UniProtKB - Q7TQP3 (GP119_MOUSE)
Protein
Glucose-dependent insulinotropic receptor
Gene
Gpr119
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.1 Publication
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- phosphatidylcholine binding Source: MGI
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- insulin secretion Source: MGI
- regulation of metabolic process Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Ligand | Lipid-binding |
Enzyme and pathway databases
Reactomei | R-MMU-381771, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-MMU-400511, Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
Names & Taxonomyi
Protein namesi | Recommended name: Glucose-dependent insulinotropic receptorAlternative name(s): G-protein coupled receptor 119 |
Gene namesi | Name:Gpr119 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2668412, Gpr119 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 6 | ExtracellularSequence analysis | 6 | |
Transmembranei | 7 – 27 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 28 – 37 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 38 – 58 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 59 – 81 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 82 – 102 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 125 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 126 – 146 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 147 – 164 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 165 – 185 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 186 – 226 | CytoplasmicSequence analysisAdd BLAST | 41 | |
Transmembranei | 227 – 247 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 248 – 262 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 263 – 283 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 284 – 335 | CytoplasmicSequence analysisAdd BLAST | 52 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069608 | 1 – 335 | Glucose-dependent insulinotropic receptorAdd BLAST | 335 |
Proteomic databases
PaxDbi | Q7TQP3 |
PRIDEi | Q7TQP3 |
PTM databases
iPTMneti | Q7TQP3 |
PhosphoSitePlusi | Q7TQP3 |
Expressioni
Tissue specificityi
Expression restricted to the beta-cells of pancreatic islets.2 Publications
Inductioni
Up-regulated in islets of obese hyperglycemic db/db mice.
Gene expression databases
Bgeei | ENSMUSG00000051209, Expressed in ileum and 11 other tissues |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000060591 |
Chemistry databases
BindingDBi | Q7TQP3 |
Miscellaneous databases
RNActi | Q7TQP3, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 305 – 308 | Poly-Leu | 4 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222365 |
HOGENOMi | CLU_009579_11_5_1 |
InParanoidi | Q7TQP3 |
OMAi | IFQQTTY |
OrthoDBi | 1245021at2759 |
PhylomeDBi | Q7TQP3 |
TreeFami | TF325411 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR028336, GPR119 |
PANTHERi | PTHR22750:SF7, PTHR22750:SF7, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7TQP3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESSFSFGVI LAVLTILIIA VNALVVVAML LSIYKNDGVG LCFTLNLAVA
60 70 80 90 100
DTLIGVAISG LVTDQLSSSA QHTQKTLCSL RMAFVTSSAA ASVLTVMLIA
110 120 130 140 150
FDRYLAIKQP LRYFQIMNGL VAGACIAGLW LVSYLIGFLP LGVSIFQQTT
160 170 180 190 200
YHGPCSFFAV FHPRFVLTLS CAGFFPAVLL FVFFYCDMLK IASVHSQQIR
210 220 230 240 250
KMEHAGAMAG AYRPPRSVND FKAVRTIAVL IGSFTLSWSP FLITSIVQVA
260 270 280 290 300
CHKCCLYQVL EKYLWLLGVG NSLLNPLIYA YWQREVRQQL YHMALGVKKF
310 320 330
FTSILLLLPA RNRGPERTRE SAYHIVTISH PELDG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY288423 mRNA Translation: AAP72132.1 AB233291 mRNA Translation: BAE80212.1 AL672042 Genomic DNA No translation available. BC115557 mRNA Translation: AAI15558.1 BC115558 mRNA Translation: AAI15559.1 |
CCDSi | CCDS30113.1 |
RefSeqi | NP_861416.1, NM_181751.2 |
Genome annotation databases
Ensembli | ENSMUST00000053970; ENSMUSP00000060591; ENSMUSG00000051209 |
GeneIDi | 236781 |
KEGGi | mmu:236781 |
UCSCi | uc009tcs.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY288423 mRNA Translation: AAP72132.1 AB233291 mRNA Translation: BAE80212.1 AL672042 Genomic DNA No translation available. BC115557 mRNA Translation: AAI15558.1 BC115558 mRNA Translation: AAI15559.1 |
CCDSi | CCDS30113.1 |
RefSeqi | NP_861416.1, NM_181751.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000060591 |
Chemistry databases
BindingDBi | Q7TQP3 |
ChEMBLi | CHEMBL5263 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q7TQP3 |
PhosphoSitePlusi | Q7TQP3 |
Proteomic databases
PaxDbi | Q7TQP3 |
PRIDEi | Q7TQP3 |
Protocols and materials databases
Antibodypediai | 30179, 266 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000053970; ENSMUSP00000060591; ENSMUSG00000051209 |
GeneIDi | 236781 |
KEGGi | mmu:236781 |
UCSCi | uc009tcs.1, mouse |
Organism-specific databases
CTDi | 139760 |
MGIi | MGI:2668412, Gpr119 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222365 |
HOGENOMi | CLU_009579_11_5_1 |
InParanoidi | Q7TQP3 |
OMAi | IFQQTTY |
OrthoDBi | 1245021at2759 |
PhylomeDBi | Q7TQP3 |
TreeFami | TF325411 |
Enzyme and pathway databases
Reactomei | R-MMU-381771, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-MMU-400511, Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
Miscellaneous databases
BioGRID-ORCSi | 236781, 0 hits in 17 CRISPR screens |
PROi | PR:Q7TQP3 |
RNActi | Q7TQP3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000051209, Expressed in ileum and 11 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR028336, GPR119 |
PANTHERi | PTHR22750:SF7, PTHR22750:SF7, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP119_MOUSE | |
Accessioni | Q7TQP3Primary (citable) accession number: Q7TQP3 Secondary accession number(s): Q2ABS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 12, 2005 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries