UniProtKB - Q7TQA1 (IGSF1_MOUSE)
Immunoglobulin superfamily member 1
Igsf1
Functioni
Caution
GO - Molecular functioni
- activin receptor antagonist activity Source: MGI
- coreceptor activity Source: MGI
- inhibin binding Source: MGI
GO - Biological processi
- negative regulation of activin receptor signaling pathway Source: MGI
- regulation of transcription, DNA-templated Source: MGI
Keywordsi
Molecular function | Receptor |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin superfamily member 1Short name: IgSF1 Alternative name(s): Inhibin-binding protein Short name: InhBP |
Gene namesi | Name:Igsf1 Synonyms:Kiaa0364 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2147913, Igsf1 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 499 | ExtracellularSequence analysisAdd BLAST | 479 | |
Transmembranei | 500 – 520 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 521 – 531 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 532 – 552 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 553 – 1317 | ExtracellularSequence analysisAdd BLAST | 765 |
Keywords - Cellular componenti
Membrane, SecretedPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000318513 | 21 – 1317 | Immunoglobulin superfamily member 1Add BLAST | 1297 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 48 ↔ 96 | PROSITE-ProRule annotation | ||
Disulfide bondi | 238 ↔ 286 | PROSITE-ProRule annotation | ||
Glycosylationi | 328 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 333 ↔ 382 | PROSITE-ProRule annotation | ||
Glycosylationi | 371 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 422 ↔ 465 | PROSITE-ProRule annotation | ||
Disulfide bondi | 780 ↔ 830 | PROSITE-ProRule annotation | ||
Glycosylationi | 871 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 876 ↔ 923 | PROSITE-ProRule annotation | ||
Glycosylationi | 967 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1063 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1068 ↔ 1115 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1164 ↔ 1207 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q7TQA1 |
PRIDEi | Q7TQA1 |
PTM databases
GlyConnecti | 2381, 1 N-Linked glycan (3 sites) |
GlyGeni | Q7TQA1, 8 sites |
iPTMneti | Q7TQA1 |
PhosphoSitePlusi | Q7TQA1 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000031111, Expressed in pituitary gland and 175 other tissues |
Genevisiblei | Q7TQA1, MM |
Interactioni
Subunit structurei
Interacts with INHA; the interaction is not confirmed by standard receptor binding assays (By similarity).
Interacts with ACVR1B; the interaction appears to be ligand-dependent as it is diminished by inhibin B and activin A.
Interacts with ACVR2A, ACVR2B, ACVRL1 and BMPR1B (By similarity).
Interacts with HECTD1 (By similarity).
By similarityGO - Molecular functioni
- activin receptor antagonist activity Source: MGI
- inhibin binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000033442 |
Miscellaneous databases
RNActi | Q7TQA1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 112 | Ig-like C2-type 1Add BLAST | 92 | |
Domaini | 114 – 211 | Ig-like C2-type 2Add BLAST | 98 | |
Domaini | 216 – 302 | Ig-like C2-type 3Add BLAST | 87 | |
Domaini | 311 – 398 | Ig-like C2-type 4Add BLAST | 88 | |
Domaini | 400 – 481 | Ig-like C2-type 5Add BLAST | 82 | |
Domaini | 570 – 658 | Ig-like C2-type 6Add BLAST | 89 | |
Domaini | 659 – 753 | Ig-like C2-type 7Add BLAST | 95 | |
Domaini | 758 – 850 | Ig-like C2-type 8Add BLAST | 93 | |
Domaini | 854 – 938 | Ig-like C2-type 9Add BLAST | 85 | |
Domaini | 946 – 1041 | Ig-like C2-type 10Add BLAST | 96 | |
Domaini | 1046 – 1131 | Ig-like C2-type 11Add BLAST | 86 | |
Domaini | 1142 – 1223 | Ig-like C2-type 12Add BLAST | 82 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RYEX, Eukaryota |
GeneTreei | ENSGT00980000198504 |
HOGENOMi | CLU_006143_0_0_1 |
InParanoidi | Q7TQA1 |
OMAi | GCWHLAI |
OrthoDBi | 1327293at2759 |
PhylomeDBi | Q7TQA1 |
TreeFami | TF336644 |
Family and domain databases
Gene3Di | 2.60.40.10, 12 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF13895, Ig_2, 4 hits |
SMARTi | View protein in SMART SM00409, IG, 11 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 12 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 6 hits |
s (5)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMLRTFTLLL LCIWLNPGMT SLAVESQPEL WIESNYPQAP WENITLWCKS
60 70 80 90 100
PSRVSSKFLL LKDNSQMTWI RPPYKTFQVS FFIGALTESN TGLYRCCYWK
110 120 130 140 150
EKGWSKPSKI LELEAPGQLP KPIFWIQAET PPLPGCNVNI FCHGWLQDLV
160 170 180 190 200
FMLFKEGYTE PVDYQVPTGT MAIFSIDNLA PENEGVYICR THIQMLPTLW
210 220 230 240 250
SEPSNPLKLV VAGLYPKPTL TAHPGPILAP GESLSLRCQG PIYGMTFALM
260 270 280 290 300
RLEDLKKSFY HKKPIKNEAY FYFQDLKIQD TGHYLCFYYD GSYRGSLLSD
310 320 330 340 350
ILKIWVTDTF PKTWLLVQPS PVIQMGQNVS LRCGGLMDGV GLALYKKGEE
360 370 380 390 400
KPLQFLDASS NTGNNSFFLK NVTYRDAGIY SCHYYLTWKT SIKMATYNTV
410 420 430 440 450
ELMVVAWPSS VFKVGKTITL QCRVSHPVLE FSLEWEERTT FQKFSVDGDF
460 470 480 490 500
LITDIEGQGT GTYSCSYRIE AHPNTWSHRS KPLKLVGPAG FLTWNSILNE
510 520 530 540 550
AVRVSLTMQL ASLLLLVVWI RWKCRRLRLR EAWLLGTAQG VAMLFILMAL
560 570 580 590 600
LCCGLCNGAL TEEIEIVMPT PKPELWAETN FPLAPWKNLT LWCRSPSGST
610 620 630 640 650
KEFVLLKDGT GWIATRPASE QVRAAFPLGA LTHSHTGSYH CHSWEEMAVS
660 670 680 690 700
EPSEALELVG TDILPKPVIS ASLPIRGQEL QIRCKGWLEG LGFALYKKGE
710 720 730 740 750
QEPVQQLGAV GREAFFTIQR MEDKDEGNYS CRTHTEMQPF KWSEPSEPLE
760 770 780 790 800
LVIKEMYPKP FFKTWASPVV TPGSRVTFNC STSHEHMSFI LYKDGNEIAS
810 820 830 840 850
SDLAWGNPGG STAHFLIISV GIGDGGNYSC RYYDFSIWSE PSNPVELVVT
860 870 880 890 900
EFYPKPTLLA QPGPVVLPGK NVTLRCQGIF QGMRFALLQE GTHTPLQFQS
910 920 930 940 950
TSGTSADFLL HTVGAQDFGN YSCVYYETTM SNRGSSLSTP LMIWVTDTFP
960 970 980 990 1000
RPWLSAEPSS VVTMGQNVTL WCQGPVRGVG YILHKEGEAT SMQLWGSTSN
1010 1020 1030 1040 1050
EGAFPIINIS GASIGRYSCC YHPDWMSPIK IQPSNTLELI VTGLLPKPSL
1060 1070 1080 1090 1100
LVQPGPMVAP GENVTLQCQG ELPDSTFVLL KEGTRQPLEQ QRPSGYRADF
1110 1120 1130 1140 1150
WMPVVRDQDS GVYSCVYYLD SAPLVASNHS NSLEIWVTDK PPKPSLSAWP
1160 1170 1180 1190 1200
STIFKLGKDI TLQCRGPLPG VEFVLEHDGE EAPQQFSEDG DFVIDNLEGK
1210 1220 1230 1240 1250
GIGNYSCSYR LQAYPDIWSE PSDTLELVGA AGPVAQECTV GNIVRSTLIV
1260 1270 1280 1290 1300
VVVVALGIVL AVEWKKWPRL RTRGSETDGR DQTVVLEECN QEGEPGTTTN
1310
SPSSASQEVS VELTVPI
The sequence of this isoform differs from the canonical sequence as follows:
214-232: LYPKPTLTAHPGPILAPGE → GCGHGCWHLTIVIPGIMAG
233-1317: Missing.
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 277 | K → E in AAP57081 (PubMed:12832474).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031198 | 1 – 542 | Missing in isoform 5. 1 PublicationAdd BLAST | 542 | |
Alternative sequenceiVSP_031199 | 214 – 232 | LYPKP…LAPGE → GCGHGCWHLTIVIPGIMAG in isoform 4. 2 PublicationsAdd BLAST | 19 | |
Alternative sequenceiVSP_031200 | 233 – 1317 | Missing in isoform 4. 2 PublicationsAdd BLAST | 1085 | |
Alternative sequenceiVSP_031201 | 755 – 762 | EMYPKPFF → DGRTKAQN in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_031202 | 763 – 1317 | Missing in isoform 3. 1 PublicationAdd BLAST | 555 | |
Alternative sequenceiVSP_031203 | 865 – 1156 | Missing in isoform 2. 1 PublicationAdd BLAST | 292 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY227771 mRNA Translation: AAP57079.1 AY227772 mRNA Translation: AAP57080.1 AY227773 mRNA Translation: AAP57081.1 AY227774 mRNA Translation: AAP57082.1 AK129126 mRNA Translation: BAC97936.1 Different initiation. AK030452 mRNA Translation: BAC26969.1 |
CCDSi | CCDS40964.1 [Q7TQA1-1] CCDS40965.1 [Q7TQA1-5] CCDS40966.1 [Q7TQA1-3] CCDS40967.1 [Q7TQA1-4] |
RefSeqi | NP_808259.2, NM_177591.4 [Q7TQA1-1] NP_808583.1, NM_177915.4 [Q7TQA1-4] NP_899178.2, NM_183335.2 [Q7TQA1-3] NP_899179.1, NM_183336.2 [Q7TQA1-5] XP_006541550.1, XM_006541487.2 [Q7TQA1-3] |
Genome annotation databases
Ensembli | ENSMUST00000033442; ENSMUSP00000033442; ENSMUSG00000031111 [Q7TQA1-1] ENSMUST00000072037; ENSMUSP00000071919; ENSMUSG00000031111 [Q7TQA1-3] ENSMUST00000114891; ENSMUSP00000110541; ENSMUSG00000031111 [Q7TQA1-4] ENSMUST00000114893; ENSMUSP00000110543; ENSMUSG00000031111 [Q7TQA1-5] |
GeneIDi | 209268 |
KEGGi | mmu:209268 |
UCSCi | uc009tdg.2, mouse [Q7TQA1-1] uc009tdi.1, mouse [Q7TQA1-3] uc009tdj.2, mouse [Q7TQA1-4] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY227771 mRNA Translation: AAP57079.1 AY227772 mRNA Translation: AAP57080.1 AY227773 mRNA Translation: AAP57081.1 AY227774 mRNA Translation: AAP57082.1 AK129126 mRNA Translation: BAC97936.1 Different initiation. AK030452 mRNA Translation: BAC26969.1 |
CCDSi | CCDS40964.1 [Q7TQA1-1] CCDS40965.1 [Q7TQA1-5] CCDS40966.1 [Q7TQA1-3] CCDS40967.1 [Q7TQA1-4] |
RefSeqi | NP_808259.2, NM_177591.4 [Q7TQA1-1] NP_808583.1, NM_177915.4 [Q7TQA1-4] NP_899178.2, NM_183335.2 [Q7TQA1-3] NP_899179.1, NM_183336.2 [Q7TQA1-5] XP_006541550.1, XM_006541487.2 [Q7TQA1-3] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000033442 |
PTM databases
GlyConnecti | 2381, 1 N-Linked glycan (3 sites) |
GlyGeni | Q7TQA1, 8 sites |
iPTMneti | Q7TQA1 |
PhosphoSitePlusi | Q7TQA1 |
Proteomic databases
PaxDbi | Q7TQA1 |
PRIDEi | Q7TQA1 |
Protocols and materials databases
Antibodypediai | 16308, 188 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000033442; ENSMUSP00000033442; ENSMUSG00000031111 [Q7TQA1-1] ENSMUST00000072037; ENSMUSP00000071919; ENSMUSG00000031111 [Q7TQA1-3] ENSMUST00000114891; ENSMUSP00000110541; ENSMUSG00000031111 [Q7TQA1-4] ENSMUST00000114893; ENSMUSP00000110543; ENSMUSG00000031111 [Q7TQA1-5] |
GeneIDi | 209268 |
KEGGi | mmu:209268 |
UCSCi | uc009tdg.2, mouse [Q7TQA1-1] uc009tdi.1, mouse [Q7TQA1-3] uc009tdj.2, mouse [Q7TQA1-4] |
Organism-specific databases
CTDi | 3547 |
MGIi | MGI:2147913, Igsf1 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYEX, Eukaryota |
GeneTreei | ENSGT00980000198504 |
HOGENOMi | CLU_006143_0_0_1 |
InParanoidi | Q7TQA1 |
OMAi | GCWHLAI |
OrthoDBi | 1327293at2759 |
PhylomeDBi | Q7TQA1 |
TreeFami | TF336644 |
Miscellaneous databases
BioGRID-ORCSi | 209268, 0 hits in 15 CRISPR screens |
ChiTaRSi | Igsf1, mouse |
PROi | PR:Q7TQA1 |
RNActi | Q7TQA1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031111, Expressed in pituitary gland and 175 other tissues |
Genevisiblei | Q7TQA1, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 12 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF13895, Ig_2, 4 hits |
SMARTi | View protein in SMART SM00409, IG, 11 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 12 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IGSF1_MOUSE | |
Accessioni | Q7TQA1Primary (citable) accession number: Q7TQA1 Secondary accession number(s): Q6ZQD0 Q8BMN5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot