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Entry version 137 (02 Dec 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Immunoglobulin superfamily member 1

Gene

Igsf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B. Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin superfamily member 1
Short name:
IgSF1
Alternative name(s):
Inhibin-binding protein
Short name:
InhBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Igsf1
Synonyms:Kiaa0364
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2147913, Igsf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 499ExtracellularSequence analysisAdd BLAST479
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Topological domaini521 – 531CytoplasmicSequence analysisAdd BLAST11
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 1317ExtracellularSequence analysisAdd BLAST765

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and fertile and show no alterations in FSH synthesis or secretion or in ovarian and testicular function. According to PubMed:23143598 male mice show diminished pituitary and serum thyroid-stimulating hormone (TSH) concentrations, reduced pituitary thyrotropin-releasing hormone (TRH) receptor expression, decreased triiodothyronine concentrations and increased body mass.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031851321 – 1317Immunoglobulin superfamily member 1Add BLAST1297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 96PROSITE-ProRule annotation
Disulfide bondi238 ↔ 286PROSITE-ProRule annotation
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi333 ↔ 382PROSITE-ProRule annotation
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi422 ↔ 465PROSITE-ProRule annotation
Disulfide bondi780 ↔ 830PROSITE-ProRule annotation
Glycosylationi871N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi876 ↔ 923PROSITE-ProRule annotation
Glycosylationi967N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1063N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1068 ↔ 1115PROSITE-ProRule annotation
Disulfide bondi1164 ↔ 1207PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TQA1

PRoteomics IDEntifications database

More...
PRIDEi
Q7TQA1

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2381, 1 N-Linked glycan (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q7TQA1, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TQA1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TQA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031111, Expressed in pituitary gland and 175 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TQA1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with INHA; the interaction is not confirmed by standard receptor binding assays (By similarity).

Interacts with ACVR1B; the interaction appears to be ligand-dependent as it is diminished by inhibin B and activin A.

Interacts with ACVR2A, ACVR2B, ACVRL1 and BMPR1B (By similarity).

Interacts with HECTD1 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000033442

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7TQA1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 112Ig-like C2-type 1Add BLAST92
Domaini114 – 211Ig-like C2-type 2Add BLAST98
Domaini216 – 302Ig-like C2-type 3Add BLAST87
Domaini311 – 398Ig-like C2-type 4Add BLAST88
Domaini400 – 481Ig-like C2-type 5Add BLAST82
Domaini570 – 658Ig-like C2-type 6Add BLAST89
Domaini659 – 753Ig-like C2-type 7Add BLAST95
Domaini758 – 850Ig-like C2-type 8Add BLAST93
Domaini854 – 938Ig-like C2-type 9Add BLAST85
Domaini946 – 1041Ig-like C2-type 10Add BLAST96
Domaini1046 – 1131Ig-like C2-type 11Add BLAST86
Domaini1142 – 1223Ig-like C2-type 12Add BLAST82

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RYEX, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00980000198504

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006143_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TQA1

Identification of Orthologs from Complete Genome Data

More...
OMAi
GCWHLAI

Database of Orthologous Groups

More...
OrthoDBi
1327293at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7TQA1

TreeFam database of animal gene trees

More...
TreeFami
TF336644

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 12 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13895, Ig_2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 11 hits
SM00408, IGc2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7TQA1-1) [UniParc]FASTAAdd to basket
Also known as: InhBP-L, long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMLRTFTLLL LCIWLNPGMT SLAVESQPEL WIESNYPQAP WENITLWCKS
60 70 80 90 100
PSRVSSKFLL LKDNSQMTWI RPPYKTFQVS FFIGALTESN TGLYRCCYWK
110 120 130 140 150
EKGWSKPSKI LELEAPGQLP KPIFWIQAET PPLPGCNVNI FCHGWLQDLV
160 170 180 190 200
FMLFKEGYTE PVDYQVPTGT MAIFSIDNLA PENEGVYICR THIQMLPTLW
210 220 230 240 250
SEPSNPLKLV VAGLYPKPTL TAHPGPILAP GESLSLRCQG PIYGMTFALM
260 270 280 290 300
RLEDLKKSFY HKKPIKNEAY FYFQDLKIQD TGHYLCFYYD GSYRGSLLSD
310 320 330 340 350
ILKIWVTDTF PKTWLLVQPS PVIQMGQNVS LRCGGLMDGV GLALYKKGEE
360 370 380 390 400
KPLQFLDASS NTGNNSFFLK NVTYRDAGIY SCHYYLTWKT SIKMATYNTV
410 420 430 440 450
ELMVVAWPSS VFKVGKTITL QCRVSHPVLE FSLEWEERTT FQKFSVDGDF
460 470 480 490 500
LITDIEGQGT GTYSCSYRIE AHPNTWSHRS KPLKLVGPAG FLTWNSILNE
510 520 530 540 550
AVRVSLTMQL ASLLLLVVWI RWKCRRLRLR EAWLLGTAQG VAMLFILMAL
560 570 580 590 600
LCCGLCNGAL TEEIEIVMPT PKPELWAETN FPLAPWKNLT LWCRSPSGST
610 620 630 640 650
KEFVLLKDGT GWIATRPASE QVRAAFPLGA LTHSHTGSYH CHSWEEMAVS
660 670 680 690 700
EPSEALELVG TDILPKPVIS ASLPIRGQEL QIRCKGWLEG LGFALYKKGE
710 720 730 740 750
QEPVQQLGAV GREAFFTIQR MEDKDEGNYS CRTHTEMQPF KWSEPSEPLE
760 770 780 790 800
LVIKEMYPKP FFKTWASPVV TPGSRVTFNC STSHEHMSFI LYKDGNEIAS
810 820 830 840 850
SDLAWGNPGG STAHFLIISV GIGDGGNYSC RYYDFSIWSE PSNPVELVVT
860 870 880 890 900
EFYPKPTLLA QPGPVVLPGK NVTLRCQGIF QGMRFALLQE GTHTPLQFQS
910 920 930 940 950
TSGTSADFLL HTVGAQDFGN YSCVYYETTM SNRGSSLSTP LMIWVTDTFP
960 970 980 990 1000
RPWLSAEPSS VVTMGQNVTL WCQGPVRGVG YILHKEGEAT SMQLWGSTSN
1010 1020 1030 1040 1050
EGAFPIINIS GASIGRYSCC YHPDWMSPIK IQPSNTLELI VTGLLPKPSL
1060 1070 1080 1090 1100
LVQPGPMVAP GENVTLQCQG ELPDSTFVLL KEGTRQPLEQ QRPSGYRADF
1110 1120 1130 1140 1150
WMPVVRDQDS GVYSCVYYLD SAPLVASNHS NSLEIWVTDK PPKPSLSAWP
1160 1170 1180 1190 1200
STIFKLGKDI TLQCRGPLPG VEFVLEHDGE EAPQQFSEDG DFVIDNLEGK
1210 1220 1230 1240 1250
GIGNYSCSYR LQAYPDIWSE PSDTLELVGA AGPVAQECTV GNIVRSTLIV
1260 1270 1280 1290 1300
VVVVALGIVL AVEWKKWPRL RTRGSETDGR DQTVVLEECN QEGEPGTTTN
1310
SPSSASQEVS VELTVPI
Note: Produced by alternative promoter usage.
Length:1,317
Mass (Da):147,010
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i09D1E7A89ADCB04D
GO
Isoform 2 (identifier: Q7TQA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     865-1156: Missing.

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:1,025
Mass (Da):114,958
Checksum:i31356E87AAFAE992
GO
Isoform 3 (identifier: Q7TQA1-3) [UniParc]FASTAAdd to basket
Also known as: InhBP-3

The sequence of this isoform differs from the canonical sequence as follows:
     755-762: EMYPKPFF → DGRTKAQN
     763-1317: Missing.

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:762
Mass (Da):86,395
Checksum:iE83752668D596F82
GO
Isoform 4 (identifier: Q7TQA1-4) [UniParc]FASTAAdd to basket
Also known as: InhBP-S, short

The sequence of this isoform differs from the canonical sequence as follows:
     214-232: LYPKPTLTAHPGPILAPGE → GCGHGCWHLTIVIPGIMAG
     233-1317: Missing.

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:232
Mass (Da):26,331
Checksum:iE34ABA3305FFB65E
GO
Isoform 5 (identifier: Q7TQA1-5) [UniParc]FASTAAdd to basket
Also known as: InhBP-4, variant 4

The sequence of this isoform differs from the canonical sequence as follows:
     1-542: Missing.

Note: Produced by alternative promoter usage.Curated
Show »
Length:775
Mass (Da):85,159
Checksum:i26E89EB2AD2CB07C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC97936 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti277K → E in AAP57081 (PubMed:12832474).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0311981 – 542Missing in isoform 5. 1 PublicationAdd BLAST542
Alternative sequenceiVSP_031199214 – 232LYPKP…LAPGE → GCGHGCWHLTIVIPGIMAG in isoform 4. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_031200233 – 1317Missing in isoform 4. 2 PublicationsAdd BLAST1085
Alternative sequenceiVSP_031201755 – 762EMYPKPFF → DGRTKAQN in isoform 3. 1 Publication8
Alternative sequenceiVSP_031202763 – 1317Missing in isoform 3. 1 PublicationAdd BLAST555
Alternative sequenceiVSP_031203865 – 1156Missing in isoform 2. 1 PublicationAdd BLAST292

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY227771 mRNA Translation: AAP57079.1
AY227772 mRNA Translation: AAP57080.1
AY227773 mRNA Translation: AAP57081.1
AY227774 mRNA Translation: AAP57082.1
AK129126 mRNA Translation: BAC97936.1 Different initiation.
AK030452 mRNA Translation: BAC26969.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40964.1 [Q7TQA1-1]
CCDS40965.1 [Q7TQA1-5]
CCDS40966.1 [Q7TQA1-3]
CCDS40967.1 [Q7TQA1-4]

NCBI Reference Sequences

More...
RefSeqi
NP_808259.2, NM_177591.4 [Q7TQA1-1]
NP_808583.1, NM_177915.4 [Q7TQA1-4]
NP_899178.2, NM_183335.2 [Q7TQA1-3]
NP_899179.1, NM_183336.2 [Q7TQA1-5]
XP_006541550.1, XM_006541487.2 [Q7TQA1-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000033442; ENSMUSP00000033442; ENSMUSG00000031111 [Q7TQA1-1]
ENSMUST00000072037; ENSMUSP00000071919; ENSMUSG00000031111 [Q7TQA1-3]
ENSMUST00000114891; ENSMUSP00000110541; ENSMUSG00000031111 [Q7TQA1-4]
ENSMUST00000114893; ENSMUSP00000110543; ENSMUSG00000031111 [Q7TQA1-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
209268

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:209268

UCSC genome browser

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UCSCi
uc009tdg.2, mouse [Q7TQA1-1]
uc009tdi.1, mouse [Q7TQA1-3]
uc009tdj.2, mouse [Q7TQA1-4]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227771 mRNA Translation: AAP57079.1
AY227772 mRNA Translation: AAP57080.1
AY227773 mRNA Translation: AAP57081.1
AY227774 mRNA Translation: AAP57082.1
AK129126 mRNA Translation: BAC97936.1 Different initiation.
AK030452 mRNA Translation: BAC26969.1
CCDSiCCDS40964.1 [Q7TQA1-1]
CCDS40965.1 [Q7TQA1-5]
CCDS40966.1 [Q7TQA1-3]
CCDS40967.1 [Q7TQA1-4]
RefSeqiNP_808259.2, NM_177591.4 [Q7TQA1-1]
NP_808583.1, NM_177915.4 [Q7TQA1-4]
NP_899178.2, NM_183335.2 [Q7TQA1-3]
NP_899179.1, NM_183336.2 [Q7TQA1-5]
XP_006541550.1, XM_006541487.2 [Q7TQA1-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033442

PTM databases

GlyConnecti2381, 1 N-Linked glycan (3 sites)
GlyGeniQ7TQA1, 8 sites
iPTMnetiQ7TQA1
PhosphoSitePlusiQ7TQA1

Proteomic databases

PaxDbiQ7TQA1
PRIDEiQ7TQA1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
16308, 188 antibodies

Genome annotation databases

EnsembliENSMUST00000033442; ENSMUSP00000033442; ENSMUSG00000031111 [Q7TQA1-1]
ENSMUST00000072037; ENSMUSP00000071919; ENSMUSG00000031111 [Q7TQA1-3]
ENSMUST00000114891; ENSMUSP00000110541; ENSMUSG00000031111 [Q7TQA1-4]
ENSMUST00000114893; ENSMUSP00000110543; ENSMUSG00000031111 [Q7TQA1-5]
GeneIDi209268
KEGGimmu:209268
UCSCiuc009tdg.2, mouse [Q7TQA1-1]
uc009tdi.1, mouse [Q7TQA1-3]
uc009tdj.2, mouse [Q7TQA1-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3547
MGIiMGI:2147913, Igsf1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG502RYEX, Eukaryota
GeneTreeiENSGT00980000198504
HOGENOMiCLU_006143_0_0_1
InParanoidiQ7TQA1
OMAiGCWHLAI
OrthoDBi1327293at2759
PhylomeDBiQ7TQA1
TreeFamiTF336644

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
209268, 0 hits in 15 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Igsf1, mouse

Protein Ontology

More...
PROi
PR:Q7TQA1
RNActiQ7TQA1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031111, Expressed in pituitary gland and 175 other tissues
GenevisibleiQ7TQA1, MM

Family and domain databases

Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
PfamiView protein in Pfam
PF13895, Ig_2, 4 hits
SMARTiView protein in SMART
SM00409, IG, 11 hits
SM00408, IGc2, 6 hits
SUPFAMiSSF48726, SSF48726, 12 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGSF1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TQA1
Secondary accession number(s): Q6ZQD0
, Q7TQ99, Q7TQA0, Q8BMN5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: December 2, 2020
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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