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Entry version 75 (08 May 2019)
Sequence version 1 (01 Oct 2003)
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Protein

Transmembrane channel-like protein 3

Gene

Tmc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable ion channel.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.17.4.12 the calcium-dependent chloride channel (ca-clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane channel-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tmc3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2669033 Tmc3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 148CytoplasmicSequence analysisAdd BLAST148
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 192ExtracellularSequence analysisAdd BLAST23
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 225CytoplasmicSequence analysisAdd BLAST12
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 319ExtracellularSequence analysisAdd BLAST73
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 361CytoplasmicSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 393ExtracellularSequence analysisAdd BLAST11
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
Topological domaini415 – 509CytoplasmicSequence analysisAdd BLAST95
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Topological domaini531 – 570ExtracellularSequence analysisAdd BLAST40
Transmembranei571 – 591HelicalSequence analysisAdd BLAST21
Topological domaini592 – 619CytoplasmicSequence analysisAdd BLAST28
Transmembranei620 – 640HelicalSequence analysisAdd BLAST21
Topological domaini641 – 680ExtracellularSequence analysisAdd BLAST40
Transmembranei681 – 701HelicalSequence analysisAdd BLAST21
Topological domaini702 – 1130CytoplasmicSequence analysisAdd BLAST429

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002596031 – 1130Transmembrane channel-like protein 3Add BLAST1130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TQ69

PRoteomics IDEntifications database

More...
PRIDEi
Q7TQ69

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TQ69

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TQ69

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in most neuronal organs and also in some non-neuronal tissues.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000046028

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMC family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF2J Eukaryota
ENOG410XTGF LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168231

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TQ69

KEGG Orthology (KO)

More...
KOi
K21988

Database of Orthologous Groups

More...
OrthoDBi
1048914at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7TQ69

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038900 TMC
IPR012496 TMC_dom

The PANTHER Classification System

More...
PANTHERi
PTHR23302 PTHR23302, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07810 TMC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q7TQ69-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKTSKASQRY RSIRRNASQC YLYQDSLLLG NSDDSFNADE TGDSSDPEQI
60 70 80 90 100
FQNIQFQKDL MANIRCRPWT MGQKLRALRR AKEIVLKFEG RLTRTRGYQA
110 120 130 140 150
AGAELWRKFA RLACNFVVIF IPWEMRIKKI ESHFGSGVAS YFIFLRWLFG
160 170 180 190 200
INIVLTVMTG AFVVLPELIA GQPFGSTASK TIPREQITSA QDLDTVWSLG
210 220 230 240 250
GYLQYSVLFY GYYGRERRIG RAGYRLPLAY FLVGMAVFAY SFIVLLKRMA
260 270 280 290 300
KNSRTSLASA SNENYTFCWR VFCAWDYLIG NPEAAESKTA AILNSIREAI
310 320 330 340 350
LEEQEKKKNK NMAVTVCLRI IANILVLLSL AGSIYLIYFV VDRSQKLEQS
360 370 380 390 400
KKELTLWEKN EVSVVVSLVT MLAPSAFDLI AALEMYHPRT TLRFQLARVL
410 420 430 440 450
VLYLGNLYSL IIALLDKVNS MNIEEAATKN ITSHWADAPT FSATRTVPEE
460 470 480 490 500
GQWPTPGSGA ELRRNTSTWV VEETSFLTSI TPHTKANKTV PYMQGPQGQC
510 520 530 540 550
WETYVGQEML KLSVIDMLFT VASILLIDFF RGLFVRYLSD YWCWDLESKF
560 570 580 590 600
PEYGEFKIAE NVLHLVYNQG MIWMGAFFSP CLPAFNVLKL IGLMYLRSWA
610 620 630 640 650
VLTCNVPHQQ VFRASRSNNF YLAMLLFMLF LCMLPTIFAI VHYKPSLNCG
660 670 680 690 700
PFSGQEKIYD IVSETIENDF PTWFHAVVGH ISSPVVILPA VLLLFMLIYY
710 720 730 740 750
LQSIARSLKL SSQQLRMQIQ NARSEDKKKV AQMVEALAIP SDARQAGSAT
760 770 780 790 800
EAESSENSKP KTLQARIQTH EESSKRLLKD SDLISQLSSV YMATSPNNGH
810 820 830 840 850
MLNFDSLSSK SLRMEAITRS LPQSPGQGSR DPCSPLLDGS RSRPEQDTNR
860 870 880 890 900
HPHRPCSSTS NLHKNRSCSS VTQTQPLKDV RSEPLSRKDF QPISPPFCGS
910 920 930 940 950
GVSTLMTHDH SPRAPRYYVV NERDSHKKTH RAFWPERHFK IDALGDIVEL
960 970 980 990 1000
YPRNVQQYMS WVPNQPCSPQ LSEEEEEMLR RDLVQWSIPA SSLTDLPRSS
1010 1020 1030 1040 1050
CFYTGDRSEN NTRDPKYQRR VYYRSGDNSF EDQLERPTFV HRKPRSRNGQ
1060 1070 1080 1090 1100
YPQHALKARV KAKFEPSFTE SDSVSAASSS DHQNSNNDQY LHVMSSQGRF
1110 1120 1130
PRSASQLGRR KAKSRQVLPT DLNDLICSNV
Length:1,130
Mass (Da):128,691
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FE2B2D4FD501FE1
GO
Isoform 21 Publication (identifier: Q7TQ69-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     723-725: RSE → SII
     726-1130: Missing.

Show »
Length:725
Mass (Da):82,735
Checksum:i8660A3021427E0E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VQI4F8VQI4_MOUSE
Transmembrane channel-like protein
Tmc3
1,130Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q6Y0E9Q6Y0_MOUSE
Transmembrane channel-like protein
Tmc3
1,101Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti248R → K in AAP69869 (PubMed:12906855).Curated1
Sequence conflicti551P → L in AAP69869 (PubMed:12906855).Curated1
Sequence conflicti695Missing in AAP69869 (PubMed:12906855).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052203723 – 725RSE → SII in isoform 2. 1 Publication3
Alternative sequenceiVSP_052204726 – 1130Missing in isoform 2. 1 PublicationAdd BLAST405

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY263157 mRNA Translation: AAP78772.1
AY236491 mRNA Translation: AAP69869.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40012.1 [Q7TQ69-1]

NCBI Reference Sequences

More...
RefSeqi
NP_808363.3, NM_177695.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
233424

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:233424

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY263157 mRNA Translation: AAP78772.1
AY236491 mRNA Translation: AAP69869.1
CCDSiCCDS40012.1 [Q7TQ69-1]
RefSeqiNP_808363.3, NM_177695.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046028

Protein family/group databases

TCDBi1.A.17.4.12 the calcium-dependent chloride channel (ca-clc) family

PTM databases

iPTMnetiQ7TQ69
PhosphoSitePlusiQ7TQ69

Proteomic databases

PaxDbiQ7TQ69
PRIDEiQ7TQ69

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
233424
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi233424
KEGGimmu:233424

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
342125
MGIiMGI:2669033 Tmc3

Phylogenomic databases

eggNOGiENOG410IF2J Eukaryota
ENOG410XTGF LUCA
HOGENOMiHOG000168231
InParanoidiQ7TQ69
KOiK21988
OrthoDBi1048914at2759
PhylomeDBiQ7TQ69

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q7TQ69

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR038900 TMC
IPR012496 TMC_dom
PANTHERiPTHR23302 PTHR23302, 1 hit
PfamiView protein in Pfam
PF07810 TMC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMC3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TQ69
Secondary accession number(s): Q7TN63
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2003
Last modified: May 8, 2019
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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