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Protein

Microtubule-associated protein 6

Gene

Map6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in microtubule stabilization in many cell types, including neuronal cells (PubMed:9600916). Specifically has microtubule cold stabilizing activity (PubMed:9600916). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (By similarity). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (PubMed:28521134).By similarity2 Publications

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB-KW
  • microtubule binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding
Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 6
Short name:
MAP-6
Alternative name(s):
Stable tubule-only polypeptide
Short name:
STOP
Gene namesi
Name:Map6
Synonyms:Mtap6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1201690 Map6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

Pathology & Biotechi

Disruption phenotypei

Mice are devoid of cold-stable microtubules and show no detectable defects in brain anatomy but show synaptic defects, with depleted synaptic vesicle pools and impaired synaptic plasticity, associated with severe behavioral disorders, including a disorganized activity with disruption of normal behavioral sequences and episodes of hyperlocomotion or apparent prostration, anxiety, severe social withdrawal and complete nurturing defects (PubMed:12231625). The behavioral defects are alleviated by long-term treatment with neuroleptics (PubMed:12231625). RNAi-mediated knockdown in brain at the E14.5 stage disrupts proper neuron migration resulting in their accumulation in the ventricular and subventricular zones (PubMed:28521134).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003440451 – 906Microtubule-associated protein 6Add BLAST906

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi5S-palmitoyl cysteineBy similarity1
Lipidationi10S-palmitoyl cysteineBy similarity1
Lipidationi11S-palmitoyl cysteineBy similarity1
Modified residuei98PhosphoserineCombined sources1
Modified residuei141PhosphotyrosineCombined sources1
Modified residuei185PhosphoserineBy similarity1
Modified residuei207PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei905PhosphoserineCombined sources1

Post-translational modificationi

Palmitoylated. Probably depalmitoylated by ABHD17A, ABHD17B and ABHD17C. During neuronal polarization, palmitoylation and depalmitoylation cycles regulate MAP6 shuttling between secretory vesicles and microtubules, and its polarized distribution in the axon.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ7TSJ2
PeptideAtlasiQ7TSJ2
PRIDEiQ7TSJ2

PTM databases

iPTMnetiQ7TSJ2
PhosphoSitePlusiQ7TSJ2

Expressioni

Tissue specificityi

Isoform 1 is specifically expressed in adult brain. Isoform 2 is predominantly expressed in embryonic brain; expression persists at low levels in the adult brain. Isoform 3 is expressed at high levels in lung and at lower levels in testis, heart, muscle and kidney (at protein level). Oligodendrocytes express a major isoform of 89 kDa (O-STOP). Astrocytes also express an isoform of 60 kDa (A-STOP).2 Publications

Developmental stagei

Isoform 2 is expressed in embryonic brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000055407 Expressed in 243 organ(s), highest expression level in forebrain
ExpressionAtlasiQ7TSJ2 baseline and differential
GenevisibleiQ7TSJ2 MM

Interactioni

Subunit structurei

Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca2+ (PubMed:14516200). Interacts with TMEM106B (By similarity). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201587, 7 interactors
IntActiQ7TSJ2, 8 interactors
MINTiQ7TSJ2
STRINGi10090.ENSMUSP00000064787

Structurei

3D structure databases

ProteinModelPortaliQ7TSJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati222 – 267Mc-1By similarityAdd BLAST46
Repeati268 – 313Mc-2By similarityAdd BLAST46
Repeati314 – 359Mc-3By similarityAdd BLAST46
Repeati360 – 405Mc-4By similarityAdd BLAST46

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 15Calmodulin-bindingBy similarityAdd BLAST15
Regioni116 – 139Mn 1By similarityAdd BLAST24
Regioni124 – 138Calmodulin-bindingBy similarityAdd BLAST15
Regioni151 – 174Mn 2By similarityAdd BLAST24
Regioni160 – 174Calmodulin-bindingBy similarityAdd BLAST15
Regioni187 – 201Calmodulin-bindingBy similarityAdd BLAST15
Regioni222 – 4054 X approximate tandem repeat McBy similarityAdd BLAST184
Regioni235 – 249Calmodulin-bindingBy similarityAdd BLAST15
Regioni280 – 294Calmodulin-bindingBy similarityAdd BLAST15
Regioni325 – 339Calmodulin-bindingBy similarityAdd BLAST15
Regioni375 – 389Calmodulin-bindingBy similarityAdd BLAST15
Regioni427 – 450Mn 3By similarityAdd BLAST24
Regioni435 – 449Calmodulin-bindingBy similarityAdd BLAST15
Regioni486 – 500Calmodulin-bindingBy similarityAdd BLAST15
Regioni513 – 527Calmodulin-bindingBy similarityAdd BLAST15

Sequence similaritiesi

Belongs to the STOP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIA0 Eukaryota
ENOG4110KV2 LUCA
GeneTreeiENSGT00530000063947
HOGENOMiHOG000113479
HOVERGENiHBG053112
InParanoidiQ7TSJ2
KOiK10432
OMAiKPGPAWM
OrthoDBiEOG091G0A3G
PhylomeDBiQ7TSJ2
TreeFamiTF338320

Family and domain databases

InterProiView protein in InterPro
IPR007882 MAP6
PANTHERiPTHR14759 PTHR14759, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: Comment: Additional isoforms seem to exist.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TSJ2-1) [UniParc]FASTAAdd to basket
Also known as: N-STOP, Neuronal STOP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWPCITRAC CIARFWNQLD KADIAVPLVF TKYSEATEHP GAPPQPPAPL
60 70 80 90 100
QPALAPPSRA VAIETQPAQG ESDAVARATG PAPGPSVDRE TVAAPGRSGL
110 120 130 140 150
GLGAASASTS GSGPADSVMR QDYRAWKVQR PEPSCRPRSE YQPSDAPFER
160 170 180 190 200
ETQYQKDFRA WPLPRRGDHP WIPKPVQIPA TSQPSQPVLG VPKRRPQSQE
210 220 230 240 250
RGPMQLSADA RDPEGAGGAG VLAAGKASGV DQRDTRRKAG PAWMVTRNEG
260 270 280 290 300
HEEKPLPPAQ SQTQEGGPAA GKASGADQRD TRRKAGPAWM VTRSEGHEEK
310 320 330 340 350
PLPPAQSQTQ EGGPAAGKAS GADQRDTRRK AGPAWMVTRT EGHEETPLPP
360 370 380 390 400
AQSQTQEGGP AAGKASGADE RDTRRKAGPA WMVRRSEGHE QTPAAHAQGT
410 420 430 440 450
GPEGGKGRAV ADALNRQIRE EVASTVSSSY RNEFRAWTDI KPVKPIKAKP
460 470 480 490 500
QYKPPDDKMV HETSYSAQFK GEANKPSAAD NKAMDRRRIR SLYSEPFKEC
510 520 530 540 550
PKVEKPSVQS SKPKKTSTSH KPPRKAKDKQ VVSGQAAKKK TTEGPSATKP
560 570 580 590 600
DDKEQSKEMN NKLAEAKESR VKPTSDASKN RGPVTKEPHK DQGSVAPGLP
610 620 630 640 650
KGQEPLKDQG PVVPGLPKDQ VPVVPGSLKG QSPTAPGPTK DQGAVLLGPV
660 670 680 690 700
KDLGPVAPAP IKVQDHIASE LLKNKDSVPL APAKAQSPLL PEPLKNQSPV
710 720 730 740 750
VPASTKDQSF PTPAPRKDPG PVIPEPEKDR APTVPERRKD QHVSIMASLK
760 770 780 790 800
NEAPMVPESV KNQGLAGPEL VKDTGTDTTA PRYLKGHDSV FVAPVKNQGP
810 820 830 840 850
VIPEPVKSQD PIIPALAKDQ GPMLPEPPKN QSPVVLGPIK NQDPIIPVPL
860 870 880 890 900
KGQDPLVPAP TKDQGPTAPD PLKTQGPKGT QLPTVSPSPP VMIPTVPHTE

YIEGSP
Note: Produced by alternative promoter usage.
Length:906
Mass (Da):96,450
Last modified:July 22, 2008 - v2
Checksum:iF3CED1FCF1E2CD83
GO
Isoform 2 (identifier: Q7TSJ2-2) [UniParc]FASTAAdd to basket
Also known as: E-STOP, Early STOP

The sequence of this isoform differs from the canonical sequence as follows:
     569-906: Missing.

Note: Produced by alternative splicing of isoform 1.
Show »
Length:568
Mass (Da):61,105
Checksum:i81B1DFF1B51D2658
GO
Isoform 3 (identifier: Q7TSJ2-3) [UniParc]FASTAAdd to basket
Also known as: F-STOP, Fibroblastic STOP

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     503-509: VEKPSVQ → EPGQTHQ
     510-906: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:306
Mass (Da):32,803
Checksum:iE19396DFF272B496
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z6W1D3Z6W1_MOUSE
Microtubule-associated protein 6
Map6 Mtap6
509Annotation score:
A0A140LIT9A0A140LIT9_MOUSE
Microtubule-associated protein 6
Map6
703Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81P → L in CAA75049 (PubMed:9501006).Curated1
Sequence conflicti87V → G in CAA75930 (PubMed:9501006).Curated1
Sequence conflicti344E → K in CAA75930 (PubMed:9501006).Curated1
Sequence conflicti344E → K in CAA75989 (PubMed:9600916).Curated1
Sequence conflicti405G → S in CAA75049 (PubMed:9501006).Curated1
Sequence conflicti755 – 757MVP → VVH in CAA75930 (PubMed:9501006).Curated3
Sequence conflicti755M → V in CAA75049 (PubMed:9501006).Curated1
Sequence conflicti825P → S in CAA75930 (PubMed:9501006).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0347241 – 203Missing in isoform 3. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_034725503 – 509VEKPSVQ → EPGQTHQ in isoform 3. 1 Publication7
Alternative sequenceiVSP_034726510 – 906Missing in isoform 3. 1 PublicationAdd BLAST397
Alternative sequenceiVSP_034727569 – 906Missing in isoform 2. 1 PublicationAdd BLAST338

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14754, Y14755, Y14756 Genomic DNA Translation: CAA75049.1
Y16008 Genomic DNA Translation: CAA75930.1
Y16032 mRNA Translation: CAA75989.1
BC053039 mRNA Translation: AAH53039.1
CCDSiCCDS21479.1 [Q7TSJ2-1]
CCDS40029.1 [Q7TSJ2-3]
CCDS85345.1 [Q7TSJ2-2]
PIRiJC5963
RefSeqiNP_001036820.2, NM_001043355.2 [Q7TSJ2-3]
NP_001041632.1, NM_001048167.1 [Q7TSJ2-2]
NP_034967.2, NM_010837.3 [Q7TSJ2-1]
UniGeneiMm.154087

Genome annotation databases

EnsembliENSMUST00000068973; ENSMUSP00000064787; ENSMUSG00000055407 [Q7TSJ2-1]
ENSMUST00000107100; ENSMUSP00000102717; ENSMUSG00000055407 [Q7TSJ2-3]
ENSMUST00000127492; ENSMUSP00000146340; ENSMUSG00000055407 [Q7TSJ2-2]
ENSMUST00000207883; ENSMUSP00000146585; ENSMUSG00000055407 [Q7TSJ2-1]
ENSMUST00000208605; ENSMUSP00000146897; ENSMUSG00000055407 [Q7TSJ2-3]
GeneIDi17760
KEGGimmu:17760
UCSCiuc009ilg.1 mouse [Q7TSJ2-1]
uc009ili.1 mouse [Q7TSJ2-3]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14754, Y14755, Y14756 Genomic DNA Translation: CAA75049.1
Y16008 Genomic DNA Translation: CAA75930.1
Y16032 mRNA Translation: CAA75989.1
BC053039 mRNA Translation: AAH53039.1
CCDSiCCDS21479.1 [Q7TSJ2-1]
CCDS40029.1 [Q7TSJ2-3]
CCDS85345.1 [Q7TSJ2-2]
PIRiJC5963
RefSeqiNP_001036820.2, NM_001043355.2 [Q7TSJ2-3]
NP_001041632.1, NM_001048167.1 [Q7TSJ2-2]
NP_034967.2, NM_010837.3 [Q7TSJ2-1]
UniGeneiMm.154087

3D structure databases

ProteinModelPortaliQ7TSJ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201587, 7 interactors
IntActiQ7TSJ2, 8 interactors
MINTiQ7TSJ2
STRINGi10090.ENSMUSP00000064787

PTM databases

iPTMnetiQ7TSJ2
PhosphoSitePlusiQ7TSJ2

Proteomic databases

PaxDbiQ7TSJ2
PeptideAtlasiQ7TSJ2
PRIDEiQ7TSJ2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068973; ENSMUSP00000064787; ENSMUSG00000055407 [Q7TSJ2-1]
ENSMUST00000107100; ENSMUSP00000102717; ENSMUSG00000055407 [Q7TSJ2-3]
ENSMUST00000127492; ENSMUSP00000146340; ENSMUSG00000055407 [Q7TSJ2-2]
ENSMUST00000207883; ENSMUSP00000146585; ENSMUSG00000055407 [Q7TSJ2-1]
ENSMUST00000208605; ENSMUSP00000146897; ENSMUSG00000055407 [Q7TSJ2-3]
GeneIDi17760
KEGGimmu:17760
UCSCiuc009ilg.1 mouse [Q7TSJ2-1]
uc009ili.1 mouse [Q7TSJ2-3]

Organism-specific databases

CTDi4135
MGIiMGI:1201690 Map6

Phylogenomic databases

eggNOGiENOG410IIA0 Eukaryota
ENOG4110KV2 LUCA
GeneTreeiENSGT00530000063947
HOGENOMiHOG000113479
HOVERGENiHBG053112
InParanoidiQ7TSJ2
KOiK10432
OMAiKPGPAWM
OrthoDBiEOG091G0A3G
PhylomeDBiQ7TSJ2
TreeFamiTF338320

Miscellaneous databases

PROiPR:Q7TSJ2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055407 Expressed in 243 organ(s), highest expression level in forebrain
ExpressionAtlasiQ7TSJ2 baseline and differential
GenevisibleiQ7TSJ2 MM

Family and domain databases

InterProiView protein in InterPro
IPR007882 MAP6
PANTHERiPTHR14759 PTHR14759, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAP6_MOUSE
AccessioniPrimary (citable) accession number: Q7TSJ2
Secondary accession number(s): O55129
, O70586, O70587, Q78DV4, Q78DV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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