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Entry version 130 (12 Aug 2020)
Sequence version 2 (23 Oct 2007)
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Protein

WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

Gene

Wfikkn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity). Inhibits the biological activity of mature myostatin, but not activin.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei135 – 136Reactive bondPROSITE-ProRule annotation2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMetalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I02.954

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
Alternative name(s):
Growth and differentiation factor-associated serum protein 1
Short name:
GASP-1
Short name:
mGASP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Wfikkn2
Synonyms:Gasp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2669209, Wfikkn2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 291 PublicationAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030782130 – 571WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 74By similarity
Disulfide bondi57 ↔ 78By similarity
Disulfide bondi61 ↔ 73By similarity
Disulfide bondi67 ↔ 83By similarity
Disulfide bondi129 ↔ 159By similarity
Disulfide bondi133 ↔ 152By similarity
Disulfide bondi141 ↔ 170By similarity
Disulfide bondi226 ↔ 282By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi323 ↔ 373By similarity
Disulfide bondi332 ↔ 356By similarity
Disulfide bondi348 ↔ 369By similarity
Disulfide bondi381 ↔ 431By similarity
Disulfide bondi390 ↔ 414By similarity
Disulfide bondi406 ↔ 427By similarity
Disulfide bondi440 ↔ 510By similarity
Disulfide bondi443 ↔ 512By similarity
Disulfide bondi454 ↔ 561By similarity
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TQN3

PRoteomics IDEntifications database

More...
PRIDEi
Q7TQN3

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q7TQN3, 2 sites

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TQN3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with high expression in skeletal muscle and heart. Also expressed in brain, lung and testis. Weakly expressed in liver and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000044177, Expressed in utricle of membranous labyrinth and 92 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TQN3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with both mature and propeptide myostatin/MSTN.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
234985, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000053238

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7TQN3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1571
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7TQN3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 87WAPPROSITE-ProRule annotationAdd BLAST54
Domaini121 – 172Kazal-likePROSITE-ProRule annotationAdd BLAST52
Domaini205 – 298Ig-like C2-typeAdd BLAST94
Domaini323 – 373BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini381 – 431BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51
Domaini440 – 561NTRPROSITE-ProRule annotationAdd BLAST122

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WFIKKN family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4597, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160624

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037211_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TQN3

KEGG Orthology (KO)

More...
KOi
K23621

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCKRECE

Database of Orthologous Groups

More...
OrthoDBi
324177at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7TQN3

TreeFam database of animal gene trees

More...
TreeFami
TF315349

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00109, KU, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.120, 1 hit
2.60.40.10, 1 hit
4.10.410.10, 2 hits
4.10.75.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036645, Elafin-like_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR020901, Prtase_inh_Kunz-CS
IPR008993, TIMP-like_OB-fold
IPR008197, WAP_dom
IPR033639, WFIKKN2

The PANTHER Classification System

More...
PANTHERi
PTHR45938:SF7, PTHR45938:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679, I-set, 1 hit
PF00014, Kunitz_BPTI, 2 hits
PF01759, NTR, 1 hit
PF00095, WAP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00759, BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00131, KU, 2 hits
SM00217, WAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895, SSF100895, 1 hit
SSF48726, SSF48726, 1 hit
SSF50242, SSF50242, 1 hit
SSF57256, SSF57256, 1 hit
SSF57362, SSF57362, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00280, BPTI_KUNITZ_1, 1 hit
PS50279, BPTI_KUNITZ_2, 2 hits
PS50835, IG_LIKE, 1 hit
PS51465, KAZAL_2, 1 hit
PS50189, NTR, 1 hit
PS51390, WAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TQN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCAPGYHRFW FHWGLLLLLL LEAPLRGLAL PPIRYSHAGI CPNDMNPNLW
60 70 80 90 100
VDAQSTCKRE CETDQECETY EKCCPNVCGT KSCVAARYMD VKGKKGPVGM
110 120 130 140 150
PKEATCDHFM CLQQGSECDI WDGQPVCKCK DRCEKEPSFT CASDGLTYYN
160 170 180 190 200
RCFMDAEACS KGITLSVVTC RYHFTWPNTS PPPPETTVHP TTASPETLGL
210 220 230 240 250
DMAAPALLNH PVHQSVTVGE TVSFLCDVVG RPRPELTWEK QLEDRENVVM
260 270 280 290 300
RPNHVRGNVV VTNIAQLVIY NVQPQDAGIY TCTARNVAGV LRADFPLSVV
310 320 330 340 350
RGGQARATSE SSLNGTAFPA TECLKPPDSE DCGEEQTRWH FDAQANNCLT
360 370 380 390 400
FTFGHCHHNL NHFETYEACM LACMSGPLAI CSLPALQGPC KAYVPRWAYN
410 420 430 440 450
SQTGLCQSFV YGGCEGNGNN FESREACEES CPFPRGNQHC RACKPRQKLV
460 470 480 490 500
TSFCRSDFVI LGRVSELTEE QDSGRALVTV DEVLKDEKMG LKFLGREPLE
510 520 530 540 550
VTLLHVDWTC PCPNVTVGET PLIIMGEVDG GMAMLRPDSF VGASSTRRVR
560 570
KLREVMYKKT CDVLKDFLGL Q
Length:571
Mass (Da):63,333
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A75A449F53703AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti380I → T in AAP72503 (PubMed:12595574).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY308804 mRNA Translation: AAP72503.1
AL645846 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25251.1

NCBI Reference Sequences

More...
RefSeqi
NP_861540.2, NM_181819.2
XP_006533561.1, XM_006533498.3
XP_006533562.1, XM_006533499.3
XP_006533563.1, XM_006533500.3
XP_006533564.1, XM_006533501.3
XP_006533565.1, XM_006533502.2
XP_011247365.1, XM_011249063.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000061469; ENSMUSP00000053238; ENSMUSG00000044177

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
278507

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:278507

UCSC genome browser

More...
UCSCi
uc007kyg.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY308804 mRNA Translation: AAP72503.1
AL645846 Genomic DNA No translation available.
CCDSiCCDS25251.1
RefSeqiNP_861540.2, NM_181819.2
XP_006533561.1, XM_006533498.3
XP_006533562.1, XM_006533499.3
XP_006533563.1, XM_006533500.3
XP_006533564.1, XM_006533501.3
XP_006533565.1, XM_006533502.2
XP_011247365.1, XM_011249063.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6MAAX-ray1.39A97-172[»]
SMRiQ7TQN3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi234985, 3 interactors
STRINGi10090.ENSMUSP00000053238

Protein family/group databases

MEROPSiI02.954

PTM databases

GlyGeniQ7TQN3, 2 sites
PhosphoSitePlusiQ7TQN3

Proteomic databases

PaxDbiQ7TQN3
PRIDEiQ7TQN3

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2618, 118 antibodies

Genome annotation databases

EnsembliENSMUST00000061469; ENSMUSP00000053238; ENSMUSG00000044177
GeneIDi278507
KEGGimmu:278507
UCSCiuc007kyg.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
124857
MGIiMGI:2669209, Wfikkn2

Phylogenomic databases

eggNOGiKOG4597, Eukaryota
GeneTreeiENSGT00940000160624
HOGENOMiCLU_037211_1_0_1
InParanoidiQ7TQN3
KOiK23621
OMAiTCKRECE
OrthoDBi324177at2759
PhylomeDBiQ7TQN3
TreeFamiTF315349

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
278507, 3 hits in 20 CRISPR screens

Protein Ontology

More...
PROi
PR:Q7TQN3
RNActiQ7TQN3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000044177, Expressed in utricle of membranous labyrinth and 92 other tissues
GenevisibleiQ7TQN3, MM

Family and domain databases

CDDicd00109, KU, 2 hits
Gene3Di2.40.50.120, 1 hit
2.60.40.10, 1 hit
4.10.410.10, 2 hits
4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645, Elafin-like_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR020901, Prtase_inh_Kunz-CS
IPR008993, TIMP-like_OB-fold
IPR008197, WAP_dom
IPR033639, WFIKKN2
PANTHERiPTHR45938:SF7, PTHR45938:SF7, 1 hit
PfamiView protein in Pfam
PF07679, I-set, 1 hit
PF00014, Kunitz_BPTI, 2 hits
PF01759, NTR, 1 hit
PF00095, WAP, 1 hit
PRINTSiPR00759, BASICPTASE
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00131, KU, 2 hits
SM00217, WAP, 1 hit
SUPFAMiSSF100895, SSF100895, 1 hit
SSF48726, SSF48726, 1 hit
SSF50242, SSF50242, 1 hit
SSF57256, SSF57256, 1 hit
SSF57362, SSF57362, 2 hits
PROSITEiView protein in PROSITE
PS00280, BPTI_KUNITZ_1, 1 hit
PS50279, BPTI_KUNITZ_2, 2 hits
PS50835, IG_LIKE, 1 hit
PS51465, KAZAL_2, 1 hit
PS50189, NTR, 1 hit
PS51390, WAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWFKN2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TQN3
Secondary accession number(s): Q5SUS5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: August 12, 2020
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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