UniProtKB - Q7TQH7 (LRP10_MOUSE)

BLAST

>sp|Q7TQH7|LRP10_MOUSE Low-density lipoprotein receptor-related protein 10 OS=Mus musculus OX=10090 GN=Lrp10 PE=2 SV=2
MLSALPLLFLLLGGALARPDRITFPRSACEAPPAVLSEVQGTLQRPLGRDSRSSPANCTW
VILGSKDQTVTVRFQKLHLACGSEHLILHSPLQPPISLCEAPSGPLQLPGGNVTITYSYA
GARAPMGQGFLLTYSQDWLLCLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGCSSDPF
PNLNPAPAPTLACNLTLEDFYGVFSSPGYSHLASVSHPQSCLWLLDPHDGRRLAVRFTAL
DLSYGDAVHVYDGAGPPETPRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSSGRGFN
ATYHVRGYCLPWDRPCGLGSGLGASENLGERCYSEAQRCDGSWDCADGTDEEGCPGCPPG
HFPCGAAGTPGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCD
GQPDCTDGSDEWDCSYALPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAP
LSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPG
GTSGGRRRQRGRSIRRLVRRLRRWGLLPRTNTPARAPETRSQVTPSVPSEALDDSTGQAC
EGGAVGGQDGEQAPPLPIKTPIPTPSTLPALATVSEPPGPLPSVPVESSLLSGVVQVLRG
RLLPSLWSPGPTWTQTGTHTTVLSPEDEDDVLLLPLAEPEVWVVEAEDEPLLA

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History
Entry version 135 (07 Nov 2018)
Sequence version 2 (27 Jul 2011)
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Protein

Low-density lipoprotein receptor-related protein 10

Gene

Lrp10

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver.1 Publication

GO - Molecular functionⁱ

low-density lipoprotein particle receptor activity
Source: MGI
Inferred from direct assayⁱ
- 11123907

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

inner ear development
Source: MGI
Inferred from direct assayⁱ
- 21795542
lipid metabolic process
Source: MGI
Inferred from direct assayⁱ
- 11123907
lipid transport
Source: MGI
Inferred from direct assayⁱ
- 11123907

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Endocytosis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-975634 Retinoid metabolism and transport

Reactomeⁱ

R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Low-density lipoprotein receptor-related protein 10 Short name: LRP-10
Gene namesⁱ	Name:Lrp10 Synonyms:Lrp9
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:1929480 Lrp10

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	18 – 441	ExtracellularSequence analysisAdd BLAST	424
Transmembraneⁱ	442 – 462	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	463 – 713	CytoplasmicSequence analysisAdd BLAST	251

Keywords - Cellular componentⁱ

Coated pit, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_0000017336	18 – 713	Low-density lipoprotein receptor-related protein 10Add BLAST		696

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	29 ↔ 58	By similarity
Glycosylationⁱ	57	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	81 ↔ 99	By similarity
Glycosylationⁱ	112	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	141 ↔ 153	By similarity
Disulfide bondⁱ	148 ↔ 166	By similarity
Disulfide bondⁱ	160 ↔ 175	By similarity
Disulfide bondⁱ	193 ↔ 221	By similarity
Glycosylationⁱ	194	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	300	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	309 ↔ 332	By similarity
Disulfide bondⁱ	316 ↔ 345	By similarity
Disulfide bondⁱ	339 ↔ 354	By similarity
Disulfide bondⁱ	357 ↔ 375	By similarity
Disulfide bondⁱ	364 ↔ 388	By similarity
Disulfide bondⁱ	382 ↔ 397	By similarity
Disulfide bondⁱ	400 ↔ 412	By similarity
Disulfide bondⁱ	407 ↔ 425	By similarity
Disulfide bondⁱ	419 ↔ 434	By similarity
Modified residueⁱ	596	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q7TQH7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7TQH7
PaxDbⁱ	Q7TQH7
PRIDEⁱ	Q7TQH7

PTM databases

iPTMnetⁱ	Q7TQH7
PhosphoSitePlusⁱ	Q7TQH7
SwissPalmⁱ	Q7TQH7

Expressionⁱ

Tissue specificityⁱ

Highly expressed in heart, lung, liver and liver. Expressed at low level in brain and spleen. Weakly or not expressed in testis and skeletal muscle. In liver, it is expressed in hepatocytes and at higher level in sinusoidal lining. In the kidney, it is expressed in peritubular capillaries. In brain, it is expressed in the epithelium of the choroid plexus ependymal cells of the third ventricle pia matter, and to lesser extent in hippocampal fields CA2 and CA3.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000022175 Expressed in 305 organ(s), highest expression level in thymus
Genevisibleⁱ	Q7TQH7 MM

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7TQH7
SMRⁱ	Q7TQH7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	29 – 137	CUB 1PROSITE-ProRule annotationAdd BLAST	109
Domainⁱ	140 – 176	LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	193 – 306	CUB 2PROSITE-ProRule annotationAdd BLAST	114
Domainⁱ	308 – 355	LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST	48
Domainⁱ	356 – 398	LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST	43
Domainⁱ	399 – 435	LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST	37

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	546 – 580	Arg-richAdd BLAST		35

Sequence similaritiesⁱ

Belongs to the LDLR family.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IPT0 Eukaryota ENOG410XV08 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125405
HOGENOMⁱ	HOG000013017
HOVERGENⁱ	HBG049162
InParanoidⁱ	Q7TQH7
KEGG Orthology (KO) More...KOⁱ	K20050
OMAⁱ	WDCSYAL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04LP
TreeFamⁱ	TF332149

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00041 CUB, 2 hits cd00112 LDLa, 3 hits
Gene3Dⁱ	2.60.120.290, 1 hit
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR035914 Sperma_CUB_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00431 CUB, 1 hit PF00057 Ldl_recept_a, 2 hits
PRINTSⁱ	PR00261 LDLRECEPTOR
SMARTⁱ	View protein in SMART SM00042 CUB, 2 hits SM00192 LDLa, 4 hits
SUPFAMⁱ	SSF49854 SSF49854, 2 hits SSF57424 SSF57424, 2 hits
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 1 hit PS01209 LDLRA_1, 1 hit PS50068 LDLRA_2, 4 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q7TQH7-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MLSALPLLFL LLGGALARPD RITFPRSACE APPAVLSEVQ GTLQRPLGRD 
        60         70         80         90        100
SRSSPANCTW VILGSKDQTV TVRFQKLHLA CGSEHLILHS PLQPPISLCE 
       110        120        130        140        150
APSGPLQLPG GNVTITYSYA GARAPMGQGF LLTYSQDWLL CLQEEFQCLN 
       160        170        180        190        200
HRCIPAAQRC DGIDACGDGS DEAGCSSDPF PNLNPAPAPT LACNLTLEDF 
       210        220        230        240        250
YGVFSSPGYS HLASVSHPQS CLWLLDPHDG RRLAVRFTAL DLSYGDAVHV 
       260        270        280        290        300
YDGAGPPETP RLLRSLTHFS NGKAVTVETL SGQAVVSYHT VAWSSGRGFN 
       310        320        330        340        350
ATYHVRGYCL PWDRPCGLGS GLGASENLGE RCYSEAQRCD GSWDCADGTD 
       360        370        380        390        400
EEGCPGCPPG HFPCGAAGTP GATACYLPAD RCNYQTFCAD GADERRCRHC 
       410        420        430        440        450
QPGNFRCRDE KCVYETWVCD GQPDCTDGSD EWDCSYALPR KVITAAVIGS 
       460        470        480        490        500
LVCGLLLVIA LGCTCKLYAI RTQEYSIFAP LSRMEAEIVQ QQAPPSYGQL 
       510        520        530        540        550
IAQGAIPPVE DFPTENPNDN SVLGNLRSLL QILRQDMTPG GTSGGRRRQR 
       560        570        580        590        600
GRSIRRLVRR LRRWGLLPRT NTPARAPETR SQVTPSVPSE ALDDSTGQAC 
       610        620        630        640        650
EGGAVGGQDG EQAPPLPIKT PIPTPSTLPA LATVSEPPGP LPSVPVESSL 
       660        670        680        690        700
LSGVVQVLRG RLLPSLWSPG PTWTQTGTHT TVLSPEDEDD VLLLPLAEPE 
       710 
VWVVEAEDEP LLA

Length:713

Mass (Da):76,461

Last modified:July 27, 2011 - v2

Checksum:ⁱ27B2B2D44E9AB6E1

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A2I3BQ24	A0A2I3BQ24_MOUSE	Low-density lipoprotein receptor-re... Low-density lipoprotein receptor-related protein 10	Lrp10	131	Annotation score:
A0A2I3BRF1	A0A2I3BRF1_MOUSE	Low-density lipoprotein receptor-re... Low-density lipoprotein receptor-related protein 10	Lrp10	25	Annotation score:

Sequence cautionⁱ

The sequence AAH11058 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	554	I → V in BAB20775 (PubMed:11123907).Curated	1
Sequence conflictⁱ	554	I → V in AAH54447 (PubMed:15489334).Curated	1
Sequence conflictⁱ	598	Q → H in BAB20775 (PubMed:11123907).Curated	1
Sequence conflictⁱ	637	P → T in BAB20775 (PubMed:11123907).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB042200 mRNA Translation: BAB20775.1 AK144035 mRNA Translation: BAE25667.1 BC011058 mRNA Translation: AAH11058.1 Different initiation. BC052378 mRNA Translation: AAH52378.1 BC054447 mRNA Translation: AAH54447.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27089.1
NCBI Reference Sequences More...RefSeqⁱ	NP_075369.2, NM_022993.3
UniGeneⁱ	Mm.472719

Genome annotation databases

Ensemblⁱ	ENSMUST00000022782; ENSMUSP00000022782; ENSMUSG00000022175
GeneIDⁱ	65107
KEGGⁱ	mmu:65107
UCSC genome browser More...UCSCⁱ	uc007twd.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7TQH7	Low-density lipoprotein receptor-related protein 10 (Fragment)		MOUSE		25	UniRef100_Q7TQH7
UPI0003D778D0		MOUSE		588

Protein	Similar proteins		Species	Score	Length	Source
Q7TQH7	Low-density lipoprotein receptor-related protein 10 (Fragment)		MOUSE		25	UniRef90_Q7TQH7
low-density lipoprotein receptor-related protein 10		MESAU		712
LDL receptor-related protein 10		RAT		711
UPI00077DC886		PERMB		715
UPI000A311B96		MUSPA		713
+7

Protein	Similar proteins		Species	Score	Length	Source
Q7TQH7	Low-density lipoprotein receptor-related protein 10 (Fragment)		MOUSE		25	UniRef50_Q7TQH7
low-density lipoprotein receptor-related protein 10		MESAU		712
LDL receptor-related protein 10		RAT		711
Uncharacterized protein		PIG		709
Low density lipoprotein receptor-related protein 10 (Fragment)		BOVIN		460
+107

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB042200 mRNA Translation: BAB20775.1 AK144035 mRNA Translation: BAE25667.1 BC011058 mRNA Translation: AAH11058.1 Different initiation. BC052378 mRNA Translation: AAH52378.1 BC054447 mRNA Translation: AAH54447.1
CCDSⁱ	CCDS27089.1
RefSeqⁱ	NP_075369.2, NM_022993.3
UniGeneⁱ	Mm.472719

3D structure databases

ProteinModelPortalⁱ	Q7TQH7
SMRⁱ	Q7TQH7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

iPTMnetⁱ	Q7TQH7
PhosphoSitePlusⁱ	Q7TQH7
SwissPalmⁱ	Q7TQH7

Proteomic databases

EPDⁱ	Q7TQH7
MaxQBⁱ	Q7TQH7
PaxDbⁱ	Q7TQH7
PRIDEⁱ	Q7TQH7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000022782; ENSMUSP00000022782; ENSMUSG00000022175
GeneIDⁱ	65107
KEGGⁱ	mmu:65107
UCSCⁱ	uc007twd.1 mouse

Organism-specific databases

CTDⁱ	26020
MGIⁱ	MGI:1929480 Lrp10

Phylogenomic databases

eggNOGⁱ	ENOG410IPT0 Eukaryota ENOG410XV08 LUCA
GeneTreeⁱ	ENSGT00810000125405
HOGENOMⁱ	HOG000013017
HOVERGENⁱ	HBG049162
InParanoidⁱ	Q7TQH7
KOⁱ	K20050
OMAⁱ	WDCSYAL
OrthoDBⁱ	EOG091G04LP
TreeFamⁱ	TF332149

Enzyme and pathway databases

Reactomeⁱ	R-MMU-975634 Retinoid metabolism and transport

Reactomeⁱ

R-MMU-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRSⁱ	Lrp10 mouse
Protein Ontology More...PROⁱ	PR:Q7TQH7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022175 Expressed in 305 organ(s), highest expression level in thymus
Genevisibleⁱ	Q7TQH7 MM

Family and domain databases

CDDⁱ	cd00041 CUB, 2 hits cd00112 LDLa, 3 hits
Gene3Dⁱ	2.60.120.290, 1 hit
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR035914 Sperma_CUB_dom_sf
Pfamⁱ	View protein in Pfam PF00431 CUB, 1 hit PF00057 Ldl_recept_a, 2 hits
PRINTSⁱ	PR00261 LDLRECEPTOR
SMARTⁱ	View protein in SMART SM00042 CUB, 2 hits SM00192 LDLa, 4 hits
SUPFAMⁱ	SSF49854 SSF49854, 2 hits SSF57424 SSF57424, 2 hits
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 1 hit PS01209 LDLRA_1, 1 hit PS50068 LDLRA_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LRP10_MOUSE
Accessionⁱ	Q7TQH7Primary (citable) accession number: Q7TQH7 Secondary accession number(s): Q3UNT0 , Q7TS95, Q921T0, Q9EPE8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7TQH7 (LRP10_MOUSE)

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Low-density lipoprotein receptor-related protein 10

Lrp10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ