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UniProtKB - Q7TQ40 (ZIC5_MOUSE)
Protein
Zinc finger protein ZIC 5
Gene
Zic5
Organism
Mus musculus (Mouse)
Status
Functioni
Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 422 – 444 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 450 – 474 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 480 – 504 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 510 – 534 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cell differentiation Source: MGI
- central nervous system development Source: GO_Central
- forebrain development Source: MGI
- neural tube closure Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein ZIC 5Alternative name(s): Odd paired-related protein Short name: Opa-related protein Zinc finger protein of the cerebellum 5 |
Gene namesi | Name:Zic5 Synonyms:Opr |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1929518, Zic5 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Mice exhibited insufficient neural tube closure at the rostral end and malformation of neural-crest-derived facial bones especially the mandible. After birth, mice were significantly smaller than their littermates and most of them died within 2 months.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000406213 | 1 – 622 | Zinc finger protein ZIC 5Add BLAST | 622 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 537 | PhosphoserineCombined sources | 1 | |
Modified residuei | 541 | PhosphoserineCombined sources | 1 | |
Modified residuei | 559 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q7TQ40 |
PRIDEi | Q7TQ40 |
ProteomicsDBi | 275065 |
PTM databases
iPTMneti | Q7TQ40 |
PhosphoSitePlusi | Q7TQ40 |
Expressioni
Developmental stagei
Expressed in the embryonic ectoderm before gastrulation, and gradually restricted to the anterior part from the mid to late streak stage. Becomes restricted to the dorsal side of the neural tube at 8 dpc. After neural tube closure, is expressed in the dorsal midline of the entire neural tube and in the roof plate. Also expressed in the developing limb buds.2 Publications
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000035754 |
Miscellaneous databases
RNActi | Q7TQ40, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 50 – 171 | DisorderedSequence analysisAdd BLAST | 122 | |
Regioni | 190 – 223 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 232 – 251 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 321 – 349 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 531 – 573 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 590 – 622 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 125 – 153 | Pro residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 325 – 345 | Pro residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 590 – 608 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 422 – 444 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 450 – 474 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 480 – 504 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 510 – 534 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | Q7TQ40 |
OrthoDBi | 592023at2759 |
PhylomeDBi | Q7TQ40 |
TreeFami | TF351425 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7TQ40-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMEPPLSKRN PPALRLADLA TAQAQQLQNM TGFPVLVGPP AHSQRRAVAM
60 70 80 90 100
HLHPRDLGTD PGVASTALGP EHMAQASGQG PCPPSQGLPG LFQVPAPAAR
110 120 130 140 150
SVASGTHPGA RTHPDGGGSS GAQASAPPPP APPLPPSQSS SPPPPPPPPP
160 170 180 190 200
ALSGYTATNS GGGSSSGKGH SRDFVLRRDL SATAPAAAMH GAPLGGEQRS
210 220 230 240 250
GSSSPQHPTP PPHPAGMFIS ASGTYAGRDG GGSALFPALH DSPGAPGGHP
260 270 280 290 300
LNGQMRLGLA AAAAAAAELY GRAEPPFAPR SGDAHYGAVA AAAAAALHGY
310 320 330 340 350
GAVNLNLNLA AAAAAAAAAG PGPHLQHHAP PPAPPPAPAP HPHHPHLPGA
360 370 380 390 400
AGAFLRYMRQ PIKRELICKW LDPEELAGPP ASADSGVKPC SKTFGTMHEL
410 420 430 440 450
VNHVTVEHVG GPEQSSHVCF WEDCPREGKP FKAKYKLINH IRVHTGEKPF
460 470 480 490 500
PCPFPGCGKV FARSENLKIH KRTHTGEKPF KCEFDGCDRK FANSSDRKKH
510 520 530 540 550
SHVHTSDKPY YCKIRGCDKS YTHPSSLRKH MKIHCKSPPP SPGALGYSSV
560 570 580 590 600
GTPVGDPLSP VLDPTRSRSS TLSPQVTNLN EWYVCQASGA PSHLHTPSSN
610 620
GTTSESEDEE MYGNPEVMRT IH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J0E2 | A0A0R4J0E2_MOUSE | Zinc finger protein ZIC 5 | Zic5 | 622 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 92 | F → S in BAB18579 (PubMed:11044622).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB042155 mRNA Translation: BAB18579.1 AB114214 mRNA Translation: BAC79075.1 |
CCDSi | CCDS27348.1 |
RefSeqi | NP_075363.1, NM_022987.3 |
Genome annotation databases
GeneIDi | 65100 |
KEGGi | mmu:65100 |
UCSCi | uc007vbb.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB042155 mRNA Translation: BAB18579.1 AB114214 mRNA Translation: BAC79075.1 |
CCDSi | CCDS27348.1 |
RefSeqi | NP_075363.1, NM_022987.3 |
3D structure databases
SMRi | Q7TQ40 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000035754 |
PTM databases
iPTMneti | Q7TQ40 |
PhosphoSitePlusi | Q7TQ40 |
Proteomic databases
PaxDbi | Q7TQ40 |
PRIDEi | Q7TQ40 |
ProteomicsDBi | 275065 |
Protocols and materials databases
DNASUi | 65100 |
Genome annotation databases
GeneIDi | 65100 |
KEGGi | mmu:65100 |
UCSCi | uc007vbb.2, mouse |
Organism-specific databases
CTDi | 85416 |
MGIi | MGI:1929518, Zic5 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | Q7TQ40 |
OrthoDBi | 592023at2759 |
PhylomeDBi | Q7TQ40 |
TreeFami | TF351425 |
Miscellaneous databases
BioGRID-ORCSi | 65100, 0 hits in 62 CRISPR screens |
PROi | PR:Q7TQ40 |
RNActi | Q7TQ40, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type IPR041643, Znf_ZIC |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits PF18366, zf_ZIC, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZIC5_MOUSE | |
Accessioni | Q7TQ40Primary (citable) accession number: Q7TQ40 Secondary accession number(s): Q9EQW1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 5, 2011 |
Last sequence update: | October 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families