTS GSGPADSVMR QDYRAWKVQR PEPSCRPRSE YQPSDAPFER 
       160        170        180        190        200
ETQYQKDFRA WPLPRRGDHP WIPKPVQIPA TSQPSQPVLG VPKRRPQSQE 
       210        220        230        240        250
RGPMQLSADA RDPEGAGGAG VLAAGKASGV DQRDTRRKAG PAWMVTRNEG 
       260        270        280        290        300
HEEKPLPPAQ SQTQEGGPAA GKASGADQRD TRRKAGPAWM VTRSEGHEEK 
       310        320        330        340        350
PLPPAQSQTQ EGGPAAGKAS GADQRDTRRK AGPAWMVTRT EGHEETPLPP 
       360        370        380        390        400
AQSQTQEGGP AAGKASGADE RDTRRKAGPA WMVRRSEGHE QTPAAHAQGT 
       410        420        430        440        450
GPEGGKGRAV ADALNRQIRE EVASTVSSSY RNEFRAWTDI KPVKPIKAKP 
       460        470        480        490        500
QYKPPDDKMV HETSYSAQFK GEANKPSAAD NKAMDRRRIR SLYSEPFKEC 
       510        520        530        540        550
PKVEKPSVQS SKPKKTSTSH KPPRKAKDKQ VVSGQAAKKK TTEGPSATKP 
       560        570        580        590        600
DDKEQSKEMN NKLAEAKESR VKPTSDASKN RGPVTKEPHK DQGSVAPGLP 
       610        620        630        640        650
KGQEPLKDQG PVVPGLPKDQ VPVVPGSLKG QSPTAPGPTK DQGAVLLGPV 
       660        670        680        690        700
KDLGPVAPAP IKVQDHIASE LLKNKDSVPL APAKAQSPLL PEPLKNQSPV 
       710        720        730        740        750
VPASTKDQSF PTPAPRKDPG PVIPEPEKDR APTVPERRKD QHVSIMASLK 
       760        770        780        790        800
NEAPMVPESV KNQGLAGPEL VKDTGTDTTA PRYLKGHDSV FVAPVKNQGP 
       810        820        830        840        850
VIPEPVKSQD PIIPALAKDQ GPMLPEPPKN QSPVVLGPIK NQDPIIPVPL 
       860        870        880        890        900
KGQDPLVPAP TKDQGPTAPD PLKTQGPKGT QLPTVSPSPP VMIPTVPHTE 

YIEGSP
Note: Produced by alternative promoter usage.
Length:906
Mass (Da):96,450
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3CED1FCF1E2CD83
GO
Isoform 2 (identifier: Q7TSJ2-2) [UniParc]FASTAAdd to basket
Also known as: E-STOP, Early STOP

The sequence of this isoform differs from the canonical sequence as follows:
     569-906: Missing.

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:568
Mass (Da):61,105
Checksum:i81B1DFF1B51D2658
GO
Isoform 3 (identifier: Q7TSJ2-3) [UniParc]FASTAAdd to basket
Also known as: F-STOP, Fibroblastic STOP

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     503-509: VEKPSVQ → EPGQTHQ
     510-906: Missing.

Note: Produced by alternative promoter usage.Curated
Show »
Length:306
Mass (Da):32,803
Checksum:iE19396DFF272B496
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z6W1D3Z6W1_MOUSE
Microtubule-associated protein 6
Map6 Mtap6
509Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LIT9A0A140LIT9_MOUSE
Microtubule-associated protein 6
Map6
703Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81P → L in CAA75049 (PubMed:9501006).Curated1
Sequence conflicti87V → G in CAA75930 (PubMed:9501006).Curated1
Sequence conflicti344E → K in CAA75930 (PubMed:9501006).Curated1
Sequence conflicti344E → K in CAA75989 (PubMed:9600916).Curated1
Sequence conflicti405G → S in CAA75049 (PubMed:9501006).Curated1
Sequence conflicti755 – 757MVP → VVH in CAA75930 (PubMed:9501006).Curated3
Sequence conflicti755M → V in CAA75049 (PubMed:9501006).Curated1
Sequence conflicti825P → S in CAA75930 (PubMed:9501006).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0347241 – 203Missing in isoform 3. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_034725503 – 509VEKPSVQ → EPGQTHQ in isoform 3. 1 Publication7
Alternative sequenceiVSP_034726510 – 906Missing in isoform 3. 1 PublicationAdd BLAST397
Alternative sequenceiVSP_034727569 – 906Missing in isoform 2. 1 PublicationAdd BLAST338

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y14754, Y14755, Y14756 Genomic DNA Translation: CAA75049.1
Y16008 Genomic DNA Translation: CAA75930.1
Y16032 mRNA Translation: CAA75989.1
BC053039 mRNA Translation: AAH53039.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS21479.1 [Q7TSJ2-1]
CCDS40029.1 [Q7TSJ2-3]
CCDS85345.1 [Q7TSJ2-2]

Protein sequence database of the Protein Information Resource

More...PIRi		JC5963

NCBI Reference Sequences

More...RefSeqi		NP_001036820.2, NM_001043355.2 [Q7TSJ2-3]
NP_001041632.1, NM_001048167.1 [Q7TSJ2-2]
NP_034967.2, NM_010837.3 [Q7TSJ2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000068973; ENSMUSP00000064787; ENSMUSG00000055407 [Q7TSJ2-1]
ENSMUST00000107100; ENSMUSP00000102717; ENSMUSG00000055407 [Q7TSJ2-3]
ENSMUST00000127492; ENSMUSP00000146340; ENSMUSG00000055407 [Q7TSJ2-2]
ENSMUST00000207883; ENSMUSP00000146585; ENSMUSG00000055407 [Q7TSJ2-1]
ENSMUST00000208605; ENSMUSP00000146897; ENSMUSG00000055407 [Q7TSJ2-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		17760

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:17760

UCSC genome browser

More...UCSCi		uc009ilg.1, mouse [Q7TSJ2-1]
uc009ili.1, mouse [Q7TSJ2-3]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14754, Y14755, Y14756 Genomic DNA Translation: CAA75049.1
Y16008 Genomic DNA Translation: CAA75930.1
Y16032 mRNA Translation: CAA75989.1
BC053039 mRNA Translation: AAH53039.1
CCDSiCCDS21479.1 [Q7TSJ2-1]
CCDS40029.1 [Q7TSJ2-3]
CCDS85345.1 [Q7TSJ2-2]
PIRiJC5963
RefSeqiNP_001036820.2, NM_001043355.2 [Q7TSJ2-3]
NP_001041632.1, NM_001048167.1 [Q7TSJ2-2]
NP_034967.2, NM_010837.3 [Q7TSJ2-1]

3D structure databases

SMRiQ7TSJ2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201587, 17 interactors
IntActiQ7TSJ2, 7 interactors
MINTiQ7TSJ2
STRINGi10090.ENSMUSP00000064787

PTM databases

iPTMnetiQ7TSJ2
PhosphoSitePlusiQ7TSJ2
SwissPalmiQ7TSJ2

Proteomic databases

PaxDbiQ7TSJ2
PeptideAtlasiQ7TSJ2
PRIDEiQ7TSJ2
ProteomicsDBi295817 [Q7TSJ2-1]
295818 [Q7TSJ2-2]
295819 [Q7TSJ2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17382, 60 antibodies

The DNASU plasmid repository

More...DNASUi		17760

Genome annotation databases

EnsembliENSMUST00000068973; ENSMUSP00000064787; ENSMUSG00000055407 [Q7TSJ2-1]
ENSMUST00000107100; ENSMUSP00000102717; ENSMUSG00000055407 [Q7TSJ2-3]
ENSMUST00000127492; ENSMUSP00000146340; ENSMUSG00000055407 [Q7TSJ2-2]
ENSMUST00000207883; ENSMUSP00000146585; ENSMUSG00000055407 [Q7TSJ2-1]
ENSMUST00000208605; ENSMUSP00000146897; ENSMUSG00000055407 [Q7TSJ2-3]
GeneIDi17760
KEGGimmu:17760
UCSCiuc009ilg.1, mouse [Q7TSJ2-1]
uc009ili.1, mouse [Q7TSJ2-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4135
MGIiMGI:1201690, Map6
VEuPathDBiHostDB:ENSMUSG00000055407

Phylogenomic databases

eggNOGiENOG502QS1F, Eukaryota
GeneTreeiENSGT00530000063947
HOGENOMiCLU_018049_1_0_1
InParanoidiQ7TSJ2
OMAiKKPGPAW
OrthoDBi577082at2759
PhylomeDBiQ7TSJ2
TreeFamiTF338320

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		17760, 2 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Map6, mouse

Protein Ontology

More...PROi		PR:Q7TSJ2
RNActiQ7TSJ2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000055407, Expressed in hindbrain and 270 other tissues
GenevisibleiQ7TSJ2, MM

Family and domain databases

InterProiView protein in InterPro
IPR007882, MAP6
PANTHERiPTHR14759, PTHR14759, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAP6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TSJ2
Secondary accession number(s): O55129
, O70586, O70587, Q78DV4, Q78DV5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 29, 2021
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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