UniProtKB - Q7TQQ0 (O1509_MOUSE)
Protein
Olfactory receptor 1509
Gene
Olfr1509
Organism
Mus musculus (Mouse)
Status
Functioni
Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanethiol (MTMT) and bis(methylthiomethyl) disulfide (PubMed:22328155, PubMed:25185561, PubMed:25901328, PubMed:29659735). Also binds odorants cis-cyclooctene and tert-butyl mercaptan (PubMed:27019154). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Potential).Curated5 Publications
Activity regulationi
Copper binding enhances receptor activity in response to odorant binding.3 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 105 | Copper2 Publications | 1 | |
Metal bindingi | 109 | Copper1 Publication | 1 | |
Metal bindingi | 260 | Copper1 Publication | 1 |
GO - Molecular functioni
- copper ion binding Source: UniProtKB
- G protein-coupled receptor activity Source: UniProtKB-KW
- odorant binding Source: UniProtKB
- olfactory receptor activity Source: UniProtKB
GO - Biological processi
- detection of chemical stimulus involved in sensory perception Source: UniProtKB
- detection of chemical stimulus involved in sensory perception of smell Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: MGI
- sensory perception of smell Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Ligand | Copper, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 1509CuratedAlternative name(s): Odorant receptor 244-35 Publications Odorant receptor 831 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3031343 Olfr1509 |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotation2 Publications3 Publications; Multi-pass membrane protein UniRule annotation1 Publication
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 24 | ExtracellularCuratedAdd BLAST | 24 | |
Transmembranei | 25 – 45 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 46 – 57 | CytoplasmicCuratedAdd BLAST | 12 | |
Transmembranei | 58 – 78 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 97 | ExtracellularCuratedAdd BLAST | 19 | |
Transmembranei | 98 – 118 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 143 | CytoplasmicCuratedAdd BLAST | 25 | |
Transmembranei | 144 – 164 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 165 – 204 | ExtracellularCuratedAdd BLAST | 40 | |
Transmembranei | 205 – 225 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 226 – 236 | CytoplasmicCuratedAdd BLAST | 11 | |
Transmembranei | 237 – 257 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 258 – 268 | ExtracellularCuratedAdd BLAST | 11 | |
Transmembranei | 269 – 289 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 308 | CytoplasmicCuratedAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 56 | H → K: Decreased receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 59 | M → A: Decreased receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 73 | H → A, K or R: No receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 73 | H → F or Y: No change in receptor activity in response to MTMT binding. No change in the copper-induced enhancement of receptor activity. 1 Publication | 1 | |
Mutagenesisi | 97 | C → A or V: No receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 97 | C → S: No receptor activity in response to MTMT binding, even in the presence of copper. Little to no expression detected on plasma membrane. 1 Publication | 1 | |
Mutagenesisi | 105 | H → A, L or R: No receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 105 | H → K: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper. 1 Publication | 1 | |
Mutagenesisi | 109 | C → M: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Shows low constitutive activity in the presence of copper. MTMT binding in the absence of copper results in an inverse agonist effect. 1 Publication | 1 | |
Mutagenesisi | 109 | C → V: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper. 2 Publications | 1 | |
Mutagenesisi | 118 | M → A: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper. 1 Publication | 1 | |
Mutagenesisi | 127 | C → V: Decreased receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 136 | M → A: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper. 1 Publication | 1 | |
Mutagenesisi | 141 | C → V: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper. 1 Publication | 1 | |
Mutagenesisi | 155 | H → A, K, N or V: No receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 155 | H → R: No receptor activity in response to MTMT binding, even in the presence of copper. Little to no expression detected on plasma membrane. 1 Publication | 1 | |
Mutagenesisi | 169 | C → A, F or V: No receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 169 | C → S: No receptor activity in response to MTMT binding, even in the presence of copper. Little to no expression detected on plasma membrane. 1 Publication | 1 | |
Mutagenesisi | 179 | C → A or V: No receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 179 | C → S: No receptor activity in response to MTMT binding, even in the presence of copper. Little to no expression detected on plasma membrane. 1 Publication | 1 | |
Mutagenesisi | 189 | C → A or V: No receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 189 | C → S: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper. 1 Publication | 1 | |
Mutagenesisi | 210 | C → A: No change in receptor activity in response to MTMT binding in the presence of copper. Decreased receptor activity in the absence of copper. 1 Publication | 1 | |
Mutagenesisi | 210 | C → S: No change in receptor activity in response to MTMT binding in the presence of copper. Complete loss of receptor activity in the absence of copper. 1 Publication | 1 | |
Mutagenesisi | 210 | C → V: No receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 243 | H → A or K: No receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 243 | H → R: No receptor activity in response to MTMT binding, even in the presence of copper. Little to no expression detected on plasma membrane. 1 Publication | 1 | |
Mutagenesisi | 254 | C → V or S: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper. 2 Publications | 1 | |
Mutagenesisi | 260 | R → H: Decreased receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 260 | R → W or A: No receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 269 | K → A: Decreased receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 269 | K → H: No receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 298 | M → A: Decreased receptor activity in response to MTMT binding, even in the presence of copper. Complete loss of receptor activity in the absence of copper. 1 Publication | 1 | |
Mutagenesisi | 300 | H → K: Decreased receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 | |
Mutagenesisi | 307 | C → V: Decreased receptor activity in response to MTMT binding, even in the presence of copper. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000444894 | 1 – 308 | Olfactory receptor 1509Add BLAST | 308 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 179 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q7TQQ0 |
PRIDEi | Q7TQQ0 |
PTM databases
iPTMneti | Q7TQQ0 |
PhosphoSitePlusi | Q7TQQ0 |
Expressioni
Tissue specificityi
Expressed in olfactory epithelium, specifically in the olfactory sensory neurons of the septal organ.3 Publications
Developmental stagei
Detected at very low levels at 18 dpc and increased to its maximum level of expression by 7 days after birth in olfactory sensory neurons of the septal organ.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000035626 Expressed in 18 organ(s), highest expression level in epithelium of nasal septum |
ExpressionAtlasi | Q7TQQ0 baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IVIK Eukaryota ENOG410YB9C LUCA |
GeneTreei | ENSGT00940000163275 |
HOGENOMi | HOG000041362 |
HOVERGENi | HBG017625 |
InParanoidi | Q7TQQ0 |
KOi | K04257 |
OMAi | IYTRPDT |
OrthoDBi | 1010638at2759 |
PhylomeDBi | Q7TQQ0 |
TreeFami | TF337251 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q7TQQ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGALNQTRVT EFIFLGLTDN WVLEILFFVP FTVTYMLTLL GNFLIVVTIV
60 70 80 90 100
FTPRLHNPMY FFLSNLSFID ICHSSVTVPK MLEGLLLERK TISFDNCIAQ
110 120 130 140 150
LFFLHLFACS EIFLLTIMAY DRYVAICIPL HYSNVMNMKV CVQLVFALWL
160 170 180 190 200
GGTIHSLVQT FLTIRLPYCG PNIIDSYFCD VPPVIKLACT DTYLTGILIV
210 220 230 240 250
SNSGTISLVC FLALVTSYTV ILFSLRKQSA EGRRKALSTC SAHFMVVALF
260 270 280 290 300
FGPCIFLYTR PDSSFSIDKV VSVFYTVVTP LLNPLIYTLR NEEVKTAMKH
LRQRRICS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RQ73 | A0A0U1RQ73_MOUSE | Olfactory receptor 1509 | Olfr1509 | 156 | Annotation score: | ||
A0A0U1RNG2 | A0A0U1RNG2_MOUSE | Olfactory receptor 1509 | Olfr1509 | 125 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 228 | Q → K in BAA86125 (PubMed:10493742).Curated | 1 | |
Sequence conflicti | 228 | Q → K in AAL60958 (PubMed:11875048).Curated | 1 | |
Sequence conflicti | 248 | A → T in BAA86125 (PubMed:10493742).Curated | 1 | |
Sequence conflicti | 248 | A → T in AAL60958 (PubMed:11875048).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB030894 Genomic DNA Translation: BAA86125.1 AY073295 Genomic DNA Translation: AAL60958.1 AY318728 Genomic DNA Translation: AAP71857.1 AC126025 Genomic DNA No translation available. CH466659 Genomic DNA Translation: EDL42235.1 BC119195 mRNA Translation: AAI19196.1 BC119199 mRNA Translation: AAI19200.1 |
CCDSi | CCDS27060.1 |
RefSeqi | NP_065260.2, NM_020514.2 |
UniGenei | Mm.88824 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB030894 Genomic DNA Translation: BAA86125.1 AY073295 Genomic DNA Translation: AAL60958.1 AY318728 Genomic DNA Translation: AAP71857.1 AC126025 Genomic DNA No translation available. CH466659 Genomic DNA Translation: EDL42235.1 BC119195 mRNA Translation: AAI19196.1 BC119199 mRNA Translation: AAI19200.1 |
CCDSi | CCDS27060.1 |
RefSeqi | NP_065260.2, NM_020514.2 |
UniGenei | Mm.88824 |
3D structure databases
ProteinModelPortali | Q7TQQ0 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000046688 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q7TQQ0 |
PhosphoSitePlusi | Q7TQQ0 |
Proteomic databases
PaxDbi | Q7TQQ0 |
PRIDEi | Q7TQQ0 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Organism-specific databases
CTDi | 57271 |
MGIi | MGI:3031343 Olfr1509 |
Phylogenomic databases
eggNOGi | ENOG410IVIK Eukaryota ENOG410YB9C LUCA |
GeneTreei | ENSGT00940000163275 |
HOGENOMi | HOG000041362 |
HOVERGENi | HBG017625 |
InParanoidi | Q7TQQ0 |
KOi | K04257 |
OMAi | IYTRPDT |
OrthoDBi | 1010638at2759 |
PhylomeDBi | Q7TQQ0 |
TreeFami | TF337251 |
Enzyme and pathway databases
Reactomei | R-MMU-381753 Olfactory Signaling Pathway |
Miscellaneous databases
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000035626 Expressed in 18 organ(s), highest expression level in epithelium of nasal septum |
ExpressionAtlasi | Q7TQQ0 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | O1509_MOUSE | |
Accessioni | Q7TQQ0Primary (citable) accession number: Q7TQQ0 Secondary accession number(s): A0A0U1RP41, Q9R0K3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 18, 2018 |
Last sequence update: | October 1, 2003 | |
Last modified: | January 16, 2019 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot