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UniProtKB - Q7TS99 (HELT_MOUSE)
Protein
Hairy and enhancer of split-related protein HELT
Gene
Helt
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Required for the development of GABAergic neurons.
4 PublicationsGO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: MGI
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- anterior/posterior pattern specification Source: GO_Central
- central nervous system development Source: MGI
- GABAergic neuron differentiation in basal ganglia Source: MGI
- gene expression Source: MGI
- multicellular organism aging Source: MGI
- multicellular organism growth Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- neuron differentiation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- post-embryonic development Source: MGI
- regulation of neurogenesis Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- suckling behavior Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding, Repressor |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Hairy and enhancer of split-related protein HELTAlternative name(s): HES/HEY-like transcription factor Protein Hes-like Protein megane |
Gene namesi | Name:Helt Synonyms:Hesl, Mgn |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3040955, Helt |
VEuPathDBi | HostDB:ENSMUSG00000047171 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation2 Publications
Nucleus
- nucleus Source: MGI
Other locations
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Death between 2 and 5 weeks of age. The mesencephalic GABAergic progenitors in these animals fail to develop into neurons.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000349379 | 1 – 240 | Hairy and enhancer of split-related protein HELTAdd BLAST | 240 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 48 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | Q7TS99 |
PRIDEi | Q7TS99 |
PTM databases
iPTMneti | Q7TS99 |
PhosphoSitePlusi | Q7TS99 |
Expressioni
Tissue specificityi
Expressed in heart and testis.
Developmental stagei
Expressed in the progenitor domains for mesencephalic GABAergic neurons.4 Publications
Gene expression databases
Bgeei | ENSMUSG00000047171, Expressed in midbrain and 43 other tissues |
ExpressionAtlasi | Q7TS99, baseline and differential |
Interactioni
Subunit structurei
Self-associates.
Interacts with HES5 and HEY2.
1 PublicationGO - Molecular functioni
- identical protein binding Source: MGI
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 231505, 3 interactors |
STRINGi | 10090.ENSMUSP00000054823 |
Miscellaneous databases
RNActi | Q7TS99, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 65 | bHLHPROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 86 – 121 | OrangePROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the HEY family.Curated
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00940000160388 |
HOGENOMi | CLU_084227_0_0_1 |
InParanoidi | Q7TS99 |
OMAi | FAWPHGA |
OrthoDBi | 1054305at2759 |
PhylomeDBi | Q7TS99 |
TreeFami | TF323617 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7TS99-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDRLKERKR TPVSHKVIEK RRRDRINRCL NELGKTVPMA LAKQSSGKLE
60 70 80 90 100
KAEILEMTVQ YLRALHSADF PRGREKELLA EFANYFHYGY HECMKNLVHY
110 120 130 140 150
LTTVERMETK DTKYARILAF LQSKARLGAE PTFPPLSLPE PDFSYQLHAA
160 170 180 190 200
SPEFPGHSPG EATMFPQGAT PGSFPWPPGA ARSPALPYLS SATVPLPSPA
210 220 230 240
QQHSPFLAPM QGLDRHYLNL IGHGHPNGLN LHTPQHPPVL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ8BRJ9 | Q8BRJ9_MOUSE | Hairy and enhancer of split-related... | Helt | 202 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB120968 mRNA Translation: BAD11127.1 AB098077 mRNA Translation: BAC77659.1 DQ294234 mRNA Translation: ABB96784.1 BC103599 mRNA Translation: AAI03600.1 BC103600 mRNA Translation: AAI03601.1 BC103601 mRNA Translation: AAI03602.1 |
CCDSi | CCDS22290.1 |
RefSeqi | NP_776150.2, NM_173789.4 |
Genome annotation databases
Ensembli | ENSMUST00000058636; ENSMUSP00000054823; ENSMUSG00000047171 |
GeneIDi | 234219 |
KEGGi | mmu:234219 |
UCSCi | uc009lqb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB120968 mRNA Translation: BAD11127.1 AB098077 mRNA Translation: BAC77659.1 DQ294234 mRNA Translation: ABB96784.1 BC103599 mRNA Translation: AAI03600.1 BC103600 mRNA Translation: AAI03601.1 BC103601 mRNA Translation: AAI03602.1 |
CCDSi | CCDS22290.1 |
RefSeqi | NP_776150.2, NM_173789.4 |
3D structure databases
AlphaFoldDBi | Q7TS99 |
SMRi | Q7TS99 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 231505, 3 interactors |
STRINGi | 10090.ENSMUSP00000054823 |
PTM databases
iPTMneti | Q7TS99 |
PhosphoSitePlusi | Q7TS99 |
Proteomic databases
PaxDbi | Q7TS99 |
PRIDEi | Q7TS99 |
Protocols and materials databases
Antibodypediai | 28910, 96 antibodies from 19 providers |
DNASUi | 234219 |
Genome annotation databases
Ensembli | ENSMUST00000058636; ENSMUSP00000054823; ENSMUSG00000047171 |
GeneIDi | 234219 |
KEGGi | mmu:234219 |
UCSCi | uc009lqb.1, mouse |
Organism-specific databases
CTDi | 391723 |
MGIi | MGI:3040955, Helt |
VEuPathDBi | HostDB:ENSMUSG00000047171 |
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00940000160388 |
HOGENOMi | CLU_084227_0_0_1 |
InParanoidi | Q7TS99 |
OMAi | FAWPHGA |
OrthoDBi | 1054305at2759 |
PhylomeDBi | Q7TS99 |
TreeFami | TF323617 |
Miscellaneous databases
BioGRID-ORCSi | 234219, 3 hits in 71 CRISPR screens |
PROi | PR:Q7TS99 |
RNActi | Q7TS99, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000047171, Expressed in midbrain and 43 other tissues |
ExpressionAtlasi | Q7TS99, baseline and differential |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HELT_MOUSE | |
Accessioni | Q7TS99Primary (citable) accession number: Q7TS99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | October 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families