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Protein
Submitted name:

RELA

Gene

Rela

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1169091 Activation of NF-kappaB in B cells
R-RNO-1810476 RIP-mediated NFkB activation via ZBP1
R-RNO-193692 Regulated proteolysis of p75NTR
R-RNO-202424 Downstream TCR signaling
R-RNO-209560 NF-kB is activated and signals survival
R-RNO-2871837 FCERI mediated NF-kB activation
R-RNO-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-RNO-3214841 PKMTs methylate histone lysines
R-RNO-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-RNO-448706 Interleukin-1 processing
R-RNO-5607764 CLEC7A (Dectin-1) signaling
R-RNO-5621575 CD209 (DC-SIGN) signaling
R-RNO-9020702 Interleukin-1 signaling
R-RNO-933542 TRAF6 mediated NF-kB activation

Names & Taxonomyi

Protein namesi
Submitted name:
RELAImported
Submitted name:
RELA proto-oncogene, NF-kB subunitImported
Submitted name:
V-rel reticuloendotheliosis viral oncogene homolog A (Avian)Imported
Gene namesi
Name:RelaImported
Synonyms:RelAImported
ORF Names:rCG_48632Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi727889 Rela

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000030888

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Nos2Q065183EBI-1187180,EBI-15919967

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-38953N
IntActiQ7TQN4, 6 interactors
STRINGi10116.ENSRNOP00000044552

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 190RHDInterPro annotationAdd BLAST175

Phylogenomic databases

eggNOGiENOG410IG8F Eukaryota
ENOG410XT64 LUCA
GeneTreeiENSGT00500000044765
HOGENOMiHOG000230474
HOVERGENiHBG017916
KOiK04735
OMAiEFSPMVF
OrthoDBiEOG091G08JD
TreeFamiTF325632

Family and domain databases

CDDicd01177 IPT_NFkappaB, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR030495 RelA
IPR030492 RHD_CS
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR24169 PTHR24169, 1 hit
PTHR24169:SF1 PTHR24169:SF1, 1 hit
PfamiView protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR00057 NFKBTNSCPFCT
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01204 REL_1, 1 hit
PS50254 REL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TQN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLFPLIFP SEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER
60 70 80 90 100
STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY
110 120 130 140 150
EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG
160 170 180 190 200
DYDLNAVRLC FQVTVRDPSG RPLRLTPVLS HPIFDNRAPN TAELKICRVN
210 220 230 240 250
RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS QADVHRQVAI
260 270 280 290 300
VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE
310 320 330 340 350
KRKRTYETFK SIMKKSPFNG PTEPRPPPRR IAVPSRGPTS VPKPAPQPYA
360 370 380 390 400
FSTSLSTINF DEFSPMVLPP GQISNQALAL APSSAPVLAQ TMVPSSAMVP
410 420 430 440 450
SLAQPPAPVP VLAPGPPQSL SAPVPKSTQA GEGTLSEALL HLQFDADEDL
460 470 480 490 500
GALLGNNTDP GVFTDLASVD NSEFQQLLNQ GVAMSHSTAE PMLMEYPEAI
510 520 530 540 550
TRLVTGSQRP PDPAPATLGT SGLPNGLSGD EDFSSIADMD FSALLSQISS
Length:550
Mass (Da):60,267
Last modified:October 1, 2003 - v1
Checksum:i2C6A8FD68F667A64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134224 Genomic DNA No translation available.
BC079457 mRNA Translation: AAH79457.1
AY307375 mRNA Translation: AAP72180.1
CH473953 Genomic DNA Translation: EDM12513.1
RefSeqiNP_954888.1, NM_199267.2
UniGeneiRn.19480

Genome annotation databases

EnsembliENSRNOT00000045233; ENSRNOP00000044552; ENSRNOG00000030888
GeneIDi309165
KEGGirno:309165
UCSCiRGD:727889 rat

Similar proteinsi

Entry informationi

Entry nameiQ7TQN4_RAT
AccessioniPrimary (citable) accession number: Q7TQN4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: July 18, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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