Helt

Functionⁱ

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Required for the development of GABAergic neurons.4 Publications

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 14764602
DNA-binding transcription factor activity
Source: MGI
Inferred from direct assayⁱ
- 14764602
microsatellite binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 14764602
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 14764602
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 14764602
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific double-stranded DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription corepressor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood vessel development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
central nervous system development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16968817
GABAergic neuron differentiation in basal ganglia
Source: MGI
Inferred from mutant phenotypeⁱ
- 16968817
gene expression
Source: MGI
Inferred from mutant phenotypeⁱ
- 16968817
heart development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
multicellular organism aging
Source: MGI
Inferred from mutant phenotypeⁱ
- 16968817
multicellular organism growth
Source: MGI
Inferred from mutant phenotypeⁱ
- 16968817
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 14764602
neuron differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 15071116
Notch signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from mutant phenotypeⁱ
- 22920256
post-embryonic development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16968817
regulation of neurogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
suckling behavior
Source: MGI
Inferred from mutant phenotypeⁱ
- 16968817

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding, Repressor
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hairy and enhancer of split-related protein HELT Alternative name(s): HES/HEY-like transcription factor Protein Hes-like Protein megane
Gene namesⁱ	Name:Helt Synonyms:Hesl, Mgn
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:3040955 Helt

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Death between 2 and 5 weeks of age. The mesencephalic GABAergic progenitors in these animals fail to develop into neurons.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000349379	1 – 240	Hairy and enhancer of split-related protein HELTAdd BLAST		240

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	48	N6-acetyllysineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

PaxDbⁱ	Q7TS99
PRIDEⁱ	Q7TS99

PTM databases

iPTMnetⁱ	Q7TS99
PhosphoSitePlusⁱ	Q7TS99

Expressionⁱ

Tissue specificityⁱ

Expressed in heart and testis.

Developmental stageⁱ

Expressed in the progenitor domains for mesencephalic GABAergic neurons.4 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000047171 Expressed in 26 organ(s), highest expression level in late tubule (mouse)
ExpressionAtlasⁱ	Q7TS99 baseline and differential

Interactionⁱ

Subunit structureⁱ

Self-associates. Interacts with HES5 and HEY2.1 Publication

GO - Molecular functionⁱ

protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 14764602
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	231505, 3 interactors
STRINGⁱ	10090.ENSMUSP00000054823

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7TS99
SMRⁱ	Q7TS99
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	10 – 65	bHLHPROSITE-ProRule annotationAdd BLAST		56
Domainⁱ	86 – 121	OrangePROSITE-ProRule annotationAdd BLAST		36

Sequence similaritiesⁱ

Belongs to the HEY family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104130
HOGENOMⁱ	HOG000082510
HOVERGENⁱ	HBG054492
InParanoidⁱ	Q7TS99
OMAⁱ	HAHPNAL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G115T
PhylomeDBⁱ	Q7TS99
TreeFamⁱ	TF323617

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07527 Hairy_orange, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q7TS99-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSDRLKERKR TPVSHKVIEK RRRDRINRCL NELGKTVPMA LAKQSSGKLE 
        60         70         80         90        100
KAEILEMTVQ YLRALHSADF PRGREKELLA EFANYFHYGY HECMKNLVHY 
       110        120        130        140        150
LTTVERMETK DTKYARILAF LQSKARLGAE PTFPPLSLPE PDFSYQLHAA 
       160        170        180        190        200
SPEFPGHSPG EATMFPQGAT PGSFPWPPGA ARSPALPYLS SATVPLPSPA 
       210        220        230        240
QQHSPFLAPM QGLDRHYLNL IGHGHPNGLN LHTPQHPPVL

Length:240

Mass (Da):26,973

Last modified:October 1, 2003 - v1

Checksum:ⁱ50B3821703D5294F

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q8BRJ9	Q8BRJ9_MOUSE		Hairy and enhancer of split-related... Hairy and enhancer of split-related protein HELT (Hey-like transcription factor (Zebrafish), isoform CRA_c)	Helt mCG_54200	202	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB120968 mRNA Translation: BAD11127.1 AB098077 mRNA Translation: BAC77659.1 DQ294234 mRNA Translation: ABB96784.1 BC103599 mRNA Translation: AAI03600.1 BC103600 mRNA Translation: AAI03601.1 BC103601 mRNA Translation: AAI03602.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22290.1
NCBI Reference Sequences More...RefSeqⁱ	NP_776150.2, NM_173789.4
UniGeneⁱ	Mm.145631

Genome annotation databases

Ensemblⁱ	ENSMUST00000058636; ENSMUSP00000054823; ENSMUSG00000047171
GeneIDⁱ	234219
KEGGⁱ	mmu:234219
UCSC genome browser More...UCSCⁱ	uc009lqb.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7TS99	Hairy and enhancer of split-related protein HELT		MOUSE		202	UniRef100_Q7TS99

Protein	Similar proteins		Species	Score	Length	Source
Q7TS99	Hairy and enhancer of split-related protein HELT		MOUSE		202	UniRef90_Q7TS99
Uncharacterized protein		PROCO		242
Uncharacterized protein		CALJA		242
Uncharacterized protein		Cebus capucinus imitator		242
HELT isoform 2		PONAB		242
+66

Protein	Similar proteins		Species	Score	Length	Source
Q7TS99	Hairy and enhancer of split-related protein HELT		MOUSE		202	UniRef50_Q7TS99
HELT isoform 2		PONAB		242
Uncharacterized protein		PROCO		242
hairy and enhancer of split-related protein HELT isoform X1		DIPOR		242
Uncharacterized protein		AOTNA		242
+127

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB120968 mRNA Translation: BAD11127.1 AB098077 mRNA Translation: BAC77659.1 DQ294234 mRNA Translation: ABB96784.1 BC103599 mRNA Translation: AAI03600.1 BC103600 mRNA Translation: AAI03601.1 BC103601 mRNA Translation: AAI03602.1
CCDSⁱ	CCDS22290.1
RefSeqⁱ	NP_776150.2, NM_173789.4
UniGeneⁱ	Mm.145631

3D structure databases

ProteinModelPortalⁱ	Q7TS99
SMRⁱ	Q7TS99
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	231505, 3 interactors
STRINGⁱ	10090.ENSMUSP00000054823

PTM databases

iPTMnetⁱ	Q7TS99
PhosphoSitePlusⁱ	Q7TS99

Proteomic databases

PaxDbⁱ	Q7TS99
PRIDEⁱ	Q7TS99

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000058636; ENSMUSP00000054823; ENSMUSG00000047171
GeneIDⁱ	234219
KEGGⁱ	mmu:234219
UCSCⁱ	uc009lqb.1 mouse

Organism-specific databases

CTDⁱ	391723
MGIⁱ	MGI:3040955 Helt

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
GeneTreeⁱ	ENSGT00700000104130
HOGENOMⁱ	HOG000082510
HOVERGENⁱ	HBG054492
InParanoidⁱ	Q7TS99
OMAⁱ	HAHPNAL
OrthoDBⁱ	EOG091G115T
PhylomeDBⁱ	Q7TS99
TreeFamⁱ	TF323617

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q7TS99
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000047171 Expressed in 26 organ(s), highest expression level in late tubule (mouse)
ExpressionAtlasⁱ	Q7TS99 baseline and differential

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
Pfamⁱ	View protein in Pfam PF07527 Hairy_orange, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HELT_MOUSE
Accessionⁱ	Q7TS99Primary (citable) accession number: Q7TS99
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
	Last sequence update:	October 1, 2003
	Last modified:	November 7, 2018
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7TS99 (HELT_MOUSE)

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Hairy and enhancer of split-related protein HELT

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ