Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger and BTB domain-containing protein 5

Gene

Zbtb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri606 – 628C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 657C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 5
Alternative name(s):
Transcription factor ZNF-POZ
Gene namesi
Name:Zbtb5
Synonyms:Kiaa0354
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1924601 Zbtb5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477141 – 670Zinc finger and BTB domain-containing protein 5Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234PhosphoserineBy similarity1
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei366PhosphoserineBy similarity1
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki410Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki535Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki587Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki590Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki638Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki651Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ7TQG0
PRIDEiQ7TQG0

PTM databases

iPTMnetiQ7TQG0
PhosphoSitePlusiQ7TQG0

Expressioni

Gene expression databases

BgeeiENSMUSG00000049657 Expressed in 228 organ(s), highest expression level in ear vesicle
CleanExiMM_ZBTB5
ExpressionAtlasiQ7TQG0 baseline and differential
GenevisibleiQ7TQG0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059919

Structurei

3D structure databases

ProteinModelPortaliQ7TQG0
SMRiQ7TQG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 93BTBPROSITE-ProRule annotationAdd BLAST70

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri606 – 628C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 657C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150831
HOGENOMiHOG000234181
HOVERGENiHBG058500
InParanoidiQ7TQG0
KOiK10492
OMAiNFSANQN
OrthoDBiEOG091G0570
PhylomeDBiQ7TQG0
TreeFamiTF330979

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7TQG0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFPGHFEQI FQQLNYQRLH GQLCDCVIVV GNRHFKAHRS VLAACSTHFR
60 70 80 90 100
ALFSVAEGDQ TMNMIQLDSE VVTAEAFAAL IDMMYTSTLM LGESNVMDVL
110 120 130 140 150
LAASHLHLNS VVKACKHYLT TRTLPMSPSS ERAQEQSARM QRSFMLQQLG
160 170 180 190 200
LSIVSSALSS SQSAEEPTAP MSSSMRSSLD QRTPFPMRRL HKRKQSVEER
210 220 230 240 250
ARQRLRSSME ESAISDVTPE SGPAGVHSRE EFFSPDSLKI VDNPKPDGMA
260 270 280 290 300
DNQEDGAMMF DRPFGAQEDA QVPSQSDGSA GNMASRATQV ETSFEQEAVA
310 320 330 340 350
EKGSFQCENP EVGLGEKEHM RVVVKSEPLS SPEPQDEVSD VTSQAEGSES
360 370 380 390 400
VEVEGVVVSA EKIDLSPESS DRSFSDPQSS TDRVGDIHIL EVTNNLEHKT
410 420 430 440 450
SFSISNFLNK SRGSNFSASQ STDDNLPNTT SDCRLEGEAP YLLSPEAGPA
460 470 480 490 500
GGPSSAPGSH VENPFSEPAD SHFVRPMQEV MGLPCVQTSG YQGEQFGMDF
510 520 530 540 550
SRSGLGLHSS FSRAMMGSPR GGASNFPYYR RIAPKMPVVT SVRSSQISEN
560 570 580 590 600
SASSQLMMNG ATSFENGHTS QPGPPQLTRA SADVLSKCKK ALSEHNVLVV
610 620 630 640 650
EGARKYACKI CCKTFLTLTD CKKHIRVHTG EKPYACLKCG KRFSQSSHLY
660 670
KHSKTTCLRW QSSNLPSTLL
Length:670
Mass (Da):73,215
Last modified:October 1, 2003 - v1
Checksum:i0DFD572C5B01B2AE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AXQ4B1AXQ4_MOUSE
Zinc finger and BTB domain-containi...
Zbtb5
189Annotation score:

Sequence cautioni

The sequence BAC97934 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182R → W in BAE35551 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY635051 mRNA Translation: AAT47717.1
AK160003 mRNA Translation: BAE35551.1
AK129124 mRNA Translation: BAC97934.1 Different initiation.
BC054551 mRNA Translation: AAH54551.1
BC057545 mRNA Translation: AAH57545.1
CCDSiCCDS18129.1
RefSeqiNP_001156755.1, NM_001163283.1
NP_001156756.1, NM_001163284.1
NP_775575.2, NM_173399.3
UniGeneiMm.44222

Genome annotation databases

EnsembliENSMUST00000055028; ENSMUSP00000059919; ENSMUSG00000049657
ENSMUST00000107817; ENSMUSP00000103447; ENSMUSG00000049657
ENSMUST00000180217; ENSMUSP00000136507; ENSMUSG00000049657
GeneIDi230119
KEGGimmu:230119
UCSCiuc008ssc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY635051 mRNA Translation: AAT47717.1
AK160003 mRNA Translation: BAE35551.1
AK129124 mRNA Translation: BAC97934.1 Different initiation.
BC054551 mRNA Translation: AAH54551.1
BC057545 mRNA Translation: AAH57545.1
CCDSiCCDS18129.1
RefSeqiNP_001156755.1, NM_001163283.1
NP_001156756.1, NM_001163284.1
NP_775575.2, NM_173399.3
UniGeneiMm.44222

3D structure databases

ProteinModelPortaliQ7TQG0
SMRiQ7TQG0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059919

PTM databases

iPTMnetiQ7TQG0
PhosphoSitePlusiQ7TQG0

Proteomic databases

PaxDbiQ7TQG0
PRIDEiQ7TQG0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055028; ENSMUSP00000059919; ENSMUSG00000049657
ENSMUST00000107817; ENSMUSP00000103447; ENSMUSG00000049657
ENSMUST00000180217; ENSMUSP00000136507; ENSMUSG00000049657
GeneIDi230119
KEGGimmu:230119
UCSCiuc008ssc.2 mouse

Organism-specific databases

CTDi9925
MGIiMGI:1924601 Zbtb5
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150831
HOGENOMiHOG000234181
HOVERGENiHBG058500
InParanoidiQ7TQG0
KOiK10492
OMAiNFSANQN
OrthoDBiEOG091G0570
PhylomeDBiQ7TQG0
TreeFamiTF330979

Miscellaneous databases

PROiPR:Q7TQG0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049657 Expressed in 228 organ(s), highest expression level in ear vesicle
CleanExiMM_ZBTB5
ExpressionAtlasiQ7TQG0 baseline and differential
GenevisibleiQ7TQG0 MM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBTB5_MOUSE
AccessioniPrimary (citable) accession number: Q7TQG0
Secondary accession number(s): Q3TVR7, Q6GV09, Q8BIB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again