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Entry version 148 (12 Aug 2020)
Sequence version 2 (27 Jul 2011)
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Protein

Low-density lipoprotein receptor-related protein 10

Gene

Lrp10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-975634, Retinoid metabolism and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 10
Short name:
LRP-10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lrp10
Synonyms:Lrp9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1929480, Lrp10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 441ExtracellularSequence analysisAdd BLAST424
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Topological domaini463 – 713CytoplasmicSequence analysisAdd BLAST251

Keywords - Cellular componenti

Coated pit, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001733618 – 713Low-density lipoprotein receptor-related protein 10Add BLAST696

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi29 ↔ 58By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi81 ↔ 99By similarity
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi141 ↔ 153By similarity
Disulfide bondi148 ↔ 166By similarity
Disulfide bondi160 ↔ 175By similarity
Disulfide bondi193 ↔ 221By similarity
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi309 ↔ 332By similarity
Disulfide bondi316 ↔ 345By similarity
Disulfide bondi339 ↔ 354By similarity
Disulfide bondi357 ↔ 375By similarity
Disulfide bondi364 ↔ 388By similarity
Disulfide bondi382 ↔ 397By similarity
Disulfide bondi400 ↔ 412By similarity
Disulfide bondi407 ↔ 425By similarity
Disulfide bondi419 ↔ 434By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei596PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7TQH7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7TQH7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TQH7

PRoteomics IDEntifications database

More...
PRIDEi
Q7TQH7

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q7TQH7, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TQH7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TQH7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7TQH7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, lung, liver and liver. Expressed at low level in brain and spleen. Weakly or not expressed in testis and skeletal muscle. In liver, it is expressed in hepatocytes and at higher level in sinusoidal lining. In the kidney, it is expressed in peritubular capillaries. In brain, it is expressed in the epithelium of the choroid plexus ependymal cells of the third ventricle pia matter, and to lesser extent in hippocampal fields CA2 and CA3.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022175, Expressed in thymus and 321 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7TQH7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TQH7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000022782

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7TQH7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7TQH7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 137CUB 1PROSITE-ProRule annotationAdd BLAST109
Domaini140 – 176LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
Domaini193 – 306CUB 2PROSITE-ProRule annotationAdd BLAST114
Domaini308 – 355LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST48
Domaini356 – 398LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST43
Domaini399 – 435LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi546 – 580Arg-richAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDLR family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1215, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160783

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013747_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TQH7

KEGG Orthology (KO)

More...
KOi
K20050

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHFPCGP

Database of Orthologous Groups

More...
OrthoDBi
135036at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332149

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 2 hits
cd00112, LDLa, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 1 hit
4.10.400.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR035914, Sperma_CUB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 1 hit
PF00057, Ldl_recept_a, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 2 hits
SM00192, LDLa, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 2 hits
SSF57424, SSF57424, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 1 hit
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q7TQH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSALPLLFL LLGGALARPD RITFPRSACE APPAVLSEVQ GTLQRPLGRD
60 70 80 90 100
SRSSPANCTW VILGSKDQTV TVRFQKLHLA CGSEHLILHS PLQPPISLCE
110 120 130 140 150
APSGPLQLPG GNVTITYSYA GARAPMGQGF LLTYSQDWLL CLQEEFQCLN
160 170 180 190 200
HRCIPAAQRC DGIDACGDGS DEAGCSSDPF PNLNPAPAPT LACNLTLEDF
210 220 230 240 250
YGVFSSPGYS HLASVSHPQS CLWLLDPHDG RRLAVRFTAL DLSYGDAVHV
260 270 280 290 300
YDGAGPPETP RLLRSLTHFS NGKAVTVETL SGQAVVSYHT VAWSSGRGFN
310 320 330 340 350
ATYHVRGYCL PWDRPCGLGS GLGASENLGE RCYSEAQRCD GSWDCADGTD
360 370 380 390 400
EEGCPGCPPG HFPCGAAGTP GATACYLPAD RCNYQTFCAD GADERRCRHC
410 420 430 440 450
QPGNFRCRDE KCVYETWVCD GQPDCTDGSD EWDCSYALPR KVITAAVIGS
460 470 480 490 500
LVCGLLLVIA LGCTCKLYAI RTQEYSIFAP LSRMEAEIVQ QQAPPSYGQL
510 520 530 540 550
IAQGAIPPVE DFPTENPNDN SVLGNLRSLL QILRQDMTPG GTSGGRRRQR
560 570 580 590 600
GRSIRRLVRR LRRWGLLPRT NTPARAPETR SQVTPSVPSE ALDDSTGQAC
610 620 630 640 650
EGGAVGGQDG EQAPPLPIKT PIPTPSTLPA LATVSEPPGP LPSVPVESSL
660 670 680 690 700
LSGVVQVLRG RLLPSLWSPG PTWTQTGTHT TVLSPEDEDD VLLLPLAEPE
710
VWVVEAEDEP LLA
Length:713
Mass (Da):76,461
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27B2B2D44E9AB6E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQ24A0A2I3BQ24_MOUSE
Low-density lipoprotein receptor-re...
Lrp10
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRF1A0A2I3BRF1_MOUSE
Low-density lipoprotein receptor-re...
Lrp10
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH11058 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti554I → V in BAB20775 (PubMed:11123907).Curated1
Sequence conflicti554I → V in AAH54447 (PubMed:15489334).Curated1
Sequence conflicti598Q → H in BAB20775 (PubMed:11123907).Curated1
Sequence conflicti637P → T in BAB20775 (PubMed:11123907).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB042200 mRNA Translation: BAB20775.1
AK144035 mRNA Translation: BAE25667.1
BC011058 mRNA Translation: AAH11058.1 Different initiation.
BC052378 mRNA Translation: AAH52378.1
BC054447 mRNA Translation: AAH54447.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27089.1

NCBI Reference Sequences

More...
RefSeqi
NP_075369.2, NM_022993.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000022782; ENSMUSP00000022782; ENSMUSG00000022175

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65107

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:65107

UCSC genome browser

More...
UCSCi
uc007twd.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042200 mRNA Translation: BAB20775.1
AK144035 mRNA Translation: BAE25667.1
BC011058 mRNA Translation: AAH11058.1 Different initiation.
BC052378 mRNA Translation: AAH52378.1
BC054447 mRNA Translation: AAH54447.1
CCDSiCCDS27089.1
RefSeqiNP_075369.2, NM_022993.3

3D structure databases

SMRiQ7TQH7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022782

PTM databases

GlyGeniQ7TQH7, 4 sites
iPTMnetiQ7TQH7
PhosphoSitePlusiQ7TQH7
SwissPalmiQ7TQH7

Proteomic databases

EPDiQ7TQH7
MaxQBiQ7TQH7
PaxDbiQ7TQH7
PRIDEiQ7TQH7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
95, 109 antibodies

Genome annotation databases

EnsembliENSMUST00000022782; ENSMUSP00000022782; ENSMUSG00000022175
GeneIDi65107
KEGGimmu:65107
UCSCiuc007twd.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26020
MGIiMGI:1929480, Lrp10

Phylogenomic databases

eggNOGiKOG1215, Eukaryota
GeneTreeiENSGT00940000160783
HOGENOMiCLU_013747_2_0_1
InParanoidiQ7TQH7
KOiK20050
OMAiGHFPCGP
OrthoDBi135036at2759
TreeFamiTF332149

Enzyme and pathway databases

ReactomeiR-MMU-975634, Retinoid metabolism and transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
65107, 1 hit in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lrp10, mouse

Protein Ontology

More...
PROi
PR:Q7TQH7
RNActiQ7TQH7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022175, Expressed in thymus and 321 other tissues
ExpressionAtlasiQ7TQH7, baseline and differential
GenevisibleiQ7TQH7, MM

Family and domain databases

CDDicd00041, CUB, 2 hits
cd00112, LDLa, 3 hits
Gene3Di2.60.120.290, 1 hit
4.10.400.10, 4 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR035914, Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431, CUB, 1 hit
PF00057, Ldl_recept_a, 2 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00042, CUB, 2 hits
SM00192, LDLa, 4 hits
SUPFAMiSSF49854, SSF49854, 2 hits
SSF57424, SSF57424, 2 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 1 hit
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRP10_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TQH7
Secondary accession number(s): Q3UNT0
, Q7TS95, Q921T0, Q9EPE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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