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Protein

Centrosomal protein of 120 kDa

Gene

Cep120

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity).By similarity3 Publications

GO - Molecular functioni

  • protein C-terminus binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 120 kDa
Short name:
Cep120
Alternative name(s):
Coiled-coil domain-containing protein 100
Gene namesi
Name:Cep120
Synonyms:Ccdc100
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2147298 Cep120

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003482631 – 988Centrosomal protein of 120 kDaAdd BLAST988

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei934PhosphoserineCombined sources1
Modified residuei938PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7TSG1
PeptideAtlasiQ7TSG1
PRIDEiQ7TSG1

PTM databases

iPTMnetiQ7TSG1
PhosphoSitePlusiQ7TSG1

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in brain, lung and kidney and weakly expressed in heart, liver, small intestine and limb (at protein level). Expressed in brain.1 Publication

Developmental stagei

Expressed in embryonic brain from 10.5 to 17.5 dpc. Expressed in neocortical neural progenitors at the ventrical surface at 12.5 dpc (at protein level). Expressed in brain, heart, lung, liver, kidney, small intestine and limb at 16.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000048799 Expressed in 251 organ(s), highest expression level in superior cervical ganglion
GenevisibleiQ7TSG1 MM

Interactioni

Subunit structurei

Interacts with TACC2, TACC3, CCDC52, TALPID3.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Talpid3E9PV873EBI-2553947,EBI-11692182

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230403, 37 interactors
IntActiQ7TSG1, 38 interactors
STRINGi10090.ENSMUSP00000062433

Structurei

Secondary structure

1988
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ7TSG1
SMRiQ7TSG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili706 – 929Sequence analysisAdd BLAST224

Sequence similaritiesi

Belongs to the CEP120 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IDYJ Eukaryota
ENOG410XNN2 LUCA
GeneTreeiENSGT00390000009378
HOVERGENiHBG107643
InParanoidiQ7TSG1
KOiK16459
OMAiLKTQNEH
OrthoDBiEOG091G074C
PhylomeDBiQ7TSG1
TreeFamiTF329430

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR022136 DUF3668
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF12416 DUF3668, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7TSG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPKSDQLLI VVSILEGRHF PKRPKHLLVV EAKFDGEQLA TDPVDHTDQP
60 70 80 90 100
EFATELAWEI DRKVLHQHRL QRTPIKLQCF ALDPQTSAKE TVGYIVLDLR
110 120 130 140 150
TAQETKQAPK WYQLLSNKYT KFKAEVQISL TLETDTKAQV DSYKAKAAPP
160 170 180 190 200
RDGKVLASLA GVDPKDIVAV LNEEGGYHQI GPAEHCTDPF ILSVTIAFAT
210 220 230 240 250
QLEQLIPCTM KLPERQPEFF FYYSLLGNDV TNEPFSDLIN PNFEPERASV
260 270 280 290 300
RIRSSVEILR VYLALHSKLQ IHLCCGDQSL GSTEIPLNGL LKKGSTEINQ
310 320 330 340 350
HPVTVEGAFT LDPPNRAKQK LAPVPLDLAP TVGVSVALQR EGIDSQSLIE
360 370 380 390 400
LKTQNGHEAE HSQKRVLTPI KEKTLTGPKS PRESPAPPPP PNQTPPTKDD
410 420 430 440 450
ATESEVESLQ YDKDPKPTVK GIGSVPASLA QPEATCGASE VVTSGQKIAV
460 470 480 490 500
PAASHHFCFS VDLRSVHDLE LSFPVNCILR YSYPFFGSAA PIMTNPPVEV
510 520 530 540 550
RKNMEVFLPQ SYCAFDFATM PHQLQDTFLR IPLLVELWHK DKMSKDLLLG
560 570 580 590 600
VARIQLSNIL SSEKTRFLGA NGEQCWRQTY SESVPVIAAQ GSNNRILDLS
610 620 630 640 650
YTMTLEDYGL VKMREIFVSE SSQGVPAVDQ KPSSPPPAPC PSEIQMEPRE
660 670 680 690 700
TLEYKAALEL EMWKEMQEDI FESQLKQKEL AHMQALAEEW KKRDRERESL
710 720 730 740 750
VKKKVAEYSI LEGKLQKALT ELETREQQLA SAEAELQRER KELQLERERN
760 770 780 790 800
LQELQDSVRR ARDDCVYQVE LERLKLKQLE EDKQRLQQQL NDAGNKYKTL
810 820 830 840 850
EKEFQQFKDQ QNNKPEIRLQ SEINLLTLEK VELERKLESA TKSKLHYKQQ
860 870 880 890 900
WGRALKELAR LKQREQESQM ARLKKQQEEL EQMRLRYLAA EEKETVRTEQ
910 920 930 940 950
QELLDIRNEL NRLRQQEQNQ YQDCKEIASG KLGSPRGSGL EEGLDDYLTR
960 970 980
LIEERDTLMR TGVYNHEDRI ISELDRQIRE VLTKNSAS
Length:988
Mass (Da):112,579
Last modified:October 1, 2003 - v1
Checksum:iAF9A80D682A93953
GO
Isoform 2 (identifier: Q7TSG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     913-988: LRQQEQNQYQ...REVLTKNSAS → YCPYNHSFSHQHRSDSQ

Note: No experimental confirmation available.
Show »
Length:929
Mass (Da):105,905
Checksum:iD2D2013E059494CC
GO
Isoform 3 (identifier: Q7TSG1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-365: SLIELKTQNGHEAEHSQKR → AGGDSAFTCQFSHARDDKR
     366-988: Missing.

Show »
Length:365
Mass (Da):40,609
Checksum:iD95BF184FC121FB7
GO
Isoform 4 (identifier: Q7TSG1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-901: Missing.
     902-911: ELLDIRNELN → MNLLRRSLHP

Show »
Length:87
Mass (Da):10,142
Checksum:i1F67C4A271CD899B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti614R → G in BAC33092 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0351261 – 901Missing in isoform 4. 1 PublicationAdd BLAST901
Alternative sequenceiVSP_035127347 – 365SLIEL…HSQKR → AGGDSAFTCQFSHARDDKR in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_035128366 – 988Missing in isoform 3. 1 PublicationAdd BLAST623
Alternative sequenceiVSP_035129902 – 911ELLDIRNELN → MNLLRRSLHP in isoform 4. 1 Publication10
Alternative sequenceiVSP_035130913 – 988LRQQE…KNSAS → YCPYNHSFSHQHRSDSQ in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038916 mRNA Translation: BAC30167.1
AK044808 mRNA Translation: BAC32100.1
AK044952 mRNA Translation: BAC32156.1
AK047594 mRNA Translation: BAC33092.1
AK079319 mRNA Translation: BAC37606.1
BC046493 mRNA Translation: AAH46493.1
BC048590 mRNA Translation: AAH48590.1
BC053439 mRNA Translation: AAH53439.1
CCDSiCCDS37822.1 [Q7TSG1-1]
RefSeqiNP_848801.2, NM_178686.3 [Q7TSG1-1]
UniGeneiMm.193678

Genome annotation databases

EnsembliENSMUST00000049811; ENSMUSP00000062433; ENSMUSG00000048799 [Q7TSG1-1]
GeneIDi225523
KEGGimmu:225523
UCSCiuc008exy.1 mouse [Q7TSG1-1]
uc008exz.1 mouse [Q7TSG1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038916 mRNA Translation: BAC30167.1
AK044808 mRNA Translation: BAC32100.1
AK044952 mRNA Translation: BAC32156.1
AK047594 mRNA Translation: BAC33092.1
AK079319 mRNA Translation: BAC37606.1
BC046493 mRNA Translation: AAH46493.1
BC048590 mRNA Translation: AAH48590.1
BC053439 mRNA Translation: AAH53439.1
CCDSiCCDS37822.1 [Q7TSG1-1]
RefSeqiNP_848801.2, NM_178686.3 [Q7TSG1-1]
UniGeneiMm.193678

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EWPX-ray1.85A/B/C436-634[»]
ProteinModelPortaliQ7TSG1
SMRiQ7TSG1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230403, 37 interactors
IntActiQ7TSG1, 38 interactors
STRINGi10090.ENSMUSP00000062433

PTM databases

iPTMnetiQ7TSG1
PhosphoSitePlusiQ7TSG1

Proteomic databases

PaxDbiQ7TSG1
PeptideAtlasiQ7TSG1
PRIDEiQ7TSG1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049811; ENSMUSP00000062433; ENSMUSG00000048799 [Q7TSG1-1]
GeneIDi225523
KEGGimmu:225523
UCSCiuc008exy.1 mouse [Q7TSG1-1]
uc008exz.1 mouse [Q7TSG1-2]

Organism-specific databases

CTDi153241
MGIiMGI:2147298 Cep120

Phylogenomic databases

eggNOGiENOG410IDYJ Eukaryota
ENOG410XNN2 LUCA
GeneTreeiENSGT00390000009378
HOVERGENiHBG107643
InParanoidiQ7TSG1
KOiK16459
OMAiLKTQNEH
OrthoDBiEOG091G074C
PhylomeDBiQ7TSG1
TreeFamiTF329430

Miscellaneous databases

PROiPR:Q7TSG1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048799 Expressed in 251 organ(s), highest expression level in superior cervical ganglion
GenevisibleiQ7TSG1 MM

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR022136 DUF3668
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF12416 DUF3668, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCE120_MOUSE
AccessioniPrimary (citable) accession number: Q7TSG1
Secondary accession number(s): Q80Y93
, Q80ZQ2, Q8BG01, Q8C580, Q8C8B6, Q8CAF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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