UniProtKB - Q7TQN4 (Q7TQN4_RAT)
Protein
Submitted name:
Nuclear factor kappaB subunit p65
Gene
Rela
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- actinin binding Source: RGD
- activating transcription factor binding Source: RGD
- ankyrin repeat binding Source: RGD
- chromatin binding Source: RGD
- chromatin DNA binding Source: RGD
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- enzyme binding Source: RGD
- histone deacetylase binding Source: RGD
- identical protein binding Source: RGD
- NF-kappaB binding Source: RGD
- peptide binding Source: RGD
- phosphate ion binding Source: RGD
- protein-containing complex binding Source: RGD
- protein homodimerization activity Source: RGD
- protein kinase binding Source: RGD
- protein N-terminus binding Source: RGD
- repressing transcription factor binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: ParkinsonsUK-UCL
- RNA polymerase II core promoter sequence-specific DNA binding Source: RGD
- RNA polymerase II transcription coactivator binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- transcription factor binding Source: RGD
- transcription regulatory region sequence-specific DNA binding Source: RGD
- ubiquitin protein ligase binding Source: RGD
GO - Biological processi
- acetaldehyde metabolic process Source: RGD
- aging Source: RGD
- animal organ morphogenesis Source: RGD
- cellular response to angiotensin Source: RGD
- cellular response to hepatocyte growth factor stimulus Source: RGD
- cellular response to hydrogen peroxide Source: RGD
- cellular response to interleukin-1 Source: RGD
- cellular response to interleukin-6 Source: RGD
- cellular response to lipopolysaccharide Source: RGD
- cellular response to lipoteichoic acid Source: RGD
- cellular response to nicotine Source: RGD
- cellular response to peptidoglycan Source: RGD
- cellular response to tumor necrosis factor Source: RGD
- cellular response to vascular endothelial growth factor stimulus Source: RGD
- chromatin organization Source: RGD
- cytokine-mediated signaling pathway Source: RGD
- defense response Source: RGD
- hair follicle development Source: RGD
- I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- inflammatory response Source: RGD
- innate immune response Source: GO_Central
- interleukin-1-mediated signaling pathway Source: RGD
- liver development Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of extrinsic apoptotic signaling pathway Source: RGD
- negative regulation of insulin receptor signaling pathway Source: RGD
- negative regulation of NIK/NF-kappaB signaling Source: RGD
- negative regulation of pri-miRNA transcription by RNA polymerase II Source: RGD
- negative regulation of protein catabolic process Source: RGD
- negative regulation of protein sumoylation Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- NIK/NF-kappaB signaling Source: GO_Central
- nucleotide-binding oligomerization domain containing 2 signaling pathway Source: RGD
- positive regulation of amyloid-beta formation Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of chondrocyte differentiation Source: RGD
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
- positive regulation of interleukin-12 production Source: RGD
- positive regulation of interleukin-8 production Source: RGD
- positive regulation of leukocyte adhesion to vascular endothelial cell Source: RGD
- positive regulation of miRNA metabolic process Source: RGD
- positive regulation of NF-kappaB transcription factor activity Source: RGD
- positive regulation of NIK/NF-kappaB signaling Source: RGD
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of Schwann cell differentiation Source: RGD
- positive regulation of T cell receptor signaling pathway Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: RGD
- postsynapse to nucleus signaling pathway Source: RGD
- regulation of DNA-templated transcription in response to stress Source: RGD
- regulation of inflammatory response Source: RGD
- regulation of NIK/NF-kappaB signaling Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- response to amino acid Source: RGD
- response to bacterium Source: RGD
- response to cAMP Source: RGD
- response to cobalamin Source: RGD
- response to cytokine Source: RGD
- response to drug Source: RGD
- response to hydrogen peroxide Source: RGD
- response to inorganic substance Source: RGD
- response to insulin Source: RGD
- response to interleukin-1 Source: RGD
- response to lipopolysaccharide Source: RGD
- response to mechanical stimulus Source: RGD
- response to morphine Source: RGD
- response to muramyl dipeptide Source: RGD
- response to muscle stretch Source: RGD
- response to organic cyclic compound Source: RGD
- response to organic substance Source: RGD
- response to progesterone Source: RGD
- response to UV-B Source: RGD
- transcription, DNA-templated Source: RGD
- tumor necrosis factor-mediated signaling pathway Source: RGD
Keywordsi
Biological process | Transcription, Transcription regulationARBA annotation |
Enzyme and pathway databases
Reactomei | R-RNO-1169091, Activation of NF-kappaB in B cells R-RNO-1810476, RIP-mediated NFkB activation via ZBP1 R-RNO-193692, Regulated proteolysis of p75NTR R-RNO-202424, Downstream TCR signaling R-RNO-209560, NF-kB is activated and signals survival R-RNO-2871837, FCERI mediated NF-kB activation R-RNO-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-RNO-3214841, PKMTs methylate histone lysines R-RNO-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-RNO-4755510, SUMOylation of immune response proteins R-RNO-5607764, CLEC7A (Dectin-1) signaling R-RNO-5621575, CD209 (DC-SIGN) signaling R-RNO-9020702, Interleukin-1 signaling R-RNO-933542, TRAF6 mediated NF-kB activation |
Names & Taxonomyi
Protein namesi | Submitted name: Nuclear factor kappaB subunit p65ImportedSubmitted name: RELAImportedSubmitted name: RELA proto-oncogene, NF-kB subunitImportedSubmitted name: V-rel reticuloendotheliosis viral oncogene homolog A (Avian)Imported |
Gene namesi | ORF Names:rCG_48632Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 727889, Rela |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: RGD
Nucleus
- nuclear chromatin Source: ParkinsonsUK-UCL
- nucleoplasm Source: GO_Central
- nucleus Source: BHF-UCL
Other locations
- cytoplasm Source: RGD
- glutamatergic synapse Source: RGD
- NF-kappaB p50/p65 complex Source: RGD
- protein-containing complex Source: RGD
- synapse Source: SynGO
- transcription regulator complex Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000030888, Expressed in lung and 20 other tissues |
Interactioni
Binary interactionsi
Q7TQN4
With | #Exp. | IntAct |
---|---|---|
Nos2 [Q06518] | 3 | EBI-1187180,EBI-15919967 |
GO - Molecular functioni
- actinin binding Source: RGD
- activating transcription factor binding Source: RGD
- ankyrin repeat binding Source: RGD
- enzyme binding Source: RGD
- histone deacetylase binding Source: RGD
- identical protein binding Source: RGD
- NF-kappaB binding Source: RGD
- protein homodimerization activity Source: RGD
- protein kinase binding Source: RGD
- protein N-terminus binding Source: RGD
- repressing transcription factor binding Source: RGD
- RNA polymerase II transcription coactivator binding Source: RGD
- transcription factor binding Source: RGD
- ubiquitin protein ligase binding Source: RGD
Protein-protein interaction databases
DIPi | DIP-38953N |
IntActi | Q7TQN4, 6 interactors |
STRINGi | 10116.ENSRNOP00000044552 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 190 | RHDInterPro annotationAdd BLAST | 175 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 60 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 311 – 345 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 505 – 531 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 320 – 345 | Pro-richSequence analysisAdd BLAST | 26 |
Phylogenomic databases
eggNOGi | ENOG502QT4Z, Eukaryota |
GeneTreei | ENSGT00940000159867 |
HOGENOMi | CLU_004343_5_1_1 |
OMAi | PTAEPML |
OrthoDBi | 916931at2759 |
TreeFami | TF325632 |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR030495, RelA IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 1 hit PTHR24169:SF1, PTHR24169:SF1, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7TQN4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDDLFPLIFP SEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER
60 70 80 90 100
STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGFY
110 120 130 140 150
EAELCPDRCI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FQVPIEEQRG
160 170 180 190 200
DYDLNAVRLC FQVTVRDPSG RPLRLTPVLS HPIFDNRAPN TAELKICRVN
210 220 230 240 250
RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS QADVHRQVAI
260 270 280 290 300
VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE
310 320 330 340 350
KRKRTYETFK SIMKKSPFNG PTEPRPPPRR IAVPSRGPTS VPKPAPQPYA
360 370 380 390 400
FSTSLSTINF DEFSPMVLPP GQISNQALAL APSSAPVLAQ TMVPSSAMVP
410 420 430 440 450
SLAQPPAPVP VLAPGPPQSL SAPVPKSTQA GEGTLSEALL HLQFDADEDL
460 470 480 490 500
GALLGNNTDP GVFTDLASVD NSEFQQLLNQ GVAMSHSTAE PMLMEYPEAI
510 520 530 540 550
TRLVTGSQRP PDPAPATLGT SGLPNGLSGD EDFSSIADMD FSALLSQISS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC134224 Genomic DNA No translation available. BC079457 mRNA Translation: AAH79457.1 AY307375 mRNA Translation: AAP72180.1 LC369719 mRNA Translation: BBC78048.1 CH473953 Genomic DNA Translation: EDM12513.1 |
RefSeqi | NP_954888.1, NM_199267.2 |
Genome annotation databases
Ensembli | ENSRNOT00000045233; ENSRNOP00000044552; ENSRNOG00000030888 |
GeneIDi | 309165 |
KEGGi | rno:309165 |
UCSCi | RGD:727889, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC134224 Genomic DNA No translation available. BC079457 mRNA Translation: AAH79457.1 AY307375 mRNA Translation: AAP72180.1 LC369719 mRNA Translation: BBC78048.1 CH473953 Genomic DNA Translation: EDM12513.1 |
RefSeqi | NP_954888.1, NM_199267.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
DIPi | DIP-38953N |
IntActi | Q7TQN4, 6 interactors |
STRINGi | 10116.ENSRNOP00000044552 |
Genome annotation databases
Ensembli | ENSRNOT00000045233; ENSRNOP00000044552; ENSRNOG00000030888 |
GeneIDi | 309165 |
KEGGi | rno:309165 |
UCSCi | RGD:727889, rat |
Organism-specific databases
CTDi | 5970 |
RGDi | 727889, Rela |
Phylogenomic databases
eggNOGi | ENOG502QT4Z, Eukaryota |
GeneTreei | ENSGT00940000159867 |
HOGENOMi | CLU_004343_5_1_1 |
OMAi | PTAEPML |
OrthoDBi | 916931at2759 |
TreeFami | TF325632 |
Enzyme and pathway databases
Reactomei | R-RNO-1169091, Activation of NF-kappaB in B cells R-RNO-1810476, RIP-mediated NFkB activation via ZBP1 R-RNO-193692, Regulated proteolysis of p75NTR R-RNO-202424, Downstream TCR signaling R-RNO-209560, NF-kB is activated and signals survival R-RNO-2871837, FCERI mediated NF-kB activation R-RNO-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-RNO-3214841, PKMTs methylate histone lysines R-RNO-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-RNO-4755510, SUMOylation of immune response proteins R-RNO-5607764, CLEC7A (Dectin-1) signaling R-RNO-5621575, CD209 (DC-SIGN) signaling R-RNO-9020702, Interleukin-1 signaling R-RNO-933542, TRAF6 mediated NF-kB activation |
Gene expression databases
Bgeei | ENSRNOG00000030888, Expressed in lung and 20 other tissues |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR030495, RelA IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 1 hit PTHR24169:SF1, PTHR24169:SF1, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7TQN4_RAT | |
Accessioni | Q7TQN4Primary (citable) accession number: Q7TQN4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2003 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |