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Protein

Tubulin polymerization-promoting protein

Gene

Tppp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin polymerization-promoting protein
Short name:
TPPP
Gene namesi
Name:Tppp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1920198 Tppp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211361 – 218Tubulin polymerization-promoting proteinAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphothreonineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei42PhosphothreonineCombined sources1
Modified residuei91PhosphothreonineBy similarity1
Glycosylationi151O-linked (GlcNAc) serine1 Publication1
Modified residuei158PhosphoserineBy similarity1
Modified residuei159PhosphoserineBy similarity1

Post-translational modificationi

Poor substrate for GSK3. Phosphorylated by LIMK1 on serine residues. Phosphorylation may alter the tubulin polymerization activity.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ7TQD2
PaxDbiQ7TQD2
PRIDEiQ7TQD2

PTM databases

iPTMnetiQ7TQD2
PhosphoSitePlusiQ7TQD2

Expressioni

Tissue specificityi

Widely expressed with higher expression in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000021573 Expressed in 186 organ(s), highest expression level in visual cortex
CleanExiMM_TPPP
ExpressionAtlasiQ7TQD2 baseline and differential
GenevisibleiQ7TQD2 MM

Interactioni

Subunit structurei

Homodimer. Binds tubulin; binding is inhibited by GTP. Interacts with GSK3. Interacts with MAPK1. Interacts with LIMK1 (via the PDZ domain); the interaction is direct. Interacts with GAPDH; the interaction is direct.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215665, 3 interactors
IntActiQ7TQD2, 2 interactors
STRINGi10090.ENSMUSP00000022057

Structurei

3D structure databases

ProteinModelPortaliQ7TQD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 115Mediates interaction with LIMK1By similarityAdd BLAST115

Sequence similaritiesi

Belongs to the TPPP family.Curated

Phylogenomic databases

eggNOGiKOG4070 Eukaryota
ENOG4111H9J LUCA
GeneTreeiENSGT00390000014993
HOGENOMiHOG000260314
HOVERGENiHBG036683
InParanoidiQ7TQD2
OMAiCHVIDGK
OrthoDBiEOG091G0PC4
PhylomeDBiQ7TQD2
TreeFamiTF314440

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR008907 P25-alpha
IPR030792 TPPP1
PANTHERiPTHR12932 PTHR12932, 1 hit
PTHR12932:SF18 PTHR12932:SF18, 1 hit
PfamiView protein in Pfam
PF05517 p25-alpha, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TQD2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSKAKPAK AANKTPPKSP GDPARAAKRL SLESEGANEG ATAAPELSAL
60 70 80 90 100
EEAFRRFAVH GDTRATGKEM HGKNWSKLCK DCHVIDGKNV TVTDVDIVFS
110 120 130 140 150
KIKGKSCRTI TFEQFQEALE ELAKKRFKDK SSEEAVREVH RLIEGRAPVI
160 170 180 190 200
SGVTKAVSSP TVSRLTDTSK FTGSHKERFD QSGKGKGKAG RVDLVDESGY
210
VPGYKHAGTY DQKVQGGK
Length:218
Mass (Da):23,575
Last modified:October 1, 2003 - v1
Checksum:iEF929B3E0D01CE19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054803 mRNA Translation: AAH54803.1
CCDSiCCDS26638.1
RefSeqiNP_878259.1, NM_182839.2
XP_006517472.1, XM_006517409.3
UniGeneiMm.39752

Genome annotation databases

EnsembliENSMUST00000022057; ENSMUSP00000022057; ENSMUSG00000021573
GeneIDi72948
KEGGimmu:72948
UCSCiuc007reo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054803 mRNA Translation: AAH54803.1
CCDSiCCDS26638.1
RefSeqiNP_878259.1, NM_182839.2
XP_006517472.1, XM_006517409.3
UniGeneiMm.39752

3D structure databases

ProteinModelPortaliQ7TQD2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215665, 3 interactors
IntActiQ7TQD2, 2 interactors
STRINGi10090.ENSMUSP00000022057

PTM databases

iPTMnetiQ7TQD2
PhosphoSitePlusiQ7TQD2

Proteomic databases

MaxQBiQ7TQD2
PaxDbiQ7TQD2
PRIDEiQ7TQD2

Protocols and materials databases

DNASUi72948
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022057; ENSMUSP00000022057; ENSMUSG00000021573
GeneIDi72948
KEGGimmu:72948
UCSCiuc007reo.2 mouse

Organism-specific databases

CTDi11076
MGIiMGI:1920198 Tppp

Phylogenomic databases

eggNOGiKOG4070 Eukaryota
ENOG4111H9J LUCA
GeneTreeiENSGT00390000014993
HOGENOMiHOG000260314
HOVERGENiHBG036683
InParanoidiQ7TQD2
OMAiCHVIDGK
OrthoDBiEOG091G0PC4
PhylomeDBiQ7TQD2
TreeFamiTF314440

Miscellaneous databases

ChiTaRSiTppp mouse
PROiPR:Q7TQD2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021573 Expressed in 186 organ(s), highest expression level in visual cortex
CleanExiMM_TPPP
ExpressionAtlasiQ7TQD2 baseline and differential
GenevisibleiQ7TQD2 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR008907 P25-alpha
IPR030792 TPPP1
PANTHERiPTHR12932 PTHR12932, 1 hit
PTHR12932:SF18 PTHR12932:SF18, 1 hit
PfamiView protein in Pfam
PF05517 p25-alpha, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPPP_MOUSE
AccessioniPrimary (citable) accession number: Q7TQD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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