Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 139 (16 Oct 2019)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

E3 ubiquitin-protein ligase SHPRH

Gene

Shprh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi368 – 375ATPPROSITE-ProRule annotation8
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri649 – 700PHD-typeAdd BLAST52
Zinc fingeri1423 – 1470RING-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Transferase
Biological processDNA damage, DNA repair, Ubl conjugation pathway
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8866654 E3 ubiquitin ligases ubiquitinate target proteins

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase SHPRH (EC:2.3.2.27, EC:3.6.4.-)
Alternative name(s):
RING-type E3 ubiquitin transferase SHPRHCurated
SNF2, histone-linker, PHD and RING finger domain-containing helicase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Shprh
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917581 Shprh

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002849191 – 1674E3 ubiquitin-protein ligase SHPRHAdd BLAST1674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei259PhosphoserineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei626PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7TPQ3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7TPQ3

PeptideAtlas

More...
PeptideAtlasi
Q7TPQ3

PRoteomics IDEntifications database

More...
PRIDEi
Q7TPQ3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7TPQ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7TPQ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000090112 Expressed in 258 organ(s), highest expression level in dorsal pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7TPQ3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7TPQ3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with HLTF, PCNA, UBE2N and RAD18.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
234474, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q7TPQ3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000039422

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7TPQ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini302 – 384Helicase ATP-binding; first partPROSITE-ProRule annotationAdd BLAST83
Domaini433 – 507H15PROSITE-ProRule annotationAdd BLAST75
Domaini701 – 859Helicase ATP-binding; second partPROSITE-ProRule annotationAdd BLAST159
Domaini1505 – 1663Helicase C-terminalPROSITE-ProRule annotationAdd BLAST159

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi810 – 813DEAQ box4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING finger mediates E3 ubiquitin ligase activity.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri649 – 700PHD-typeAdd BLAST52
Zinc fingeri1423 – 1470RING-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0298 Eukaryota
COG0553 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111123

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7TPQ3

KEGG Orthology (KO)

More...
KOi
K15710

Identification of Orthologs from Complete Genome Data

More...
OMAi
KGKSQPF

Database of Orthologous Groups

More...
OrthoDBi
357670at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7TPQ3

TreeFam database of animal gene trees

More...
TreeFami
TF324273

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00073 H15, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
3.30.40.10, 2 hits
3.40.50.10810, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR005818 Histone_H1/H5_H15
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271 Helicase_C, 1 hit
PF00538 Linker_histone, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00526 H15, 1 hit
SM00490 HELICc, 1 hit
SM00249 PHD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 3 hits
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51504 H15, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7TPQ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSRRKRAPP MKVDEERQQQ LHWNMHEDLR SEPLTMTVGE QACSDADSSS
60 70 80 90 100
DCIIIDEGPP ESALHRDKKR RSETVSVLEA TEEETRLSVT LNVTVSPYRV
110 120 130 140 150
DNSWKAFLGD FALQLLPKES LVEHFSERTF TLSPSESSSQ FLIYVHSECK
160 170 180 190 200
NVEKQENVLE GSAGVCSKGI RVESSFSSDM LQDLAWLQKR RGIKLYQRPD
210 220 230 240 250
GTHTIKVGIY ILEAGLTRLD FMSDAGSRMK KFNQLMKRVM EKLHNFIIPD
260 270 280 290 300
VLEEEEEGSE SEPEGQDIDE LYHFVKQTHQ QETRSVQVDV QHPALIPVLR
310 320 330 340 350
PYQREAVNWM LQQEQFRSAP PADNSLHFLW REIVTPDGLK LYYNPYTGCI
360 370 380 390 400
IRDFPHAGPQ LLGGILADEM GLGKTVEVLA LILTHTRQDV KQDALTLPEG
410 420 430 440 450
KVVNYFIPTH CPREKVKNRE IQDTEYEPKE KVHCPPTRVM ILTAVKEMNG
460 470 480 490 500
KKGVSILSIY KYVSSIFRYD VQRNRGLLKR MLKCLIFEGL VKQIKGHGFS
510 520 530 540 550
GTFTLGKNYK EDVFDKTKKQ AVGSPRKIEK ELRKSVNKDA DSEYLPSNTS
560 570 580 590 600
DDDEPYYYYC KAGKSRSKLK KPALLTKKGK GQSVHLDSQG DAPAAGVCAS
610 620 630 640 650
TDVHVSENTC VSEDKQTQEA KDCAESPNPA AEELAQSNTS SPCETSDYRF
660 670 680 690 700
ECICGEFDQI GHKPRVQCLK CHLWQHAKCV NYEEKNLKVK PFYCPHCLVA
710 720 730 740 750
MEPVSTRATL IISPSSICHQ WVDEINRHVR SSSLRVLVYQ GVKKHGFLQP
760 770 780 790 800
HFLAEQDIVI ITYDVLRSEL NYVNIPHSNS EDGRRLRNQK RYMAIPSPLV
810 820 830 840 850
AVEWWRICLD EAQMVECPTV KAAEMAQRLS GINRWCISGT PVQRGLEDLF
860 870 880 890 900
GLVVFLGIEP YCVKHWWIRL LYHPYCKKNP QHLYSFIAKI MWRSAKKDVI
910 920 930 940 950
DQIQIPPQTE EMHWLHFSPV ERHFYHRQHE VCCQDAIVKL RKISDWALKL
960 970 980 990 1000
SSLDRRTVSS ILYPLLRLRQ ACCHPQAVRG EFLPLQKSTM TMEELLTSLQ
1010 1020 1030 1040 1050
KKCGTECEEA HRQLVCALNG LAGIHIIKGE YALAAELYRE VLRSSEEHKG
1060 1070 1080 1090 1100
KLKTDSLQRL HATHNLMELL GAKHPGIPPT LRDGRLEEEA KQLREHYMSK
1110 1120 1130 1140 1150
CNTEVAEAQQ ALQPVQQSIR ELQRKIHSNS PWWLNVIHRA MEFSVDEELV
1160 1170 1180 1190 1200
QRVRNEISSN YKQQTDKLSM SEKFRDCRGL QFLLTTQMEE LHKFQKLVRE
1210 1220 1230 1240 1250
AVKKLEKPPS REVIESATVC HLRPARLPLN CCVFCKADEL FTEYESKLFF
1260 1270 1280 1290 1300
NTVKGQTAIF EEMIEDEEGL VDDRVPTTTR GLWAVSETER SMKAILSFAR
1310 1320 1330 1340 1350
SHRFDVEYVD EGSVSMDLFE AWKKEYKLLH EYWMTLRNRV SAVDELAMAT
1360 1370 1380 1390 1400
ERLRVRHPKE PKPNPPVHHI IEPHEVEQNR IKLVNDKAVA TSQLQKKLGQ
1410 1420 1430 1440 1450
LLYLTNLEKS QDKTSGGINP EPCPICARQL GKQWAVLTCG HCFCNECTSI
1460 1470 1480 1490 1500
IIEQYSVGSH RSSIKCAICR QTTSHKEVSY VFTSEKANQE DDIPVKGSHS
1510 1520 1530 1540 1550
TKVEAVVRTL MKIQLRDPGA KALVFSTWQD VLDIISKALT DNNMEFTQIS
1560 1570 1580 1590 1600
RIKTFQENLS AFKYDPHINI LLLPLHTGSN GLTIIEATHV LLVEPILNPA
1610 1620 1630 1640 1650
HELQAIGRVH RIGQTKPTIV HRFLIKATIE ERMQAMLKTA ERSHTSSSGK
1660 1670
HSEASVLTVA GLADLFTKEN EELE
Length:1,674
Mass (Da):191,490
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2491B2F32F326393
GO
Isoform 2 (identifier: Q7TPQ3-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1617-1674: Missing.

Show »
Length:1,616
Mass (Da):185,068
Checksum:i64D639BE774E29B6
GO
Isoform 3 (identifier: Q7TPQ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1030-1031: EY → RR
     1032-1674: Missing.

Show »
Length:1,031
Mass (Da):118,054
Checksum:i08CB942E51F9AB41
GO
Isoform 4 (identifier: Q7TPQ3-5) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1617-1662: PTIVHRFLIK...EASVLTVAGL → SIRGLECLKTYRYTSTHDHTLSTYLVLLSI
     1663-1674: Missing.

Show »
Length:1,646
Mass (Da):188,535
Checksum:i02C9E8FD7E75B2E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7D4T4F7D4T4_MOUSE
E3 ubiquitin-protein ligase SHPRH
Shprh
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO26655 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti177S → G in BAC38428 (PubMed:16141072).Curated1
Sequence conflicti582Q → H in BAC38428 (PubMed:16141072).Curated1
Sequence conflicti928Q → R in BAC38428 (PubMed:16141072).Curated1
Sequence conflicti1285V → I in AAO26654 (PubMed:12837266).Curated1
Sequence conflicti1285V → I in AAO26655 (PubMed:12837266).Curated1
Sequence conflicti1285V → I in AAO26656 (PubMed:12837266).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0247661030 – 1031EY → RR in isoform 3. 1 Publication2
Alternative sequenceiVSP_0247671032 – 1674Missing in isoform 3. 1 PublicationAdd BLAST643
Alternative sequenceiVSP_0247681617 – 1674Missing in isoform 2. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_0247691617 – 1662PTIVH…TVAGL → SIRGLECLKTYRYTSTHDHT LSTYLVLLSI in isoform 4. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_0247701663 – 1674Missing in isoform 4. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY162264 mRNA Translation: AAO26654.1
AY162265 mRNA Translation: AAO26655.1 Sequence problems.
AY162266 mRNA Translation: AAO26656.1
AK053448 mRNA Translation: BAC35389.1
AK082160 mRNA Translation: BAC38428.1
BC006883 mRNA Translation: AAH06883.1
BC055003 mRNA Translation: AAH55003.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35838.1 [Q7TPQ3-1]
CCDS35839.1 [Q7TPQ3-2]
CCDS70003.1 [Q7TPQ3-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001071175.1, NM_001077707.1 [Q7TPQ3-1]
NP_001271283.1, NM_001284354.1 [Q7TPQ3-5]
NP_766525.3, NM_172937.3 [Q7TPQ3-2]
XP_006512803.1, XM_006512740.3 [Q7TPQ3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000044053; ENSMUSP00000039422; ENSMUSG00000090112 [Q7TPQ3-1]
ENSMUST00000054814; ENSMUSP00000125849; ENSMUSG00000090112 [Q7TPQ3-2]
ENSMUST00000159541; ENSMUSP00000132870; ENSMUSG00000090112 [Q7TPQ3-5]
ENSMUST00000159810; ENSMUSP00000125457; ENSMUSG00000090112 [Q7TPQ3-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
268281

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:268281

UCSC genome browser

More...
UCSCi
uc007ejp.1 mouse [Q7TPQ3-1]
uc033fop.1 mouse [Q7TPQ3-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY162264 mRNA Translation: AAO26654.1
AY162265 mRNA Translation: AAO26655.1 Sequence problems.
AY162266 mRNA Translation: AAO26656.1
AK053448 mRNA Translation: BAC35389.1
AK082160 mRNA Translation: BAC38428.1
BC006883 mRNA Translation: AAH06883.1
BC055003 mRNA Translation: AAH55003.1
CCDSiCCDS35838.1 [Q7TPQ3-1]
CCDS35839.1 [Q7TPQ3-2]
CCDS70003.1 [Q7TPQ3-5]
RefSeqiNP_001071175.1, NM_001077707.1 [Q7TPQ3-1]
NP_001271283.1, NM_001284354.1 [Q7TPQ3-5]
NP_766525.3, NM_172937.3 [Q7TPQ3-2]
XP_006512803.1, XM_006512740.3 [Q7TPQ3-1]

3D structure databases

SMRiQ7TPQ3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi234474, 4 interactors
IntActiQ7TPQ3, 1 interactor
STRINGi10090.ENSMUSP00000039422

PTM databases

iPTMnetiQ7TPQ3
PhosphoSitePlusiQ7TPQ3

Proteomic databases

EPDiQ7TPQ3
PaxDbiQ7TPQ3
PeptideAtlasiQ7TPQ3
PRIDEiQ7TPQ3

Genome annotation databases

EnsembliENSMUST00000044053; ENSMUSP00000039422; ENSMUSG00000090112 [Q7TPQ3-1]
ENSMUST00000054814; ENSMUSP00000125849; ENSMUSG00000090112 [Q7TPQ3-2]
ENSMUST00000159541; ENSMUSP00000132870; ENSMUSG00000090112 [Q7TPQ3-5]
ENSMUST00000159810; ENSMUSP00000125457; ENSMUSG00000090112 [Q7TPQ3-3]
GeneIDi268281
KEGGimmu:268281
UCSCiuc007ejp.1 mouse [Q7TPQ3-1]
uc033fop.1 mouse [Q7TPQ3-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
257218
MGIiMGI:1917581 Shprh

Phylogenomic databases

eggNOGiKOG0298 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00730000111123
InParanoidiQ7TPQ3
KOiK15710
OMAiKGKSQPF
OrthoDBi357670at2759
PhylomeDBiQ7TPQ3
TreeFamiTF324273

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-8866654 E3 ubiquitin ligases ubiquitinate target proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Shprh mouse

Protein Ontology

More...
PROi
PR:Q7TPQ3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000090112 Expressed in 258 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiQ7TPQ3 baseline and differential
GenevisibleiQ7TPQ3 MM

Family and domain databases

CDDicd00073 H15, 1 hit
Gene3Di1.10.10.10, 1 hit
3.30.40.10, 2 hits
3.40.50.10810, 2 hits
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR005818 Histone_H1/H5_H15
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00538 Linker_histone, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00526 H15, 1 hit
SM00490 HELICc, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 3 hits
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHPRH_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7TPQ3
Secondary accession number(s): Q7TQ27
, Q7TQ28, Q7TQ29, Q8BKE2, Q8BUW0, Q922Q3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2003
Last modified: October 16, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again