UniProtKB - Q7TQH7 (LRP10_MOUSE)
Protein
Low-density lipoprotein receptor-related protein 10
Gene
Lrp10
Organism
Mus musculus (Mouse)
Status
Functioni
Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver.1 Publication
GO - Molecular functioni
GO - Biological processi
- inner ear development Source: MGI
- lipid metabolic process Source: MGI
- lipid transport Source: MGI
Keywordsi
Molecular function | Receptor |
Biological process | Endocytosis |
Enzyme and pathway databases
Reactomei | R-MMU-975634, Retinoid metabolism and transport |
Names & Taxonomyi
Protein namesi | Recommended name: Low-density lipoprotein receptor-related protein 10Short name: LRP-10 |
Gene namesi | Name:Lrp10 Synonyms:Lrp9 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1929480, Lrp10 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
- coated pit By similarity
Plasma Membrane
- clathrin-coated pit Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 18 – 441 | ExtracellularSequence analysisAdd BLAST | 424 | |
Transmembranei | 442 – 462 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 463 – 713 | CytoplasmicSequence analysisAdd BLAST | 251 |
Keywords - Cellular componenti
Coated pit, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000017336 | 18 – 713 | Low-density lipoprotein receptor-related protein 10Add BLAST | 696 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 58 | By similarity | ||
Glycosylationi | 57 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 81 ↔ 99 | By similarity | ||
Glycosylationi | 112 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 141 ↔ 153 | By similarity | ||
Disulfide bondi | 148 ↔ 166 | By similarity | ||
Disulfide bondi | 160 ↔ 175 | By similarity | ||
Disulfide bondi | 193 ↔ 221 | By similarity | ||
Glycosylationi | 194 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 300 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 309 ↔ 332 | By similarity | ||
Disulfide bondi | 316 ↔ 345 | By similarity | ||
Disulfide bondi | 339 ↔ 354 | By similarity | ||
Disulfide bondi | 357 ↔ 375 | By similarity | ||
Disulfide bondi | 364 ↔ 388 | By similarity | ||
Disulfide bondi | 382 ↔ 397 | By similarity | ||
Disulfide bondi | 400 ↔ 412 | By similarity | ||
Disulfide bondi | 407 ↔ 425 | By similarity | ||
Disulfide bondi | 419 ↔ 434 | By similarity | ||
Modified residuei | 596 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q7TQH7 |
MaxQBi | Q7TQH7 |
PaxDbi | Q7TQH7 |
PRIDEi | Q7TQH7 |
PTM databases
GlyGeni | Q7TQH7, 4 sites |
iPTMneti | Q7TQH7 |
PhosphoSitePlusi | Q7TQH7 |
SwissPalmi | Q7TQH7 |
Expressioni
Tissue specificityi
Highly expressed in heart, lung, liver and liver. Expressed at low level in brain and spleen. Weakly or not expressed in testis and skeletal muscle. In liver, it is expressed in hepatocytes and at higher level in sinusoidal lining. In the kidney, it is expressed in peritubular capillaries. In brain, it is expressed in the epithelium of the choroid plexus ependymal cells of the third ventricle pia matter, and to lesser extent in hippocampal fields CA2 and CA3.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000022175, Expressed in thymus and 321 other tissues |
ExpressionAtlasi | Q7TQH7, baseline and differential |
Genevisiblei | Q7TQH7, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000022782 |
Miscellaneous databases
RNActi | Q7TQH7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 137 | CUB 1PROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 140 – 176 | LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 193 – 306 | CUB 2PROSITE-ProRule annotationAdd BLAST | 114 | |
Domaini | 308 – 355 | LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 356 – 398 | LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 399 – 435 | LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 546 – 580 | Arg-richAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the LDLR family.Curated
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000160783 |
HOGENOMi | CLU_013747_2_0_1 |
InParanoidi | Q7TQH7 |
OMAi | GHFPCGP |
OrthoDBi | 135036at2759 |
TreeFami | TF332149 |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd00112, LDLa, 3 hits |
Gene3Di | 2.60.120.290, 1 hit 4.10.400.10, 4 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR002172, LDrepeatLR_classA_rpt IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00431, CUB, 1 hit PF00057, Ldl_recept_a, 2 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00042, CUB, 2 hits SM00192, LDLa, 4 hits |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF57424, SSF57424, 2 hits |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS01209, LDLRA_1, 1 hit PS50068, LDLRA_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q7TQH7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSALPLLFL LLGGALARPD RITFPRSACE APPAVLSEVQ GTLQRPLGRD
60 70 80 90 100
SRSSPANCTW VILGSKDQTV TVRFQKLHLA CGSEHLILHS PLQPPISLCE
110 120 130 140 150
APSGPLQLPG GNVTITYSYA GARAPMGQGF LLTYSQDWLL CLQEEFQCLN
160 170 180 190 200
HRCIPAAQRC DGIDACGDGS DEAGCSSDPF PNLNPAPAPT LACNLTLEDF
210 220 230 240 250
YGVFSSPGYS HLASVSHPQS CLWLLDPHDG RRLAVRFTAL DLSYGDAVHV
260 270 280 290 300
YDGAGPPETP RLLRSLTHFS NGKAVTVETL SGQAVVSYHT VAWSSGRGFN
310 320 330 340 350
ATYHVRGYCL PWDRPCGLGS GLGASENLGE RCYSEAQRCD GSWDCADGTD
360 370 380 390 400
EEGCPGCPPG HFPCGAAGTP GATACYLPAD RCNYQTFCAD GADERRCRHC
410 420 430 440 450
QPGNFRCRDE KCVYETWVCD GQPDCTDGSD EWDCSYALPR KVITAAVIGS
460 470 480 490 500
LVCGLLLVIA LGCTCKLYAI RTQEYSIFAP LSRMEAEIVQ QQAPPSYGQL
510 520 530 540 550
IAQGAIPPVE DFPTENPNDN SVLGNLRSLL QILRQDMTPG GTSGGRRRQR
560 570 580 590 600
GRSIRRLVRR LRRWGLLPRT NTPARAPETR SQVTPSVPSE ALDDSTGQAC
610 620 630 640 650
EGGAVGGQDG EQAPPLPIKT PIPTPSTLPA LATVSEPPGP LPSVPVESSL
660 670 680 690 700
LSGVVQVLRG RLLPSLWSPG PTWTQTGTHT TVLSPEDEDD VLLLPLAEPE
710
VWVVEAEDEP LLA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2I3BQ24 | A0A2I3BQ24_MOUSE | Low-density lipoprotein receptor-re... | Lrp10 | 131 | Annotation score: | ||
A0A2I3BRF1 | A0A2I3BRF1_MOUSE | Low-density lipoprotein receptor-re... | Lrp10 | 25 | Annotation score: |
Sequence cautioni
The sequence AAH11058 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 554 | I → V in BAB20775 (PubMed:11123907).Curated | 1 | |
Sequence conflicti | 554 | I → V in AAH54447 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 598 | Q → H in BAB20775 (PubMed:11123907).Curated | 1 | |
Sequence conflicti | 637 | P → T in BAB20775 (PubMed:11123907).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB042200 mRNA Translation: BAB20775.1 AK144035 mRNA Translation: BAE25667.1 BC011058 mRNA Translation: AAH11058.1 Different initiation. BC052378 mRNA Translation: AAH52378.1 BC054447 mRNA Translation: AAH54447.1 |
CCDSi | CCDS27089.1 |
RefSeqi | NP_075369.2, NM_022993.3 |
Genome annotation databases
Ensembli | ENSMUST00000022782; ENSMUSP00000022782; ENSMUSG00000022175 |
GeneIDi | 65107 |
KEGGi | mmu:65107 |
UCSCi | uc007twd.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB042200 mRNA Translation: BAB20775.1 AK144035 mRNA Translation: BAE25667.1 BC011058 mRNA Translation: AAH11058.1 Different initiation. BC052378 mRNA Translation: AAH52378.1 BC054447 mRNA Translation: AAH54447.1 |
CCDSi | CCDS27089.1 |
RefSeqi | NP_075369.2, NM_022993.3 |
3D structure databases
SMRi | Q7TQH7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000022782 |
PTM databases
GlyGeni | Q7TQH7, 4 sites |
iPTMneti | Q7TQH7 |
PhosphoSitePlusi | Q7TQH7 |
SwissPalmi | Q7TQH7 |
Proteomic databases
EPDi | Q7TQH7 |
MaxQBi | Q7TQH7 |
PaxDbi | Q7TQH7 |
PRIDEi | Q7TQH7 |
Protocols and materials databases
Antibodypediai | 95, 109 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000022782; ENSMUSP00000022782; ENSMUSG00000022175 |
GeneIDi | 65107 |
KEGGi | mmu:65107 |
UCSCi | uc007twd.1, mouse |
Organism-specific databases
CTDi | 26020 |
MGIi | MGI:1929480, Lrp10 |
Phylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000160783 |
HOGENOMi | CLU_013747_2_0_1 |
InParanoidi | Q7TQH7 |
OMAi | GHFPCGP |
OrthoDBi | 135036at2759 |
TreeFami | TF332149 |
Enzyme and pathway databases
Reactomei | R-MMU-975634, Retinoid metabolism and transport |
Miscellaneous databases
BioGRID-ORCSi | 65107, 1 hit in 18 CRISPR screens |
ChiTaRSi | Lrp10, mouse |
PROi | PR:Q7TQH7 |
RNActi | Q7TQH7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022175, Expressed in thymus and 321 other tissues |
ExpressionAtlasi | Q7TQH7, baseline and differential |
Genevisiblei | Q7TQH7, MM |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd00112, LDLa, 3 hits |
Gene3Di | 2.60.120.290, 1 hit 4.10.400.10, 4 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR002172, LDrepeatLR_classA_rpt IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00431, CUB, 1 hit PF00057, Ldl_recept_a, 2 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00042, CUB, 2 hits SM00192, LDLa, 4 hits |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF57424, SSF57424, 2 hits |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS01209, LDLRA_1, 1 hit PS50068, LDLRA_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRP10_MOUSE | |
Accessioni | Q7TQH7Primary (citable) accession number: Q7TQH7 Secondary accession number(s): Q3UNT0 Q9EPE8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families