UniProtKB - Q7TQ62 (PODN_MOUSE)
Protein
Podocan
Gene
Podn
Organism
Mus musculus (Mouse)
Status
Functioni
Negatively regulates cell proliferation and cell migration, especially in smooth muscle cells.By similarity
GO - Molecular functioni
- collagen binding Source: MGI
GO - Biological processi
- negative regulation of cell migration Source: UniProtKB
- negative regulation of cell population proliferation Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Podocan |
Gene namesi | Name:Podn |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2674939, Podn |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix 1 Publication
Extracellular region or secreted
- extracellular space Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000262525 | 24 – 611 | PodocanAdd BLAST | 588 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 215 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 282 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 411 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
CPTACi | non-CPTAC-3608 |
PaxDbi | Q7TQ62 |
PRIDEi | Q7TQ62 |
PTM databases
GlyGeni | Q7TQ62, 3 sites |
PhosphoSitePlusi | Q7TQ62 |
Expressioni
Tissue specificityi
Kidney. Expressed in podocytes and likely vascular endothelial cells within the glomerulus.1 Publication
Developmental stagei
Detected at low levels in normal embryonic kidney from embryonic day 14 through birth. Expression increases dramatically within 24 hours following birth and maximal levels coincide with the completion of morphogenesis at 2 weeks of age.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000028600, Expressed in basioccipital bone and 174 other tissues |
ExpressionAtlasi | Q7TQ62, baseline and differential |
Genevisiblei | Q7TQ62, MM |
Interactioni
Subunit structurei
Binds to type I collagen.
By similarityProtein-protein interaction databases
IntActi | Q7TQ62, 1 interactor |
STRINGi | 10090.ENSMUSP00000102320 |
Miscellaneous databases
RNActi | Q7TQ62, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 60 – 97 | LRRNTAdd BLAST | 38 | |
Repeati | 98 – 119 | LRR 1Add BLAST | 22 | |
Repeati | 122 – 145 | LRR 2Add BLAST | 24 | |
Repeati | 148 – 169 | LRR 3Add BLAST | 22 | |
Repeati | 170 – 190 | LRR 4Add BLAST | 21 | |
Repeati | 193 – 213 | LRR 5Add BLAST | 21 | |
Repeati | 219 – 239 | LRR 6Add BLAST | 21 | |
Repeati | 240 – 261 | LRR 7Add BLAST | 22 | |
Repeati | 264 – 284 | LRR 8Add BLAST | 21 | |
Repeati | 290 – 311 | LRR 9Add BLAST | 22 | |
Repeati | 312 – 332 | LRR 10Add BLAST | 21 | |
Repeati | 335 – 358 | LRR 11Add BLAST | 24 | |
Repeati | 361 – 382 | LRR 12Add BLAST | 22 | |
Repeati | 383 – 403 | LRR 13Add BLAST | 21 | |
Repeati | 406 – 427 | LRR 14Add BLAST | 22 | |
Repeati | 432 – 453 | LRR 15Add BLAST | 22 | |
Repeati | 477 – 490 | LRR 16Add BLAST | 14 | |
Repeati | 503 – 523 | LRR 17Add BLAST | 21 | |
Repeati | 524 – 545 | LRR 18Add BLAST | 22 | |
Repeati | 548 – 569 | LRR 19Add BLAST | 22 | |
Repeati | 574 – 583 | LRR 20 | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 595 – 609 | Glu-richAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, Repeat, SignalPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000160740 |
HOGENOMi | CLU_000288_186_3_1 |
InParanoidi | Q7TQ62 |
OMAi | TINCPRD |
OrthoDBi | 826997at2759 |
PhylomeDBi | Q7TQ62 |
TreeFami | TF336377 |
Family and domain databases
Gene3Di | 3.80.10.10, 5 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR026906, LRR_5 IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF13306, LRR_5, 1 hit PF13855, LRR_8, 4 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 13 hits SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 17 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7TQ62-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGSRGLPLL LLVLQLFLGP VLPVRAPVFG RSDTPTLSPE ENEFVEEENQ
60 70 80 90 100
PVLVLSSEEP EPGPATVDCP RDCACSQEGV VDCGGIDLRE FPGDLPEHTN
110 120 130 140 150
HLSLQNNQLE KIYPEELSRL QRLETLNLQN NRLTSRGLPE EAFEHLTSLN
160 170 180 190 200
YLYLANNKLT LAPRFLPNAL ISVDFAANYL TKIYGLTFGQ KPNLRSVYLH
210 220 230 240 250
NNKLADAGLP DHMFNGSSNV EILILSSNFL RHVPKHLPPA LYKLHLKNNK
260 270 280 290 300
LEKIPPGAFS ELSNLRELYL QNNYLTDEGL DNETFWKLSS LEYLDLSSNN
310 320 330 340 350
LSRVPAGLPR SLVLLHLEKN AIQSVEADVL TPIRNLEYLL LHSNQLQAKG
360 370 380 390 400
IHPLAFQGLK KLHTVHLYNN ALERVPSGLP RRVRTLMILH NQITGIGRED
410 420 430 440 450
FATTYFLEEL NLSYNRITSP QMHRDAFRKL RLLRSLDLSG NRLQTLPPGL
460 470 480 490 500
PKNVHVLKVK RNELAALARG ALAGMAQLRE LYLTGNRLRS RALGPRAWVD
510 520 530 540 550
LAGLQLLDIA GNQLTEVPEG LPPSLEYLYL QNNKISAVPA NAFDSTPNLK
560 570 580 590 600
GIFLRFNKLA VGSVVESAFR RLKHLQVLDI EGNFEFGNGS KDKDEEEEEE
610
EEEEDEEEET R
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6XS92 | F6XS92_MOUSE | Podocan | Podn | 205 | Annotation score: | ||
Q6P3D8 | Q6P3D8_MOUSE | Podn protein | Podn | 409 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021785 | 1 – 212 | Missing in isoform 2. 1 PublicationAdd BLAST | 212 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY313606 mRNA Translation: AAP79897.1 AK034987 mRNA Translation: BAC28904.1 AL611936 Genomic DNA No translation available. CH466527 Genomic DNA Translation: EDL30756.1 CH466527 Genomic DNA Translation: EDL30757.1 BC094340 mRNA Translation: AAH94340.1 |
CCDSi | CCDS18445.1 [Q7TQ62-1] |
RefSeqi | NP_001272885.1, NM_001285956.1 [Q7TQ62-1] NP_001272887.1, NM_001285958.1 [Q7TQ62-1] NP_766462.2, NM_172874.3 [Q7TQ62-1] XP_006503155.1, XM_006503092.3 [Q7TQ62-1] XP_011238834.1, XM_011240532.1 [Q7TQ62-2] XP_011238835.1, XM_011240533.1 XP_011238836.1, XM_011240534.1 [Q7TQ62-2] |
Genome annotation databases
Ensembli | ENSMUST00000044248; ENSMUSP00000048962; ENSMUSG00000028600 [Q7TQ62-1] ENSMUST00000106708; ENSMUSP00000102319; ENSMUSG00000028600 [Q7TQ62-1] ENSMUST00000106709; ENSMUSP00000102320; ENSMUSG00000028600 [Q7TQ62-1] |
GeneIDi | 242608 |
KEGGi | mmu:242608 |
UCSCi | uc008uaq.1, mouse [Q7TQ62-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY313606 mRNA Translation: AAP79897.1 AK034987 mRNA Translation: BAC28904.1 AL611936 Genomic DNA No translation available. CH466527 Genomic DNA Translation: EDL30756.1 CH466527 Genomic DNA Translation: EDL30757.1 BC094340 mRNA Translation: AAH94340.1 |
CCDSi | CCDS18445.1 [Q7TQ62-1] |
RefSeqi | NP_001272885.1, NM_001285956.1 [Q7TQ62-1] NP_001272887.1, NM_001285958.1 [Q7TQ62-1] NP_766462.2, NM_172874.3 [Q7TQ62-1] XP_006503155.1, XM_006503092.3 [Q7TQ62-1] XP_011238834.1, XM_011240532.1 [Q7TQ62-2] XP_011238835.1, XM_011240533.1 XP_011238836.1, XM_011240534.1 [Q7TQ62-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q7TQ62, 1 interactor |
STRINGi | 10090.ENSMUSP00000102320 |
PTM databases
GlyGeni | Q7TQ62, 3 sites |
PhosphoSitePlusi | Q7TQ62 |
Proteomic databases
CPTACi | non-CPTAC-3608 |
PaxDbi | Q7TQ62 |
PRIDEi | Q7TQ62 |
Protocols and materials databases
Antibodypediai | 2151, 114 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000044248; ENSMUSP00000048962; ENSMUSG00000028600 [Q7TQ62-1] ENSMUST00000106708; ENSMUSP00000102319; ENSMUSG00000028600 [Q7TQ62-1] ENSMUST00000106709; ENSMUSP00000102320; ENSMUSG00000028600 [Q7TQ62-1] |
GeneIDi | 242608 |
KEGGi | mmu:242608 |
UCSCi | uc008uaq.1, mouse [Q7TQ62-1] |
Organism-specific databases
CTDi | 127435 |
MGIi | MGI:2674939, Podn |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000160740 |
HOGENOMi | CLU_000288_186_3_1 |
InParanoidi | Q7TQ62 |
OMAi | TINCPRD |
OrthoDBi | 826997at2759 |
PhylomeDBi | Q7TQ62 |
TreeFami | TF336377 |
Miscellaneous databases
BioGRID-ORCSi | 242608, 0 hits in 17 CRISPR screens |
ChiTaRSi | Podn, mouse |
PROi | PR:Q7TQ62 |
RNActi | Q7TQ62, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028600, Expressed in basioccipital bone and 174 other tissues |
ExpressionAtlasi | Q7TQ62, baseline and differential |
Genevisiblei | Q7TQ62, MM |
Family and domain databases
Gene3Di | 3.80.10.10, 5 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR026906, LRR_5 IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF13306, LRR_5, 1 hit PF13855, LRR_8, 4 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 13 hits SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 17 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PODN_MOUSE | |
Accessioni | Q7TQ62Primary (citable) accession number: Q7TQ62 Secondary accession number(s): A2A8F3, Q8BM45 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families