Zic5

Functionⁱ

Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	422 – 444	C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	450 – 474	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	480 – 504	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	510 – 534	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 15465018
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15465018
metal ion binding Source: UniProtKB-KW
RNA polymerase II regulatory region sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 18298960

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15136147
forebrain development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15736266
neural tube closure
Source: MGI
Inferred from mutant phenotypeⁱ
- 15136147

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Neurogenesis
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein ZIC 5 Alternative name(s): Odd paired-related protein Short name: Opa-related protein Zinc finger protein of the cerebellum 5
Gene namesⁱ	Name:Zic5 Synonyms:Opr
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:1929518 Zic5

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice exhibited insufficient neural tube closure at the rostral end and malformation of neural-crest-derived facial bones especially the mandible. After birth, mice were significantly smaller than their littermates and most of them died within 2 months.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000406213	1 – 622	Zinc finger protein ZIC 5Add BLAST		622

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	537	PhosphoserineCombined sources	1
Modified residueⁱ	541	PhosphoserineCombined sources	1
Modified residueⁱ	559	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q7TQ40
PRIDEⁱ	Q7TQ40

PTM databases

iPTMnetⁱ	Q7TQ40
PhosphoSitePlusⁱ	Q7TQ40

Expressionⁱ

Developmental stageⁱ

Expressed in the embryonic ectoderm before gastrulation, and gradually restricted to the anterior part from the mid to late streak stage. Becomes restricted to the dorsal side of the neural tube at 8 dpc. After neural tube closure, is expressed in the dorsal midline of the entire neural tube and in the roof plate. Also expressed in the developing limb buds.2 Publications

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000035754

STRINGⁱ

10090.ENSMUSP00000035754

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7TQ40
SMRⁱ	Q7TQ40
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	81 – 150	Pro-richAdd BLAST		70
Compositional biasⁱ	260 – 353	Ala-richAdd BLAST		94

Sequence similaritiesⁱ

Belongs to the GLI C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	422 – 444	C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	450 – 474	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	480 – 504	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	510 – 534	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
HOGENOMⁱ	HOG000232057
HOVERGENⁱ	HBG007135
InParanoidⁱ	Q7TQ40
KEGG Orthology (KO) More...KOⁱ	K09226
PhylomeDBⁱ	Q7TQ40
TreeFamⁱ	TF351425

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q7TQ40-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMEPPLSKRN PPALRLADLA TAQAQQLQNM TGFPVLVGPP AHSQRRAVAM 
        60         70         80         90        100
HLHPRDLGTD PGVASTALGP EHMAQASGQG PCPPSQGLPG LFQVPAPAAR 
       110        120        130        140        150
SVASGTHPGA RTHPDGGGSS GAQASAPPPP APPLPPSQSS SPPPPPPPPP 
       160        170        180        190        200
ALSGYTATNS GGGSSSGKGH SRDFVLRRDL SATAPAAAMH GAPLGGEQRS 
       210        220        230        240        250
GSSSPQHPTP PPHPAGMFIS ASGTYAGRDG GGSALFPALH DSPGAPGGHP 
       260        270        280        290        300
LNGQMRLGLA AAAAAAAELY GRAEPPFAPR SGDAHYGAVA AAAAAALHGY 
       310        320        330        340        350
GAVNLNLNLA AAAAAAAAAG PGPHLQHHAP PPAPPPAPAP HPHHPHLPGA 
       360        370        380        390        400
AGAFLRYMRQ PIKRELICKW LDPEELAGPP ASADSGVKPC SKTFGTMHEL 
       410        420        430        440        450
VNHVTVEHVG GPEQSSHVCF WEDCPREGKP FKAKYKLINH IRVHTGEKPF 
       460        470        480        490        500
PCPFPGCGKV FARSENLKIH KRTHTGEKPF KCEFDGCDRK FANSSDRKKH 
       510        520        530        540        550
SHVHTSDKPY YCKIRGCDKS YTHPSSLRKH MKIHCKSPPP SPGALGYSSV 
       560        570        580        590        600
GTPVGDPLSP VLDPTRSRSS TLSPQVTNLN EWYVCQASGA PSHLHTPSSN 
       610        620 
GTTSESEDEE MYGNPEVMRT IH

Length:622

Mass (Da):64,542

Last modified:October 1, 2003 - v1

Checksum:ⁱE9D2B5D27DCAF640

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0R4J0E2	A0A0R4J0E2_MOUSE		Zinc finger protein ZIC 5 Zinc finger protein ZIC 5	Zic5	622	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	92	F → S in BAB18579 (PubMed:11044622).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB042155 mRNA Translation: BAB18579.1 AB114214 mRNA Translation: BAC79075.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27348.1
NCBI Reference Sequences More...RefSeqⁱ	NP_075363.1, NM_022987.3
UniGeneⁱ	Mm.390761

Genome annotation databases

GeneIDⁱ	65100
KEGGⁱ	mmu:65100
UCSC genome browser More...UCSCⁱ	uc007vbb.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7TQ40	Zinc finger protein of the cerebellum 5 (Fragment)		synthetic construct		275	UniRef100_Q7TQ40

Protein	Similar proteins		Species	Score	Length	Source
Q7TQ40	Zinc finger protein of the cerebellum 5 (Fragment)		synthetic construct		275	UniRef90_Q7TQ40
Zinc finger protein ZIC 5		MOUSE		622
Zic family member 5		RAT		265
UPI000A311A2A		MUSPA		622
UPI000A31A2A3		MUSCR		622
+2

Protein	Similar proteins		Species	Score	Length	Source
Q7TQ40	Zinc finger protein ZIC 5		HUMAN		663	UniRef50_Q7TQ40
Zinc finger protein of the cerebellum 5 (Fragment)		synthetic construct		275
Zinc finger protein ZIC 5		MOUSE		622
Zic family member 5		RAT		265
LOW QUALITY PROTEIN: zinc finger protein ZIC 5		Enhydra lutris kenyoni		773
+62

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB042155 mRNA Translation: BAB18579.1 AB114214 mRNA Translation: BAC79075.1
CCDSⁱ	CCDS27348.1
RefSeqⁱ	NP_075363.1, NM_022987.3
UniGeneⁱ	Mm.390761

3D structure databases

ProteinModelPortalⁱ	Q7TQ40
SMRⁱ	Q7TQ40
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000035754

STRINGⁱ

10090.ENSMUSP00000035754

PTM databases

iPTMnetⁱ	Q7TQ40
PhosphoSitePlusⁱ	Q7TQ40

Proteomic databases

PaxDbⁱ	Q7TQ40
PRIDEⁱ	Q7TQ40

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	65100
KEGGⁱ	mmu:65100
UCSCⁱ	uc007vbb.2 mouse

Organism-specific databases

CTDⁱ	85416
MGIⁱ	MGI:1929518 Zic5

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
HOGENOMⁱ	HOG000232057
HOVERGENⁱ	HBG007135
InParanoidⁱ	Q7TQ40
KOⁱ	K09226
PhylomeDBⁱ	Q7TQ40
TreeFamⁱ	TF351425

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q7TQ40
SOURCEⁱ	Search...

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZIC5_MOUSE
Accessionⁱ	Q7TQ40Primary (citable) accession number: Q7TQ40 Secondary accession number(s): Q9EQW1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 5, 2011
	Last sequence update:	October 1, 2003
	Last modified:	October 10, 2018
	This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7TQ40 (ZIC5_MOUSE)

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Zinc finger protein ZIC 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ