Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G-protein coupled receptor 135

Gene

Gpr135

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor. Has spontaneous activity for beta-arrestin recruitment. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 135
Gene namesi
Name:Gpr135
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi727844 Gpr135

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 64ExtracellularSequence analysisAdd BLAST64
Transmembranei65 – 85Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini86 – 109CytoplasmicSequence analysisAdd BLAST24
Transmembranei110 – 130Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini131 – 156ExtracellularSequence analysisAdd BLAST26
Transmembranei157 – 177Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini178 – 189CytoplasmicSequence analysisAdd BLAST12
Transmembranei190 – 210Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini211 – 235ExtracellularSequence analysisAdd BLAST25
Transmembranei236 – 256Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini257 – 295CytoplasmicSequence analysisAdd BLAST39
Transmembranei296 – 316Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini317 – 329ExtracellularSequence analysisAdd BLAST13
Transmembranei330 – 350Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini351 – 457CytoplasmicSequence analysisAdd BLAST107

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696141 – 457G-protein coupled receptor 135Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7TQN7
PRIDEiQ7TQN7

PTM databases

PhosphoSitePlusiQ7TQN7

Expressioni

Gene expression databases

BgeeiENSRNOG00000004499
GenevisibleiQ7TQN7 RN

Interactioni

Subunit structurei

Interacts with MTNR1B (By similarity). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR135 in the endosomal compartment (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005933

Structurei

3D structure databases

ProteinModelPortaliQ7TQN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00440000033318
HOGENOMiHOG000001555
HOVERGENiHBG051780
InParanoidiQ7TQN7
KOiK08427
OMAiLGNCAVM
OrthoDBiEOG091G0FMJ
PhylomeDBiQ7TQN7
TreeFamiTF333332

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TQN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEQARPPSR PAASATLPGS AHPGGAASTA TAAALSFSSV ATVTLGNQSD
60 70 80 90 100
AGRPEAAGSR GPAPLLWHGA AVAAQALVLL LIFLLSSLGN CAVMGVIVKH
110 120 130 140 150
RQLRTVTNAF ILSLSLSDLL TALLCLPAAF LDLFAPPGDS GPWRSFCAAS
160 170 180 190 200
RFFSSCFGIV STFSVALISL DRYCAIVRPP RDKLGRRRAL QLLAGAWLAA
210 220 230 240 250
LGFSLPWELL RAPREPPTPQ SFHRCLYRTS PDPAQLGAAY SVGLVVACYL
260 270 280 290 300
LPFLLMCFCR YHICKTVRLS DVRVRPMTTY ARVLRFFSEV RTATTVLIMI
310 320 330 340 350
VFVICCWGPY CFLVLLAATR QGQTTQAPSL LNVAAVWLTW ANGAINPVIY
360 370 380 390 400
AIRNPNISMF LGRNREEGYR TRNMDVFLPS QGLGFQARSR NRLRNGCANR
410 420 430 440 450
LGACSRMPSS NPASGSGGEV VMWARKNPVV LFFREDPPDP VMAVYKQHKS

ETRDSSI
Length:457
Mass (Da):49,581
Last modified:October 1, 2003 - v1
Checksum:i879BE6477F8EC0BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288430 mRNA Translation: AAP72139.1
RefSeqiNP_861436.1, NM_181771.1
UniGeneiRn.56673

Genome annotation databases

EnsembliENSRNOT00000005933; ENSRNOP00000005933; ENSRNOG00000004499
GeneIDi314213
KEGGirno:314213
UCSCiRGD:727844 rat

Similar proteinsi

Entry informationi

Entry nameiGP135_RAT
AccessioniPrimary (citable) accession number: Q7TQN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: June 20, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health