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Protein

RNA polymerase II subunit A C-terminal domain phosphatase

Gene

Ctdp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-112382 Formation of RNA Pol II elongation complex
R-MMU-113418 Formation of the Early Elongation Complex
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-MMU-75955 RNA Polymerase II Transcription Elongation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase (EC:3.1.3.16)
Alternative name(s):
TFIIF-associating CTD phosphatase
Gene namesi
Name:Ctdp1
Synonyms:Fcp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1926953 Ctdp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125651 – 960RNA polymerase II subunit A C-terminal domain phosphataseAdd BLAST960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei530PhosphoserineCombined sources1
Modified residuei664PhosphoserineBy similarity1
Modified residuei730PhosphoserineCombined sources1
Modified residuei770N6-acetyllysineCombined sources1
Modified residuei830PhosphoserineCombined sources1
Modified residuei860PhosphoserineCombined sources1
Modified residuei863PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated. In the presence of TFIIF, the phosphorylated form has an increased CTD phosphatase activity. The phosphorylation is required for the physical interaction with GTF2F1 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7TSG2
PaxDbiQ7TSG2
PRIDEiQ7TSG2

PTM databases

iPTMnetiQ7TSG2
PhosphoSitePlusiQ7TSG2

Expressioni

Gene expression databases

BgeeiENSMUSG00000033323 Expressed in 268 organ(s), highest expression level in testis
ExpressionAtlasiQ7TSG2 baseline and differential
GenevisibleiQ7TSG2 MM

Interactioni

Subunit structurei

Homodimer. Interacts with GTF2F1 (By similarity). Interacts with WDR77, SNRPB and SNRNP70 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038938

Structurei

3D structure databases

ProteinModelPortaliQ7TSG2
SMRiQ7TSG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 341FCP1 homologyPROSITE-ProRule annotationAdd BLAST164
Domaini619 – 718BRCTPROSITE-ProRule annotationAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi414 – 417Poly-Ser4
Compositional biasi568 – 572Poly-Glu5
Compositional biasi573 – 578Poly-Asp6

Phylogenomic databases

eggNOGiKOG0323 Eukaryota
COG5190 LUCA
GeneTreeiENSGT00390000015641
HOGENOMiHOG000112039
HOVERGENiHBG051213
InParanoidiQ7TSG2
KOiK15732
OMAiTREHYHA
OrthoDBiEOG091G05JF
PhylomeDBiQ7TSG2
TreeFamiTF315104

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di3.40.50.1000, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR039189 Fcp1
IPR015388 FCP1_C
IPR004274 FCP1_dom
IPR011947 FCP1_euk
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR011053 Single_hybrid_motif
PANTHERiPTHR23081 PTHR23081, 1 hit
PfamiView protein in Pfam
PF09309 FCP1_C, 1 hit
PF03031 NIF, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SM00577 CPDc, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF52113 SSF52113, 1 hit
SSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02250 FCP1_euk, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS50969 FCP1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TSG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAPPAAGVP TECTPAVAGA EVRCPGPTPL RLLEWKVAAG ATVRIGSVLA
60 70 80 90 100
VCETAASAQP AGPAPARAAS GGCVRAARTE RRLRSERAGV VRELCAQPGQ
110 120 130 140 150
VVAPGALLVR LEGCSHPVVM KGLCAECGQD LTQLQSKNGR QQVPLSTATV
160 170 180 190 200
SMVHSVPELM VSSEQAEKLG REDQQRLHRN RKLVLMVDLD QTLIHTTEQH
210 220 230 240 250
CPQMSNKGIF HFQLGRGEPM LHTRLRPHCK DFLEKIAKLY ELHVFTFGSR
260 270 280 290 300
LYAHTIAGFL DPEKKLFSHR ILSRDECIDP FSKTGNLRNL FPCGDSMVCI
310 320 330 340 350
IDDREDVWKF APNLITVKKY VYFPGTGDVN APPAARETQA RRKVNHSSKG
360 370 380 390 400
GDALEQALSV RDPEDGRPAP GVEHSNGLGK ASRELNGGEA VPGVFPSKAD
410 420 430 440 450
EKEAWPLTRA SPASSSSGHE PTEAPELPVS CEWDGRTTPG VQPTQGDAAT
460 470 480 490 500
QDLDFDLSSD SESSESSSRS EGQRAPAPQE RTKAAPEHSG PQDTSGGRAA
510 520 530 540 550
ASPLGESGPS IHPHDKGSDL DTQEEGERDS LCGLGNGSVD RKEAETESQN
560 570 580 590 600
SEQSGVTAGE SLDQSVGEEE EEDTDDDDHL IHLEEILVRV HTDYYTKYDR
610 620 630 640 650
YLNKELEEAP DIRKIVPELK SKVLADVAVI FSGLHPTNFP VEKTREHYHA
660 670 680 690 700
TALGAKVLTQ LVLSPDAPDR ATHLIAARAG TEKVRQAQEC KHLHVVSPDW
710 720 730 740 750
LWSCLERWDK VEEQLFPLID DDTRTHRDNS PAVFPDRHSV LPTALFHPTP
760 770 780 790 800
IHSKAHPGPE VRIYDSNTGK LIRMGPQGSA PAPSSAPLNH GEPSSFRAVQ
810 820 830 840 850
PHQQQMFGEE LPESQDGEQP GPARRKRQPS MSEAMPLYTL CKEDLESMDK
860 870 880 890 900
EVDDILGEGS DDSDIEKKKP EDQDNEQERA PKPRKPRAPG IRREQPVGLP
910 920 930 940 950
SSGERSTPGM RGPRGHKRKL NEEDAASESS GESSNDDEEG SSSEADEMAA
960
ALEAELNDLM
Length:960
Mass (Da):104,554
Last modified:October 1, 2003 - v1
Checksum:i7D1EB42C6D15C95C
GO
Isoform 2 (identifier: Q7TSG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-788: Missing.
     789-796: NHGEPSSF → MSRIILVV

Note: No experimental confirmation available.
Show »
Length:172
Mass (Da):19,043
Checksum:iE3243D9122FC5811
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CZ13E0CZ13_MOUSE
CTD (Carboxy-terminal domain, RNA p...
Ctdp1 mCG_121298
172Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti759 – 761PEV → GTR in AAH52934 (PubMed:15489334).Curated3
Sequence conflicti897V → I in AAH52934 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0098661 – 788Missing in isoform 2. 1 PublicationAdd BLAST788
Alternative sequenceiVSP_009867789 – 796NHGEPSSF → MSRIILVV in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016213 mRNA Translation: BAB30150.1
BC052934 mRNA Translation: AAH52934.1
BC053435 mRNA Translation: AAH53435.1
CCDSiCCDS29368.1 [Q7TSG2-1]
RefSeqiNP_080571.2, NM_026295.2 [Q7TSG2-1]
UniGeneiMm.312893

Genome annotation databases

EnsembliENSMUST00000036229; ENSMUSP00000038938; ENSMUSG00000033323 [Q7TSG2-1]
GeneIDi67655
KEGGimmu:67655
UCSCiuc008ftb.1 mouse [Q7TSG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016213 mRNA Translation: BAB30150.1
BC052934 mRNA Translation: AAH52934.1
BC053435 mRNA Translation: AAH53435.1
CCDSiCCDS29368.1 [Q7TSG2-1]
RefSeqiNP_080571.2, NM_026295.2 [Q7TSG2-1]
UniGeneiMm.312893

3D structure databases

ProteinModelPortaliQ7TSG2
SMRiQ7TSG2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038938

PTM databases

iPTMnetiQ7TSG2
PhosphoSitePlusiQ7TSG2

Proteomic databases

EPDiQ7TSG2
PaxDbiQ7TSG2
PRIDEiQ7TSG2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036229; ENSMUSP00000038938; ENSMUSG00000033323 [Q7TSG2-1]
GeneIDi67655
KEGGimmu:67655
UCSCiuc008ftb.1 mouse [Q7TSG2-1]

Organism-specific databases

CTDi9150
MGIiMGI:1926953 Ctdp1

Phylogenomic databases

eggNOGiKOG0323 Eukaryota
COG5190 LUCA
GeneTreeiENSGT00390000015641
HOGENOMiHOG000112039
HOVERGENiHBG051213
InParanoidiQ7TSG2
KOiK15732
OMAiTREHYHA
OrthoDBiEOG091G05JF
PhylomeDBiQ7TSG2
TreeFamiTF315104

Enzyme and pathway databases

ReactomeiR-MMU-112382 Formation of RNA Pol II elongation complex
R-MMU-113418 Formation of the Early Elongation Complex
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-MMU-75955 RNA Polymerase II Transcription Elongation

Miscellaneous databases

PROiPR:Q7TSG2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033323 Expressed in 268 organ(s), highest expression level in testis
ExpressionAtlasiQ7TSG2 baseline and differential
GenevisibleiQ7TSG2 MM

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di3.40.50.1000, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR039189 Fcp1
IPR015388 FCP1_C
IPR004274 FCP1_dom
IPR011947 FCP1_euk
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR011053 Single_hybrid_motif
PANTHERiPTHR23081 PTHR23081, 1 hit
PfamiView protein in Pfam
PF09309 FCP1_C, 1 hit
PF03031 NIF, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SM00577 CPDc, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF52113 SSF52113, 1 hit
SSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02250 FCP1_euk, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS50969 FCP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTDP1_MOUSE
AccessioniPrimary (citable) accession number: Q7TSG2
Secondary accession number(s): Q7TSS7, Q9D4S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: October 10, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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