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Protein

Transmembrane channel-like protein 3

Gene

Tmc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable ion channel.By similarity

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Protein family/group databases

TCDBi1.A.17.4.12 the calcium-dependent chloride channel (ca-clc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane channel-like protein 3
Gene namesi
Name:Tmc3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2669033 Tmc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 148CytoplasmicSequence analysisAdd BLAST148
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 192ExtracellularSequence analysisAdd BLAST23
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 225CytoplasmicSequence analysisAdd BLAST12
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 319ExtracellularSequence analysisAdd BLAST73
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 361CytoplasmicSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 393ExtracellularSequence analysisAdd BLAST11
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
Topological domaini415 – 509CytoplasmicSequence analysisAdd BLAST95
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Topological domaini531 – 570ExtracellularSequence analysisAdd BLAST40
Transmembranei571 – 591HelicalSequence analysisAdd BLAST21
Topological domaini592 – 619CytoplasmicSequence analysisAdd BLAST28
Transmembranei620 – 640HelicalSequence analysisAdd BLAST21
Topological domaini641 – 680ExtracellularSequence analysisAdd BLAST40
Transmembranei681 – 701HelicalSequence analysisAdd BLAST21
Topological domaini702 – 1130CytoplasmicSequence analysisAdd BLAST429

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002596031 – 1130Transmembrane channel-like protein 3Add BLAST1130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7TQ69
PRIDEiQ7TQ69

PTM databases

iPTMnetiQ7TQ69
PhosphoSitePlusiQ7TQ69

Expressioni

Tissue specificityi

Detected in most neuronal organs and also in some non-neuronal tissues.1 Publication

Gene expression databases

CleanExiMM_TMC3

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046028

Family & Domainsi

Sequence similaritiesi

Belongs to the TMC family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF2J Eukaryota
ENOG410XTGF LUCA
HOGENOMiHOG000168231
HOVERGENiHBG036209
InParanoidiQ7TQ69
KOiK21988
PhylomeDBiQ7TQ69

Family and domain databases

InterProiView protein in InterPro
IPR038900 TMC
IPR012496 TMC_dom
PANTHERiPTHR23302 PTHR23302, 1 hit
PfamiView protein in Pfam
PF07810 TMC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q7TQ69-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKTSKASQRY RSIRRNASQC YLYQDSLLLG NSDDSFNADE TGDSSDPEQI
60 70 80 90 100
FQNIQFQKDL MANIRCRPWT MGQKLRALRR AKEIVLKFEG RLTRTRGYQA
110 120 130 140 150
AGAELWRKFA RLACNFVVIF IPWEMRIKKI ESHFGSGVAS YFIFLRWLFG
160 170 180 190 200
INIVLTVMTG AFVVLPELIA GQPFGSTASK TIPREQITSA QDLDTVWSLG
210 220 230 240 250
GYLQYSVLFY GYYGRERRIG RAGYRLPLAY FLVGMAVFAY SFIVLLKRMA
260 270 280 290 300
KNSRTSLASA SNENYTFCWR VFCAWDYLIG NPEAAESKTA AILNSIREAI
310 320 330 340 350
LEEQEKKKNK NMAVTVCLRI IANILVLLSL AGSIYLIYFV VDRSQKLEQS
360 370 380 390 400
KKELTLWEKN EVSVVVSLVT MLAPSAFDLI AALEMYHPRT TLRFQLARVL
410 420 430 440 450
VLYLGNLYSL IIALLDKVNS MNIEEAATKN ITSHWADAPT FSATRTVPEE
460 470 480 490 500
GQWPTPGSGA ELRRNTSTWV VEETSFLTSI TPHTKANKTV PYMQGPQGQC
510 520 530 540 550
WETYVGQEML KLSVIDMLFT VASILLIDFF RGLFVRYLSD YWCWDLESKF
560 570 580 590 600
PEYGEFKIAE NVLHLVYNQG MIWMGAFFSP CLPAFNVLKL IGLMYLRSWA
610 620 630 640 650
VLTCNVPHQQ VFRASRSNNF YLAMLLFMLF LCMLPTIFAI VHYKPSLNCG
660 670 680 690 700
PFSGQEKIYD IVSETIENDF PTWFHAVVGH ISSPVVILPA VLLLFMLIYY
710 720 730 740 750
LQSIARSLKL SSQQLRMQIQ NARSEDKKKV AQMVEALAIP SDARQAGSAT
760 770 780 790 800
EAESSENSKP KTLQARIQTH EESSKRLLKD SDLISQLSSV YMATSPNNGH
810 820 830 840 850
MLNFDSLSSK SLRMEAITRS LPQSPGQGSR DPCSPLLDGS RSRPEQDTNR
860 870 880 890 900
HPHRPCSSTS NLHKNRSCSS VTQTQPLKDV RSEPLSRKDF QPISPPFCGS
910 920 930 940 950
GVSTLMTHDH SPRAPRYYVV NERDSHKKTH RAFWPERHFK IDALGDIVEL
960 970 980 990 1000
YPRNVQQYMS WVPNQPCSPQ LSEEEEEMLR RDLVQWSIPA SSLTDLPRSS
1010 1020 1030 1040 1050
CFYTGDRSEN NTRDPKYQRR VYYRSGDNSF EDQLERPTFV HRKPRSRNGQ
1060 1070 1080 1090 1100
YPQHALKARV KAKFEPSFTE SDSVSAASSS DHQNSNNDQY LHVMSSQGRF
1110 1120 1130
PRSASQLGRR KAKSRQVLPT DLNDLICSNV
Length:1,130
Mass (Da):128,691
Last modified:October 1, 2003 - v1
Checksum:i9FE2B2D4FD501FE1
GO
Isoform 21 Publication (identifier: Q7TQ69-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     723-725: RSE → SII
     726-1130: Missing.

Show »
Length:725
Mass (Da):82,735
Checksum:i8660A3021427E0E9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VQI4F8VQI4_MOUSE
Transmembrane channel-like protein
Tmc3
1,130Annotation score:
E9Q6Y0E9Q6Y0_MOUSE
Transmembrane channel-like protein
Tmc3
1,101Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti248R → K in AAP69869 (PubMed:12906855).Curated1
Sequence conflicti551P → L in AAP69869 (PubMed:12906855).Curated1
Sequence conflicti695Missing in AAP69869 (PubMed:12906855).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052203723 – 725RSE → SII in isoform 2. 1 Publication3
Alternative sequenceiVSP_052204726 – 1130Missing in isoform 2. 1 PublicationAdd BLAST405

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY263157 mRNA Translation: AAP78772.1
AY236491 mRNA Translation: AAP69869.1
CCDSiCCDS40012.1 [Q7TQ69-1]
RefSeqiNP_808363.3, NM_177695.4
UniGeneiMm.486619

Genome annotation databases

GeneIDi233424
KEGGimmu:233424

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY263157 mRNA Translation: AAP78772.1
AY236491 mRNA Translation: AAP69869.1
CCDSiCCDS40012.1 [Q7TQ69-1]
RefSeqiNP_808363.3, NM_177695.4
UniGeneiMm.486619

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046028

Protein family/group databases

TCDBi1.A.17.4.12 the calcium-dependent chloride channel (ca-clc) family

PTM databases

iPTMnetiQ7TQ69
PhosphoSitePlusiQ7TQ69

Proteomic databases

PaxDbiQ7TQ69
PRIDEiQ7TQ69

Protocols and materials databases

DNASUi233424
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi233424
KEGGimmu:233424

Organism-specific databases

CTDi342125
MGIiMGI:2669033 Tmc3

Phylogenomic databases

eggNOGiENOG410IF2J Eukaryota
ENOG410XTGF LUCA
HOGENOMiHOG000168231
HOVERGENiHBG036209
InParanoidiQ7TQ69
KOiK21988
PhylomeDBiQ7TQ69

Miscellaneous databases

PROiPR:Q7TQ69
SOURCEiSearch...

Gene expression databases

CleanExiMM_TMC3

Family and domain databases

InterProiView protein in InterPro
IPR038900 TMC
IPR012496 TMC_dom
PANTHERiPTHR23302 PTHR23302, 1 hit
PfamiView protein in Pfam
PF07810 TMC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMC3_MOUSE
AccessioniPrimary (citable) accession number: Q7TQ69
Secondary accession number(s): Q7TN63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2003
Last modified: July 18, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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