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Protein

G protein-coupled receptor kinase

Gene

Grk2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei275Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorImported, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinaseUniRule annotation (EC:2.7.11.-UniRule annotation)
Gene namesi
Name:Grk2Imported
Synonyms:Adrbk1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:87940 Grk2

Expressioni

Gene expression databases

BgeeiENSMUSG00000024858 Expressed in 317 organ(s), highest expression level in cerebellum

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 133RGSInterPro annotationAdd BLAST122
Domaini149 – 411Protein kinaseInterPro annotationAdd BLAST263
Domaini412 – 479AGC-kinase C-terminalInterPro annotationAdd BLAST68
Domaini516 – 610PHInterPro annotationAdd BLAST95

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili598 – 625Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0986 Eukaryota
ENOG410YRQZ LUCA
GeneTreeiENSGT00860000133699
HOGENOMiHOG000006742
HOVERGENiHBG050559
TreeFamiTF313940

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000239 GPCR_kinase
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016137 RGS
IPR036305 RGS_sf
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR00717 GPCRKINASE
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00315 RGS, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50132 RGS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.iShow all

Q7TS64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKYLEDRGE VTFEKIFSQK LGYLLFRDFC LNHLEEAKPL VEFYEEIKKY
60 70 80 90 100
EKLETEEERV VRSREIFDSY IMKELLACSH PFSKNATEHV QGHLVKKQVP
110 120 130 140 150
PDLFQPYIEE ICQNLRGDVF QKFIESDKFT RFCQWKNVEL NIHLTMNDFS
160 170 180 190 200
VHRIIGRGGF GEVYGCRKAD TGKMYAMKCL DKKRIKMKQG ETLALNERIM
210 220 230 240 250
LSLVSTGDCP FIVCMSYAFH TPDKLSFILD LMNGGDLHYH LSQHGVFSEA
260 270 280 290 300
DMRFYAAEII LGLEHMHNRF VVYRDLKPAN ILLDEHGHVR ISDLGLACDF
310 320 330 340 350
SKKRPHASVG THGYMAPEVL QKGVAYDSSA DWFSLGCMLF KLLRGHSPFR
360 370 380 390 400
QHKTKDKHEI DRMTLTMAVE LPDSFSPELR SLLEGLLQRD VNRRLGCLGR
410 420 430 440 450
GAQEVKESPF FRSLDWQMVF LQKYPPPLIP PRGEVNAADA FDIGSFDEED
460 470 480 490 500
TKGIKLLDSD QELYRNFPLT ISERWQQEVA ETVFDTINAE TDRLEARKKA
510 520 530 540 550
KNKQLGHEED YALGKDCIVH GYMSKMGNPF LTQWQRRYFY LFPNRLEWRG
560 570 580 590 600
EGEAPQSLLT MEEIQSVEET QIKERKCLLL KIRGGKQFVL QCDSDPELVQ
610 620 630 640
WKKELRDAYR EAQQLVQRVP KMKNKPRSPV VELSKVPLIQ RGSANGL
Length:647
Mass (Da):75,153
Last modified:October 1, 2003 - v1
Checksum:iEA7A7DB50C6F4DB7
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q99MK8ARBK1_MOUSE
Beta-adrenergic receptor kinase 1
Grk2 Adrbk1
689Annotation score:
E9PW16E9PW16_MOUSE
G protein-coupled receptor kinase
Grk2
408Annotation score:
F6QY34F6QY34_MOUSE
Beta-adrenergic receptor kinase 1
Grk2
208Annotation score:
F7AEX1F7AEX1_MOUSE
Beta-adrenergic receptor kinase 1
Grk2
87Annotation score:
E9Q419E9Q419_MOUSE
Beta-adrenergic receptor kinase 1
Grk2
225Annotation score:
F6Y9P3F6Y9P3_MOUSE
Beta-adrenergic receptor kinase 1
Grk2
134Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140073 Genomic DNA No translation available.
BC053922 mRNA Translation: AAH53922.1
RefSeqiNP_570933.1, NM_130863.2
UniGeneiMm.254144

Genome annotation databases

EnsembliENSMUST00000025791; ENSMUSP00000025791; ENSMUSG00000024858
GeneIDi110355

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140073 Genomic DNA No translation available.
BC053922 mRNA Translation: AAH53922.1
RefSeqiNP_570933.1, NM_130863.2
UniGeneiMm.254144

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025791; ENSMUSP00000025791; ENSMUSG00000024858
GeneIDi110355

Organism-specific databases

CTDi156
MGIiMGI:87940 Grk2

Phylogenomic databases

eggNOGiKOG0986 Eukaryota
ENOG410YRQZ LUCA
GeneTreeiENSGT00860000133699
HOGENOMiHOG000006742
HOVERGENiHBG050559
TreeFamiTF313940

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024858 Expressed in 317 organ(s), highest expression level in cerebellum

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000239 GPCR_kinase
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016137 RGS
IPR036305 RGS_sf
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR00717 GPCRKINASE
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00315 RGS, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ7TS64_MOUSE
AccessioniPrimary (citable) accession number: Q7TS64
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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