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Protein

Inositol-trisphosphate 3-kinase C

Gene

Itpkc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.By similarity

Catalytic activityi

ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

Enzyme regulationi

Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei426ATPBy similarity1
Binding sitei479ATPBy similarity1
Binding sitei481SubstrateBy similarity1
Binding sitei553ATPBy similarity1
Binding sitei633ATPBy similarity1
Binding sitei636SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi466 – 468ATPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-trisphosphate 3-kinase C (EC:2.7.1.127)
Alternative name(s):
Inositol 1,4,5-trisphosphate 3-kinase C
Short name:
IP3 3-kinase C
Short name:
IP3K C
Short name:
InsP 3-kinase C
Gene namesi
Name:Itpkc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2442554 Itpkc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340711 – 678Inositol-trisphosphate 3-kinase CAdd BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei160PhosphoserineCombined sources1
Modified residuei330PhosphothreonineBy similarity1
Modified residuei398PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7TS72
PaxDbiQ7TS72
PeptideAtlasiQ7TS72
PRIDEiQ7TS72

PTM databases

iPTMnetiQ7TS72
PhosphoSitePlusiQ7TS72

Expressioni

Gene expression databases

BgeeiENSMUSG00000003752
CleanExiMM_ITPKC
GenevisibleiQ7TS72 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Il16O548243EBI-648015,EBI-641708

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ7TS72, 1 interactor
STRINGi10090.ENSMUSP00000003850

Structurei

3D structure databases

ProteinModelPortaliQ7TS72
SMRiQ7TS72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni502 – 508Substrate bindingBy similarity7
Regioni504 – 512Calmodulin-bindingBy similarity9
Regioni529 – 536Substrate bindingBy similarity8

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi318 – 326Nuclear export signalBy similarity9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1621 Eukaryota
ENOG410Y8AC LUCA
GeneTreeiENSGT00390000017438
HOGENOMiHOG000113089
HOVERGENiHBG081804
InParanoidiQ7TS72
KOiK00911
OMAiMRRCPCR
OrthoDBiEOG091G03J3
PhylomeDBiQ7TS72
TreeFamiTF318394

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TS72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRCPCRGSL SEAEAGALPA EARMGLEALR GGRRRQPGLQ RPGPGAGGPT
60 70 80 90 100
GRPEGGGPRA WIEESSLHSE AERTDLEPAP CPNGPQAESC GDGHAECEAA
110 120 130 140 150
GLVVASEKPR QNKELDGSNL QTHPRRNSPL VEMEMAGSWT DGFRTDLHRS
160 170 180 190 200
DLQSRPKRAS LCTQPGFDES WTELDRSDMW QTLPERDNKP RVDNLRTHHG
210 220 230 240 250
VSKLQTHPVC LSPESSADNS GKELSADASR TPHDTDGFWI ESQTDDSLKG
260 270 280 290 300
PSTQTACRQP GSDGFSSKDT ESALTQPGTD GLRDDSVLGE SNGNDPLDLS
310 320 330 340 350
EPGELVTNLC SHLECSSLCP VPRLIITPET PEPEAQPVGP QSRIEGGTGG
360 370 380 390 400
FSSASSFDES EDDLVAGGGG TSDPEDRAGS KPWKKLKTVL KYSPFVVSFH
410 420 430 440 450
KHYYPWVQLS GHAGNFQAGE DGRILKRFCQ CEQRSLELLM GDPLRPFVPA
460 470 480 490 500
YYGMVQRDGQ AFNQMEDLLA DFEGPSIMDC KMGSRTYLEE ELVKARERPK
510 520 530 540 550
PRKDMYEKMV AVDPGAPTPE EHAQGAITKP RYMQWRETLS STSTLGFRIE
560 570 580 590 600
GIKKADGTCN TNFKKTQALE QVTKVLEDFV NGDLGILRKY VARLEDLRET
610 620 630 640 650
LENSPFFKTH EVVGSSLLFV HDHTGLAKVW MIDFGKTVAL PDHQMLSHRL
660 670
PWTEGNREDG YLWGLDNLIC LLQGLAQS
Length:678
Mass (Da):74,493
Last modified:October 1, 2003 - v1
Checksum:i0D3705B3D682B6ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti458D → N in BAE32904 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154888 mRNA Translation: BAE32904.1
BC053450 mRNA Translation: AAH53450.1
CCDSiCCDS21015.1
RefSeqiNP_853624.1, NM_181593.2
UniGeneiMm.30963
Mm.474636

Genome annotation databases

EnsembliENSMUST00000003850; ENSMUSP00000003850; ENSMUSG00000003752
GeneIDi233011
KEGGimmu:233011
UCSCiuc009fvk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIP3KC_MOUSE
AccessioniPrimary (citable) accession number: Q7TS72
Secondary accession number(s): Q3U384
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2003
Last modified: June 20, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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