BCL-WEL

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• BH domain binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members."
    Hsu S.Y., Kaipia A., McGee E., Lomeli M., Hsueh A.J.W.
    Proc. Natl. Acad. Sci. U.S.A. 94:12401-12406(1997) [PubMed] [Europe PMC] [Abstract]
• disordered domain specific binding Source: RGD
• identical protein binding Source: RGD
• protein-containing complex binding Source: RGDInferred from physical interactionⁱ
  • "Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members."
    Hsu S.Y., Kaipia A., McGee E., Lomeli M., Hsueh A.J.W.
    Proc. Natl. Acad. Sci. U.S.A. 94:12401-12406(1997) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• apoptotic process Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "p,p'-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells."
    Song Y., Liang X., Hu Y., Wang Y., Yu H., Yang K.
    Toxicology 253:53-61(2008) [PubMed] [Europe PMC] [Abstract]
• brain development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Differential expression of bcl-w and bcl-x messenger RNA in the developing and adult rat nervous system."
    Hamner S., Skoglosa Y., Lindholm D.
    Neuroscience 91:673-684(1999) [PubMed] [Europe PMC] [Abstract]
• cellular response to amino acid stimulus Source: RGDInferred from expression patternⁱ
  • "Improvement of the viability of cultured rat neurons by the non-essential amino acids L-serine and glycine that upregulates expression of the anti-apoptotic gene product Bcl-w."
    Yang L., Zhang B., Toku K., Maeda N., Sakanaka M., Tanaka J.
    Neurosci Lett 295:97-100(2000) [PubMed] [Europe PMC] [Abstract]
• cellular response to amyloid-beta Source: RGDInferred from expression patternⁱ
  • "Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death."
    Yao M., Nguyen T.V., Pike C.J.
    J Neurosci 27:1422-1433(2007) [PubMed] [Europe PMC] [Abstract]
• cellular response to estradiol stimulus Source: RGDInferred from expression patternⁱ
  • "Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death."
    Yao M., Nguyen T.V., Pike C.J.
    J Neurosci 27:1422-1433(2007) [PubMed] [Europe PMC] [Abstract]
• cellular response to glycine Source: RGDInferred from expression patternⁱ
  • "Improvement of the viability of cultured rat neurons by the non-essential amino acids L-serine and glycine that upregulates expression of the anti-apoptotic gene product Bcl-w."
    Yang L., Zhang B., Toku K., Maeda N., Sakanaka M., Tanaka J.
    Neurosci Lett 295:97-100(2000) [PubMed] [Europe PMC] [Abstract]
• extrinsic apoptotic signaling pathway in absence of ligand Source: RGD
• intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: RGD
• negative regulation of intrinsic apoptotic signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of mitochondrial membrane permeability Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Overexpression of the cell death suppressor Bcl-w in ischemic brain: implications for a neuroprotective role via the mitochondrial pathway."
    Yan C., Chen J., Chen D., Minami M., Pei W., Yin X.M., Simon R.P.
    J Cereb Blood Flow Metab 20:620-630(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of release of cytochrome c from mitochondria Source: RGDInferred from direct assayⁱ
  • "Overexpression of the cell death suppressor Bcl-w in ischemic brain: implications for a neuroprotective role via the mitochondrial pathway."
    Yan C., Chen J., Chen D., Minami M., Pei W., Yin X.M., Simon R.P.
    J Cereb Blood Flow Metab 20:620-630(2000) [PubMed] [Europe PMC] [Abstract]
• response to ischemia Source: RGDInferred from expression patternⁱ
  • "Overexpression of the cell death suppressor Bcl-w in ischemic brain: implications for a neuroprotective role via the mitochondrial pathway."
    Yan C., Chen J., Chen D., Minami M., Pei W., Yin X.M., Simon R.P.
    J Cereb Blood Flow Metab 20:620-630(2000) [PubMed] [Europe PMC] [Abstract]
• Sertoli cell proliferation Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• BH domain binding Source: RGDInferred from physical interactionⁱ
  • "Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members."
    Hsu S.Y., Kaipia A., McGee E., Lomeli M., Hsueh A.J.W.
    Proc. Natl. Acad. Sci. U.S.A. 94:12401-12406(1997) [PubMed] [Europe PMC] [Abstract]
• disordered domain specific binding Source: RGD
• identical protein binding Source: RGD
• protein heterodimerization activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSLFGLCQYF SYIYVSLSSL PLSAARMATP ASTPDTRALV ADFVGYKLRQ 
        60         70         80         90        100
KGYVCGAGPG EGPAADPLHQ AMRAAGDEFE TRFRRTFSDL AAQLHVTPGS 
       110        120        130        140        150
AQQRFTQVSD ELFQGGPNWG RLVAFFVFGA ALCAESVNKE MEPLVGQVQD 
       160        170        180        190        200
WMVTYLETRL ADWIHSSGGW AEFTALYGDG ALEEARRLRE GNWASVRTVL 
       210 
TGAVALGALV TVGAFFASK                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ