UniProtKB - Q7TQP2 (GP135_MOUSE)
Protein
G-protein coupled receptor 135
Gene
Gpr135
Organism
Mus musculus (Mouse)
Status
Functioni
Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity).By similarity
GO - Molecular functioni
- arrestin family protein binding Source: MGI
- G protein-coupled receptor activity Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor 135 |
Gene namesi | Name:Gpr135 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2676315, Gpr135 |
Subcellular locationi
Endosome
- Endosome membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Note: Colocalizes with ARRB2/beta-arrestin-2 in the endosome (By similarity).By similarity
Endosome
- endosome Source: MGI
- endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 64 | ExtracellularSequence analysisAdd BLAST | 64 | |
Transmembranei | 65 – 85 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 86 – 109 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 110 – 130 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 131 – 156 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 157 – 177 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 189 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 190 – 210 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 211 – 235 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 236 – 256 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 257 – 295 | CytoplasmicSequence analysisAdd BLAST | 39 | |
Transmembranei | 296 – 316 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 317 – 329 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 330 – 350 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 351 – 457 | CytoplasmicSequence analysisAdd BLAST | 107 |
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069613 | 1 – 457 | G-protein coupled receptor 135Add BLAST | 457 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 47 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q7TQP2 |
PRIDEi | Q7TQP2 |
PTM databases
GlyGeni | Q7TQP2, 1 site |
PhosphoSitePlusi | Q7TQP2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000043398, Expressed in Ammon's horn and 44 other tissues |
ExpressionAtlasi | Q7TQP2, baseline and differential |
Interactioni
Subunit structurei
Interacts with MTNR1B.
Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR135 in the endosomal compartment (By similarity).
By similarityGO - Molecular functioni
- arrestin family protein binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000058762 |
Miscellaneous databases
RNActi | Q7TQP2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00950000182998 |
HOGENOMi | CLU_048891_0_0_1 |
InParanoidi | Q7TQP2 |
OMAi | FYSEMRT |
OrthoDBi | 770796at2759 |
PhylomeDBi | Q7TQP2 |
TreeFami | TF333332 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7TQP2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEQARPPGR PAASATLQGS AHPGGAASTA TAAALSFSSV ATVTLGNQSD
60 70 80 90 100
AGRPEAAGSR GPAPLLWHGA AVAAQALVLL LIFLLSSLGN CAVMGVIVKH
110 120 130 140 150
RQLRTVTNAF ILSLSLSDLL TALLCLPAAF LDLFAPPGDS GPWRSFCAAS
160 170 180 190 200
RFFSSCFGIV STFSVALISL DRYCAIVRPP RDKLGRRRAL QLLAGAWLAA
210 220 230 240 250
LGFSLPWDLL RAPREPPAPQ SFHRCLYRTS PDPAQLGVAY SVGLVVACYL
260 270 280 290 300
LPFLLMCFCR YHICKTVRLS DVRVRPMTTY ARVLRFFSEV RTATTVLIMI
310 320 330 340 350
IFVMCCWGPY CFLVLLAATR QGQATQAPSL LNVAAVWLTW ANGAINPVIY
360 370 380 390 400
AIRNPNISML LGRNREEGYR TRNMDAFLPS QGLGFQARSR NRLRNGCANR
410 420 430 440 450
LGACSRMPSS NPASGSGGEV VMWARKNPVV LFFREGPPDS VMEVGKLHNS
ETRDSSI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY288425 mRNA Translation: AAP72134.1 |
CCDSi | CCDS25965.1 |
RefSeqi | NP_861417.1, NM_181752.1 |
Genome annotation databases
Ensembli | ENSMUST00000050649; ENSMUSP00000058762; ENSMUSG00000043398 |
GeneIDi | 238252 |
KEGGi | mmu:238252 |
UCSCi | uc007nvc.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY288425 mRNA Translation: AAP72134.1 |
CCDSi | CCDS25965.1 |
RefSeqi | NP_861417.1, NM_181752.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000058762 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q7TQP2, 1 site |
PhosphoSitePlusi | Q7TQP2 |
Proteomic databases
PaxDbi | Q7TQP2 |
PRIDEi | Q7TQP2 |
Protocols and materials databases
Antibodypediai | 24279, 91 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000050649; ENSMUSP00000058762; ENSMUSG00000043398 |
GeneIDi | 238252 |
KEGGi | mmu:238252 |
UCSCi | uc007nvc.1, mouse |
Organism-specific databases
CTDi | 64582 |
MGIi | MGI:2676315, Gpr135 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00950000182998 |
HOGENOMi | CLU_048891_0_0_1 |
InParanoidi | Q7TQP2 |
OMAi | FYSEMRT |
OrthoDBi | 770796at2759 |
PhylomeDBi | Q7TQP2 |
TreeFami | TF333332 |
Miscellaneous databases
BioGRID-ORCSi | 238252, 0 hits in 17 CRISPR screens |
PROi | PR:Q7TQP2 |
RNActi | Q7TQP2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000043398, Expressed in Ammon's horn and 44 other tissues |
ExpressionAtlasi | Q7TQP2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP135_MOUSE | |
Accessioni | Q7TQP2Primary (citable) accession number: Q7TQP2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | October 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries