UniProtKB - Q7TPV4 (MBB1A_MOUSE)
Protein
Myb-binding protein 1A
Gene
Mybbp1a
Organism
Mus musculus (Mouse)
Status
Functioni
May activate or repress transcription via interactions with sequence specific DNA-binding proteins (PubMed:9447996, PubMed:11956195, PubMed:14744933). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (PubMed:14744933). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (PubMed:19129230). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (PubMed:19129230). Has a role in rRNA biogenesis together with PWP1 (By similarity).By similarity4 Publications
GO - Molecular functioni
- E-box binding Source: UniProtKB
- sequence-specific DNA binding Source: MGI
- transcription corepressor activity Source: UniProtKB
- transcription factor binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cellular response to glucose starvation Source: MGI
- circadian regulation of gene expression Source: UniProtKB
- intrinsic apoptotic signaling pathway by p53 class mediator Source: MGI
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of anoikis Source: MGI
- positive regulation of cell cycle arrest Source: MGI
- respiratory electron transport chain Source: MGI
- ribosome biogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, Repressor |
Biological process | Biological rhythms, Ribosome biogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-5250924, B-WICH complex positively regulates rRNA expression |
Names & Taxonomyi
Protein namesi | Recommended name: Myb-binding protein 1AAlternative name(s): Myb-binding protein of 160 kDa |
Gene namesi | Name:Mybbp1a Synonyms:P160 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106181, Mybbp1a |
Subcellular locationi
Nucleus
Other locations
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: MGI
- NLS-dependent protein nuclear import complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 249 | L → A: Reduced nuclear export; when associated with A-251. 1 Publication | 1 | |
Mutagenesisi | 251 | V → A: Reduced nuclear export; when associated with A-249. 1 Publication | 1 | |
Mutagenesisi | 272 | L → A: Reduced nuclear export; when associated with A-274. 1 Publication | 1 | |
Mutagenesisi | 274 | L → A: Reduced nuclear export; when associated with A-272. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000096256 | 2 – 1344 | Myb-binding protein 1AAdd BLAST | 1343 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 69 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 156 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 1149 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1160 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1164 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1187 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1191 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1219 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1244 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1251 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1253 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1256 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1277 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1280 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1303 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1318 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1322 | Citrulline1 Publication | 1 | |
Modified residuei | 1323 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1325 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1329 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Citrullinated by PADI4.1 Publication
Keywords - PTMi
Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q7TPV4 |
jPOSTi | Q7TPV4 |
MaxQBi | Q7TPV4 |
PaxDbi | Q7TPV4 |
PRIDEi | Q7TPV4 |
PTM databases
iPTMneti | Q7TPV4 |
PhosphoSitePlusi | Q7TPV4 |
SwissPalmi | Q7TPV4 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000040463, Expressed in embryonic post-anal tail and 329 other tissues |
ExpressionAtlasi | Q7TPV4, baseline and differential |
Genevisiblei | Q7TPV4, MM |
Interactioni
Subunit structurei
Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (By similarity). Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2.
Interacts with CLOCK and CRY1.
By similarity5 PublicationsBinary interactionsi
Q7TPV4
With | #Exp. | IntAct |
---|---|---|
Nr4a1 [P12813] | 3 | EBI-1373622,EBI-10896863 |
GO - Molecular functioni
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 201999, 38 interactors |
ComplexPortali | CPX-1133, B-WICH chromatin remodelling complex |
CORUMi | Q7TPV4 |
DIPi | DIP-39831N |
IntActi | Q7TPV4, 17 interactors |
MINTi | Q7TPV4 |
STRINGi | 10090.ENSMUSP00000044827 |
Miscellaneous databases
RNActi | Q7TPV4, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 580 | Interaction with MYB1 PublicationAdd BLAST | 579 | |
Regioni | 1152 – 1344 | Required for nuclear and nucleolar localization1 PublicationAdd BLAST | 193 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 238 – 256 | Nuclear export signal 11 PublicationAdd BLAST | 19 | |
Motifi | 261 – 279 | Nuclear export signal 21 PublicationAdd BLAST | 19 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 698 – 752 | Asp-richAdd BLAST | 55 |
Sequence similaritiesi
Belongs to the MYBBP1A family.Curated
Phylogenomic databases
eggNOGi | KOG1926, Eukaryota |
GeneTreei | ENSGT00390000017457 |
HOGENOMi | CLU_005997_1_0_1 |
InParanoidi | Q7TPV4 |
OMAi | RKWIIHR |
OrthoDBi | 86051at2759 |
PhylomeDBi | Q7TPV4 |
TreeFami | TF317401 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR007015, DNA_pol_V/MYBBP1A |
PANTHERi | PTHR13213, PTHR13213, 1 hit |
Pfami | View protein in Pfam PF04931, DNA_pol_phi, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q7TPV4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEMKSPTKA EPATPAEAAQ SDRHSLLEHS REFLDFFWDI AKPDQETRLR
60 70 80 90 100
ATEKLLEYLR TRPNDSEMKY ALKRLITGLG VGREAARPCY SLALAQLLQS
110 120 130 140 150
FEDIPLCDIL DQIQEKYSLQ AMNKAMMRPS LFANLFGVLA LFQSGRLVKD
160 170 180 190 200
KEALMKSVQL LKILSQHPNH LQGQPIKALV DILSEVPESM FQEILPKVLK
210 220 230 240 250
GNMKVILRSP KYLELFLLAK QRVPTKLESL MGSVDLFSED NIPSLVNILK
260 270 280 290 300
VAANSVKKEH KLPNVALDLL RLALKESRFE LFWKKVLEEG LLKNPSWTSS
310 320 330 340 350
YMCFRLLGAS LPLLSEEQLQ LVMRGDLIRH FGENMVISKP QNLFKIIPEI
360 370 380 390 400
STYVGTFLEG CQDDPKRQLT MMVAFTTITN QGLPVMPTFW RVTRFLNAEA
410 420 430 440 450
LQSYVAWLRD MFLQPDLNSL VDFSTANQKR AQDASLNVPE RAVFRLRKWI
460 470 480 490 500
IHRLVSLVDH LHLEKDEAVV EQIARFCLFH AFFKTKKATP QIPETKQHFS
510 520 530 540 550
FPLDDRNRGV FVSAFFSLLQ TLSVKFRQTP DLAENGKPWT YRLVQLADML
560 570 580 590 600
LNHNRNVTSV TSLTTQQRQA WDQMMSTLKE LEARSSETRA IAFQHLLLLV
610 620 630 640 650
GLHIFKSPAE SCDVLGDIQT CIKKSMEQNP RRSRSRAKAS QEPVWVEVMV
660 670 680 690 700
EILLSLLAQP SNLMRQVVRS VFGHICPHLT PRCLQLILAV LSPVTNEDED
710 720 730 740 750
DNVVVTDDAD EKQLQHGEDE DSDNEDNKNS ESDMDSEDGE ESEEEDRDKD
760 770 780 790 800
VDPGFRQQLM EVLKAGNALG GVDNEEEEEL GDEAMMALDQ NLASLFKEQK
810 820 830 840 850
MRIQARNEEK NKLQKEKKLR RDFQIRALDL IEVLVTKQPE HPLILELLEP
860 870 880 890 900
LLNVIQHSMR SKGSTKQEQD LLHKTARIFM HHLCRARRYC HEVGPCAEAL
910 920 930 940 950
HAQVERLVQQ AGSQADASVA LYYFNASLYL LRVLKGNTNK RHQDGHKLHG
960 970 980 990 1000
ADTEDSEDQA ANCLDLDFVT RVYSASLESL LTKRNSSLTV PMFLSLFSRY
1010 1020 1030 1040 1050
PVICKNLLPV LAQHVAGPSR PRHQAQACLM LQKTLSAREL RVCFEDPEWE
1060 1070 1080 1090 1100
QLITQLLGKA TQTLQTLGEA QSKGEHQKEL SILELLNTLL RTVNHEKLSV
1110 1120 1130 1140 1150
DLTAPLGVLQ SKQQKLQQSL QQGNHSSGSN RLYDLYWQAM RMLGVQRPKS
1160 1170 1180 1190 1200
EKKNAKDIPS DTQSPVSTKR KKKGFLPETK KRKKLKSEGT TPEKNAASQQ
1210 1220 1230 1240 1250
DAVTEGAMPA ATGKDQPPST GKKKRKRVKA STPSQVNGIT GAKSPAPSNP
1260 1270 1280 1290 1300
TLSPSTPAKT PKLQKKKEKL SQVNGATPVS PIEPESKKHH QEALSTKEVI
1310 1320 1330 1340
RKSPHPQSAL PKKRARLSLV SRSPSLLQSG VKKRRVASRR VQTP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 87 | R → T in AAC39954 (PubMed:9447996).Curated | 1 | |
Sequence conflicti | 87 | R → T in AAL83748 (Ref. 2) Curated | 1 | |
Sequence conflicti | 88 | P → A in AAC39954 (PubMed:9447996).Curated | 1 | |
Sequence conflicti | 505 – 508 | DRNR → HASG in AAH04078 (PubMed:15489334).Curated | 4 | |
Sequence conflicti | 1282 | I → V in AAH52889 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U63648 mRNA Translation: AAC39954.1 AF345640 Genomic DNA Translation: AAL83748.1 AL662812 Genomic DNA No translation available. BC004078 mRNA Translation: AAH04078.1 BC048858 mRNA Translation: AAH48858.1 BC052889 mRNA Translation: AAH52889.1 |
CCDSi | CCDS24986.1 |
PIRi | T34188 |
RefSeqi | NP_058056.2, NM_016776.2 |
Genome annotation databases
Ensembli | ENSMUST00000045633; ENSMUSP00000044827; ENSMUSG00000040463 |
GeneIDi | 18432 |
KEGGi | mmu:18432 |
UCSCi | uc007jyy.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U63648 mRNA Translation: AAC39954.1 AF345640 Genomic DNA Translation: AAL83748.1 AL662812 Genomic DNA No translation available. BC004078 mRNA Translation: AAH04078.1 BC048858 mRNA Translation: AAH48858.1 BC052889 mRNA Translation: AAH52889.1 |
CCDSi | CCDS24986.1 |
PIRi | T34188 |
RefSeqi | NP_058056.2, NM_016776.2 |
3D structure databases
SMRi | Q7TPV4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201999, 38 interactors |
ComplexPortali | CPX-1133, B-WICH chromatin remodelling complex |
CORUMi | Q7TPV4 |
DIPi | DIP-39831N |
IntActi | Q7TPV4, 17 interactors |
MINTi | Q7TPV4 |
STRINGi | 10090.ENSMUSP00000044827 |
PTM databases
iPTMneti | Q7TPV4 |
PhosphoSitePlusi | Q7TPV4 |
SwissPalmi | Q7TPV4 |
Proteomic databases
EPDi | Q7TPV4 |
jPOSTi | Q7TPV4 |
MaxQBi | Q7TPV4 |
PaxDbi | Q7TPV4 |
PRIDEi | Q7TPV4 |
Protocols and materials databases
Antibodypediai | 23280, 246 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000045633; ENSMUSP00000044827; ENSMUSG00000040463 |
GeneIDi | 18432 |
KEGGi | mmu:18432 |
UCSCi | uc007jyy.1, mouse |
Organism-specific databases
CTDi | 10514 |
MGIi | MGI:106181, Mybbp1a |
Phylogenomic databases
eggNOGi | KOG1926, Eukaryota |
GeneTreei | ENSGT00390000017457 |
HOGENOMi | CLU_005997_1_0_1 |
InParanoidi | Q7TPV4 |
OMAi | RKWIIHR |
OrthoDBi | 86051at2759 |
PhylomeDBi | Q7TPV4 |
TreeFami | TF317401 |
Enzyme and pathway databases
Reactomei | R-MMU-5250924, B-WICH complex positively regulates rRNA expression |
Miscellaneous databases
BioGRID-ORCSi | 18432, 9 hits in 18 CRISPR screens |
ChiTaRSi | Mybbp1a, mouse |
PROi | PR:Q7TPV4 |
RNActi | Q7TPV4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040463, Expressed in embryonic post-anal tail and 329 other tissues |
ExpressionAtlasi | Q7TPV4, baseline and differential |
Genevisiblei | Q7TPV4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR007015, DNA_pol_V/MYBBP1A |
PANTHERi | PTHR13213, PTHR13213, 1 hit |
Pfami | View protein in Pfam PF04931, DNA_pol_phi, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MBB1A_MOUSE | |
Accessioni | Q7TPV4Primary (citable) accession number: Q7TPV4 Secondary accession number(s): O35851 Q99KP0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families