UniProtKB - Q7TSB7 (KISS1_RAT)
Protein
Metastasis-suppressor KiSS-1
Gene
Kiss1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Intracerebroventricular administration induces an increase in serum LH and FSH levels in prepubertal male and female as well as in adult animals.2 Publications
GO - Molecular functioni
- G protein-coupled receptor binding Source: RGD
- kisspeptin receptor binding Source: RGD
GO - Biological processi
- decidualization Source: RGD
- generation of ovulation cycle rhythm Source: RGD
- G protein-coupled receptor signaling pathway Source: RGD
- negative regulation of cell migration Source: RGD
- negative regulation of cell population proliferation Source: RGD
- positive regulation of cytosolic calcium ion concentration Source: RGD
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: RGD
- positive regulation of growth hormone secretion Source: RGD
- positive regulation of luteinizing hormone secretion Source: RGD
- positive regulation of MAPK cascade Source: RGD
- positive regulation of synaptic transmission Source: RGD
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors R-RNO-416476, G alpha (q) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Metastasis-suppressor KiSS-1Alternative name(s): Kisspeptin-1 Cleaved into the following 2 chains: |
Gene namesi | Name:Kiss1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 727850, Kiss1 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: RGD
Plasma Membrane
- apical plasma membrane Source: RGD
Other locations
- cytoplasm Source: RGD
- neuron projection Source: RGD
- neuronal cell body Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000021555 | 20 – 130 | Metastasis-suppressor KiSS-1Add BLAST | 111 | |
PeptideiPRO_0000021556 | 68 – 119 | MetastinAdd BLAST | 52 | |
PeptideiPRO_0000021557 | 110 – 119 | Kisspeptin-10 | 10 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 71 ↔ 85 | Sequence analysis | ||
Modified residuei | 110 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 119 | Tyrosine amideBy similarity | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residues, Disulfide bond, PhosphoproteinProteomic databases
PaxDbi | Q7TSB7 |
PTM databases
PhosphoSitePlusi | Q7TSB7 |
Expressioni
Tissue specificityi
Highest levels in the cecum and colon. Moderate levels present in the liver, spleen, kidney, ovary, uterus and small intestine. Low levels in the stomach, pancreas and placenta. Expressed only moderately in the placenta. Persistent expression is detected in hypothalamus throughout postnatal development, with maximum expression levels at puberty in both male and female. Hypothalamic expression is sensitive to neonatal imprinting by estrogen. Expression is higher in the hypothalamus than in the brainstem and spinal cord. In the brain, metastin-like immunoreactivity is found mainly in three groups of cells: dorsomedial hypothalamic nucleus, nucleus of the solitary tract, and caudal ventrolateral medulla.3 Publications
Developmental stagei
Expression observed in trophoblast giant cells (TGCs), the placenta-derived cell lineage aligned at the boundary between the uterus and placenta, at embryonic days 12.5 (E12.5). Expressions gradually decreased during placental maturation, and the signal is no more detectable in the cells at E18.5.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000047481, Expressed in pancreas and 14 other tissues |
ExpressionAtlasi | Q7TSB7, baseline and differential |
Interactioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: RGD
- kisspeptin receptor binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 252772, 1 interactor |
STRINGi | 10116.ENSRNOP00000068332 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 110 – 119 | Essential for receptor binding and receptor activation | 10 |
Sequence similaritiesi
Belongs to the KISS1 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SFM2, Eukaryota |
GeneTreei | ENSGT00390000008827 |
HOGENOMi | CLU_119112_0_0_1 |
InParanoidi | Q7TSB7 |
OMAi | PNYNWNS |
OrthoDBi | 1513721at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR020207, Metastasis-suppressor_KiSS-1 |
PANTHERi | PTHR16955, PTHR16955, 1 hit |
Pfami | View protein in Pfam PF15152, Kisspeptin, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q7TSB7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISLASWQLL LLLCVASFGE PLAKMAPVVN PEPTGQQSGP QELVNAWQKG
60 70 80 90 100
PRYAESKPGA AGLRARRTSP CPPVENPTGH QRPPCATRSR LIPAPRGSVL
110 120 130
VQREKDMSAY NWNSFGLRYG RRQVARAARG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY196983 mRNA Translation: AAP22375.1 |
RefSeqi | NP_859043.1, NM_181692.1 XP_008767665.1, XM_008769443.2 XP_017454186.1, XM_017598697.1 |
Genome annotation databases
Ensembli | ENSRNOT00000076506; ENSRNOP00000068332; ENSRNOG00000047481 ENSRNOT00000077054; ENSRNOP00000068288; ENSRNOG00000047481 |
GeneIDi | 289023 |
KEGGi | rno:289023 |
UCSCi | RGD:727850, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY196983 mRNA Translation: AAP22375.1 |
RefSeqi | NP_859043.1, NM_181692.1 XP_008767665.1, XM_008769443.2 XP_017454186.1, XM_017598697.1 |
3D structure databases
SMRi | Q7TSB7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 252772, 1 interactor |
STRINGi | 10116.ENSRNOP00000068332 |
PTM databases
PhosphoSitePlusi | Q7TSB7 |
Proteomic databases
PaxDbi | Q7TSB7 |
Genome annotation databases
Ensembli | ENSRNOT00000076506; ENSRNOP00000068332; ENSRNOG00000047481 ENSRNOT00000077054; ENSRNOP00000068288; ENSRNOG00000047481 |
GeneIDi | 289023 |
KEGGi | rno:289023 |
UCSCi | RGD:727850, rat |
Organism-specific databases
CTDi | 3814 |
RGDi | 727850, Kiss1 |
Phylogenomic databases
eggNOGi | ENOG502SFM2, Eukaryota |
GeneTreei | ENSGT00390000008827 |
HOGENOMi | CLU_119112_0_0_1 |
InParanoidi | Q7TSB7 |
OMAi | PNYNWNS |
OrthoDBi | 1513721at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors R-RNO-416476, G alpha (q) signalling events |
Miscellaneous databases
PROi | PR:Q7TSB7 |
Gene expression databases
Bgeei | ENSRNOG00000047481, Expressed in pancreas and 14 other tissues |
ExpressionAtlasi | Q7TSB7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR020207, Metastasis-suppressor_KiSS-1 |
PANTHERi | PTHR16955, PTHR16955, 1 hit |
Pfami | View protein in Pfam PF15152, Kisspeptin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KISS1_RAT | |
Accessioni | Q7TSB7Primary (citable) accession number: Q7TSB7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2005 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families