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Protein

Coiled-coil domain-containing protein 93

Gene

Ccdc93

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2.By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 93
Gene namesi
Name:Ccdc93
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1918079 Ccdc93

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002346051 – 629Coiled-coil domain-containing protein 93Add BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei298PhosphoserineBy similarity1
Modified residuei301PhosphoserineBy similarity1
Modified residuei305PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7TQK5
MaxQBiQ7TQK5
PaxDbiQ7TQK5
PeptideAtlasiQ7TQK5
PRIDEiQ7TQK5

PTM databases

iPTMnetiQ7TQK5
PhosphoSitePlusiQ7TQK5

Expressioni

Gene expression databases

BgeeiENSMUSG00000026339 Expressed in 268 organ(s), highest expression level in camera-type eye
CleanExiMM_CCDC93
ExpressionAtlasiQ7TQK5 baseline and differential
GenevisibleiQ7TQK5 MM

Interactioni

Subunit structurei

Interacts with COMMD1, COMMD2 COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10, WASHC1. Interacts directly with WASHC2. Interacts with CCDC93 and C16orf62 homolog; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22, CCDC93 and C16orf62 homolog; in the complex interacts directly with CCDC22.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043442

Structurei

3D structure databases

ProteinModelPortaliQ7TQK5
SMRiQ7TQK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 428Sufficient for interaction with CCDC22By similarityAdd BLAST428
Regioni446 – 629Sufficient for interaction with WASHC2CBy similarityAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili231 – 430Sequence analysisAdd BLAST200
Coiled coili558 – 599Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the CCDC93 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2701 Eukaryota
ENOG410XRRE LUCA
GeneTreeiENSGT00390000011294
HOGENOMiHOG000230742
HOVERGENiHBG054413
InParanoidiQ7TQK5
OrthoDBiEOG091G0DGN
PhylomeDBiQ7TQK5
TreeFamiTF323318

Family and domain databases

InterProiView protein in InterPro
IPR039116 CCDC93
IPR019159 CCDC93_CC
PANTHERiPTHR16441 PTHR16441, 1 hit
PfamiView protein in Pfam
PF09762 KOG2701, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7TQK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLPKGPEGQ GLPEVETRED EEQNVKLTEI LELLVAAGYF RARIKGLSPF
60 70 80 90 100
DKVVGGMTWC ITTCSFDVDV DLLFQENSTI GQKIALSEKI VSVLPRMKCP
110 120 130 140 150
HQLEPHQIQG MDFIHIFPVV QWLVKRAIET KEEMGDYIRS YSISQFQKTY
160 170 180 190 200
SLPEDDDFIK RKDKAVKTVV GLSDAYKPRR KYRRQRGAEE LPDEESRVHS
210 220 230 240 250
TLLEYGRRYG FSRQSKTEKA EDKKTALAAG LSAAEKVDAH EEDELQAAEE
260 270 280 290 300
QRIQSLMTKM TAMANEESRL TASSVGQIVG LCSEEIKQIV SEYAGKQSEL
310 320 330 340 350
SAEESPEKLG TSQLHQRKVI SLNKQILQKS KHLEELQANH TSLKAKYSDR
360 370 380 390 400
KKTLTELKDH GEKLDKEQAA LEKLEAKADP SMLQNLRALV AMNESLKSQE
410 420 430 440 450
QEFKAHCREE MARLQQEIET LKAERAPGEK IISGGEPQGA LTSTMTHNED
460 470 480 490 500
LDRRYNMEKE KLYKIRLLQA RRNREIAILH RKIDEVPSRA ELIQYQKRFI
510 520 530 540 550
ELYRQISAVH KETKQFFTLY NTLDDKKVYL EKEISLLNSI HENFSQAMAS
560 570 580 590 600
PAARDQFLRQ MEQIVEGIKQ SRMKMEKKKQ ENKMRRDQLN DQYLELLEKQ
610 620
RLYFKTVKEF KEEGRKNELL LSKIKAKAS
Length:629
Mass (Da):72,603
Last modified:October 1, 2003 - v1
Checksum:i77404E34035FA440
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QAD4E9QAD4_MOUSE
Coiled-coil domain-containing prote...
Ccdc93
628Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106H → L in BAE35063 (PubMed:16141072).Curated1
Sequence conflicti293Y → N in BAE35063 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142302 mRNA Translation: BAE25021.1
AK159415 mRNA Translation: BAE35063.1
BC054083 mRNA Translation: AAH54083.1
CCDSiCCDS15237.1
RefSeqiNP_001020327.1, NM_001025156.2
UniGeneiMm.25788

Genome annotation databases

EnsembliENSMUST00000036025; ENSMUSP00000043442; ENSMUSG00000026339
GeneIDi70829
KEGGimmu:70829
UCSCiuc007cju.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142302 mRNA Translation: BAE25021.1
AK159415 mRNA Translation: BAE35063.1
BC054083 mRNA Translation: AAH54083.1
CCDSiCCDS15237.1
RefSeqiNP_001020327.1, NM_001025156.2
UniGeneiMm.25788

3D structure databases

ProteinModelPortaliQ7TQK5
SMRiQ7TQK5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043442

PTM databases

iPTMnetiQ7TQK5
PhosphoSitePlusiQ7TQK5

Proteomic databases

EPDiQ7TQK5
MaxQBiQ7TQK5
PaxDbiQ7TQK5
PeptideAtlasiQ7TQK5
PRIDEiQ7TQK5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036025; ENSMUSP00000043442; ENSMUSG00000026339
GeneIDi70829
KEGGimmu:70829
UCSCiuc007cju.2 mouse

Organism-specific databases

CTDi54520
MGIiMGI:1918079 Ccdc93

Phylogenomic databases

eggNOGiKOG2701 Eukaryota
ENOG410XRRE LUCA
GeneTreeiENSGT00390000011294
HOGENOMiHOG000230742
HOVERGENiHBG054413
InParanoidiQ7TQK5
OrthoDBiEOG091G0DGN
PhylomeDBiQ7TQK5
TreeFamiTF323318

Miscellaneous databases

PROiPR:Q7TQK5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026339 Expressed in 268 organ(s), highest expression level in camera-type eye
CleanExiMM_CCDC93
ExpressionAtlasiQ7TQK5 baseline and differential
GenevisibleiQ7TQK5 MM

Family and domain databases

InterProiView protein in InterPro
IPR039116 CCDC93
IPR019159 CCDC93_CC
PANTHERiPTHR16441 PTHR16441, 1 hit
PfamiView protein in Pfam
PF09762 KOG2701, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCD93_MOUSE
AccessioniPrimary (citable) accession number: Q7TQK5
Secondary accession number(s): Q3TX53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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