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Protein

Desmoglein-1-beta

Gene

Dsg1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-351906 Apoptotic cleavage of cell adhesion proteins
R-MMU-6798695 Neutrophil degranulation
R-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-1-beta
Short name:
Dsg1-beta
Alternative name(s):
Desmoglein-5
Gene namesi
Name:Dsg1b
Synonyms:Dsg5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2664357 Dsg1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini50 – 567ExtracellularSequence analysisAdd BLAST518
Transmembranei568 – 588HelicalSequence analysisAdd BLAST21
Topological domaini589 – 1060CytoplasmicSequence analysisAdd BLAST472

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000000384124 – 49Sequence analysisAdd BLAST26
ChainiPRO_000000384250 – 1060Desmoglein-1-betaAdd BLAST1011

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiQ7TSF1
PaxDbiQ7TSF1
PRIDEiQ7TSF1

PTM databases

iPTMnetiQ7TSF1
PhosphoSitePlusiQ7TSF1

Expressioni

Tissue specificityi

Expressed in epidermis.2 Publications

Developmental stagei

Expressed in embryo at 17 dpc.2 Publications

Gene expression databases

BgeeiENSMUSG00000061928 Expressed in 8 organ(s), highest expression level in zone of skin
CleanExiMM_DSG1B
ExpressionAtlasiQ7TSF1 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230374, 1 interactor
IntActiQ7TSF1, 2 interactors
MINTiQ7TSF1
STRINGi10090.ENSMUSP00000076026

Structurei

3D structure databases

ProteinModelPortaliQ7TSF1
SMRiQ7TSF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 157Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini158 – 269Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini270 – 389Cadherin 3PROSITE-ProRule annotationAdd BLAST120
Domaini386 – 493Cadherin 4PROSITE-ProRule annotationAdd BLAST108
Repeati835 – 861Desmoglein repeat 1Add BLAST27
Repeati862 – 891Desmoglein repeat 2Add BLAST30
Repeati892 – 921Desmoglein repeat 3Add BLAST30
Repeati922 – 949Desmoglein repeat 4Add BLAST28
Repeati950 – 978Desmoglein repeat 5Add BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi485 – 601Gly-richAdd BLAST117
Compositional biasi980 – 1024Gly-richAdd BLAST45

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00910000144083
HOGENOMiHOG000236266
HOVERGENiHBG005532
InParanoidiQ7TSF1
KOiK07596
OMAiEFFFISG
OrthoDBiEOG091G01PF
PhylomeDBiQ7TSF1
TreeFamiTF331809

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
IPR009123 Desmoglein
IPR009122 Desmosomal_cadherin
PANTHERiPTHR24025 PTHR24025, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 3 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
PR01818 DESMOCADHERN
PR01819 DESMOGLEIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 4 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TSF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDWHSFRIAA LLLTSLVVLE VNSEFQIQVR DHNAKNGTIK WHSIRRQKRE
60 70 80 90 100
WIKFAAACRE GEDNSKRNPI AKIHSDCAAN QPVTYRISGV GIDQPPYGIF
110 120 130 140 150
IINQKTGEIN ITSIVDREVT PFFIIYCRAL NAQGQDLENP LELRVRVMDI
160 170 180 190 200
NDNPPVFSMT TFLGQIEENS NANTLVMKLN ATDADEPNNL NSMIAFKIIR
210 220 230 240 250
QEPSDSPMFI INRKTGEIRT MNNFLDREQY SQYSLVVRGS DRDGGADGMS
260 270 280 290 300
AESECSITIL DVNDNIPYLE QSSYDIEIEE NALHSQLVQI RVIDLDEEFS
310 320 330 340 350
DNWKAIIFFI SGNEGNWFEI EMNERTNVGT LKVVKPLDYE AMKNLQLSIG
360 370 380 390 400
VRNVAEFHQS IISQYRLTAT MVTVTVLNVI EGSVFRPGSK TFVVDSRMEA
410 420 430 440 450
NHRVGEFVAT DLDTGRASTN VRYEMGNNPE NLLVVDSRTG IITLRNRVTM
460 470 480 490 500
EQYQRLNGEY KGTVLSIDDS LQRTCTGTIV IELSGTGWVP GSDGGGSSSG
510 520 530 540 550
SGGNRDPVTN GYQGTSTVGP QRVTGSGGVT SSGGGSGVNN TPGRQNPLDE
560 570 580 590 600
PEPEPFDITE DNVHFGPAGI GLLIMGFLVL GLVPFLLICC DCGGAPGGGA
610 620 630 640 650
GFEPVPECSD GAIHTWAIEG PQPEPHDGIT TICVPQMPPG NANVIEYIDN
660 670 680 690 700
SGVYTNEYCG REMQDLGGGE RTTGFELMDG VKTSAAPEIC QEYSGTLRRN
710 720 730 740 750
SMRECRDGGL NMNFMESYFC QKAYAYADED EGRPSNDCLL IYDIEGVGSP
760 770 780 790 800
AGSVGCCSFI GEDLDESFLD TLGPKFKKLA DISLGKEIDS YPDPDSSWPP
810 820 830 840 850
QSTEPMCPQS TEPLGSGYPP ISPHFGTTTV ISENAYPSGP GVQHPLPIPD
860 870 880 890 900
PLGYGNVTVR ESYATSGTLK PSVHFHDNQQ ASNVVVTERV VGPVPGADLH
910 920 930 940 950
GMLEIPDLRD GTNVIVTERV IAPGSSLPTS LTIPNPRETS NVVVTERVIQ
960 970 980 990 1000
PTSGMIGNLS MTPELSSAQN VIVTERVVSG AGMSGIAGTA GLGGVGGIGS
1010 1020 1030 1040 1050
SGLVSTTMGA AGTGLNMGGT ATIGHMRSSS DHHFSQTIGS ASPNMARSRI
1060
TKYSTVQYSK
Length:1,060
Mass (Da):114,454
Last modified:October 1, 2003 - v1
Checksum:i58873A358C52B9C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti929T → N in AAP80571 (PubMed:12631242).Curated1
Sequence conflicti1038I → V in AAP80571 (PubMed:12631242).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY192158 mRNA Translation: AAP31152.1
AY315940 mRNA Translation: AAP80571.1
CCDSiCCDS29081.1
RefSeqiNP_859010.1, NM_181682.2
UniGeneiMm.269128
Mm.355485

Genome annotation databases

EnsembliENSMUST00000076737; ENSMUSP00000076026; ENSMUSG00000061928
GeneIDi225256
KEGGimmu:225256
UCSCiuc008eem.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY192158 mRNA Translation: AAP31152.1
AY315940 mRNA Translation: AAP80571.1
CCDSiCCDS29081.1
RefSeqiNP_859010.1, NM_181682.2
UniGeneiMm.269128
Mm.355485

3D structure databases

ProteinModelPortaliQ7TSF1
SMRiQ7TSF1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230374, 1 interactor
IntActiQ7TSF1, 2 interactors
MINTiQ7TSF1
STRINGi10090.ENSMUSP00000076026

PTM databases

iPTMnetiQ7TSF1
PhosphoSitePlusiQ7TSF1

Proteomic databases

MaxQBiQ7TSF1
PaxDbiQ7TSF1
PRIDEiQ7TSF1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076737; ENSMUSP00000076026; ENSMUSG00000061928
GeneIDi225256
KEGGimmu:225256
UCSCiuc008eem.1 mouse

Organism-specific databases

CTDi225256
MGIiMGI:2664357 Dsg1b

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00910000144083
HOGENOMiHOG000236266
HOVERGENiHBG005532
InParanoidiQ7TSF1
KOiK07596
OMAiEFFFISG
OrthoDBiEOG091G01PF
PhylomeDBiQ7TSF1
TreeFamiTF331809

Enzyme and pathway databases

ReactomeiR-MMU-351906 Apoptotic cleavage of cell adhesion proteins
R-MMU-6798695 Neutrophil degranulation
R-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

PROiPR:Q7TSF1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061928 Expressed in 8 organ(s), highest expression level in zone of skin
CleanExiMM_DSG1B
ExpressionAtlasiQ7TSF1 baseline and differential

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
IPR009123 Desmoglein
IPR009122 Desmosomal_cadherin
PANTHERiPTHR24025 PTHR24025, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 3 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
PR01818 DESMOCADHERN
PR01819 DESMOGLEIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 4 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDSG1B_MOUSE
AccessioniPrimary (citable) accession number: Q7TSF1
Secondary accession number(s): Q7TQ60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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